SUPER AQUA-SERUM - BODY SERUM - OPTIMUM HYDRATION - REVITALIZER (2007 formulation) || Skin Deep: Cosmetic Safety Reviews

SUPER AQUA-SERUM - BODY SERUM - OPTIMUM HYDRATION - REVITALIZER (2007 FORMULATION)

last updated: 12/01/07 brand: by

SCORE

high hazard (out of 10)

83%

data gap

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COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: WATER, CAPRYLIC/CAPRIC/SUCCINIC TRIGLYCERIDE, BENZOPHENONE-3, CYCLOPENTASILOXANE, DICAPRYLYL CARBONATE, C12-15 ALKYL BENZOATE, GLYCERYL STEARATE, POLYMETHYL METHACRYLATE, UREA, STEARIC ACID, TROMETHAMINE, ETHYLHEXYL METHOXYCINNAMATE, BUTYL METHOXYDIBENZOYLMETHANE, SODIUM PCA, XANTHAN GUM, METHYLPARABEN, GLYCINE, LAURETH-23, FRAGRANCE, TOCOPHERYL ACETATE, CHLORPHENESIN, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, GLYCERIN, LACTIC ACID, SORBIC ACID, STEARALKONIUM HECTORITE, DISODIUM EDTA, TETRASODIUM EDTA, YEAST EXTRACT, ETHYLPARABEN, BUTYLPARABEN, PROPYLENE CARBONATE, CERAMIDE 3, BUTYLENE GLYCOL, SERINE, SODIUM HYALURONATE, PROPYLPARABEN, ISOBUTYLPARABEN, CARBOMER, RUMEX CRISPUS ROOT EXTRACT, UNDARIA PINNATIFIDA EXTRACT, POLYSORBATE 20, PHENOXYETHANOL, ASCORBIC ACID, BEESWAX, WHITE, XYLOSE, HYDROLYZED SOY PROTEIN, BHT, GOLD, GLYCINE SOJA (SOYBEAN) PROTEIN, PLANKTON EXTRACT, DISODIUM COCOAMPHODIACETATE, PALMITOYL PENTAPEPTIDE-3, MYRISTYL MYRISTATE, SQUALANE, ISOHEXADECANE, STEARETH-20

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
GOLD (CI 77480)	9	77%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption, Biochemical or cellular level changes
OXYBENZONE (BENZOPHENONE-3) (Active Ingredient)	9	55%	Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
OCTINOXATE (OCTYL METHOXYCINNAMATE) ETHYLHEXYL METHOXYCINNAMATE (Active Ingredient)	8	65%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
BUTYLPARABEN	6	79%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
BHT	6	61%	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
LAURETH-23	5	83%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
ETHYLPARABEN	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
LACTIC ACID	5	70%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
MYRISTYL MYRISTATE	1	89%	Irritation (skin, eyes, or lungs)
TOCOPHERYL ACETATE	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
PHENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
UREA	4	67%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption
ISOBUTYLPARABEN	3	83%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
SORBIC ACID	3	80%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CYCLOPENTASILOXANE	2	79%	Persistence and bioaccumulation
DISODIUM EDTA	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
POLYMETHYL METHACRYLATE	1	89%	Organ system toxicity (non-reproductive)
TETRASODIUM EDTA	2	81%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID	2	74%	Neurotoxicity, Irritation (skin, eyes, or lungs)
AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE) (Active Ingredient)	2	73%	Violations, restrictions & warnings, Contamination concerns (BENZOIC ACID, 4-T-BUTYLBENZOIC ACID, BENZALDEHYDE, P-ANISIC ACID, ACETOPHENONE, DIBENZOYLMETHANE)
CHLORPHENESIN	2	72%	Violations, restrictions & warnings
SODIUM PCA	2	71%	Contamination concerns (NITROSAMINES)
C12-15 ALKYL BENZOATE	0	94%	none identified
ISOHEXADECANE	0	94%	none identified
SQUALANE	1	93%	Irritation (skin, eyes, or lungs)
STEARALKONIUM HECTORITE	1	93%	Contamination concerns (NITROSAMINES, FREE AMINES)
ASCORBIC ACID (VITAMIN C)	1	91%	none identified
YEAST EXTRACT	1	90%	none identified
XYLOSE	1	89%	Organ system toxicity (non-reproductive)
GLYCERYL MONOSTEARATE GLYCERYL STEARATE	1	88%	none identified
STEARETH-20	1	88%	none identified
DISODIUM COCOAMPHODIACETATE	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TROMETHAMINE	1	87%	none identified
PROPYLENE CARBONATE	1	85%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
POLYSORBATE-20	1	84%	none identified
SODIUM HYALURONATE	1	83%	none identified
BUTYLENE GLYCOL	1	79%	Irritation (skin, eyes, or lungs)
GLYCINE	1	79%	none identified
ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER	0	100%	none identified
CAPRYLIC/ CAPRIC/ SUCCINIC TRIGLYCERIDE	0	100%	none identified
CERAMIDE 3	0	100%	none identified
DICAPRYLYL CARBONATE	0	100%	none identified
PALMITOYL PENTAPEPTIDE-3 (MATRIXYL)	0	100%	none identified
PLANKTON EXTRACT	0	100%	none identified
RUMEX CRISPUS (YELLOW DOCK) ROOT EXTRACT RUMEX CRISPUS ROOT EXTRACT	0	100%	none identified
UNDARIA PINNATIFIDA EXTRACT	0	100%	none identified
BEESWAX, WHITE	0	100%	none identified
GLYCINE SOJA PROTEIN GLYCINE SOJA (SOYBEAN) PROTEIN	0	94%	none identified
HYDROLYZED GLYCINE SOJA (SOY) PROTEIN HYDROLYZED SOY PROTEIN	0	94%	none identified
SERINE	0	94%	none identified
XANTHAN GUM	0	94%	none identified
CARBOMER	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL, LAURETH-23, OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show tumor formation at moderate doses		CYCLOPENTASILOXANE
One or more in vitro tests on mammalian cells show positive mutation results		GOLD (CI 77480), UREA, TOCOPHERYL ACETATE, SORBIC ACID, PROPYLPARABEN, METHYLPARABEN, GLYCINE, GLYCERIN, ETHYLPARABEN, DISODIUM EDTA, BUTYLPARABEN, ASCORBIC ACID (VITAMIN C),
One or more in vitro tests on mammalian cells show positive mutation results		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - not classifiable/not likely to be human carcinogen		LACTIC ACID
Cancer - not classifiable/not likely to be human carcinogen		POLYMETHYL METHACRYLATE, BHT

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		UREA, DISODIUM EDTA, POLYSORBATE-20, ETHYLPARABEN, BHT, BUTYLENE GLYCOL
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at moderate doses		GLYCERIN, SODIUM HYALURONATE
Limited evidence of developmental toxicity		OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show any effects at very low doses		BUTYLPARABEN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		LACTIC ACID, SODIUM PCA
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		UREA
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		LACTIC ACID, OXYBENZONE (BENZOPHENONE-3), PHENOXYETHANOL, CHLORPHENESIN, AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), CHLORPHENESIN
Violation of government restrictions - Banned or found unsafe for use in cosmetics		GOLD (CI 77480)
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits		LACTIC ACID
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		YEAST EXTRACT, OXYBENZONE (BENZOPHENONE-3), GLYCINE, LACTIC ACID, GLYCERIN, BUTYLENE GLYCOL
One or more animal studies show brain and nervous system effects at moderate doses		UREA, TROMETHAMINE, SODIUM HYALURONATE, PHENOXYETHANOL, METHYLPARABEN, CHLORPHENESIN
One or more animal studies show brain and nervous system effects at low doses		LAURETH-23
One or more animal studies show any effects at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA, BHT
One or more animal studies show brain and nervous system effects at very low doses		STEARIC ACID
Moderate evidence of human neurotoxicity		FRAGRANCE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		SODIUM PCA, GLYCINE, DISODIUM EDTA, GLYCERIN, BUTYLENE GLYCOL, BHT
One or more animal studies show endocrine disruption at moderate doses		ISOBUTYLPARABEN,
One or more animal studies show endocrine disruption at moderate doses		CYCLOPENTASILOXANE
Human any disruptor - moderate evidence		OXYBENZONE (BENZOPHENONE-3)
Human any disruptor - strong evidence		PROPYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE), METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Associated with immunotoxicity		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
Human skin toxicant - strong evidence		TOCOPHERYL ACETATE
Human skin and immune toxicant - moderate evidence		GOLD (CI 77480)
Human skin toxicant - strong evidence		SORBIC ACID, PROPYLPARABEN, METHYLPARABEN, ISOBUTYLPARABEN, ETHYLPARABEN, BUTYLPARABEN
Possible human photoallergenic toxicant		OXYBENZONE (BENZOPHENONE-3)
Known human immune system toxicant		FRAGRANCE, BHT

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		POLYMETHYL METHACRYLATE
Not suspected to be persistent		LAURETH-23
Ingredient is suspected or measured to accumulate in people		OXYBENZONE (BENZOPHENONE-3), OCTINOXATE (OCTYL METHOXYCINNAMATE)
Persistent, bioaccumulative in wildlife		CYCLOPENTASILOXANE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as expected to be toxic or harmful		POLYMETHYL METHACRYLATE
One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	YEAST EXTRACT
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		POLYSORBATE-20, STEARIC ACID, SODIUM PCA, GLYCINE
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	SODIUM HYALURONATE, BUTYLENE GLYCOL, CYCLOPENTASILOXANE
One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)		OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		TOCOPHERYL ACETATE, TROMETHAMINE, STEARETH-20, UREA, GLYCERYL MONOSTEARATE
Limited evidence of sense organ toxicity		XYLOSE, SORBIC ACID, PROPYLPARABEN, ISOBUTYLPARABEN, ETHYLPARABEN, BUTYLPARABEN
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	PROPYLENE CARBONATE
One or more animal studies show broad systemic effects at low doses		DISODIUM EDTA, BHT
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	PHENOXYETHANOL, LAURETH-23
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN,
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	DISODIUM COCOAMPHODIACETATE, LACTIC ACID
Possible human hematologic toxicant		GOLD (CI 77480)
Limited evidence of eye toxicity	products for use around the eyes	TETRASODIUM EDTA
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		LAURETH-23
Not suspected to be an environmental toxin		POLYMETHYL METHACRYLATE
Wildlife and environmental toxicity		OXYBENZONE (BENZOPHENONE-3), OCTINOXATE (OCTYL METHOXYCINNAMATE)
Wildlife and environmental toxicity		PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not likely to be a skin irritant in humans		OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show skin irritation at moderate doses		SODIUM HYALURONATE, POLYSORBATE-20, GLYCERIN, CYCLOPENTASILOXANE, BUTYLPARABEN
One or more animal studies show skin irritation at low doses		UREA, TETRASODIUM EDTA, STEARIC ACID, SQUALANE, METHYLPARABEN, BHT
One or more animal studies show skin irritation at very low doses		SORBIC ACID, LACTIC ACID, DISODIUM COCOAMPHODIACETATE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	MYRISTYL MYRISTATE, LAURETH-23, BUTYLENE GLYCOL
Classified as irritant		PROPYLENE CARBONATE, PHENOXYETHANOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		STEARETH-20, ASCORBIC ACID (VITAMIN C), LAURETH-23, ISOBUTYLPARABEN
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		STEARETH-20, UREA, TOCOPHERYL ACETATE, TETRASODIUM EDTA, SORBIC ACID, STEARALKONIUM HECTORITE, STEARIC ACID, PROPYLPARABEN, PROPYLENE CARBONATE, MYRISTYL MYRISTATE, POLYSORBATE-20, PHENOXYETHANOL, METHYLPARABEN, OXYBENZONE (BENZOPHENONE-3), LAURETH-23, DISODIUM EDTA, ETHYLPARABEN, GLYCERYL MONOSTEARATE, BUTYLPARABEN, BUTYLENE GLYCOL, BHT, DISODIUM COCOAMPHODIACETATE, CARBOMER
Not assessed for safety in cosmetics by industry panel		XANTHAN GUM, YEAST EXTRACT, GOLD (CI 77480), UNDARIA PINNATIFIDA EXTRACT, XYLOSE, BEESWAX, WHITE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		ASCORBIC ACID (VITAMIN C)
Not assessed for safety in cosmetics by industry panel		TROMETHAMINE, SQUALANE, SERINE, RUMEX CRISPUS (YELLOW DOCK) ROOT EXTRACT, POLYMETHYL METHACRYLATE, PLANKTON EXTRACT, PALMITOYL PENTAPEPTIDE-3 (MATRIXYL), GLYCERIN, GLYCINE, GLYCINE SOJA PROTEIN, HYDROLYZED GLYCINE SOJA (SOY) PROTEIN, ISOHEXADECANE, FRAGRANCE, DICAPRYLYL CARBONATE, CYCLOPENTASILOXANE, CHLORPHENESIN, CERAMIDE 3, CAPRYLIC/ CAPRIC/ SUCCINIC TRIGLYCERIDE, C12-15 ALKYL BENZOATE, AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
No workplace limits set		LACTIC ACID
Allowed workplace exposures restricted to moderate doses		GLYCERIN
Allowed workplace exposures restricted to low doses		BHT,
Allowed workplace exposures restricted to low doses		TETRASODIUM EDTA
Allowed workplace exposures restricted to very low doses		GOLD (CI 77480)
Allowed workplace exposures restricted to low doses		PHENOXYETHANOL

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OCTINOXATE (OCTYL METHOXYCINNAMATE), OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CYCLOPENTASILOXANE, GLYCERIN, GLYCINE
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		LAURETH-23
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		BHT
Interferes with gene expresion		BUTYLPARABEN, METHYLPARABEN
Cancer - limited evidence - immune system		GOLD (CI 77480)