

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: ETHYL ACETATE, CALCIUM ALUMINUM BOROSILICATE, CALCIUM SODIUM BOROSILICATE, OXIDIZED POLYETHYLENE, DIMETHICONE, CITRIC ACID, SYNTHETIC FLUORPHLOGOPITE, ETHYLENE/VA COPOLYMER, POLYACRYLATE-4, POLYBUTYLENE TEREPHTHALATE, POLYMETHYL METHACRYLATE, BUTYL ACETATE, POLYSILICONE-8, BENZOPHENONE-1, BENZOPHENONE-3, RED 6 LAKE (LABEL ABBREVIATION), RED 7 LAKE (LABEL ABBREVIATION), RED 34 LAKE (LABEL ABBREVIATION), YELLOW 5 LAKE (LABEL ABBREVIATION), BLUE 1 LAKE (LABEL ABBREVIATION), BISMUTH OXYCHLORIDE, CHROMIUM HYDROXIDE GREEN, NITROCELLULOSE, IRON OXIDES, FERRIC FERROCYANIDE, MANGANESE VIOLET, TITANIUM DIOXIDE, PHTHALIC ANHYDRIDE-GLYCERIN-GLYCIDYL DECANOATE COPOLYMER, ISOPROPYL ALCOHOL, ETHYL TOSYLAMIDE, FRAGRANCE, ACETYL TRIBUTYL CITRATE, STEARALKONIUM HECTORITE
| score | data gap | concerns | |
| OXYBENZONE (BENZOPHENONE-3) (Active Ingredient) | 9 | 55% | Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes |
| FRAGRANCE | 8 | 100% | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |
| OXIDIZED POLYETHYLENE | 4 | 75% | Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| BENZOPHENONE-1 | 5 | 79% | Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| ETHYL ACETATE | 4 | 78% | Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| FD&C BLUE 1 ALUMINUM LAKE BLUE 1 LAKE (LABEL ABBREVIATION) | 4 | 91% | Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive) |
| FD&C YELLOW 5 ALUMINUM LAKE YELLOW 5 LAKE (LABEL ABBREVIATION) | 4 | 91% | Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive) |
| CALCIUM ALUMINUM BOROSILICATE | 4 | 83% | Developmental/reproductive toxicity, Neurotoxicity, Occupational hazards |
| TITANIUM DIOXIDE (NON-NANO) | 1 | 81% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes |
| D&C RED 34 CALCIUM LAKE RED 34 LAKE (LABEL ABBREVIATION) | 0 | 75% | none identified |
| D&C RED 7 LAKE RED 7 LAKE (LABEL ABBREVIATION) | 4 | 73% | Developmental/reproductive toxicity, Neurotoxicity |
| ISOPROPYL ALCOHOL | 4 | 72% | Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| FERRIC FERROCYANIDE | 3 | 76% | Organ system toxicity (non-reproductive), Occupational hazards |
| DIMETHICONE | 2 | 74% | Violations, restrictions & warnings |
| CITRIC ACID | 2 | 72% | Violations, restrictions & warnings |
| POLYMETHYL METHACRYLATE | 1 | 89% | Organ system toxicity (non-reproductive) |
| ACETYL TRIBUTYL CITRATE | 2 | 88% | Multiple, additive exposure sources |
| IRON OXIDES | 2 | 85% | Persistence and bioaccumulation, Enhanced skin absorption |
| CHROMIUM HYDROXIDE GREEN | 1 | 84% | Persistence and bioaccumulation |
| ETHYLENE/ VINYL ACETATE COPOLYMER ETHYLENE/VA COPOLYMER | 1 | 94% | Organ system toxicity (non-reproductive) |
| MANGANESE VIOLET | 0 | 94% | none identified |
| NITROCELLULOSE | 1 | 94% | Organ system toxicity (non-reproductive) |
| STEARALKONIUM HECTORITE | 1 | 93% | Contamination concerns (NITROSAMINES, FREE AMINES) |
| BISMUTH OXYCHLORIDE | 1 | 89% | none identified |
| BUTYL ACETATE | 1 | 78% | Irritation (skin, eyes, or lungs), Occupational hazards |
| CALCIUM SODIUM BOROSILICATE | 0 | 100% | none identified |
| POLYSILICONE-8 | 0 | 100% | none identified |
| PHTHALIC ANHYDRIDE/GLYCERIN/GLYCIDYL DECANOATE COPOLYMER | 0 | 100% | none identified |
| POLYACRYLATE-4 | 0 | 100% | none identified |
| ETHYL TOSYLAMIDE | 0 | 94% | none identified |
| SYNTHETIC FLUORPHLOGOPITE | 0 | 94% | none identified |
| POLYBUTYLENE TEREPHTHALATE | 0 | 94% | none identified |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests non-mammalian cells show positive mutation results | OXYBENZONE (BENZOPHENONE-3) | |
| One or more in vitro tests on mammalian cells show positive mutation results | TITANIUM DIOXIDE (NON-NANO), ETHYL ACETATE, CALCIUM ALUMINUM BOROSILICATE | |
| Cancer - not classifiable/not likely to be human carcinogen | CHROMIUM HYDROXIDE GREEN, POLYMETHYL METHACRYLATE, ISOPROPYL ALCOHOL |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human nervous system toxicant - moderate evidence | FD&C BLUE 1 ALUMINUM LAKE, FD&C YELLOW 5 ALUMINUM LAKE | |
| Limited evidence of developmental toxicity | ISOPROPYL ALCOHOL, OXYBENZONE (BENZOPHENONE-3) | |
| Human nervous system toxicant - moderate evidence | ETHYL ACETATE, D&C RED 7 LAKE, CALCIUM ALUMINUM BOROSILICATE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | OXIDIZED POLYETHYLENE, D&C RED 7 LAKE | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | DIMETHICONE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | OXYBENZONE (BENZOPHENONE-3), CITRIC ACID |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | BENZOPHENONE-1, OXYBENZONE (BENZOPHENONE-3) | |
| nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | BUTYL ACETATE | |
| Strong evidence of human neurotoxicity | FD&C YELLOW 5 ALUMINUM LAKE | |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
| One or more animal studies show brain and nervous system effects at moderate doses | FERRIC FERROCYANIDE | |
| Strong evidence of human neurotoxicity | CALCIUM ALUMINUM BOROSILICATE, D&C RED 7 LAKE, ETHYL ACETATE, FD&C BLUE 1 ALUMINUM LAKE, ISOPROPYL ALCOHOL |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human any disruptor - strong evidence | BENZOPHENONE-1 | |
| Human any disruptor - moderate evidence | OXYBENZONE (BENZOPHENONE-3) |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human skin toxicant - strong evidence | BENZOPHENONE-1 | |
| One or more animal studies show immune effects at low doses | TITANIUM DIOXIDE (NON-NANO) | |
| Possible human photoallergenic toxicant | OXYBENZONE (BENZOPHENONE-3) | |
| Known human immune system toxicant | FRAGRANCE |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Persistent, bioaccumulative in wildlife and humans | IRON OXIDES | |
| Persistent, bioaccumulative in wildlife | CHROMIUM HYDROXIDE GREEN | |
| Ingredient is suspected or measured to accumulate in people | OXYBENZONE (BENZOPHENONE-3) | |
| Not suspected to be bioaccumulative | ETHYLENE/ VINYL ACETATE COPOLYMER, ISOPROPYL ALCOHOL, OXIDIZED POLYETHYLENE, POLYMETHYL METHACRYLATE, TITANIUM DIOXIDE (NON-NANO) |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Classified as expected to be toxic or harmful | ETHYLENE/ VINYL ACETATE COPOLYMER, NITROCELLULOSE, POLYMETHYL METHACRYLATE | |
| One or more animal studies show no adverse any effects at high doses | CHROMIUM HYDROXIDE GREEN | |
| One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) | BISMUTH OXYCHLORIDE, ACETYL TRIBUTYL CITRATE | |
| One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient) | OXYBENZONE (BENZOPHENONE-3) | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | CITRIC ACID | |
| Limited evidence of sense organ toxicity | ISOPROPYL ALCOHOL, OXIDIZED POLYETHYLENE, FD&C BLUE 1 ALUMINUM LAKE, FD&C YELLOW 5 ALUMINUM LAKE, ETHYL ACETATE | |
| One or more animal studies show broad systemic effects at low doses | BENZOPHENONE-1 | |
| One or more animal studies show cardiovascular effects at very low doses | TITANIUM DIOXIDE (NON-NANO) | |
| Known human respiratory toxicant | FERRIC FERROCYANIDE |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | ISOPROPYL ALCOHOL, ETHYL ACETATE, BUTYL ACETATE | |
| Ingredient not fully labeled - identity unknown | FRAGRANCE |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | TITANIUM DIOXIDE (NON-NANO), IRON OXIDES, ISOPROPYL ALCOHOL, OXIDIZED POLYETHYLENE, DIMETHICONE, ETHYL ACETATE, FD&C BLUE 1 ALUMINUM LAKE, CITRIC ACID, BUTYL ACETATE | |
| Used in food or as an additive with limited or no toxicity information available | ACETYL TRIBUTYL CITRATE |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Wildlife and environmental toxicity | OXYBENZONE (BENZOPHENONE-3) | |
| Not suspected to be an environmental toxin | ETHYLENE/ VINYL ACETATE COPOLYMER, ISOPROPYL ALCOHOL, NITROCELLULOSE, OXIDIZED POLYETHYLENE, POLYMETHYL METHACRYLATE, TITANIUM DIOXIDE (NON-NANO) |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Classified as irritant | ETHYL ACETATE, ISOPROPYL ALCOHOL | |
| Classified as skin irritant | products for use on skin | BUTYL ACETATE |
| One or more animal studies show skin irritation at moderate doses | CITRIC ACID, TITANIUM DIOXIDE (NON-NANO) | |
| Not likely to be a skin irritant in humans | OXYBENZONE (BENZOPHENONE-3) |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | STEARALKONIUM HECTORITE, OXYBENZONE (BENZOPHENONE-3), ETHYL ACETATE, DIMETHICONE | |
| Not assessed for safety in cosmetics by industry panel | CALCIUM ALUMINUM BOROSILICATE, CALCIUM SODIUM BOROSILICATE, CHROMIUM HYDROXIDE GREEN, CITRIC ACID, ETHYL TOSYLAMIDE, ETHYLENE/ VINYL ACETATE COPOLYMER, FRAGRANCE, ISOPROPYL ALCOHOL, NITROCELLULOSE, OXIDIZED POLYETHYLENE, POLYMETHYL METHACRYLATE, POLYSILICONE-8, SYNTHETIC FLUORPHLOGOPITE, TITANIUM DIOXIDE (NON-NANO), PHTHALIC ANHYDRIDE/GLYCERIN/GLYCIDYL DECANOATE COPOLYMER, POLYACRYLATE-4, POLYBUTYLENE TEREPHTHALATE | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | ACETYL TRIBUTYL CITRATE, BENZOPHENONE-1, BUTYL ACETATE |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to high doses | ISOPROPYL ALCOHOL, ETHYL ACETATE, BUTYL ACETATE | |
| Allowed workplace exposures restricted to moderate doses | CALCIUM ALUMINUM BOROSILICATE | |
| Allowed workplace exposures restricted to low doses | TITANIUM DIOXIDE (NON-NANO) | |
| Allowed workplace exposures restricted to low doses | FERRIC FERROCYANIDE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood | TITANIUM DIOXIDE (NON-NANO) | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CITRIC ACID | |
| Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease. | OXYBENZONE (BENZOPHENONE-3) |
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