Kinerase Cream, SPF 30 || Skin Deep: Cosmetic Safety Reviews

KINERASE CREAM, SPF 30

last updated: 04/03/08 brand: Kinerase by Valeant Pharmaceuticals International

SCORE

	health hazard
	sun hazard

80%

data gap

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49% of facial moisturizer/treatments have lower concerns
34% of sunscreen: SPF 15-30s have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Sunscreen effectiveness* breakdown

1	UVB hazard/exposure score
6	UVA hazard/exposure score
4	sunscreen instability

*Note that the same active ingredient combination may score differently in two different products depending on the concentration of the ingredients and the mixture of inactive ingredients.

Active ingredient UV
blocking strength

Product total

NANO TITANIUM DIOXIDE (6%)

OCTINOXATE (OCTYL METHOXYCINNAMATE) (7%)

Skin Deep has multiple formulations for this product in the database. Please read the ingredients carefully.
See formulation: | 1 | 2 |

Note to manufacturers: We have assumed a typical particle size for the mineral(s) in your product based on typical industry use. We welcome specific data from manufacturers if actual particle size is different.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Note from EWG: Unlike many other kinds of personal care products, sunscreen can provide health benefits, protecting against the sun's cancer-causing UV radiation. More than one million cases of skin cancer are diagnosed in the U.S. every year. Health officials recommend wearing sunscreen as one of many important steps to minimize skin cancer risk. (more sun safety tips)

Ingredients from packaging: Active Ingredients: Titanium Dioxide 6%, Ethylhexyl Methoxycinnamate 7%Inactive Ingredients: Purified Water, C12-15 Alkyl Benzoate, Ethoxydiglycol, Cyclopentasiloxane, Glycerin, Caprylic/Capric Triglycerides, Stearic Acid, Dimethicone, Cetyl Alcohol, Silica, Phenoxyethanol, PEG-100 Stearate, Glyceryl Stearate, Alumina, PEG-12 Glyceryl Distearate, Sorbitan Stearate, Sodium Hexamethaphosphate, Triethanolamine, Methylparaben, Carbomer, Disodium EDTA, Camellia Sinensis Leaf Extract, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Propylparaben, Pyris Communis (Pear) Fruit Extract, Kinetin, Hibiscus Sabdariffa Flower Extract, Ferula Assa Foetida Root Extract, Ethylparaben, Laminaria Digitata (Algae) Extract, Ammonium Acryloyldimethyltaurate/VP Copolymer, Butylparaben.

Directions from packaging: 1. Wash your face with a mild cleanser such as Kinerase Daily Cleanser. Apply a dime-size amount of Kinerase to the face and neck. Rub in thoroughly. Apply in the morning and at bedtime for best results. May be applied to sun-damaged areas such as the face, chest, neck, or hands.2. Sunscreen and makeup may be applied directly after using Kinerase.3. after using Kinerase for three months, it is recommended that you Follow up with your physician for further evaluation. You physician should also be consulted for your specific skin care regimen needs.

Warnings from packaging: Warnings For external use only. Do not use on children under 6 months of age unless directed by a doctor. When using this product: keep out of eyes. rinse with water to remove. Stop use and ask a doctor if rash or irritation develops and lasts. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

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ingredients

	score	data gap	concerns
NANO TITANIUM DIOXIDE (Active Ingredient)	2	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
OCTINOXATE (OCTYL METHOXYCINNAMATE) ETHYLHEXYL METHOXYCINNAMATE (Active Ingredient)	8	65%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
SILICA	1	69%	Biochemical or cellular level changes
PEG-100 STEARATE	4	69%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ALUMINA	6	85%	Developmental/reproductive toxicity, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Enhanced skin absorption, Occupational hazards
BUTYLPARABEN	6	79%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PEG-12 GLYCERYL DISTEARATE	4	76%	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
TRIETHANOLAMINE	6	58%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
ETHYLPARABEN	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PHENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
CYCLOPENTASILOXANE	2	79%	Persistence and bioaccumulation
DISODIUM EDTA	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
DIMETHICONE	2	74%	Violations, restrictions & warnings
SODIUM HEXAMETAPHOSPHATE SODIUM HEXAMETHAPHOSPHATE	3	72%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (LEAD)
ETHOXYDIGLYCOL	2	82%	Organ system toxicity (non-reproductive)
CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT CAMELLIA SINENSIS LEAF EXTRACT	2	76%	Violations, restrictions & warnings
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID	2	74%	Neurotoxicity, Irritation (skin, eyes, or lungs)
C12-15 ALKYL BENZOATE	0	94%	none identified
CAPRYLIC/ CAPRIC TRIGLYCERIDE	0	94%	none identified
SORBITAN STEARATE	1	92%	none identified
GLYCERYL MONOSTEARATE GLYCERYL STEARATE	1	88%	none identified
N6-FURFURYLADENINE KINETIN	1	88%	Organ system toxicity (non-reproductive)
CETYL ALCOHOL	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
PYRUS COMMUNIS (PEAR) FRUIT EXTRACT PYRIS COMMUNIS (PEAR) FRUIT EXTRACT	1	87%	none identified
ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER	0	100%	none identified
AMMONIUM ACRYLOYLDIMETHYL TAURATE/ VP COPOLYMER	0	100%	none identified
FERULA ASSA-FOETIDA (ASAFETIDA) EXTRACT FERULA ASSA FOETIDA ROOT EXTRACT	0	100%	none identified
HIBISCUS SABDARIFFA (ROSELLE) FLOWER EXTRACT HIBISCUS SABDARIFFA FLOWER EXTRACT	0	100%	none identified
LAMINARIA DIGITATA (HORSETAIL KELP) EXTRACT LAMINARIA DIGITATA (ALGAE) EXTRACT	0	100%	none identified
FERULA FOETIDA ROOT EXTRACT FERULA ASSA FOETIDA ROOT EXTRACT	0	100%	none identified
CARBOMER	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL
One or more animal studies show tumor formation at moderate doses		CYCLOPENTASILOXANE
One or more in vitro tests non-mammalian cells show positive mutation results		ETHOXYDIGLYCOL
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE, ALUMINA
One or more in vitro tests on mammalian cells show positive mutation results		NANO TITANIUM DIOXIDE
One or more in vitro tests on mammalian cells show positive mutation results		PROPYLPARABEN, N6-FURFURYLADENINE, METHYLPARABEN, GLYCERIN, ETHYLPARABEN, DISODIUM EDTA, BUTYLPARABEN
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - not classifiable/not likely to be human carcinogen		TRIETHANOLAMINE

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		PYRUS COMMUNIS (PEAR) FRUIT EXTRACT, PEG-100 STEARATE, ETHYLPARABEN, ETHOXYDIGLYCOL, DISODIUM EDTA
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at moderate doses		GLYCERIN
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show any effects at very low doses		BUTYLPARABEN
Human nervous system toxicant - moderate evidence		ALUMINA

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PEG-100 STEARATE, TRIETHANOLAMINE, PEG-12 GLYCERYL DISTEARATE, SODIUM HEXAMETAPHOSPHATE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		PHENOXYETHANOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at moderate doses		METHYLPARABEN, PHENOXYETHANOL
One or more animal studies show brain and nervous system effects at high doses		ETHOXYDIGLYCOL, SODIUM HEXAMETAPHOSPHATE, GLYCERIN
One or more animal studies show any effects at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA
Strong evidence of human neurotoxicity		ALUMINA
One or more animal studies show brain and nervous system effects at very low doses		STEARIC ACID

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		TRIETHANOLAMINE, GLYCERIN, DISODIUM EDTA
Human any disruptor - strong evidence		OCTINOXATE (OCTYL METHOXYCINNAMATE), PROPYLPARABEN
One or more animal studies show endocrine disruption at moderate doses		CYCLOPENTASILOXANE
Human any disruptor - strong evidence		METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
respiratory - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		NANO TITANIUM DIOXIDE
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
Human skin toxicant - strong evidence		PROPYLPARABEN, METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN
Known human immune system toxicant		TRIETHANOLAMINE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		NANO TITANIUM DIOXIDE, TRIETHANOLAMINE, ALUMINA
Not suspected to be persistent		CETYL ALCOHOL
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Persistent, bioaccumulative in wildlife		CYCLOPENTASILOXANE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		STEARIC ACID
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	SILICA, CYCLOPENTASILOXANE, CETYL ALCOHOL
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		ALUMINA
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		PYRUS COMMUNIS (PEAR) FRUIT EXTRACT, GLYCERYL MONOSTEARATE
Limited evidence of sense organ toxicity		PROPYLPARABEN, PEG-100 STEARATE, PEG-12 GLYCERYL DISTEARATE, ETHYLPARABEN, BUTYLPARABEN
One or more animal studies show broad systemic effects at low doses		SODIUM HEXAMETAPHOSPHATE,
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	ETHOXYDIGLYCOL
One or more animal studies show broad systemic effects at low doses		DISODIUM EDTA, N6-FURFURYLADENINE
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN,
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	PHENOXYETHANOL
Possible human immune system toxicant		TRIETHANOLAMINE
One or more animal studies show cardiovascular effects at very low doses		NANO TITANIUM DIOXIDE
Known human any toxicant		METHYLPARABEN

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		CETYL ALCOHOL, ALUMINA
Not suspected to be an environmental toxin		TRIETHANOLAMINE
Wildlife and environmental toxicity		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Wildlife and environmental toxicity		NANO TITANIUM DIOXIDE
Wildlife and environmental toxicity		PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		SORBITAN STEARATE, GLYCERIN, ETHOXYDIGLYCOL, CYCLOPENTASILOXANE, BUTYLPARABEN
One or more animal studies show skin irritation at low doses		METHYLPARABEN, STEARIC ACID,
One or more animal studies show significant but moderate pulmonary irritation at low doses		NANO TITANIUM DIOXIDE
One or more animal studies show skin irritation at very low doses		PEG-100 STEARATE, CETYL ALCOHOL, TRIETHANOLAMINE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	SODIUM HEXAMETAPHOSPHATE
Classified as irritant		PHENOXYETHANOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		STEARIC ACID, PEG-100 STEARATE
Safety assessment was based on related chemical		PEG-100 STEARATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		SORBITAN STEARATE, PROPYLPARABEN, PHENOXYETHANOL, ETHYLPARABEN, ETHOXYDIGLYCOL, METHYLPARABEN, GLYCERYL MONOSTEARATE, DISODIUM EDTA, DIMETHICONE, CETYL ALCOHOL, CARBOMER, BUTYLPARABEN
Not assessed for safety in cosmetics by industry panel		NANO TITANIUM DIOXIDE, PYRUS COMMUNIS (PEAR) FRUIT EXTRACT, FERULA FOETIDA ROOT EXTRACT, PEG-12 GLYCERYL DISTEARATE, N6-FURFURYLADENINE, LAMINARIA DIGITATA (HORSETAIL KELP) EXTRACT, HIBISCUS SABDARIFFA (ROSELLE) FLOWER EXTRACT, GLYCERIN, FERULA ASSA-FOETIDA (ASAFETIDA) EXTRACT, CYCLOPENTASILOXANE, CAPRYLIC/ CAPRIC TRIGLYCERIDE, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, C12-15 ALKYL BENZOATE, AMMONIUM ACRYLOYLDIMETHYL TAURATE/ VP COPOLYMER, ALUMINA, ACRYLATES/ C10-30 ALKYL ACRYLATE CROSSPOLYMER

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		PHENOXYETHANOL
Allowed workplace exposures restricted to moderate doses		ALUMINA, TRIETHANOLAMINE, GLYCERIN
Allowed workplace exposures restricted to low doses		NANO TITANIUM DIOXIDE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		SILICA, NANO TITANIUM DIOXIDE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CYCLOPENTASILOXANE, GLYCERIN
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		BUTYLPARABEN, METHYLPARABEN