GUERLAIN KIT FRENCH MANUCURE-KIT OF 2 NAIL ENAMELS & 1 TOP COAT-TOP COAT for THE NAILS (2007 formulation) || Skin Deep: Cosmetic Safety Reviews

GUERLAIN KIT FRENCH MANUCURE-KIT OF 2 NAIL ENAMELS & 1 TOP COAT-TOP COAT FOR THE NAILS (2007 FORMULATION)

last updated: 12/01/07 brand: Guerlain by Guerlain SA

SCORE

moderate hazard (out of 10)

69%

data gap

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COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards, Biochemical or cellular level changes

Note: This product formulation was obtained from the FDA VCRD.

Ingredients from packaging: BUTYL ACETATE, ETHYL ACETATE, HEPTANE, NITROCELLULOSE, ADIPIC ACID/NEOPENTYL GLYCOL/TRIMELLITIC ANHYDRIDE COPOLYMER, ISOPROPYL ALCOHOL, ACETYL TRIBUTYL CITRATE, BENZOPHENONE-3

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ingredients

	score	data gap	concerns
OXYBENZONE (BENZOPHENONE-3) (Active Ingredient)	9	55%	Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
ETHYL ACETATE	4	78%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
ISOPROPYL ALCOHOL	4	72%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
ACETYL TRIBUTYL CITRATE	2	88%	Multiple, additive exposure sources
HEPTANE	2	75%	Irritation (skin, eyes, or lungs), Occupational hazards
NITROCELLULOSE	1	94%	Organ system toxicity (non-reproductive)
BUTYL ACETATE	1	78%	Irritation (skin, eyes, or lungs), Occupational hazards
ADIPIC ACID/ NEOPENTYL GLYCOL/ TRIMELLITIC ANHYDRIDE COPOLYMER	0	94%	none identified

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		OXYBENZONE (BENZOPHENONE-3)
One or more in vitro tests on mammalian cells show positive mutation results		ETHYL ACETATE
Cancer - not classifiable/not likely to be human carcinogen		HEPTANE
Cancer - not classifiable/not likely to be human carcinogen		ISOPROPYL ALCOHOL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human nervous system toxicant - moderate evidence		ETHYL ACETATE
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL, OXYBENZONE (BENZOPHENONE-3)

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		OXYBENZONE (BENZOPHENONE-3)

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		BUTYL ACETATE
One or more animal studies show brain and nervous system effects at high doses		OXYBENZONE (BENZOPHENONE-3)
Strong evidence of human neurotoxicity		ETHYL ACETATE, ISOPROPYL ALCOHOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		HEPTANE
One or more studies show weak endocrine disruption		OXYBENZONE (BENZOPHENONE-3)

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Possible human photoallergenic toxicant		OXYBENZONE (BENZOPHENONE-3)

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be persistent		HEPTANE, ETHYL ACETATE, ISOPROPYL ALCOHOL, ADIPIC ACID/ NEOPENTYL GLYCOL/ TRIMELLITIC ANHYDRIDE COPOLYMER, BUTYL ACETATE, ACETYL TRIBUTYL CITRATE
Ingredient is suspected or measured to accumulate in people		OXYBENZONE (BENZOPHENONE-3)

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		HEPTANE, ACETYL TRIBUTYL CITRATE
One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)		OXYBENZONE (BENZOPHENONE-3)
Limited evidence of sense organ toxicity		ISOPROPYL ALCOHOL, ETHYL ACETATE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Low human health concern based on exposure and toxicity		HEPTANE, ETHYL ACETATE, BUTYL ACETATE
Moderate human health concern based on exposure and toxicity		NITROCELLULOSE, ISOPROPYL ALCOHOL
Designated as safe for general or specific, limited use in food		ETHYL ACETATE, ISOPROPYL ALCOHOL, BUTYL ACETATE
Used in food or as an additive with limited or no toxicity information available		ACETYL TRIBUTYL CITRATE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not known to be a wildlife or environmental toxin		NITROCELLULOSE, ISOPROPYL ALCOHOL, ETHYL ACETATE, BUTYL ACETATE, ADIPIC ACID/ NEOPENTYL GLYCOL/ TRIMELLITIC ANHYDRIDE COPOLYMER, ACETYL TRIBUTYL CITRATE
Wildlife and environmental toxicity		OXYBENZONE (BENZOPHENONE-3)
Wildlife and environmental toxicity		HEPTANE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as irritant		ETHYL ACETATE, ISOPROPYL ALCOHOL, HEPTANE
Classified as skin irritant	products for use on skin	BUTYL ACETATE
Not likely to be a skin irritant in humans		OXYBENZONE (BENZOPHENONE-3)

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		ETHYL ACETATE, BUTYL ACETATE
Not assessed for safety in cosmetics by industry panel		NITROCELLULOSE, HEPTANE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		ACETYL TRIBUTYL CITRATE
Not assessed for safety in cosmetics by industry panel		ISOPROPYL ALCOHOL, ADIPIC ACID/ NEOPENTYL GLYCOL/ TRIMELLITIC ANHYDRIDE COPOLYMER
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		OXYBENZONE (BENZOPHENONE-3)
Insufficient data to determine safety		HEPTANE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		HEPTANE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OXYBENZONE (BENZOPHENONE-3)