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Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: Ultra-Purified Water Aqua, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Glycol Stearate, Mentha Piperita Leaf Extract Peppermint, Ocimum Basilicum Extract Basil, Polygala Senega Root Extract, Nasturtium Officinale Extract Watercress, Salva Officinalis Leaf Extract Sage, Thymus Vulgaris Extract Thyme, Rosmarinus Officinalis Leaf Extract Rosemary, Citrus Grandis Seed Extract Grapefruit, Actinidia Chinensis Fruit Extract Kiwi, Mentha Piperita Oil Peppermint, Citrus Aurantifolia Oil Lime, Mentha Viridis Leaf Oil Spearmint, Cocos Nucifera Oil Coconut, Allantoin, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Hydrolyzed Wheat Starch, Wheat Amino Acids, Amodimethicone, Butylene Glycol, PEG-12 Dimethicone, Polyquaternium-10, Polyquaternium-59, Glycerin, Citric Acid, Polysorbate 20, Fragrance Parfum, Eugenia Caryophyllus Flower Oil Clove, Citrus Aurantium Dulcis Oil Orange, Citrus Grandis Seed Oil Grapefruit, Cymbopogon Schoenanthus Oil, Benzyl Salicylate, Citronellol, Coumarin, Hydroxycitronellal, Limonene, Linalool, Alpha-Isomethyl Ionone, Methylparaben, Propylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Yellow 5 CI 19140, Yellow 6 CI 15985, Caramel, Ultra-Purified Water Aqua, Stearyl Alcohol, Amodimethicone, Cetyl Alcohol, Stearamidopropyl Dimethylamine, Benzyl Alcohol, Mentha Piperita Leaf Extract Peppermint, Ocimum Basilicum Extract Basil, Polygala Senega Root Extract, Nasturtium Officinale Extract Watercress, Salva Officinalis Leaf Extract Sage, Thymus Vulgaris Extract Thyme, Rosmarinus Officinalis Leaf Extract Rosemary, Citrus Grandis Seed Extract Grapefruit, Chamomilla Recutita Extract Matricaria, Symphytum Officinale Leaf Extract, Citrus Aurantium Dulcis Oil Orange, Mentha Piperita Oil Peppermint, Citrus Aurantifolia Oil Lime, Mentha Viridis Leaf Oil Spearmint, Allantoin, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Lactic Acid, Ceteareth-20, Polyquaternium-37, Polyquaternium-59, Butylene Glycol, Propylene Glycol, Dicaprylate/Dicaprate, PPG-1 Trideceth-6, Fragrance Parfum, Eucalyptus Globulus Leaf Oil, Cymbopogon Schoenanthus Oil, Citrus Aurantium Bergamia Fruit Oil Bergamot, Citronellol, Coumarin, Hydroxycitronellal, Limonene, Linalool, Alpha-Isomethyl Ionone, Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isobutylparaben, Phenoxyethanol, Ultra-Purified Water Aqua, Hydrogen Peroxide, Cetearyl Alcohol, Amodimethicone, Cetrimonium Chloride, Trideceth-12, Ceteareth-60, Ceteareth-23, Acrylates/Steareth-20 Itaconate Copolymer, Pentasodium Pentetate, Methylparaben, Phosphoric Acid, Sodium Stannate, Ultra-Purified Water Aqua, Propylene Glycol, Laureth-1, Isostearic Acid, Glyceryl Stearate SE, Ammonium Hydroxide, Ethanolamine, Cocamidopropyl Betaine, Ammonium Lauryl Sulfate, Steartrimonium Chloride, Polyquaternium-10, Polyquaternium-28, Hydrolyzed Wheat Protein, Hydrolyzed Collagen, Erythorbic Acid, Sodium Sulfite, Tetrasodium EDTA, P-Phenylenediamine, Resorcinol, P-Aminophenol, 2-Methylresorcinol, 0-Aminophenol, Hydroquinone
Directions from packaging: Read all instructions carefully before use.Allow 14 days after relaxer or permanent wave before applying permanent hair color.
Warnings from packaging: Do not apply if you damaged, irritated or itchy scalp.Important:Hair color use may cause allergic reaction, which in rare cases, can be serious.It is important to find out your sensitivity to hair coloring.Follow enclosed instructions carefully.Wait 48 hours without washing the area.If you do not show any abnormalities of the skin - redness, rashes, proceed with the use of Cream of Nature.If you show a reaction, wash thoroughly with water and do not use this product.Keep out of reach of children.This product contains ingredients which may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made.This product must not be used for dyeing eyelashes or eyebrows.To do so may cause blindness.
| score | data gap | concerns | |
| RESORCINOL | 8 | 55% | Cancer, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| HYDROQUINONE | 10 | 52% | Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| P-PHENYLENEDIAMINE | 10 | 52% | Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| CETEARETH-20 | 5 | 71% | Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |
| CETEARETH-60 | 5 | 71% | Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| CETEARETH-23 | 5 | 71% | Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| ETHANOLAMINE | 7 | 63% | Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| O-AMINOPHENOL 0-AMINOPHENOL | 8 | 57% | Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards |
| P-AMINOPHENOL | 8 | 57% | Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards |
| FRAGRANCE | 8 | 100% | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |
| HYDROGEN PEROXIDE | 3 | 65% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| METHYLPARABEN | 8 | 65% | Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| BENZYL ALCOHOL | 6 | 64% | Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards |
| PROPYLENE GLYCOL | 4 | 58% | Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| SODIUM LAURETH SULFATE | 4 | 85% | Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |
| PEG-12 DIMETHICONE | 4 | 75% | Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| CYMBOPOGON SCHOENANTHUS OIL | 4 | 71% | Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| METHYLCHLOROISOTHIAZOLINONE | 6 | 63% | Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| METHYLISOTHIAZOLINONE | 6 | 63% | Violations, restrictions & warnings, Allergies/immunotoxicity |
| HYDROXYCITRONELLAL | 5 | 62% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| LIMONENE | 6 | 56% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| COUMARIN | 6 | 50% | Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| BUTYLPARABEN | 5 | 79% | Developmental/reproductive toxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes |
| LACTIC ACID | 4 | 72% | Violations, restrictions & warnings, Irritation (skin, eyes, or lungs) |
| LINALOOL | 5 | 65% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| COCAMIDOPROPYL BETAINE | 5 | 63% | Allergies/immunotoxicity, Contamination concerns (NITROSAMINES) |
| EUGENIA CARYOPHYLLUS (CLOVE) EUGENIA CARYOPHYLLUS FLOWER OIL CLOVE | 5 | 63% | Violations, restrictions & warnings, Allergies/immunotoxicity |
| LAURETH-1 | 4 | 95% | Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| PROPYLPARABEN | 4 | 82% | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| TOCOPHERYL ACETATE | 4 | 81% | Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE) |
| TETRASODIUM EDTA | 1 | 80% | Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards |
| CITRIC ACID | 4 | 72% | Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive) |
| BENZYL SALICYLATE | 4 | 70% | Allergies/immunotoxicity |
| FD&C YELLOW 6 YELLOW 6 CI 15985 | 1 | 70% | none identified |
| PHENOXYETHANOL | 4 | 66% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards |
| CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT CITRUS GRANDIS SEED EXTRACT GRAPEFRUIT | 3 | 100% | Multiple, additive exposure sources, Contamination concerns (BENZETHONIUM CHLORIDE, METHYLPARABEN, TRICLOSAN) |
| SODIUM SULFITE | 3 | 84% | Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| ISOBUTYLPARABEN | 3 | 83% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| FD&C YELLOW 5 YELLOW 5 CI 19140 | 2 | 82% | Neurotoxicity, Organ system toxicity (non-reproductive) |
| ETHYLPARABEN | 3 | 80% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| AMMONIUM HYDROXIDE | 1 | 78% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| CITRONELLOL | 3 | 75% | Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| AMMONIUM LAURYL SULFATE | 1 | 73% | Irritation (skin, eyes, or lungs) |
| CETRIMONIUM CHLORIDE | 3 | 71% | Allergies/immunotoxicity |
| MENTHA PIPERITA (PEPPERMINT) OIL MENTHA PIPERITA OIL PEPPERMINT | 3 | 71% | Enhanced skin absorption, Contamination concerns (LIMONENE, MENTHOL, MENTHONE) |
| QUATERNIUM-10 STEARTRIMONIUM CHLORIDE | 3 | 70% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| 2-METHYLRESORCINOL | 2 | 84% | Allergies/immunotoxicity |
| PHOSPHORIC ACID | 2 | 80% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| ALPHA-ISOMETHYL IONONE | 2 | 78% | Allergies/immunotoxicity |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| CITRUS AURANTIFOLIA (LIME) OIL CITRUS AURANTIFOLIA OIL LIME | 2 | 73% | Violations, restrictions & warnings |
| CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL CITRUS AURANTIUM BERGAMIA FRUIT OIL BERGAMOT | 2 | 73% | Violations, restrictions & warnings |
| OCIMUM BASILICUM (SWEET BASIL) EXTRACT OCIMUM BASILICUM EXTRACT BASIL | 1 | 100% | Multiple, additive exposure sources |
| THYMUS VULGARIS (COMMON THYME) EXTRACT THYMUS VULGARIS EXTRACT THYME | 1 | 100% | Multiple, additive exposure sources |
| HYDROLYZED WHEAT PROTEIN | 1 | 95% | Allergies/immunotoxicity |
| SALVIA OFFICINALIS (SAGE) LEAF EXTRACT SALVA OFFICINALIS LEAF EXTRACT SAGE | 1 | 95% | none identified |
| SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT SYMPHYTUM OFFICINALE LEAF EXTRACT | 1 | 95% | Organ system toxicity (non-reproductive) |
| POLYQUATERNIUM-37 | 0 | 94% | none identified |
| STEARAMIDOPROPYL DIMETHYLAMINE | 0 | 94% | none identified |
| CETEARYL ALCOHOL | 0 | 93% | none identified |
| ISOSTEARIC ACID | 0 | 93% | none identified |
| CARAMEL | 1 | 92% | none identified |
| COCOS NUCIFERA (COCONUT) OIL COCOS NUCIFERA OIL COCONUT | 1 | 89% | none identified |
| HYDROLYZED COLLAGEN | 0 | 88% | none identified |
| SODIUM STANNATE | 1 | 88% | Occupational hazards |
| TRIDECETH-12 | 1 | 88% | none identified |
| CETYL ALCOHOL | 1 | 87% | Irritation (skin, eyes, or lungs) |
| ERYTHORBIC ACID | 1 | 87% | none identified |
| GLYCOL STEARATE | 1 | 87% | none identified |
| EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL EUCALYPTUS GLOBULUS LEAF OIL | 1 | 86% | Irritation (skin, eyes, or lungs) |
| STEARYL ALCOHOL | 1 | 84% | Irritation (skin, eyes, or lungs) |
| POLYSORBATE-20 | 1 | 81% | none identified |
| MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT CHAMOMILLA RECUTITA EXTRACT MATRICARIA | 1 | 80% | Enhanced skin absorption |
| BUTYLENE GLYCOL | 1 | 79% | Irritation (skin, eyes, or lungs) |
| MENTHA PIPERITA (PEPPERMINT) LEAF EXTRACT MENTHA PIPERITA LEAF EXTRACT PEPPERMINT | 1 | 75% | Enhanced skin absorption |
| PENTASODIUM PENTETATE | 0 | 74% | none identified |
| ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE | 1 | 72% | none identified |
| ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER | 0 | 100% | none identified |
| ACTINIDIA CHINENSIS (KIWI) EXTRACT ACTINIDIA CHINENSIS FRUIT EXTRACT KIWI | 0 | 100% | none identified |
| CITRUS ARANTIUM DULCIS OIL CITRUS AURANTIUM DULCIS OIL ORANGE | 0 | 100% | none identified |
| DICAPRYLATE/ DICAPRATE | 0 | 100% | none identified |
| HYDROLYZED WHEAT STARCH | 0 | 100% | none identified |
| MENTHA SPICATA (SPEARMINT) LEAF OIL MENTHA VIRIDIS LEAF OIL SPEARMINT | 0 | 100% | none identified |
| NASTURTIUM OFFICINALE (WATERCRESS) EXTRACT NASTURTIUM OFFICINALE EXTRACT WATERCRESS | 0 | 100% | none identified |
| POLYGALA SENEGA (SENEGA SNAKE) ROOT EXTRACT POLYGALA SENEGA ROOT EXTRACT | 0 | 100% | none identified |
| POLYQUATERNIUM-28 | 0 | 100% | none identified |
| POLYQUATERNIUM-59 | 0 | 100% | none identified |
| PPG-1 TRIDECETH-6 | 0 | 100% | none identified |
| ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT ROSMARINUS OFFICINALIS LEAF EXTRACT ROSEMARY | 0 | 100% | none identified |
| WHEAT AMINO ACIDS | 0 | 100% | none identified |
| CITRUS GRANDIS (GRAPEFRUIT) SEED OIL CITRUS GRANDIS SEED OIL GRAPEFRUIT | 0 | 100% | none identified |
| AMODIMETHICONE | 0 | 99% | none identified |
| ALLANTOIN | 0 | 94% | none identified |
| GLYCERYL STEARATE SE | 0 | 93% | none identified |
| POLYQUATERNIUM-10 | 0 | 93% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests on mammalian cells show positive mutation results | ETHANOLAMINE | |
| One or more animal studies show tumor formation at high doses | STEARYL ALCOHOL | |
| One or more in vitro tests non-mammalian cells show positive mutation results | PHENOXYETHANOL, METHYLCHLOROISOTHIAZOLINONE, MENTHA PIPERITA (PEPPERMINT) OIL, LINALOOL, CITRUS AURANTIFOLIA (LIME) OIL, AMMONIUM HYDROXIDE | |
| One or more in vitro tests on mammalian cells show positive mutation results | TOCOPHERYL ACETATE, SODIUM SULFITE, PROPYLPARABEN, SALVIA OFFICINALIS (SAGE) LEAF EXTRACT, PROPYLENE GLYCOL, METHYLPARABEN, LAURETH-1, GLYCERIN, FD&C YELLOW 5, ETHYLPARABEN, ERYTHORBIC ACID, CETRIMONIUM CHLORIDE, CARAMEL, BUTYLPARABEN, BENZYL ALCOHOL | |
| Cancer - not classifiable/not likely to be human carcinogen | LACTIC ACID | |
| Mutagen - limited evidence | P-AMINOPHENOL, O-AMINOPHENOL | |
| Cancer - not classifiable/not likely to be human carcinogen | EUGENIA CARYOPHYLLUS (CLOVE), RESORCINOL, P-PHENYLENEDIAMINE, HYDROGEN PEROXIDE, FD&C YELLOW 6, LIMONENE, COUMARIN | |
| Limited evidence of carcinogenicity | HYDROQUINONE |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | POLYSORBATE-20, FD&C YELLOW 5, ETHYLPARABEN, ETHANOLAMINE, COUMARIN, BUTYLENE GLYCOL, BENZYL ALCOHOL | |
| One or more animal studies show reproductive effects at moderate doses | PROPYLENE GLYCOL | |
| One or more animal studies show developmental effects at high doses | LIMONENE | |
| One or more animal studies show reproductive effects at moderate doses | P-AMINOPHENOL, O-AMINOPHENOL, GLYCERIN, | |
| One or more animal studies show any effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) GEL | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN | |
| One or more animal studies show any effects at very low doses | BUTYLPARABEN | |
| Human nervous system toxicant - moderate evidence | P-PHENYLENEDIAMINE, HYDROQUINONE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | CETEARETH-23, PEG-12 DIMETHICONE, PROPYLENE GLYCOL, QUATERNIUM-10, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, MENTHA PIPERITA (PEPPERMINT) OIL, MENTHA PIPERITA (PEPPERMINT) LEAF EXTRACT, LACTIC ACID, COCAMIDOPROPYL BETAINE, HYDROQUINONE, ETHANOLAMINE, CETEARETH-20, CETEARETH-60, CETRIMONIUM CHLORIDE, P-PHENYLENEDIAMINE, RESORCINOL, ALOE BARBADENSIS (ALOE VERA) GEL, AMMONIUM LAURYL SULFATE, BENZYL ALCOHOL, HYDROQUINONE, O-AMINOPHENOL, P-AMINOPHENOL | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | P-PHENYLENEDIAMINE, P-AMINOPHENOL, HYDROXYCITRONELLAL, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, EUGENIA CARYOPHYLLUS (CLOVE), O-AMINOPHENOL, BENZYL ALCOHOL, CITRUS AURANTIFOLIA (LIME) OIL, LINALOOL | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, P-PHENYLENEDIAMINE | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limits, according to industry safety panel (International Fragrance Association) | LIMONENE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | CITRIC ACID, HYDROQUINONE, LACTIC ACID, RESORCINOL, PHENOXYETHANOL, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE | |
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Safe for brief discontinuous use followed by thorough rinsing | products that are intended to be left on the skin | HYDROQUINONE, ETHANOLAMINE |
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits | LACTIC ACID | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests on mammalian cells demonstrate neurotoxicity | METHYLISOTHIAZOLINONE | |
| One or more animal studies show brain and nervous system effects at high doses | PROPYLENE GLYCOL, LACTIC ACID, GLYCERIN, FD&C YELLOW 6, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, BUTYLENE GLYCOL | |
| One or more animal studies show brain and nervous system effects at moderate doses | CETEARETH-23, RESORCINOL, QUATERNIUM-10, PHOSPHORIC ACID, PHENOXYETHANOL, P-AMINOPHENOL, METHYLPARABEN, O-AMINOPHENOL, MENTHA PIPERITA (PEPPERMINT) OIL, LINALOOL, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, COUMARIN, ETHANOLAMINE, CETEARETH-20, CETEARETH-60, CITRONELLOL | |
| One or more animal studies show brain and nervous system effects at very low doses | FD&C YELLOW 5, HYDROGEN PEROXIDE | |
| One or more animal studies show brain and nervous system effects at low doses | SODIUM SULFITE | |
| One or more animal studies show brain and nervous system effects at very low doses | CITRIC ACID | |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
| Strong evidence of human neurotoxicity | HYDROQUINONE, P-PHENYLENEDIAMINE, BENZYL ALCOHOL |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | PROPYLENE GLYCOL, POLYSORBATE-20, PHENOXYETHANOL, P-PHENYLENEDIAMINE, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, GLYCERIN, HYDROGEN PEROXIDE, HYDROQUINONE, FD&C YELLOW 6, ETHANOLAMINE, COUMARIN, BUTYLENE GLYCOL, BENZYL ALCOHOL | |
| One or more studies show weak endocrine disruption | METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN | |
| One or more animal studies show endocrine disruption at moderate doses | ISOBUTYLPARABEN | |
| Limited evidence of any disruption | PROPYLPARABEN, RESORCINOL |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | PHOSPHORIC ACID, AMMONIUM HYDROXIDE, LIMONENE, ETHANOLAMINE, HYDROGEN PEROXIDE | |
| Prohibited for use in food | COUMARIN | |
| Ingredient not fully labeled - identity unknown | FRAGRANCE |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Wildlife and environmental toxicity | RESORCINOL, P-PHENYLENEDIAMINE, P-AMINOPHENOL, HYDROQUINONE, LIMONENE, AMMONIUM HYDROXIDE, PROPYLPARABEN |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| No workplace limits set | LACTIC ACID | |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN | |
| Allowed workplace exposures restricted to low doses | SODIUM STANNATE, PHOSPHORIC ACID, HYDROQUINONE, | |
| Allowed workplace exposures restricted to low doses | TETRASODIUM EDTA, RESORCINOL, PHENOXYETHANOL, P-AMINOPHENOL, O-AMINOPHENOL, HYDROGEN PEROXIDE, ETHANOLAMINE, BENZYL ALCOHOL | |
| Allowed workplace exposures restricted to very low doses | P-PHENYLENEDIAMINE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Interferes with gene expresion | METHYLPARABEN | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | PROPYLENE GLYCOL, HYDROGEN PEROXIDE, GLYCERIN | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | P-AMINOPHENOL | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CITRIC ACID | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | COUMARIN | |
| Interferes with gene expresion | BUTYLPARABEN |
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