COLGATE 12 HOUR MULTI PROTECTION TOTAL TOOTHPASTE (2006 FORMULATION)
last updated: 05/01/06 brand: Colgate by Colgate-Palmolive Company
COMPANY POLICIES
Compact for Safe Cosmetics
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Animal Testing Policy |
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Restrictions & warnings |
| Allergies/immunotoxicity |
| Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: ACTIVE INGREDIENTS: SODIUM FLUORIDE 0.24% (0.14% W/V FLUORIDE ION); TRICLOSAN 0.30%. INACTIVE INGREDIENTS: WATER; HYDRATED SILICA; GLYCERIN; SORBITOL; PVM/MA COPOLYMER; SODIUM LAURYL SULFATE; CELLULOSE GUM; FLAVOR; SODIUM HYDROXIDE; PROPYLENE GLYCOL; CARRAGEENAN; SODIUM SACCHARIN; TITANIUM DIOXIDE .
Directions from packaging: + Adults and children 6 years of age and older: Brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or a physician. + Instruct children under 12 years of age in good brushing and rinsing habits (to minimize swallowing). Supervise children as necessary until capable of using without supervision. + Children under 6 years of age: Do not use unless directed by a dentist or a physician.
Warnings from packaging: Keep out of the reach of children under 6 years of age. If you accidentally swallow more than used for brushing, seek professional assistance or contact a Poison Control Center immediately.
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ingredients
| score | data gap | concerns | |
| SODIUM FLUORIDE (Active Ingredient) | 9 | 63% | Cancer, Developmental/reproductive toxicity, Restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes |
| TRICLOSAN (Active Ingredient) | 7 | 67% | Restrictions & warnings, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (CHLOROFORM, DIOXIN) |
| FLAVOR | 4 | 100% | Miscellaneous |
| PROPYLENE GLYCOL | 4 | 60% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| TITANIUM DIOXIDE | 0 | 83% | Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes |
| SODIUM HYDROXIDE | 3 | 77% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| CARRAGEENAN | 2 | 75% | Organ system toxicity (non-reproductive), Contamination concerns (DEGRADED CARRAGEENAN), Biochemical or cellular level changes |
| SODIUM LAURYL SULFATE | 3 | 68% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| SODIUM SACCHARIN | 2 | 80% | Multiple, additive exposure sources |
| HYDRATED SILICA | 2 | 79% | Persistence and bioaccumulation |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| PVM/ MA COPOLYMER | 1 | 93% | Irritation (skin, eyes, or lungs) |
| SORBITOL | 1 | 88% | None Identified |
| CELLULOSE GUM | 1 | 80% | None Identified |
| WATER | 0 | 0% | Innocuous |
Cancer*
*Listed below are cancer concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show tumor formation at high doses | CELLULOSE GUM | |
| One or more in vitro tests non-mammalian cells show positive mutation results | TRICLOSAN | |
| One or more in vitro tests on mammalian cells show positive mutation results | TITANIUM DIOXIDE, SORBITOL, SODIUM LAURYL SULFATE, SODIUM HYDROXIDE, PROPYLENE GLYCOL, GLYCERIN | |
| One or more animal studies show tumor formation at low doses | SODIUM FLUORIDE | |
| Not likely to be carcinogenic in humans | CARRAGEENAN | |
| Cancer - not classifiable/not likely to be human carcinogen | HYDRATED SILICA, SODIUM SACCHARIN |
Developmental/reproductive toxicity*
*Listed below are developmental/reproductive toxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | TRICLOSAN | |
| One or more animal studies show reproductive effects at moderate doses | PROPYLENE GLYCOL | |
| One or more animal studies show reproductive effects at high doses | SODIUM LAURYL SULFATE, SODIUM SACCHARIN | |
| Human nervous system toxicant - moderate evidence | SODIUM FLUORIDE | |
| One or more animal studies show reproductive effects at moderate doses | CELLULOSE GUM, GLYCERIN |
Restrictions & warnings*
*Listed below are restrictions & warnings concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | SODIUM LAURYL SULFATE, PROPYLENE GLYCOL | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | TRICLOSAN, SODIUM FLUORIDE, TRICLOSAN |
Neurotoxicity*
*Listed below are neurotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain, nervous system, or behavioral effect effects at high doses | SODIUM SACCHARIN, PROPYLENE GLYCOL, GLYCERIN | |
| One or more animal studies show brain, nervous system, or behavioral effects at moderate doses | SODIUM LAURYL SULFATE, CARRAGEENAN | |
| One or more animal studies show brain, nervous system, or behavioral effects at very low doses | SODIUM HYDROXIDE | |
| Strong evidence of human neurotoxicity | SODIUM FLUORIDE |
Endocrine disruption*
*Listed below are endocrine disruption concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | SODIUM LAURYL SULFATE, GLYCERIN | |
| One or more studies show endocrine disruption at very low doses | TRICLOSAN | |
| One or more studies show endocrine system disruption at low doses | SODIUM FLUORIDE |
Allergies/immunotoxicity*
*Listed below are allergies/immunotoxicity concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL |
Persistence and bioaccumulation*
*Listed below are persistence and bioaccumulation concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be bioaccumulative | TITANIUM DIOXIDE | |
| Not suspected to be persistent | SODIUM LAURYL SULFATE | |
| Not suspected to be bioaccumulative | SODIUM HYDROXIDE | |
| Persistent, bioaccumulative in wildlife | TRICLOSAN | |
| Persistent, bioaccumulative in wildlife and humans | HYDRATED SILICA |
Organ system toxicity (non-reproductive)*
*Listed below are organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient) | SORBITOL, SODIUM SACCHARIN, CELLULOSE GUM | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | PROPYLENE GLYCOL |
| One or more animal studies show broad systemic effects at low doses | TRICLOSAN, SODIUM LAURYL SULFATE | |
| One or more animal studies show metabolic effects at very low doses | SODIUM HYDROXIDE, GLYCERIN, SODIUM FLUORIDE, TITANIUM DIOXIDE, CARRAGEENAN |
Miscellaneous*
*Listed below are miscellaneous concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | SODIUM HYDROXIDE, SODIUM FLUORIDE | |
| Ingredient not fully labeled - identity unknown | FLAVOR |
Multiple, additive exposure sources*
*Listed below are multiple, additive exposure sources concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | TITANIUM DIOXIDE, SORBITOL, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, SODIUM HYDROXIDE, PROPYLENE GLYCOL, SODIUM FLUORIDE, GLYCERIN, CARRAGEENAN, CELLULOSE GUM | |
| Used in food or as an additive with limited or no toxicity information available | SODIUM SACCHARIN, SODIUM FLUORIDE |
Ecotoxicology*
*Listed below are ecotoxicology concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin | SODIUM LAURYL SULFATE | |
| Not suspected to be an environmental toxin | TITANIUM DIOXIDE, SODIUM HYDROXIDE | |
| Wildlife and environmental toxicity | TRICLOSAN |
Irritation (skin, eyes, or lungs)*
*Listed below are irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN, TITANIUM DIOXIDE | |
| One or more animal studies show skin irritation at low doses | PVM/ MA COPOLYMER | |
| One or more animal studies show skin irritation at very low doses | SODIUM LAURYL SULFATE, SODIUM HYDROXIDE | |
| Classified as skin irritant | PROPYLENE GLYCOL, TRICLOSAN |
Data gaps*
*Listed below are data gaps concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | CELLULOSE GUM | |
| Not assessed for safety in cosmetics by industry panel | SORBITOL, TITANIUM DIOXIDE, TRICLOSAN, FLAVOR, HYDRATED SILICA, SODIUM SACCHARIN, SODIUM HYDROXIDE, CARRAGEENAN, GLYCERIN, PVM/ MA COPOLYMER |
Occupational hazards*
*Listed below are occupational hazards concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to very low doses | SODIUM FLUORIDE | |
| Allowed workplace exposures restricted to low doses | TITANIUM DIOXIDE | |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN | |
| No workplace limits set | SODIUM HYDROXIDE |
Biochemical or cellular level changes*
*Listed below are biochemical or cellular level changes concerns for the ingredients used by this manufacturer, drawn from Skin Deep data sources. Some concerns may be specific to how a product is used or formulated; product scores reflect those variances.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood | CARRAGEENAN, SODIUM FLUORIDE, TITANIUM DIOXIDE | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | SODIUM LAURYL SULFATE | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CELLULOSE GUM, GLYCERIN, PROPYLENE GLYCOL |
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