KINERASE INTENSIVE EYE CREAM
last updated: 05/01/06 brand: Kinerase by Valeant Pharmaceuticals International
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29% of anti-agings have lower concerns
29% of around-eye creams have lower concerns
COMPANY POLICIES
Compact for Safe Cosmetics
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Animal Testing Policy |
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
 | Cancer |
 | Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: PURIFIED WATER, GLYCERYL, STEARATE AND LAURETH-23, ISOSTEARIC ACID, CETYL ALCOHOL, CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL, SOYA STEROL, STEARYL ALCOHOL, DIMETHICONE, IMIDAZOLIDINYL UREA, CITRIC ACID, SODIUM HYDROXIDE, METHYLPARABEN, SOLUBLE COLLAGEN, CARBOMER, N6-FURFURYLADENINE, PANTHENOL, PROPYLPARABEN, TRIETHANOLAMINE, ASCORBIC ACID, HYDROLYZED ELASTIN, AND ALOE BARBADENSIS LEAF JUICE.
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ingredients
| score | data gap | concerns | |
| METHYLPARABEN | 8 | 65% | Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| TRIETHANOLAMINE | 6 | 58% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards |
| LAURETH-23 | 5 | 81% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| IMIDAZOLIDINYL UREA | 5 | 70% | Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE) |
| PROPYLPARABEN | 4 | 82% | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| CITRIC ACID | 4 | 72% | Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive) |
| SODIUM HYDROXIDE | 3 | 77% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| DIMETHICONE | 2 | 74% | Violations, restrictions & warnings |
| PANTHENOL | 2 | 88% | Multiple, additive exposure sources |
| GLYCERIN GLYCERYL | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| ISOSTEARIC ACID | 0 | 93% | none identified |
| ASCORBIC ACID (VITAMIN C) | 1 | 91% | none identified |
| N6-FURFURYLADENINE | 1 | 88% | Organ system toxicity (non-reproductive) |
| CETYL ALCOHOL | 1 | 87% | Irritation (skin, eyes, or lungs) |
| CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL | 1 | 84% | none identified |
| STEARYL ALCOHOL | 1 | 84% | Irritation (skin, eyes, or lungs) |
| ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE | 1 | 72% | none identified |
| GLYCINE SOJA (SOYBEAN) STEROLS SOYA STEROL | 0 | 100% | none identified |
| SOLUBLE COLLAGEN | 0 | 100% | none identified |
| STEARATE | 0 | 100% | none identified |
| HYDROLYZED ELASTIN | 0 | 94% | none identified |
| CARBOMER | 0 | 93% | none identified |
| WATER (PURIFIED) | 0 | 0% | innocuous |
Cancer*
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show tumor formation at high doses | STEARYL ALCOHOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL | |
| One or more in vitro tests non-mammalian cells show positive mutation results | LAURETH-23 | |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM HYDROXIDE, PROPYLPARABEN, N6-FURFURYLADENINE, METHYLPARABEN, GLYCERIN, ASCORBIC ACID (VITAMIN C) | |
| Cancer - not classifiable/not likely to be human carcinogen | TRIETHANOLAMINE |
Developmental/reproductive toxicity*
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN, | |
| One or more animal studies show any effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) GEL | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN |
Violations, restrictions & warnings*
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | TRIETHANOLAMINE, ALOE BARBADENSIS (ALOE VERA) GEL | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | DIMETHICONE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | CITRIC ACID | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN |
Neurotoxicity*
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | GLYCERIN | |
| One or more animal studies show brain and nervous system effects at moderate doses | METHYLPARABEN | |
| One or more animal studies show brain and nervous system effects at low doses | LAURETH-23 | |
| One or more animal studies show brain and nervous system effects at very low doses | SODIUM HYDROXIDE, CITRIC ACID |
Endocrine disruption*
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | TRIETHANOLAMINE, LAURETH-23, GLYCERIN | |
| One or more studies show weak endocrine disruption | METHYLPARABEN | |
| Limited evidence of any disruption | PROPYLPARABEN |
Allergies/immunotoxicity*
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human skin toxicant - strong evidence | PROPYLPARABEN, METHYLPARABEN | |
| Known human immune system toxicant | TRIETHANOLAMINE, IMIDAZOLIDINYL UREA |
Organ system toxicity (non-reproductive)*
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient) | IMIDAZOLIDINYL UREA, PANTHENOL | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | STEARYL ALCOHOL, CETYL ALCOHOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | ALOE BARBADENSIS (ALOE VERA) GEL | |
| Limited evidence of sense organ toxicity | PROPYLPARABEN | |
| One or more animal studies show blood effects at low doses | N6-FURFURYLADENINE | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | LAURETH-23 |
| One or more animal studies show metabolic effects at very low doses | SODIUM HYDROXIDE, GLYCERIN, CITRIC ACID | |
| Possible human immune system toxicant | TRIETHANOLAMINE | |
| Known human any toxicant | METHYLPARABEN |
Multiple, additive exposure sources*
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | TRIETHANOLAMINE, STEARYL ALCOHOL, SODIUM HYDROXIDE, PROPYLPARABEN, METHYLPARABEN, LAURETH-23, GLYCERIN, DIMETHICONE, CITRIC ACID, CETYL ALCOHOL, ASCORBIC ACID (VITAMIN C), ALOE BARBADENSIS (ALOE VERA) GEL | |
| Used in food or as an additive with limited or no toxicity information available | PANTHENOL |
Ecotoxicology*
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Wildlife and environmental toxicity | PROPYLPARABEN |
Irritation (skin, eyes, or lungs)*
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN, CITRIC ACID, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL | |
| One or more animal studies show skin irritation at low doses | METHYLPARABEN | |
| One or more animal studies show skin irritation at very low doses | TRIETHANOLAMINE, SODIUM HYDROXIDE, CETYL ALCOHOL | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | STEARYL ALCOHOL, LAURETH-23 |
Data gaps*
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | ASCORBIC ACID (VITAMIN C), LAURETH-23 | |
| Missing safety data noted by cosmetic industry review | ALOE BARBADENSIS (ALOE VERA) GEL, ISOSTEARIC ACID | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | STEARYL ALCOHOL, PROPYLPARABEN, PANTHENOL, METHYLPARABEN, LAURETH-23, ISOSTEARIC ACID, IMIDAZOLIDINYL UREA, DIMETHICONE, CETYL ALCOHOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, CARBOMER, ASCORBIC ACID (VITAMIN C) | |
| Not assessed for safety in cosmetics by industry panel | STEARATE, SOLUBLE COLLAGEN, SODIUM HYDROXIDE, N6-FURFURYLADENINE, HYDROLYZED ELASTIN, GLYCINE SOJA (SOYBEAN) STEROLS, GLYCERIN, CITRIC ACID |
Occupational hazards*
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | TRIETHANOLAMINE | |
| No workplace limits set | SODIUM HYDROXIDE | |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN |
Biochemical or cellular level changes*
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Interferes with gene expresion | METHYLPARABEN | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | LAURETH-23 | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CITRIC ACID, GLYCERIN |
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