MEROXAPOL 108
Surfactant - Cleansing Agent; Surfactant - Emulsifying Agent; Surfactant - Solubilizing Agent
Also listed as
ETHYLENE GLYCOL-PROPYLENE GLYCOL BLOCK COPOLYMER; ETHYLENE OXIDE-PROPYLENE OXIDE BLOCK POLYMER; METHYLOXIRANE-OXIRANE BLOCK COPOLYMER; OXYETHYLENE-OXYPROPYLENE BLOCK COPOLYMER; POLYOXYETHYLENE-POLYOXYPROPYLENE BLOCK
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Other moderate concerns for this ingredient: Persistence and bioaccumulation, Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Neurotoxicity, Ecotoxicology, Data gaps |
About MEROXAPOL 108: Meroxapol 108 is the polyoxypropylene, polyoxyethylene block polymer that conformsgenerally to the formula: in which the average values of x, y and z are respectively 7, 91 and 7.
Allergies/immunotoxicity
| type of concern | product conditions | reference |
| Human immune system toxicant - strong evidence | products that may be aerosolized (airborne) | CHE Toxicant and Disease Database |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Persistent or bioaccumulative and moderate to high toxicity concern in humans | Environmental Canada Domestic Substance List | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Classified as expected to be toxic or harmful | Environmental Canada Domestic Substance List | |
| Classified as medium human health priority | Environmental Canada Domestic Substance List | |
| show more | ||
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at high doses | RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1984 |
Ecotoxicology
| type of concern | product conditions | reference |
| Suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 105 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| CHE Toxicant and Disease Database | POLYPROPYLENE | •Strong evidence in humans: respiratory system toxicity, immune system toxicity; Condition: asthma - allergic; Organs/tissues affected: lungs |
| FDA Everything Added to Food | ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER | • Fully up-to-date toxicology information has been sought. |
| Environmental Canada Domestic Substance List | OXIRANE, METHYL-, POLYMER WITH OXIRANE | •This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention. The chemical was flagged for suspected persistence and aquatic toxicity. |
| RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1984 | MEROXAPOL 108 | • gastrointestinal - Hypermotility, diarrhea (mouse LD50) • brain and nervous system - Somnolence (general depressed activity) (mouse LD50) |
| RTECS®- Microvascular Research 1974 | MEROXAPOL 108 | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- National Technical Information Service 8164 | MEROXAPOL 108 | • kidney or renal system - Changes in bladder weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) |
| RTECS®- Therapie 1959 | MEROXAPOL 108 | • broad systemic - Broad systemic toxicity (mouse LDLo) |
| RTECS®- Toxicology and Applied Pharmacology 1970 | MEROXAPOL 108 | • broad systemic - Broad systemic toxicity (rat LDLo) |
references
| government/industry list/academic study | reference |
| CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| RTECS®- Gigiena Truda i Professional'nye Zabolevaniya 1984 | RTECS®- Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI 28(12),56,1984 |
| RTECS®- Microvascular Research 1974 | RTECS®- Microvascular Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- -1968 8,320,1974 |
| RTECS®- National Technical Information Service 8164 | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. OTS0538164 |
| RTECS®- Therapie 1959 | RTECS®- Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- 14,721,1959 |
| RTECS®- Toxicology and Applied Pharmacology 1970 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 16,675,1970 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
All rights reserved.
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