PROPYLENE GLYCOL t-BUTYL ETHER || Skin Deep: Cosmetic Safety Reviews

PROPYLENE GLYCOL t-BUTYL ETHER

SOLVENT

SCORE

	3	moderate hazard
	79%	data gap
(why scores have changed)

Also listed as

PROPANOL, TERT-BUTOXY- (8CI)

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other strong concerns for this ingredient: Irritation (skin, eyes, or lungs)
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Data gaps, Occupational hazards

Cancer

type of concern

product conditions

reference

Cancer - strong evidence

Proposition 65 List of Carcinogens

Possible human carcinogen

California EPA Proposition 65

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Limited evidence of eye toxicity

products for use around the eyes

European Union - Classification & Labelling

Irritation (skin, eyes, or lungs)

type of concern	product conditions	reference
Classified as irritant		European Union - Classification & Labelling

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
3 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Miscellaneous

type of concern	product conditions	reference
Occupational hazards related to handling		European Union - Classification & Labelling

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be persistent

Environmental Canada Domestic Substance List

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
European Union - Classification & Labelling	1-TERT-BUTOXYPROPAN-2-OL	•Flammable •Irritant (eyes, skin, or lungs) •Risk of serious damage to eyes
Environmental Canada Domestic Substance List	2-PROPANOL, 1-(1,1-DIMETHYLETHOXY)-	•This chemical was NOT flagged by CEPA for further attention.
Int'l Agency for Research on Cancer (IARC) - Carcinogens	1-TERT-BUTOXYPROPAN-2-OL	•IARC Group 3 (no cancer link)
California EPA Proposition 65	PROPYLENE GLYCOL MONO-T-BUTYL ETHER	•Carcinogen: California Proposition 65
Proposition 65 List of Carcinogens	PROPYLENE GLYCOL BUTYL ETHER	•Cancer hazards: recognized

references

government/industry list/academic study	reference
European Union - Classification & Labelling	CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
Int'l Agency for Research on Cancer (IARC) - Carcinogens	IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
California EPA Proposition 65	California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
Scorecard.org Toxicity Information	Proposition 65 List of Carcinogens (July 2004) can be obtained from http://www.oehha.ca.gov/prop65/prop65_list/Newlist.html.

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