Neostrata Daily Acne System || Skin Deep: Cosmetic Safety Reviews

NEOSTRATA DAILY ACNE SYSTEM

last updated: 03/15/09 brand: NeoStrata by NeoStrata

SCORE

high hazard (out of 10)

79%

data gap

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99% of acne treatments have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Antibacterial Facial Cleanser: Active Ingredient: Triclosan 0.3%.Other Ingredients: Ammonium Chloride, Ammonium Laureth Sulfate, Anthemis Nobilis (Chamomile) Flower Extract, Aqua (Water), Cocamidopropyl Betaine, Disodium Cocoamphodiacetate, Gluconolactone, Glycine, Lauryl Alcohol, Methylparaben, Panthenol, PEG-80 Sorbitan Laurate, Phenoxyethanol, Polyquaternium-10, Propylene Glycol, Propylparaben, Sodium Chloride, Sodium Laureth Sulfate, Triethanolamine.Oil- Free Lotion SPF 15: Active Ingredients: Ethylhexyl Methoxycinnamate, Titanium Dioxide.Other Ingredients: Aqua (Water), Gluconolactone, C12-15 Alkyl Benzoate, Dimethicone, Propylene Glycol Dicaprylate/Dicaprate, Glyceryl Stearate, Isononyl Isononanoate, Propylene Glycol, PEG-100 Stearate, Octyldodecyl Neopentanoate, Glycerin, Cyclopentasiloxane, Magnesium Aluminum Silicate, Tocopheryl (Vitamin E) Acetate, Biotin (Vitamin H), Pyridoxine (Vitamin B6), Panthenol, Niacinamide (Vitamin B3), Aluminum Starch Octenylsuccinate, Triundecanoin, Allantoin, Hydrolyzed Yeast Protein, Aluminum Hydroxide, Stearic Acid, Xanthan Gum, Disodium EDTA, Arginine, Ammonium Hydroxide, Fatty Alcohol/ Polysorbate Blend, Chlorphenesin, Methylparaben. NeoStrata Oil Control Gel - PHA / AHA 8Ingredients: Aqua (Water), Alcohol Denat., Gluconolactone, Mandelic Acid, Butylene Glycol, Triethanolamine, Glycerin, Arginine, Niacinamide(Vitamin B3), Biotin (Vitamin H), Pyridoxine Hydrochloride (Vitamin B6), Panthenol, Hydrolyzed Yeast Protein, Propylene Glycol, Allantoin, Polyquaternium-10, Sclerotium Gum, Ethylene /Acrylic Acid Copolymer, Ammonium Hydroxide, Methylparaben, Chlorphenesin.Acne Treatment Solution- ACTIVE INGREDIENT: Salicylic Acid 2.0%. INACTIVE INGREDIENTS: Acetyl Mandelic Acid, Alcohol Denat., Anthemis Nobilis (Chamomile) Extract, Citric Acid, Cyclomethicone, Diisopropyl Adipate, Propylene Glycol, Tartaric Acid, Triethyl Citrate. Acne Spot Treatment Gel- ACTIVE INGREDIENT: Salicylic Acid 2.0%. INACTIVE INGREDIENTS: Acetyl Mandelic Acid, Alcohol Denat., Butylene Glycol, C13-14 Isoparaffin, Citric Acid, Laureth-7, PEG-8, Polyacrylamide, Propylene Glycol, Retinyl (Vitamin A) Acetate/ Arachis Hypogaea (Peanut) Oil, Tartaric Acid.

Directions from packaging: Antibacterial Facial Cleanser: Apply to wet skin and gently massage to develope foaming action. Rinse thoroughly with water. Use twice daily.Acne Treatment Solution:Clean skin thoroughly . Using the pad, cover the affected area with a thin layer 1-3 times daily, avoiding eye area. Because too much drying of the skin may occur, start with 1 application daily, then gradually increase to 2-3 times daily if needed or as directed by a doctor.wash hands after applying.Oil- Control Gel:Apply to th eface and neck daily, following cleansing or as directed by a physician. Let dry thoroughly before applying other cosmetic products. If desired, reapply throughout day as needed. Daily use of a sunscreen is recommended with this product.Ance Spot Treatment Gel: Clean skin thoroughly before applying medication. Using fingertip, cover the entire affected area with 1-3 times daily. At first use start with 1 application daily and then slowly graduate to 2-3 times per day.Oil Free SPF 15: Apply to face and neck daily following cleansing. Apply before using other cosmetic products. Fr Adult use only. Apply additional sunscreen as needed for prolonged outdoor activities.

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ingredients

	score	data gap	concerns
METHYLPARABEN (Active Ingredient)	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
ALUMINUM STARCH OCTENYLSUCCINATE (Active Ingredient)	9	74%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ARSENIC, LEAD, HEAVY METALS)
PEG-80 SORBITAN LAURATE (Active Ingredient)	8	70%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
OCTINOXATE (OCTYL METHOXYCINNAMATE) ETHYLHEXYL METHOXYCINNAMATE (Active Ingredient)	6	65%	Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
PEG-100 STEARATE (Active Ingredient)	7	69%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TRICLOSAN (Active Ingredient)	7	67%	Violations, restrictions & warnings, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (CHLOROFORM, DIOXIN)
SALICYLIC ACID (Active Ingredient)	7	66%	Violations, restrictions & warnings, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
PEG-8 (Active Ingredient)	6	76%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TRIETHANOLAMINE (Active Ingredient)	6	58%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
ALCOHOL DENATURED (Active Ingredient)	5	71%	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PROPYLPARABEN (Active Ingredient)	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
RETINYL ACETATE RETINYL (VITAMIN A) ACETATE/ ARACHIS HYPOGAEA (PEANUT) OIL	5	67%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
COCAMIDOPROPYL BETAINE (Active Ingredient)	5	63%	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
MAGNESIUM ALUMINUM SILICATE (Active Ingredient)	4	88%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
SODIUM LAURETH SULFATE (Active Ingredient)	4	88%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ALUMINUM HYDROXIDE (Active Ingredient)	4	86%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
TITANIUM DIOXIDE (NON-NANO) TITANIUM DIOXIDE.OTHER INGREDIENTS (Active Ingredient)	1	81%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
TOCOPHERYL ACETATE TOCOPHERYL (VITAMIN E) ACETATE	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
PHENOXYETHANOL (Active Ingredient)	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL (Active Ingredient)	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
LAURETH-7	3	100%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
AMMONIUM LAURETH SULFATE (Active Ingredient)	3	87%	Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
ARGININE (Active Ingredient)	3	79%	Neurotoxicity, Organ system toxicity (non-reproductive)
CYCLOPENTASILOXANE (Active Ingredient)	2	79%	Persistence and bioaccumulation
PYRIDOXINE HCL PYRIDOXINE HYDROCHLORIDE (VITAMIN B6) (Active Ingredient)	3	79%	Developmental/reproductive toxicity, Neurotoxicity
DISODIUM EDTA (Active Ingredient)	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
AMMONIUM CHLORIDE (Active Ingredient)	3	77%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
DIMETHICONE (Active Ingredient)	2	74%	Violations, restrictions & warnings
ETHYLENE/ ACRYLIC ACID COPOLYMER (Active Ingredient)	3	74%	Organ system toxicity (non-reproductive), Contamination concerns (METHACRYLIC ACID, ACRYLIC ACID, 2-ETHYLHEXYL ACRYLATE)
CITRIC ACID (Active Ingredient)	2	72%	Violations, restrictions & warnings
POLYACRYLAMIDE	3	71%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Contamination concerns (ACRYLAMIDE)
PANTHENOL (Active Ingredient)	2	88%	Multiple, additive exposure sources
CYCLOMETHICONE (Active Ingredient)	2	83%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
PYRIDOXINE (Active Ingredient)	2	83%	Multiple, additive exposure sources
BIOTIN (Active Ingredient)	2	82%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
AMMONIUM HYDROXIDE (Active Ingredient)	2	81%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
NIACINAMIDE (Active Ingredient)	2	81%	Organ system toxicity (non-reproductive), Biochemical or cellular level changes
GLYCERIN (Active Ingredient)	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID (Active Ingredient)	2	74%	Neurotoxicity, Irritation (skin, eyes, or lungs)
CHLORPHENESIN (Active Ingredient)	2	72%	Violations, restrictions & warnings
POLYSORBATE (Active Ingredient)	1	98%	Organ system toxicity (non-reproductive)
C12-15 ALKYL BENZOATE (Active Ingredient)	0	94%	none identified
C13-14 ISOPARAFFIN	1	93%	none identified
GLUCONOLACTONE (Active Ingredient)	1	93%	none identified
PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE (Active Ingredient)	0	90%	Enhanced skin absorption
MANDELIC ACID (Active Ingredient)	1	89%	none identified
GLYCERYL MONOSTEARATE GLYCERYL STEARATE (Active Ingredient)	1	88%	none identified
DIISOPROPYL ADIPATE (Active Ingredient)	1	87%	none identified
DISODIUM COCOAMPHODIACETATE (Active Ingredient)	1	87%	Irritation (skin, eyes, or lungs)
TARTARIC ACID (Active Ingredient)	1	87%	none identified
TRIETHYL CITRATE (Active Ingredient)	1	87%	none identified
ARACHIS HYPOGAEA (PEANUT) OIL	1	85%	Irritation (skin, eyes, or lungs), Enhanced skin absorption
1-DODECANOL LAURYL ALCOHOL (Active Ingredient)	1	84%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT ANTHEMIS NOBILIS (CHAMOMILE) EXTRACT (Active Ingredient)	1	80%	Enhanced skin absorption
BUTYLENE GLYCOL (Active Ingredient)	1	79%	Irritation (skin, eyes, or lungs)
GLYCINE (Active Ingredient)	1	79%	none identified
FATTY ALCOHOLS FATTY ALCOHOL/ POLYSORBATE BLEND (Active Ingredient)	0	100%	none identified
HYDROLYZED YEAST PROTEIN (Active Ingredient)	0	100%	none identified
ISONONYL ISONONANOATE (Active Ingredient)	0	100%	none identified
OCTYLDODECYL NEOPENTANOATE (Active Ingredient)	0	100%	none identified
SCLEROTIUM GUM (Active Ingredient)	0	100%	none identified
ACETYL MANDELIC ACID (Active Ingredient)	0	100%	none identified
ALLANTOIN (Active Ingredient)	0	94%	none identified
XANTHAN GUM (Active Ingredient)	0	94%	none identified
POLYQUATERNIUM-10 (Active Ingredient)	0	93%	none identified
TRIUNDECANOIN (Active Ingredient)	0	92%	Enhanced skin absorption
SODIUM CHLORIDE (Active Ingredient)	0	0%	innocuous
WATER (Active Ingredient)	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show tumor formation at high doses		1-DODECANOL
One or more in vitro tests non-mammalian cells show positive mutation results		TRICLOSAN, PHENOXYETHANOL, GLUCONOLACTONE, ARACHIS HYPOGAEA (PEANUT) OIL, AMMONIUM HYDROXIDE
One or more animal studies show tumor formation at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE
One or more in vitro tests on mammalian cells show positive mutation results		TOCOPHERYL ACETATE, TITANIUM DIOXIDE (NON-NANO), SODIUM CHLORIDE, PYRIDOXINE HCL, PROPYLPARABEN, PROPYLENE GLYCOL, NIACINAMIDE, METHYLPARABEN, GLYCINE, GLYCERIN, DISODIUM EDTA, ARGININE, AMMONIUM CHLORIDE
Cancer - not classifiable/not likely to be human carcinogen		SALICYLIC ACID
Cancer - limited evidence		RETINYL ACETATE, ALCOHOL DENATURED
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - not classifiable/not likely to be human carcinogen		TRIETHANOLAMINE

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		PEG-100 STEARATE, TRICLOSAN, PYRIDOXINE, PEG-80 SORBITAN LAURATE, DISODIUM EDTA, BUTYLENE GLYCOL
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at moderate doses		SALICYLIC ACID, PROPYLENE GLYCOL, GLYCERIN, ARGININE
Limited evidence of reproductive toxicity		ALCOHOL DENATURED
One or more animal studies show reproductive effects at low doses		RETINYL ACETATE, BIOTIN,
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at very low doses		PYRIDOXINE HCL
Human nervous system toxicant - moderate evidence		MAGNESIUM ALUMINUM SILICATE, ALUMINUM STARCH OCTENYLSUCCINATE, ALUMINUM HYDROXIDE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PEG-100 STEARATE, TRIETHANOLAMINE, SALICYLIC ACID, PROPYLENE GLYCOL, POLYACRYLAMIDE, PEG-80 SORBITAN LAURATE, ETHYLENE/ ACRYLIC ACID COPOLYMER, PEG-8, ALUMINUM STARCH OCTENYLSUCCINATE, COCAMIDOPROPYL BETAINE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		TRICLOSAN
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		RETINYL ACETATE, SALICYLIC ACID, CITRIC ACID, CHLORPHENESIN, SALICYLIC ACID, TRICLOSAN, PHENOXYETHANOL
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-80 SORBITAN LAURATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics		CHLORPHENESIN
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-100 STEARATE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-8

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		RETINYL ACETATE, TRIETHYL CITRATE, PROPYLENE GLYCOL, POLYACRYLAMIDE, NIACINAMIDE, GLYCINE, GLYCERIN, BUTYLENE GLYCOL
One or more animal studies show brain and nervous system effects at moderate doses		TARTARIC ACID, METHYLPARABEN, PHENOXYETHANOL, PYRIDOXINE, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, CHLORPHENESIN, AMMONIUM CHLORIDE,
One or more animal studies show any effects at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show brain and nervous system effects at low doses		SALICYLIC ACID, PYRIDOXINE HCL, DISODIUM EDTA, BIOTIN
One or more animal studies show brain and nervous system effects at very low doses		STEARIC ACID, ARGININE
Strong evidence of human neurotoxicity		ALUMINUM HYDROXIDE, ALUMINUM STARCH OCTENYLSUCCINATE, MAGNESIUM ALUMINUM SILICATE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		AMMONIUM CHLORIDE, TRIETHANOLAMINE, PYRIDOXINE HCL, GLYCINE, GLYCERIN, DISODIUM EDTA, BUTYLENE GLYCOL, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, ALCOHOL DENATURED
One or more animal studies show endocrine disruption at moderate doses		NIACINAMIDE, ARGININE,
One or more animal studies show endocrine disruption at moderate doses		CYCLOPENTASILOXANE
One or more studies show endocrine disruption at very low doses		TRICLOSAN
Human any disruptor - strong evidence		PROPYLPARABEN, METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE)

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show immune effects at low doses		TITANIUM DIOXIDE (NON-NANO)
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human skin toxicant - strong evidence		TOCOPHERYL ACETATE, PROPYLPARABEN, PEG-80 SORBITAN LAURATE
Known human immune system toxicant		TRIETHANOLAMINE
Human skin toxicant - strong evidence		METHYLPARABEN
Known human immune system toxicant		COCAMIDOPROPYL BETAINE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TITANIUM DIOXIDE (NON-NANO), TRIETHANOLAMINE, ETHYLENE/ ACRYLIC ACID COPOLYMER, POLYACRYLAMIDE, AMMONIUM HYDROXIDE, AMMONIUM CHLORIDE, ALCOHOL DENATURED, ALUMINUM HYDROXIDE
Not suspected to be persistent		1-DODECANOL
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Persistent, bioaccumulative in wildlife		TRICLOSAN, SALICYLIC ACID, CYCLOPENTASILOXANE, CYCLOMETHICONE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as expected to be toxic or harmful		ETHYLENE/ ACRYLIC ACID COPOLYMER
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		TRIETHYL CITRATE, PROPYLENE GLYCOL,
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		CYCLOPENTASILOXANE, CYCLOMETHICONE, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, STEARIC ACID, PANTHENOL, GLYCINE, MANDELIC ACID, BUTYLENE GLYCOL
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)		PYRIDOXINE HCL, POLYACRYLAMIDE, PHENOXYETHANOL, TOCOPHERYL ACETATE, SODIUM LAURETH SULFATE, PYRIDOXINE, GLYCERYL MONOSTEARATE, CITRIC ACID, DIISOPROPYL ADIPATE, AMMONIUM LAURETH SULFATE, 1-DODECANOL, TARTARIC ACID,
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)		C13-14 ISOPARAFFIN
Limited evidence of skin toxicity		RETINYL ACETATE, PEG-100 STEARATE, PROPYLPARABEN, POLYSORBATE, PEG-80 SORBITAN LAURATE, PEG-8, ALCOHOL DENATURED, MAGNESIUM ALUMINUM SILICATE, ALUMINUM STARCH OCTENYLSUCCINATE
One or more animal studies show metabolic effects at low doses		SALICYLIC ACID, TRICLOSAN, DISODIUM EDTA, AMMONIUM HYDROXIDE, ALUMINUM HYDROXIDE, BIOTIN
One or more animal studies show liver effects at very low doses		NIACINAMIDE, GLYCERIN, TITANIUM DIOXIDE (NON-NANO), ARGININE
Possible human immune system toxicant		TRIETHANOLAMINE
One or more animal studies show broad systemic effects at very low doses		AMMONIUM CHLORIDE
Known human any toxicant		METHYLPARABEN

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		PEG-100 STEARATE, XANTHAN GUM, TRIETHYL CITRATE, TRIETHANOLAMINE, TOCOPHERYL ACETATE, TARTARIC ACID, TITANIUM DIOXIDE (NON-NANO), STEARIC ACID, SODIUM CHLORIDE, SALICYLIC ACID, RETINYL ACETATE, PYRIDOXINE HCL, PROPYLPARABEN, PROPYLENE GLYCOL, POLYACRYLAMIDE, PEG-80 SORBITAN LAURATE, PEG-8, NIACINAMIDE, METHYLPARABEN, GLYCINE, GLYCERYL MONOSTEARATE, GLYCERIN, GLUCONOLACTONE, DISODIUM EDTA, DIMETHICONE, CITRIC ACID, BUTYLENE GLYCOL, BIOTIN, ARGININE, ARACHIS HYPOGAEA (PEANUT) OIL, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, AMMONIUM CHLORIDE, AMMONIUM HYDROXIDE, ALUMINUM STARCH OCTENYLSUCCINATE, ALUMINUM HYDROXIDE, ALCOHOL DENATURED, 1-DODECANOL
Used in food or as an additive with limited or no toxicity information available		SALICYLIC ACID, PYRIDOXINE, PANTHENOL, ALCOHOL DENATURED

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		CYCLOMETHICONE, POLYACRYLAMIDE, AMMONIUM CHLORIDE
Not suspected to be an environmental toxin		TRIETHANOLAMINE
Suspected to be an environmental toxin		1-DODECANOL
Not suspected to be an environmental toxin		TITANIUM DIOXIDE (NON-NANO), ETHYLENE/ ACRYLIC ACID COPOLYMER, ALUMINUM HYDROXIDE, ALCOHOL DENATURED
Wildlife and environmental toxicity		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Wildlife and environmental toxicity		TRICLOSAN, AMMONIUM HYDROXIDE, PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		TITANIUM DIOXIDE (NON-NANO), SODIUM CHLORIDE, SALICYLIC ACID, PEG-80 SORBITAN LAURATE, GLYCERIN, DIISOPROPYL ADIPATE, CYCLOPENTASILOXANE, CYCLOMETHICONE, CITRIC ACID, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT
One or more animal studies show skin irritation at low doses		STEARIC ACID, METHYLPARABEN, ARACHIS HYPOGAEA (PEANUT) OIL
One or more animal studies show skin irritation at very low doses		PEG-100 STEARATE
One or more animal studies show skin irritation at low doses		ALCOHOL DENATURED
One or more animal studies show skin irritation at very low doses		TRIETHANOLAMINE, DISODIUM COCOAMPHODIACETATE, 1-DODECANOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	BUTYLENE GLYCOL
Human skin irritant - moderate evidence		AMMONIUM HYDROXIDE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	SODIUM LAURETH SULFATE, AMMONIUM LAURETH SULFATE
Classified as skin irritant		PROPYLENE GLYCOL, TRICLOSAN, AMMONIUM CHLORIDE, PHENOXYETHANOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		PEG-100 STEARATE, TRIUNDECANOIN, PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		SODIUM LAURETH SULFATE
Considered safe based on assumption of low absorption		ETHYLENE/ ACRYLIC ACID COPOLYMER, POLYACRYLAMIDE
Insufficient data to determine safety		ALCOHOL DENATURED
Safety assessment was based on related chemical		PEG-80 SORBITAN LAURATE, PROPYLENE GLYCOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		TOCOPHERYL ACETATE, PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE, PEG-100 STEARATE, STEARIC ACID, PROPYLPARABEN, METHYLPARABEN, NIACINAMIDE, RETINYL ACETATE, PANTHENOL, POLYQUATERNIUM-10, MAGNESIUM ALUMINUM SILICATE, PHENOXYETHANOL, AMMONIUM LAURETH SULFATE, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, GLYCERYL MONOSTEARATE, DISODIUM EDTA, DISODIUM COCOAMPHODIACETATE, DIISOPROPYL ADIPATE, BUTYLENE GLYCOL, CYCLOMETHICONE, BIOTIN, DIMETHICONE, ARACHIS HYPOGAEA (PEANUT) OIL
Not assessed for safety in cosmetics by industry panel		TITANIUM DIOXIDE (NON-NANO), TRICLOSAN, TRIETHYL CITRATE, XANTHAN GUM, ACETYL MANDELIC ACID, HYDROLYZED YEAST PROTEIN, ISONONYL ISONONANOATE, LAURETH-7, MANDELIC ACID, OCTYLDODECYL NEOPENTANOATE, POLYSORBATE, PYRIDOXINE, PYRIDOXINE HCL, RETINYL ACETATE, SCLEROTIUM GUM, TARTARIC ACID, GLYCINE, GLYCERIN, GLUCONOLACTONE, FATTY ALCOHOLS, CYCLOPENTASILOXANE, CITRIC ACID, CHLORPHENESIN, C13-14 ISOPARAFFIN, C12-15 ALKYL BENZOATE, ARGININE, ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT, AMMONIUM HYDROXIDE, AMMONIUM CHLORIDE, ALUMINUM HYDROXIDE, ALLANTOIN, 1-DODECANOL

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to moderate doses		TRIETHANOLAMINE
Allowed workplace exposures restricted to high doses		ALCOHOL DENATURED
Allowed workplace exposures restricted to low doses		PHENOXYETHANOL, AMMONIUM CHLORIDE
Allowed workplace exposures restricted to moderate doses		GLYCERIN
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO)

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CITRIC ACID, CYCLOMETHICONE, CYCLOPENTASILOXANE, GLYCERIN, GLYCINE, POLYACRYLAMIDE, PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL ACETATE, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		METHYLPARABEN
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		ARGININE, ALCOHOL DENATURED
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		PYRIDOXINE HCL
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		TITANIUM DIOXIDE (NON-NANO), NIACINAMIDE