PPG-40 BUTYL ETHER || Skin Deep: Cosmetic Safety Reviews

PPG-40 BUTYL ETHER

Hair Conditioning Agent; Skin-Conditioning Agent - Miscellaneous

SCORE

	1	low hazard
	71%	data gap
(why scores have changed)

Also listed as

POLYOXYPROPYLENE (40) BUTYL ETHER; POLYPROPYLENE GLYCOL (40) BUTYL ETHER; PPG BUTYL ETHER 1715

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Neurotoxicity, Irritation (skin, eyes, or lungs), Data gaps
	See products containing PPG-40 BUTYL ETHER

About PPG-40 BUTYL ETHER: PPG-40 Butyl Ether is the polypropylene glycol ether of butyl alcohol that conforms generallyto the formula: where n has an average value of 40.

PPG-40 BUTYL ETHER has reported used in the following product types: hair spray (3); styling gel/lotion (2); conditioner (2)

Neurotoxicity

type of concern

product conditions

reference

One or more animal studies show brain and nervous system effects at moderate doses

RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show broad systemic effects at low doses

RTECS^®- Journal of Agricultural and Food Chemistry 1959

One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Journal of Agricultural and Food Chemistry 1959
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Agricultural Research Service, USDA Information Memorandum 1966
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Special Publication of the Entomological Society of America 1978
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951
One or more animal studies show kidney or renal system effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951
One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- Journal of Agricultural and Food Chemistry 1959
One or more animal studies show respiratory effects at high doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951
One or more animal studies show blood effects at high doses (low dose studies may be unavailable for this ingredient)		RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951
Classified as not expected to be potentially toxic or harmful		Environmental Canada Domestic Substance List

Violations, restrictions & warnings

type of concern	product conditions	reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		Cosmetic Ingredient Review Assessments

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

One or more animal studies show skin irritation at moderate doses

RTECS^®- Union Carbide Data Sheet 1970

Data gaps

type of concern	product conditions	reference
Safety assessment was based on related chemical		Cosmetic Ingredient Review Assessments

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Cosmetic Ingredient Review Assessments	PPG-40 BUTYL ETHER	•Safe for use in cosmetics with some qualifications •Safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) is based on safety or product use data for a different, related ingredient
Environmental Canada Domestic Substance List	POLY[OXY(METHYL-1,2-ETHANEDIYL)], _-BUTYL-_-HYDROXY-	•This chemical was NOT flagged by CEPA for further attention.
IFRA Fragrance Ingredient List	POLY[OXY(METHYL-1,2-ETHANEDIYL)], .ALPHA;.-BUTYL-.OMEGA;.-HYDROXY-	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	PPG-40 BUTYL ETHER	• sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit )
RTECS^®- Agricultural Research Service, USDA Information Memorandum 1966	PPG-40 BUTYL ETHER	• broad systemic - Broad systemic toxicity (rat LD50)
RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951	PPG-40 BUTYL ETHER	• blood - Hemorrhage (guinea pig LD50) • kidney or renal system - Changes in bladder weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) • respiratory - Chronic pulmonary edema (rabbit LD50) • brain and nervous system - Convulsions or effect on seizure threshold (rat LD50) • skin - Dermatitis, allergic (rabbit LD50) • gastrointestinal - Gastritis (rabbit LD50) • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit ) • brain and nervous system - Somnolence (general depressed activity) (rat LD50) • brain and nervous system - Tremor (rat LD50) • gastrointestinal - Ulceration or bleeding from stomach (guinea pig LD50)
RTECS^®- Journal of Agricultural and Food Chemistry 1959	PPG-40 BUTYL ETHER	• broad systemic - Broad systemic toxicity (rabbit LD50)
RTECS^®- Special Publication of the Entomological Society of America 1978	PPG-40 BUTYL ETHER	• broad systemic - Broad systemic toxicity (rabbit LD50)
RTECS^®- Union Carbide Data Sheet 1970	PPG-40 BUTYL ETHER	• skin - Primary skin irritant (rabbit )
RTECS^®- Union Carbide Data Sheet 1968	PPG-40 BUTYL ETHER	• skin - Primary skin irritant (rabbit )

references

government/industry list/academic study	reference
Cosmetic Ingredient Review Assessments	CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986	RTECS^®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,1404,1986
RTECS^®- Agricultural Research Service, USDA Information Memorandum 1966	RTECS^®- Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) 20,6,1966
RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine 1951	RTECS^®- AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. 4,261,1951
RTECS^®- Journal of Agricultural and Food Chemistry 1959	RTECS^®- Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- 7,763,1959
RTECS^®- Special Publication of the Entomological Society of America 1978	RTECS^®- Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) 78-1,53,1978
RTECS^®- Union Carbide Data Sheet 1970	RTECS^®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 3/13/1970
RTECS^®- Union Carbide Data Sheet 1968	RTECS^®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 5/23/1968

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