PROPANEDIOL
Solvent; Viscosity Decreasing Agent; VISCOSITY CONTROLLING
Also listed as
1,3-DIHYDROXYPROPANE; 1,3-PROPYLENE GLYCOL; 1,3PROPANEDIOL; PROPANE-1,3-DIOL; 1,3-DIHYDROXYPROPANE; 1,3-PROPYLENE GLYCOL; 2- (HYDROXYMETHYL) ETHANOL; 2-DEOXYGLYCEROL; BETA-PROPYLENE GLYCOL; NSC 65426; PG
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
 | Other strong concerns for this ingredient: Irritation (skin, eyes, or lungs) |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive), Data gaps |
|
See products containing PROPANEDIOL | |
About PROPANEDIOL: Propanediol is the organic compound.
PROPANEDIOL has reported used in the following product types: facial moisturizer/treatment (4); antiperspirant/deodorant (2); sunless tanning (1); mask (1); exfoliant/scrub (1); toners/astringents (1); anti-aging (1); moisturizer (1); hand cream (1); facial cleanser (1)
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- Chemico-Biological Interactions 1984 |
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| Classified as skin irritant | National Library of Medicine HazMap | |
| show more | ||
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain and nervous system effects at high doses | RTECS®- Journal of Pharmacology and Experimental Therapeutics 1941 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 15,154 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be persistent | Environmental Canada Domestic Substance List | |
| show more | ||
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environmental Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Environmental Canada Domestic Substance List | 1,3-PROPANEDIOL | •This chemical was NOT flagged by CEPA for further attention. |
| National Library of Medicine HazMap | PROPYLENE GLYCOL | •Skin Sensitizer - An agent that can induce an allergic reaction in the skin or lungs: Yes; •Lacrimator - A substance that irritates the eyes and induces the flow of tears: Yes; |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 | PROPANEDIOL | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Chemico-Biological Interactions 1984 | PROPANEDIOL | • mutagenic - Positive mutation assay: DNA Damage (rat orl) |
| RTECS®- Chemico-Biological Interactions 1984 | PROPANEDIOL | • mutagenic - Positive mutation assay: DNA Damage (rat orl) |
| RTECS®- Contact Dermatitis 1985 | PROPANEDIOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Contact Dermatitis 1970 | PROPANEDIOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Contact Dermatitis 1990 | PROPANEDIOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Contact Dermatitis 1985 | PROPANEDIOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Contact Dermatitis 1970 | PROPANEDIOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Contact Dermatitis 1990 | PROPANEDIOL | • skin - Primary skin irritant ( human ) |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1941 | PROPANEDIOL | • brain and nervous system - Somnolence (general depressed activity) (rabbit LDLo) |
| RTECS®- National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program 1986 | PROPANEDIOL | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- Toxicology and Applied Pharmacology 1979 | PROPANEDIOL | • broad systemic - Broad systemic toxicity (mouse LD50) |
references
| government/industry list/academic study | reference |
| Environmental Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,157,1984 |
| RTECS®- Chemico-Biological Interactions 1984 | RTECS®- Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- 50,87,1984 |
| RTECS®- Chemico-Biological Interactions 1984 | RTECS®- Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 50,87,1984 |
| RTECS®- Contact Dermatitis 1985 | RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- 13,310,1985 |
| RTECS®- Contact Dermatitis 1970 | RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- 55,190,1970 |
| RTECS®- Contact Dermatitis 1990 | RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- 95,711,1990 |
| RTECS®- Contact Dermatitis 1985 | RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 13,310,1985 |
| RTECS®- Contact Dermatitis 1970 | RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 55,190,1970 |
| RTECS®- Contact Dermatitis 1990 | RTECS®- Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 95,711,1990 |
| RTECS®- Journal of Pharmacology and Experimental Therapeutics 1941 | RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 72,227,1941 |
| RTECS®- National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program 1986 | RTECS®- National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) JAN1986 |
| RTECS®- Toxicology and Applied Pharmacology 1979 | RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 49,385,1979 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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