PROPYLENE GLYCOL PROPYL ETHER || Skin Deep: Cosmetic Safety Reviews

PROPYLENE GLYCOL PROPYL ETHER

Solvent

SCORE

	1	low hazard
	86%	data gap
(why scores have changed)

Also listed as

2-PROPANOL, 1-PROPOXY-; PROPOXYPROPANOL; 1-PROPOXYPROPAN-2-OL; PROPYLENE GLYCOL MONOPROPYL ETHER; 1,2-PROPYLENE GLYCOL 1-PROPYL ETHER; 1-PROPOXY- 2-PROPANOL; 1-PROPOXY-2-PROPANOL; 1-PROPOXY-2-PROPANOL; 2PROPANOL, 1PROPOXY; 1-PROPOXY-2-PROPANOL; N-PROPOXYPROPANOL (MIXED ISOMERS) ; PROPASOL P

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Neurotoxicity, Irritation (skin, eyes, or lungs), Data gaps

About PROPYLENE GLYCOL PROPYL ETHER: Propylene Glycol Propyl Ether is the propylene glycol ether of n-propanol that conforms to theformula:

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show sense organ effects at very low doses

products for use around the eyes, mouth, or lips

RTECS^®- Union Carbide Data Sheet 1970

Neurotoxicity

type of concern	product conditions	reference
One or more animal studies show brain and nervous system effects at high doses		RTECS^®- Veterinary and Human Toxicology 1988

Irritation (skin, eyes, or lungs)

type of concern

product conditions

reference

One or more animal studies show skin irritation at moderate doses

RTECS^®- Union Carbide Data Sheet 1967

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
1 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be bioaccumulative

Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
Environmental Canada Domestic Substance List	2-PROPANOL, 1-PROPOXY-	•This chemical was NOT flagged by CEPA for further attention.
IFRA Fragrance Ingredient List	1-PROPOXYPROPAN-2-OL	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
RTECS^®- "Patty's Industrial Hygiene and Toxicology," 3rd rev 1982	PROPYLENE GLYCOL PROPYL ETHER	• broad systemic - Broad systemic toxicity (rabbit LD50)
RTECS^®- Union Carbide Data Sheet 1970	PROPYLENE GLYCOL PROPYL ETHER	• sense organ - Primary eye irritant (rabbit )
RTECS^®- Union Carbide Data Sheet 1967	PROPYLENE GLYCOL PROPYL ETHER	• skin - Primary skin irritant (rabbit )
RTECS^®- Veterinary and Human Toxicology 1988	PROPYLENE GLYCOL PROPYL ETHER	• sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit )
RTECS^®- Veterinary and Human Toxicology 1988	PROPYLENE GLYCOL PROPYL ETHER	• brain and nervous system - Altered sleep time (including change in righting reflex) (rat LD50) • brain and nervous system - Ataxia (rat LD50) • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit )

references

government/industry list/academic study	reference
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS^®- "Patty's Industrial Hygiene and Toxicology," 3rd rev 1982	RTECS^®- "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. 2C,3983,1982
RTECS^®- Union Carbide Data Sheet 1970	RTECS^®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 12/15/1970
RTECS^®- Union Carbide Data Sheet 1967	RTECS^®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 4/25/1967
RTECS^®- Veterinary and Human Toxicology 1988	RTECS^®- Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 30,126,1988
RTECS^®- Veterinary and Human Toxicology 1988	RTECS^®- Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- 30,126,1988

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