L'Oréal Couleur Experte Multi-Tonal Color System, Permanent Color, Ginger Twist/Warmer 6.4 || Skin Deep: Cosmetic Safety Reviews

L'ORéAL COULEUR EXPERTE MULTI-TONAL COLOR SYSTEM, PERMANENT COLOR, GINGER TWIST/WARMER 6.4

last updated: 02/01/08 brand: L'Oréal by L'Oréal

SCORE

high hazard (out of 10)

78%

data gap

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72% of hair color and bleachings have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Multi-Tonal Gel Creme Color Base: Aqua/Water, Deceth-3, Laureth-12, Oleth-30, Deceth-5, Trideceth-2 Carboxamide Mea, Ammonium Hydroxide, Glycerin, Oleic Acid, Hexadimethrine Chloride, Oleyl Alcohol, Polyquaternium-6, Parfum/ Fragrance, P-Aminophenol, Ethanolamine, Ammonium Thiolactate, Resorcinol, Limonene, P-Phenylenediamine, Ascorbic Acid, EDTA, Polyquaternium-24, Linalool, 4-Amino-2-Hydroxytoluene, 6-Hydroxyindole, M-Aminophenol, O-Aminophenol, Geraniol, Citronellol. Micro-Fine Illuminating Powder: Potassium Persulfate, Sodium Silicate, Sodium Persulfate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Urea, Kaolin, Magnesium Stearate, Ammonium Chloride, Diethylhexyl Sodium Sulfosuccinate, VP/VA Copolymer, Polydecene, Sodium Metasilicate, Magnesium Peroxide, EDTA, CI 77891/Titanium Dioxide, Cyamopsis Tetragonoloba/Guar Gum, Sodium Carboxymethyl Starch, Sodium Benzoate. Multi-Tonal Creme Developer: Aqua/Water, Hydrogen Peroxide, Cetearyl Alcohol, Trideceth-2 Carboxamide MEA, Ceteareth-30, Glycerin, Pentasodium Pentetate, Sodium Stannate, Tetrasodium Pyrophosphate. Multi-Moisture Creme Conditioner: Aqua/Water, Cetearyl Alcohol, Behentrimonium Chloride, Candelilla Cera/Candelilla Wax, Amodimethicone, Cetyl Esters, Isopropyl Alcohol, Parfum/Fragrance, Methylparaben, Trideceth-12, Prunus Armeniaca/Apricot Kernel Oil, Butylphenyl Methylpropional, Chlorhexidine Dihydrochloride, Cetrimonium Chloride, Linalool, Limonene, Geraniol, Amyl Cinnamal, Hexyl Cinnamal.

Directions from packaging: Read and follow directions. Store between 50 and 80 degrees F.

Warnings from packaging: Haircolor can cause an allergic reaction which, in certain rare cases, can be serious, Therefore, you must follow these precautions: Do not use if: you have already had a reaction to a haircolor or hair lightening product; you have a sensitive, itchy or damaged scalp. Perform a skin allergy test 48 hours before each use of this product (see insert). Remember to buy your product 2 days ahead of time. Avoid contact of this product with eyes and skin. If product gets into eyes, rinse immediately. Wear gloves provided in kit. Thoroughly rinse hair after application. Do not use on compound henna or progressive color. Do not inhale or ingest. Keep product out of the reach of children. Do not apply on children. This product contains ingredients which may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dyeing the eyelashes or eyebrows. To do so may cause blindness. This product contains persulfates and other ingredients which may cause serious irritant, respiratory and/or allergenic reactions. Prepare and use only in a well-ventilated area. Enclosed insert contains important health and safety information.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
P-PHENYLENEDIAMINE	10	52%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
RESORCINOL	10	52%	Cancer, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
O-AMINOPHENOL	8	57%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
P-AMINOPHENOL	8	57%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-30	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ETHANOLAMINE	7	66%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
POTASSIUM PERSULFATE	6	66%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
SODIUM PERSULFATE	6	69%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
HYDROGEN PEROXIDE	3	65%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
M-AMINOPHENOL	6	65%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Occupational hazards
LILIAL BUTYLPHENYL METHYLPROPIONAL	5	64%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
AMYLCINNAMALDEHYDE	6	61%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
GERANIOL	6	61%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
LIMONENE	6	56%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
CHLORHEXIDINE DIHYDROCHLORIDE	4	73%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
4-AMINO-2-HYDROXYTOLUENE	5	67%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
CITRONELLOL	4	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LINALOOL	5	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
OLETH-30	3	87%	Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TITANIUM DIOXIDE (NON-NANO) CI 77891/TITANIUM DIOXIDE	1	81%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
ISOPROPYL ALCOHOL	4	72%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
6-HYDROXYINDOLE	3	67%	Cancer, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
UREA	4	67%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption
HEXYL CINNAMAL	4	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
SODIUM METASILICATE	4	64%	Developmental/reproductive toxicity, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LAURETH-12	3	100%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
CYAMOPSIS TETRAGONOLOBA (GUAR) GUM	1	79%	none identified
EDTA	3	78%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
AMMONIUM CHLORIDE	3	77%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
CETRIMONIUM CHLORIDE	3	71%	Allergies/immunotoxicity
SODIUM SILICATE	3	70%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
POLYQUATERNIUM-6	2	87%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
OLEIC ACID	1	82%	Irritation (skin, eyes, or lungs)
TETRASODIUM PYROPHOSPHATE	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
AMMONIUM HYDROXIDE	2	81%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
DIOCTYL SODIUM SULFOSUCCINATE DIETHYLHEXYL SODIUM SULFOSUCCINATE	2	81%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
KAOLIN	1	79%	Occupational hazards
MAGNESIUM PEROXIDE	0	76%	none identified
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
SODIUM BENZOATE	2	69%	Organ system toxicity (non-reproductive)
BEHENTRIMONIUM CHLORIDE	0	94%	none identified
SODIUM CARBOXYMETHYL STARCH	0	94%	none identified
CETEARYL ALCOHOL	0	93%	none identified
ASCORBIC ACID (VITAMIN C)	1	91%	none identified
VP/ VA COPOLYMER	1	89%	none identified
DECETH-5	1	88%	Irritation (skin, eyes, or lungs)
SODIUM STANNATE	1	88%	Occupational hazards
TRIDECETH-12	1	88%	Organ system toxicity (non-reproductive)
OLEYL ALCOHOL	1	87%	Irritation (skin, eyes, or lungs)
MAGNESIUM STEARATE	1	83%	Occupational hazards
PENTASODIUM PENTETATE	0	74%	none identified
ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER	0	100%	none identified
DECETH-3	0	100%	none identified
HEXADIMETHRINE CHLORIDE	0	100%	none identified
POLYDECENE	0	100%	none identified
TRIDECETH-2 CARBOXAMIDE MEA	0	100%	none identified
AMMONIUM THIOLACTATE	0	100%	none identified
KYOUNIN YU PRUNUS ARMENIACA/APRICOT KERNEL OIL	0	100%	none identified
AMODIMETHICONE	0	99%	none identified
POLYQUATERNIUM-24	0	94%	none identified
PRUNUS ARMENIACA (APRICOT) KERNEL OIL	0	94%	none identified
PRUNUS ARMENIACA (APRICOT) OIL PRUNUS ARMENIACA/APRICOT KERNEL OIL	0	94%	none identified
EUPHORBIA CERIFERA (CANDELILLA) WAX CANDELILLA CERA/CANDELILLA WAX	0	93%	none identified
CETYL ESTERS	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show tumor formation at high doses		CYAMOPSIS TETRAGONOLOBA (GUAR) GUM
One or more in vitro tests non-mammalian cells show positive mutation results		LINALOOL, AMMONIUM HYDROXIDE
One or more in vitro tests on mammalian cells show positive mutation results		UREA, TITANIUM DIOXIDE (NON-NANO), SODIUM BENZOATE, OLEIC ACID, METHYLPARABEN, GLYCERIN, GERANIOL, ETHANOLAMINE, EDTA, CETRIMONIUM CHLORIDE, ASCORBIC ACID (VITAMIN C), AMMONIUM CHLORIDE
Cancer - limited evidence		M-AMINOPHENOL, 6-HYDROXYINDOLE, 4-AMINO-2-HYDROXYTOLUENE
Mutagen - limited evidence		P-AMINOPHENOL, O-AMINOPHENOL
Cancer - not classifiable/not likely to be human carcinogen		RESORCINOL, P-PHENYLENEDIAMINE, ISOPROPYL ALCOHOL, HYDROGEN PEROXIDE, LIMONENE

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		UREA, SODIUM BENZOATE, M-AMINOPHENOL, KAOLIN, ETHANOLAMINE, EDTA, DIOCTYL SODIUM SULFOSUCCINATE, LILIAL,
One or more animal studies show developmental effects at high doses		LIMONENE
One or more animal studies show reproductive effects at moderate doses		P-AMINOPHENOL, O-AMINOPHENOL, GLYCERIN
One or more animal studies show reproductive effects at low doses		SODIUM METASILICATE
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL
Human nervous system toxicant - moderate evidence		P-PHENYLENEDIAMINE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		SODIUM PERSULFATE, SODIUM SILICATE, SODIUM METASILICATE, POTASSIUM PERSULFATE, SODIUM BENZOATE, CETRIMONIUM CHLORIDE, ETHANOLAMINE, CHLORHEXIDINE DIHYDROCHLORIDE, RESORCINOL, CETEARETH-30, P-PHENYLENEDIAMINE, P-AMINOPHENOL, O-AMINOPHENOL, M-AMINOPHENOL, 6-HYDROXYINDOLE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		SODIUM PERSULFATE
Determined safe for use in cosmetics, subject to concentration or use limitations - any		4-AMINO-2-HYDROXYTOLUENE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		P-AMINOPHENOL, P-PHENYLENEDIAMINE, POTASSIUM PERSULFATE, O-AMINOPHENOL, M-AMINOPHENOL, AMYLCINNAMALDEHYDE, LILIAL, CITRONELLOL, GERANIOL, HEXYL CINNAMAL, 4-AMINO-2-HYDROXYTOLUENE, LINALOOL, LIMONENE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		P-PHENYLENEDIAMINE, UREA, CHLORHEXIDINE DIHYDROCHLORIDE, CHLORHEXIDINE DIHYDROCHLORIDE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Unsafe in products left on skin and not rinsed off	products that are intended to be left on the skin	ETHANOLAMINE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		RESORCINOL
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Safe for brief discontinuous use followed by thorough rinsing	products that are intended to be left on the skin	SODIUM PERSULFATE, POTASSIUM PERSULFATE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		GLYCERIN, HEXYL CINNAMAL, AMYLCINNAMALDEHYDE, 4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show brain and nervous system effects at moderate doses		UREA, SODIUM BENZOATE, RESORCINOL, POLYQUATERNIUM-6, P-AMINOPHENOL, OLEIC ACID, O-AMINOPHENOL, METHYLPARABEN, M-AMINOPHENOL, LINALOOL, KAOLIN, DIOCTYL SODIUM SULFOSUCCINATE, EDTA, ETHANOLAMINE, GERANIOL, CITRONELLOL, CETEARETH-30, LILIAL, AMMONIUM CHLORIDE
One or more animal studies show brain and nervous system effects at low doses		TETRASODIUM PYROPHOSPHATE
One or more animal studies show brain and nervous system effects at very low doses		HYDROGEN PEROXIDE
Moderate evidence of human neurotoxicity		FRAGRANCE
Strong evidence of human neurotoxicity		ISOPROPYL ALCOHOL, P-PHENYLENEDIAMINE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Associated with endocrine disruption		LILIAL
One or more animal studies show endocrine system disruption at high doses		P-PHENYLENEDIAMINE, HYDROGEN PEROXIDE, GLYCERIN, CYAMOPSIS TETRAGONOLOBA (GUAR) GUM, AMMONIUM CHLORIDE, 4-AMINO-2-HYDROXYTOLUENE
Human any disruptor - strong evidence		RESORCINOL, METHYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show immune effects at low doses		TITANIUM DIOXIDE (NON-NANO)
Human immune system toxicant - moderate evidence		CHLORHEXIDINE DIHYDROCHLORIDE
Limited evidence of immune system toxicity	products for use on skin	6-HYDROXYINDOLE
Human skin toxicant - strong evidence		SODIUM SILICATE, SODIUM PERSULFATE, SODIUM METASILICATE, POTASSIUM PERSULFATE, METHYLPARABEN, M-AMINOPHENOL, ETHANOLAMINE, CETRIMONIUM CHLORIDE, 4-AMINO-2-HYDROXYTOLUENE
Possible human immune system toxicant		LINALOOL, HEXYL CINNAMAL, CITRONELLOL, LILIAL
Known human immune system toxicant		RESORCINOL, P-PHENYLENEDIAMINE, P-AMINOPHENOL, O-AMINOPHENOL, GERANIOL, FRAGRANCE, LIMONENE, AMYLCINNAMALDEHYDE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TITANIUM DIOXIDE (NON-NANO), SODIUM SILICATE, POLYQUATERNIUM-6, ISOPROPYL ALCOHOL, EDTA, AMMONIUM HYDROXIDE, AMMONIUM CHLORIDE
Not suspected to be persistent		TRIDECETH-12

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as expected to be toxic or harmful		SODIUM SILICATE
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		VP/ VA COPOLYMER, TRIDECETH-12, MAGNESIUM STEARATE, POLYQUATERNIUM-6, LINALOOL, HEXYL CINNAMAL, LIMONENE, CYAMOPSIS TETRAGONOLOBA (GUAR) GUM, CITRONELLOL
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)		CETEARETH-30, SODIUM METASILICATE, OLEIC ACID, OLETH-30, POTASSIUM PERSULFATE, CETRIMONIUM CHLORIDE, 4-AMINO-2-HYDROXYTOLUENE, UREA
Limited evidence of sense organ toxicity		ISOPROPYL ALCOHOL
One or more animal studies show metabolic effects at low doses		TETRASODIUM PYROPHOSPHATE, SODIUM BENZOATE, SODIUM PERSULFATE, RESORCINOL, GERANIOL, EDTA, DIOCTYL SODIUM SULFOSUCCINATE, AMMONIUM HYDROXIDE
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN, HYDROGEN PEROXIDE, TITANIUM DIOXIDE (NON-NANO), AMMONIUM CHLORIDE
Possible human immune system toxicant		P-AMINOPHENOL, ETHANOLAMINE, O-AMINOPHENOL, CHLORHEXIDINE DIHYDROCHLORIDE
Known human respiratory toxicant		P-PHENYLENEDIAMINE, METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM METASILICATE, POTASSIUM PERSULFATE, ISOPROPYL ALCOHOL, HYDROGEN PEROXIDE, ETHANOLAMINE, LIMONENE, AMMONIUM HYDROXIDE
Ingredient not fully labeled - identity unknown		FRAGRANCE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		TRIDECETH-12, POLYQUATERNIUM-6, AMMONIUM CHLORIDE
Not suspected to be an environmental toxin		TITANIUM DIOXIDE (NON-NANO), SODIUM SILICATE, EDTA, ISOPROPYL ALCOHOL
Wildlife and environmental toxicity		RESORCINOL, P-PHENYLENEDIAMINE, P-AMINOPHENOL, LIMONENE, M-AMINOPHENOL, AMMONIUM HYDROXIDE, 6-HYDROXYINDOLE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at high doses		SODIUM BENZOATE, 4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show skin irritation at moderate doses		TRIDECETH-12, TITANIUM DIOXIDE (NON-NANO), P-AMINOPHENOL, M-AMINOPHENOL, GLYCERIN
One or more animal studies show skin irritation at low doses		OLETH-30, UREA, OLEIC ACID, METHYLPARABEN, DIOCTYL SODIUM SULFOSUCCINATE, DECETH-5, CETEARETH-30, LILIAL
One or more animal studies show skin irritation at very low doses		LINALOOL, HEXYL CINNAMAL, AMYLCINNAMALDEHYDE, CITRONELLOL, GERANIOL
Human skin irritant - moderate evidence		ETHANOLAMINE, HYDROGEN PEROXIDE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	SODIUM SILICATE
Human skin irritant - moderate evidence		CHLORHEXIDINE DIHYDROCHLORIDE, AMMONIUM HYDROXIDE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	OLEYL ALCOHOL
Classified as irritant		SODIUM METASILICATE, RESORCINOL, POTASSIUM PERSULFATE, P-PHENYLENEDIAMINE, ISOPROPYL ALCOHOL, EDTA, LIMONENE, AMMONIUM CHLORIDE, 6-HYDROXYINDOLE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		OLETH-30, MAGNESIUM STEARATE, ASCORBIC ACID (VITAMIN C), CETYL ESTERS, AMODIMETHICONE, OLETH-30, SODIUM METASILICATE
Insufficient data to determine safety		4-AMINO-2-HYDROXYTOLUENE
Safety assessment was based on related chemical		PENTASODIUM PENTETATE
Insufficient data to determine safety		M-AMINOPHENOL, O-AMINOPHENOL, P-AMINOPHENOL, P-PHENYLENEDIAMINE
Missing safety data noted by cosmetic industry review		PENTASODIUM PENTETATE, P-PHENYLENEDIAMINE, P-AMINOPHENOL, O-AMINOPHENOL, 4-AMINO-2-HYDROXYTOLUENE, M-AMINOPHENOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		SODIUM METASILICATE, PENTASODIUM PENTETATE, RESORCINOL, O-AMINOPHENOL, SODIUM SILICATE
Considered safe based on assumption of low absorption		SODIUM SILICATE, 4-AMINO-2-HYDROXYTOLUENE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		OLETH-30, UREA
Considered safe based on assumption of low absorption		SODIUM METASILICATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		P-AMINOPHENOL, P-PHENYLENEDIAMINE, OLEYL ALCOHOL, MAGNESIUM STEARATE, OLEIC ACID, EDTA, M-AMINOPHENOL, METHYLPARABEN, CETEARYL ALCOHOL, DIOCTYL SODIUM SULFOSUCCINATE, CETYL ESTERS, EUPHORBIA CERIFERA (CANDELILLA) WAX, ASCORBIC ACID (VITAMIN C), AMODIMETHICONE, 4-AMINO-2-HYDROXYTOLUENE
Not assessed for safety in cosmetics by industry panel		TRIDECETH-12, KYOUNIN YU, AMMONIUM THIOLACTATE, VP/ VA COPOLYMER, TRIDECETH-2 CARBOXAMIDE MEA, TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, SODIUM STANNATE, SODIUM CARBOXYMETHYL STARCH, PRUNUS ARMENIACA (APRICOT) OIL, PRUNUS ARMENIACA (APRICOT) KERNEL OIL, POLYQUATERNIUM-6, POLYQUATERNIUM-24, POLYDECENE, MAGNESIUM PEROXIDE, LINALOOL, LAURETH-12, ISOPROPYL ALCOHOL, HYDROGEN PEROXIDE, HEXYL CINNAMAL, HEXADIMETHRINE CHLORIDE, GLYCERIN, GERANIOL, FRAGRANCE, LIMONENE, DECETH-5, DECETH-3, CYAMOPSIS TETRAGONOLOBA (GUAR) GUM, CITRONELLOL, LILIAL, BEHENTRIMONIUM CHLORIDE, AMYLCINNAMALDEHYDE, AMMONIUM HYDROXIDE, AMMONIUM CHLORIDE, ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER, 6-HYDROXYINDOLE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		P-AMINOPHENOL, RESORCINOL
Allowed workplace exposures restricted to very low doses		POTASSIUM PERSULFATE, SODIUM PERSULFATE
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), 6-HYDROXYINDOLE, AMMONIUM CHLORIDE, ETHANOLAMINE, HYDROGEN PEROXIDE
Allowed workplace exposures restricted to high doses		ISOPROPYL ALCOHOL
Allowed workplace exposures restricted to moderate doses		TETRASODIUM PYROPHOSPHATE, GLYCERIN, MAGNESIUM STEARATE
Allowed workplace exposures restricted to low doses		KAOLIN, SODIUM STANNATE,
Allowed workplace exposures restricted to low doses		M-AMINOPHENOL, O-AMINOPHENOL
Allowed workplace exposures restricted to very low doses		P-PHENYLENEDIAMINE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Interferes with gene expresion		METHYLPARABEN
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		SODIUM BENZOATE, HYDROGEN PEROXIDE, GLYCERIN, DIOCTYL SODIUM SULFOSUCCINATE
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		P-AMINOPHENOL
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		TITANIUM DIOXIDE (NON-NANO)