BIS(2-METHOXYETHYL) PHTHALATE || Skin Deep: Cosmetic Safety Reviews

BIS(2-METHOXYETHYL) PHTHALATE

SCORE

	5	moderate hazard to moderate hazard depending on product usage
	6
	73%	data gap
(why scores have changed)

Also listed as

1,2-BENZENEDICARBOXYLIC ACID, BIS (2-METHOXYETHYL) ESTER (9CI) ; 2-METHOXYETHYL PHTHALATE; BIS (METHOXYETHYL) PHTHALATE; DI (2-METHOXYETHYL) PHTHALATE; DI- (2-METHOXYETHYL) ESTER KYSELINY FTALOVE (CZECH) ; DIMETHOXY ETHYL PHTHALATE; DMEP; KESSCOFLEX MCP; PHTHALIC ACID, BIS (2-METHOXYETHYL) ESTER

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Other moderate concerns for this ingredient: Organ system toxicity (non-reproductive)
	Lesser or emerging concerns for this ingredient: Irritation (skin, eyes, or lungs), Data gaps

Violations, restrictions & warnings

type of concern	product conditions	reference
Violation of government restrictions - Banned or found unsafe for use in cosmetics		European Union - Banned or Restricted in Cosmetics

Developmental/reproductive toxicity

type of concern	product conditions	reference
Possible human reproductive or developmental toxin		Environmental Canada Domestic Substance List
Limited evidence of reproductive toxicity		European Union - Classification & Labelling

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

Classified as a high human health priority

Environmental Canada Domestic Substance List

Cancer

type of concern

product conditions

reference

One or more in vitro tests on mammalian cells show positive mutation results

RTECS^®- Toxicology and Applied Pharmacology 1974

Irritation (skin, eyes, or lungs)

type of concern	product conditions	reference
One or more animal studies show skin irritation at moderate doses		RTECS^®- Kodak Company Reports 2511

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
18 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Persistence and bioaccumulation

type of concern

product conditions

reference

Not suspected to be bioaccumulative

Environmental Canada Domestic Substance List

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environmental Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
European Union - Classification & Labelling	BIS(2-METHOXYETHYL) PHTHALATE	•May be toxic to the reproductive system •May cause harm to the unborn child •Limited evidence of reproductive toxicity •Possible risk of impaired fertility
Environmental Canada Domestic Substance List	1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHOXYETHYL) ESTER	•This chemical was deemed a high human health priority even though it did not meet the strict criteria of the categorization exercise of CEPA. The chemical was flagged for developmental and reproductive concerns.
European Union - Banned or Restricted in Cosmetics	BIS(2-METHOXYETHYL) PHTHALATE	•Prohibited in EU cosmetics: must not form part of the composition of cosmetic products
RTECS^®- Archives of Toxicology 1983	BIS(2-METHOXYETHYL) PHTHALATE	• mutagenic - Positive mutation assay: sperm (rat orl)
RTECS^®- Kodak Company Reports 2511	BIS(2-METHOXYETHYL) PHTHALATE	• sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (guinea pig )
RTECS^®- Toxicology and Applied Pharmacology 1974	BIS(2-METHOXYETHYL) PHTHALATE	• mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse ipr)

references

government/industry list/academic study	reference
European Union - Classification & Labelling	CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
Environmental Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Union - Banned or Restricted in Cosmetics	EC (European Commission of the European Union). 1999-2006. Enterprise Directorate-General Pharmaceuticals and Cosmetics. The rules governing cosmetic products in the European Union, Volume 1, "Cosmetics legislation."
RTECS^®- Archives of Toxicology 1983	RTECS^®- Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 53,71,1983
RTECS^®- Kodak Company Reports 2511	RTECS^®- Kodak Company Reports. (343 State St., Rochester, NY 14650) #902511
RTECS^®- Toxicology and Applied Pharmacology 1974	RTECS^®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 29,35,1974

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