PEG-75 PROPYLENE GLYCOL STEARATE || Skin Deep: Cosmetic Safety Reviews

PEG-75 PROPYLENE GLYCOL STEARATE

Surfactant - Cleansing Agent; Surfactant - Solubilizing Agent; EMULSIFYING

SCORE

	4	moderate hazard to moderate hazard depending on product usage
	6
	75%	data gap
(why scores have changed)

Also listed as

POLYETHYLENE GLYCOL 4000 PROPYLENE GLYCOL MONOSTEARATE; POLYOXYETHYLENE (75) PROPYLENE GLYCOL MONOSTEARATE

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns - ETHYLENE OXIDE, 1,4-DIOXANE
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Data gaps

About PEG-75 PROPYLENE GLYCOL STEARATE: PEG-75 Propylene Glycol Stearate is the polyethylene glycol ester of Propylene GlycolStearate (q.v.). where n has an average value of 75.

Violations, restrictions & warnings

type of concern	product conditions	reference
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	Cosmetic Ingredient Review Assessments
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Organ system toxicity (non-reproductive)

type of concern	product conditions	reference
Limited evidence of sense organ toxicity		Harvell, J, 1994

Data gaps

type of concern	product conditions	reference
Safety assessment was based on related chemical		Cosmetic Ingredient Review Assessments

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Food Additive Status

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	PEG-75 PROPYLENE GLYCOL STEARATE	•Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Determined safe for use in cosmetics based on concentrations of surrogate, related chemical in cosmetics, by industry safety panel (Cosmetic Ingredient Review, CIR) •May contain harmful impurities
FDA Food Additive Status	POLYETHYLENE GLYCOL	• Food additive: boiler compound • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • In boiler water -173.310 • Food additive: antifoaming (or defoaming) agent • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Comp of defoaming agent -173.340 • CTG • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Ctg on fresh citrus fruits -172.210
FDA Food Additive Status	POLYETHYLENE GLYCOL	• miscellaneous • Food additive: food additive for which a petition has been filed and a regulation issued • Food additive: must be in accordance with good manufacturing practices, or sufficient for purpose; or in quantity not greater than required • Ctg • binder • plasticizing agent • and/or lubricant in tablets used for food • Adjuvant in nonnutritive sweeteners • vitamin and mineral preparations • Ctg for sodium nitrite to inhibit hygroscopic properties - CFR172.820 • ZERO - In milk - CFR172.820; 526.820
Cosmetic Ingredient Review Assessments	PEG-6	•Safe for use in cosmetics with some qualifications •Not safe for use on injured or damaged skin •May contain harmful impurities
CIR	PEG-6	•Ethylene oxide
Harvell, J, 1994	POLYETHYLENE GLYCOL	•Skin or sense organ toxicity hazards: suspected

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Impurities - Open Scientific Literature	CIR
Scorecard.org Toxicity Information	Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).

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