OPI Nail Lacquer, All Lacquered Up || Skin Deep: Cosmetic Safety Reviews

OPI NAIL LACQUER, ALL LACQUERED UP

last updated: 04/03/08 brand: OPI by OPI Products

SCORE

moderate hazard (out of 10)

76%

data gap

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COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company does not test on animals.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Butyl Acetate, Toluene, Nitrocellulose, Ethyl Acetate, Tosylamide/Formaldehyde Resin, Dibutyl Phthalate, Isopropyl Alcohol, Stearalkonium Hectorite, Camphor, Benzophenone 1, CI 77891, CI 77491, CI 77499, CI 19140, CI 15850

Warnings from packaging: Do not use near heat or flame. Keep away from children.

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ingredients

	score	data gap	concerns
TOLUENE	10	54%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (BENZENE), Occupational hazards
DIBUTYL PHTHALATE	10	49%	Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
BENZOPHENONE-1	5	79%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
ETHYL ACETATE	4	78%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
TITANIUM DIOXIDE (NON-NANO) CI 77891	1	81%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
ISOPROPYL ALCOHOL	4	72%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
TOSYLAMIDE/ FORMALDEHYDE RESIN	4	72%	Allergies/immunotoxicity
CAMPHOR	4	69%	Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
CI 19140	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive)
CI 77491	2	76%	Persistence and bioaccumulation, Occupational hazards, Biochemical or cellular level changes
CI 77499	3	74%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
NITROCELLULOSE	1	94%	Organ system toxicity (non-reproductive)
STEARALKONIUM HECTORITE	1	93%	Contamination concerns (NITROSAMINES, FREE AMINES)
BUTYL ACETATE	1	78%	Irritation (skin, eyes, or lungs), Occupational hazards
CI 15850	0	94%	none identified

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results		CI 19140, TITANIUM DIOXIDE (NON-NANO), ETHYL ACETATE, CAMPHOR
Cancer - not classifiable/not likely to be human carcinogen		DIBUTYL PHTHALATE
Cancer - not classifiable/not likely to be human carcinogen		CI 77499, CI 77491, TOLUENE, ISOPROPYL ALCOHOL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		CI 19140
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL
Human nervous system toxicant - moderate evidence		ETHYL ACETATE
Possible human developmental toxicant		TOLUENE, DIBUTYL PHTHALATE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		CAMPHOR
Determined safe for use in cosmetics, subject to concentration or use limitations - Restrictions on impurities recommended by industry safety panel		TOLUENE
Violation of industry recommendations - Unsafe for use in cosmetics		TOLUENE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		DIBUTYL PHTHALATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		BUTYL ACETATE
One or more animal studies show brain and nervous system effects at high doses		BENZOPHENONE-1
One or more animal studies show brain and nervous system effects at low doses		CAMPHOR
One or more animal studies show brain and nervous system effects at very low doses		CI 19140
Strong evidence of human neurotoxicity		TOLUENE, ISOPROPYL ALCOHOL, DIBUTYL PHTHALATE, ETHYL ACETATE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		DIBUTYL PHTHALATE, BENZOPHENONE-1

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show immune effects at low doses		TITANIUM DIOXIDE (NON-NANO)
Human skin toxicant - strong evidence		BENZOPHENONE-1
Limited evidence of immune system toxicity		TOLUENE
Known human immune system toxicant		TOSYLAMIDE/ FORMALDEHYDE RESIN, DIBUTYL PHTHALATE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TOLUENE, TITANIUM DIOXIDE (NON-NANO)
Persistent, bioaccumulative in wildlife		DIBUTYL PHTHALATE
Not suspected to be bioaccumulative		ISOPROPYL ALCOHOL
Persistent, bioaccumulative in wildlife and humans		CI 77499

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as expected to be toxic or harmful		NITROCELLULOSE
Limited evidence of sense organ toxicity		ISOPROPYL ALCOHOL, ETHYL ACETATE, CI 77499
One or more animal studies show broad systemic effects at low doses		BENZOPHENONE-1, CAMPHOR
One or more animal studies show musculoskeletal effects at very low doses		CI 19140, TITANIUM DIOXIDE (NON-NANO)
Known human respiratory toxicant		DIBUTYL PHTHALATE, TOLUENE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be an environmental toxin		TITANIUM DIOXIDE (NON-NANO), NITROCELLULOSE, ISOPROPYL ALCOHOL
Wildlife and environmental toxicity		TOLUENE, DIBUTYL PHTHALATE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		TITANIUM DIOXIDE (NON-NANO)
Classified as skin irritant	products for use on skin	TOLUENE, BUTYL ACETATE
Classified as irritant		ISOPROPYL ALCOHOL, ETHYL ACETATE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Insufficient data to determine safety		DIBUTYL PHTHALATE, TOLUENE
Considered safe based on assumption of low absorption		TOLUENE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		TOLUENE, STEARALKONIUM HECTORITE, DIBUTYL PHTHALATE, ETHYL ACETATE, BUTYL ACETATE
Not assessed for safety in cosmetics by industry panel		CI 77499
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		BENZOPHENONE-1
Not assessed for safety in cosmetics by industry panel		CI 19140, CI 15850, TITANIUM DIOXIDE (NON-NANO), NITROCELLULOSE, ISOPROPYL ALCOHOL, CAMPHOR

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CI 77491
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO)
Allowed workplace exposures restricted to high doses		ISOPROPYL ALCOHOL, BUTYL ACETATE
Allowed workplace exposures restricted to moderate doses		CI 77499, DIBUTYL PHTHALATE, CAMPHOR
Allowed workplace exposures restricted to high doses		TOLUENE, ETHYL ACETATE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		CI 77491, CI 77499
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		DIBUTYL PHTHALATE