

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: ACTIVE INGREDIENTS: SODIUM FLUORIDE (0.15% W/V FLUORIDE ION). INACTIVE INGREDIENTS: SORBITOL, WATER, HYDRATED SILICA, TRISODIUM PHOSPHATE, SODIUM LAURYL SULFATE, FLAVOR, SODIUM PHOSPHATE, XANTHAN GUM, CARBOMER 956, SODIUM SACCHARIN, TITANIUM DIOXIDE, BLUE 1.
Directions from packaging: Adults and children 2 yrs. and older: Brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist or physician. Do not swallow. Children under 6 yrs: To minimize swallowing use a pea-sized amount and supervise brushing until good habits are established. Children under 2 yrs: Ask a dentist or physician.
Warnings from packaging: Keep out of the reach of children under 6 years of age.
| score | data gap | concerns | |
| SODIUM FLUORIDE (Active Ingredient) | 9 | 63% | Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes |
| FLAVOR | 4 | 100% | Miscellaneous |
| TITANIUM DIOXIDE (NON-NANO) | 1 | 82% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes |
| SODIUM LAURYL SULFATE | 2 | 68% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| FD&C BLUE 1 | 1 | 83% | none identified |
| HYDRATED SILICA | 2 | 79% | Persistence and bioaccumulation |
| SODIUM SACCHARIN | 2 | 78% | Neurotoxicity |
| SODIUM PHOSPHATE | 1 | 89% | none identified |
| SORBITOL | 1 | 88% | none identified |
| TRISODIUM PHOSPHATE | 1 | 88% | none identified |
| CARBOMER 956 | 0 | 100% | none identified |
| XANTHAN GUM | 0 | 94% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests non-mammalian cells show positive mutation results | TRISODIUM PHOSPHATE | |
| One or more in vitro tests on mammalian cells show positive mutation results | TITANIUM DIOXIDE (NON-NANO), SORBITOL, SODIUM SACCHARIN, SODIUM LAURYL SULFATE | |
| One or more animal studies show tumor formation at low doses | SODIUM FLUORIDE | |
| Cancer - not classifiable/not likely to be human carcinogen | HYDRATED SILICA, FD&C BLUE 1 |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | SODIUM SACCHARIN, SODIUM LAURYL SULFATE | |
| Human nervous system toxicant - moderate evidence | SODIUM FLUORIDE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | SODIUM LAURYL SULFATE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | SODIUM FLUORIDE |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | FD&C BLUE 1 | |
| One or more animal studies show brain and nervous system effects at moderate doses | SODIUM LAURYL SULFATE | |
| One or more animal studies show brain and nervous system effects at very low doses | SODIUM SACCHARIN | |
| Strong evidence of human neurotoxicity | SODIUM FLUORIDE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | SODIUM SACCHARIN, SODIUM LAURYL SULFATE | |
| One or more studies show endocrine system disruption at low doses | SODIUM FLUORIDE |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show immune effects at low doses | TITANIUM DIOXIDE (NON-NANO) |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Persistent, bioaccumulative in wildlife and humans | HYDRATED SILICA |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient) | SORBITOL, SODIUM SACCHARIN | |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | FD&C BLUE 1 | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | TRISODIUM PHOSPHATE, SODIUM PHOSPHATE | |
| One or more animal studies show broad systemic effects at low doses | SODIUM LAURYL SULFATE | |
| One or more animal studies show gastrointestinal effects at very low doses | SODIUM FLUORIDE, TITANIUM DIOXIDE (NON-NANO) |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | SODIUM FLUORIDE | |
| Ingredient not fully labeled - identity unknown | FLAVOR |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | TITANIUM DIOXIDE (NON-NANO), SORBITOL, SODIUM SACCHARIN, SODIUM PHOSPHATE, SODIUM LAURYL SULFATE, SODIUM FLUORIDE, FD&C BLUE 1 | |
| Used in food or as an additive with limited or no toxicity information available | SODIUM FLUORIDE | |
| Designated as safe for general or specific, limited use in food | TRISODIUM PHOSPHATE, XANTHAN GUM |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at very low doses | SODIUM LAURYL SULFATE | |
| One or more animal studies show skin irritation at moderate doses | TITANIUM DIOXIDE (NON-NANO) |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not assessed for safety in cosmetics by industry panel | CARBOMER 956, SODIUM PHOSPHATE, SODIUM SACCHARIN, SORBITOL, TITANIUM DIOXIDE (NON-NANO), TRISODIUM PHOSPHATE, XANTHAN GUM, FLAVOR, HYDRATED SILICA |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to very low doses | SODIUM FLUORIDE | |
| Allowed workplace exposures restricted to low doses | TITANIUM DIOXIDE (NON-NANO) |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood | SODIUM FLUORIDE, TITANIUM DIOXIDE (NON-NANO) | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | SODIUM LAURYL SULFATE |
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