PEG-4 DIMETHACRYLATE || Skin Deep: Cosmetic Safety Reviews

PEG-4 DIMETHACRYLATE

Not Reported; BINDING; FILM FORMING

SCORE

	9	high hazard to high hazard depending on product usage
	10	high hazard to high hazard depending on product usage
	62%	data gap
(why scores have changed)

Also listed as

POLYETHYLENE GLYCOL (4) DIMETHACRYLATE; POLYOXYETHYLENE (4) DIMETHACRYLATE; 2-PROPENOIC ACID, 2-METHYL-, OXYBIS (2,1-ETHANEDIYLOXY-2,1-ETHANEDIYL) ESTER; OXYBIS (2,1-ETHANEDIYLOXY-2,1-ETHANEDIYL) ESTER 2-PROPENOIC ACID, 2-METHYL-; 2-METHYL- OXYBIS (2,1-ETHANEDIYLOXY-2,1-ETHANEDIYL) ESTER 2-PROPENOIC ACID; 2PROPENOIC ACID, 2METHYL, OXYBIS (2,1ETHANEDIYLOXY2,1ETHANEDIYL) ESTER; 3,6,9-TRIOXAUNDECAMETHYLENE DIMETHACRYLATE; TETRAETHYLENE GLYCOL, DIMETHACRYLATE; 2-PROPENOIC ACID, 2-METHYL-, OXYBIS (2,1-ETHANEDIYLOXY-2,1-ETHANEDIYL) ESTER; SR 209; TE EGDMA

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - ETHYLENE OXIDE, 1,4-DIOXANE
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Irritation (skin, eyes, or lungs)

About PEG-4 DIMETHACRYLATE: PEG-4 Dimethacrylate is the organic compound that conforms generally to the formula: where n has an average value of 4.

Allergies/immunotoxicity

type of concern	product conditions	reference
Known human immune system toxicant		National Library of Medicine HazMap
Human Product must include directions to avoid skin contact because of sensitizing potential of methacrylates: restriction established by industry safety panel (Cosmetic Ingredient Review, CIR) toxicant - strong evidence		Cosmetic Ingredient Review Assessments

Violations, restrictions & warnings

type of concern	product conditions	reference
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	Cosmetic Ingredient Review Assessments
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Avoid skin contact	products for use on skin	Cosmetic Ingredient Review Assessments
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		Cosmetic Ingredient Review Assessments
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Cancer

type of concern	product conditions	reference
One or more in vitro tests on mammalian cells show positive mutation results		RTECS^®- Mutagenesis 1989

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Limited evidence of sense organ toxicity

Harvell, J, 1994

Irritation (skin, eyes, or lungs)

type of concern	product conditions	reference
One or more animal studies show skin irritation at moderate doses		RTECS^®- Journal of Toxicology and Environmental Health 1986

Data gaps

type of concern	product conditions	reference
10 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Food Additive Status

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	PEG-4 DIMETHACRYLATE	•Safe for use in cosmetics with some qualifications •Avoid skin contact •Product must include directions to avoid skin contact because of sensitizing potential of methacrylates: restriction established by industry safety panel (Cosmetic Ingredient Review, CIR) •Product type restrictions or differences noted in safety assessment by industry panel •
Environmental Canada Domestic Substance List	2-PROPENOIC ACID, 2-METHYL-, OXYBIS(2,1-ETHANEDIYLOXY-2,1-ETHANEDIYL) ESTER	•This chemical was NOT flagged by CEPA for further attention.
National Library of Medicine HazMap	TETRAETHYLENE GLYCOL DIMETHACRYLATE	•Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes;
FDA Food Additive Status	POLYETHYLENE GLYCOL	• Food additive: boiler compound • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • In boiler water -173.310 • Food additive: antifoaming (or defoaming) agent • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Comp of defoaming agent -173.340 • CTG • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Ctg on fresh citrus fruits -172.210
FDA Food Additive Status	POLYETHYLENE GLYCOL	• miscellaneous • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Ctg • binder • plasticizing agent • and/or lubricant in tablets used for food • Adjuvant in nonnutritive sweeteners • vitamin and mineral preparations • Ctg for sodium nitrite to inhibit hygroscopic properties - CFR172.820 • ZERO - In milk - CFR172.820; 526.820
Cosmetic Ingredient Review Assessments	PEG-6	•Safe for use in cosmetics with some qualifications •Not safe for use on injured or damaged skin •May contain harmful impurities
CIR	PEG-6	•Ethylene oxide
Harvell, J, 1994	POLYETHYLENE GLYCOL	•Skin or sense organ toxicity hazards: suspected
RTECS^®- Journal of Toxicology and Environmental Health 1986	PEG-4 DIMETHACRYLATE	• skin - Primary skin irritant (rabbit )
RTECS^®- Journal of Toxicology and Environmental Health 1986	PEG-4 DIMETHACRYLATE	• skin - Primary skin irritant (rabbit )
RTECS^®- Mutagenesis 1989	PEG-4 DIMETHACRYLATE	• mutagenic - Positive mutation assay: Cytogenetic Analysis (mouse lym) • mutagenic - Positive mutation assay: Micronucleus test (mouse lym)
RTECS^®- Mutagenesis 1989	PEG-4 DIMETHACRYLATE	• mutagenic - Positive mutation assay: Cytogenetic Analysis (mouse lym) • mutagenic - Positive mutation assay: Micronucleus test (mouse lym)

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
National Library of Medicine HazMap	NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Impurities - Open Scientific Literature	CIR
Scorecard.org Toxicity Information	Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
RTECS^®- Journal of Toxicology and Environmental Health 1986	RTECS^®- Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- 19,149,1986
RTECS^®- Journal of Toxicology and Environmental Health 1986	RTECS^®- Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 19,149,1986
RTECS^®- Mutagenesis 1989	RTECS^®- Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- 4,381,1989
RTECS^®- Mutagenesis 1989	RTECS^®- Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 4,381,1989

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