Colgate 2-In-1 Toothpaste & Mouthwash, Icy Blast || Skin Deep: Cosmetic Safety Reviews

COLGATE 2-IN-1 TOOTHPASTE & MOUTHWASH, ICY BLAST

last updated: 10/01/09 brand: Colgate by Colgate-Palmolive Company

SCORE

moderate hazard (out of 10)

74%

data gap

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93% of mouthwashs have lower concerns
92% of toothpastes have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: ACTIVE INGREDIENTS: SODIUM FLOURIDE (0.24% (0.15% W/V FLOURIDE ION)). INACTIVE INGREDIENTS: WATER, HYDRATED SILICA, SORBITOL, GLYCERIN, PENTASODIUM TRIPHOSPHATE, SODIUM LAURYL SULFATE, FLAVOR, PVM/MA COPOLYMER, TETRASODIUM PYROPHOSPHATE, POLYETHYLENE, SODIUM SACCHARIN, COCAMIDOPROPYL BETAINE, CELLULOSE GUM, SODIUM HYDROXIDE, CARRAGEENAN, MICA, TITANIUM DIOXIDE, FD&C BLUE 1.

Directions from packaging: Adults and children 2 years of age and older: brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or physician. Children 2 to 6 years: use only a pea sized amount and supervise child's brushing and rinsing (to minimize swallowing). Children under 2 years: ask a dentist or physician. .

Warnings from packaging: Keep out of the reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.

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ingredients

	score	data gap	concerns
SODIUM FLUORIDE SODIUM FLOURIDE (0.24% (0.15% W/V FLOURIDE ION)) (Active Ingredient)	9	63%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
POLYETHYLENE	5	69%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
COCAMIDOPROPYL BETAINE	5	63%	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
FLAVOR	4	100%	Miscellaneous
TITANIUM DIOXIDE (NON-NANO)	1	81%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
SODIUM HYDROXIDE	3	77%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CARRAGEENAN	2	75%	Organ system toxicity (non-reproductive), Contamination concerns (DEGRADED CARRAGEENAN), Biochemical or cellular level changes
MICA	3	75%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards
SODIUM LAURYL SULFATE	3	68%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
FD&C BLUE 1	1	83%	none identified
TETRASODIUM PYROPHOSPHATE	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
SODIUM SACCHARIN	2	80%	Neurotoxicity
HYDRATED SILICA	2	79%	Persistence and bioaccumulation
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
PVM/ MA COPOLYMER	1	93%	Irritation (skin, eyes, or lungs)
SORBITOL	1	88%	none identified
PENTASODIUM TRIPHOSPHATE	1	83%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CELLULOSE GUM	1	80%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show tumor formation at high doses		CELLULOSE GUM
One or more in vitro tests on mammalian cells show positive mutation results		TITANIUM DIOXIDE (NON-NANO), SORBITOL, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, SODIUM HYDROXIDE, GLYCERIN
One or more animal studies show tumor formation at low doses		SODIUM FLUORIDE
Not likely to be carcinogenic in humans		CARRAGEENAN
Cancer - not classifiable/not likely to be human carcinogen		HYDRATED SILICA, POLYETHYLENE, FD&C BLUE 1

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		SODIUM SACCHARIN, SODIUM LAURYL SULFATE
One or more animal studies show reproductive effects at moderate doses		CELLULOSE GUM, GLYCERIN
Human nervous system toxicant - moderate evidence		SODIUM FLUORIDE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		SODIUM LAURYL SULFATE, POLYETHYLENE, COCAMIDOPROPYL BETAINE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		SODIUM FLUORIDE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		POLYETHYLENE, GLYCERIN, FD&C BLUE 1
One or more animal studies show brain and nervous system effects at moderate doses		SODIUM LAURYL SULFATE, PENTASODIUM TRIPHOSPHATE, CARRAGEENAN
One or more animal studies show brain and nervous system effects at low doses		TETRASODIUM PYROPHOSPHATE
One or more animal studies show brain and nervous system effects at very low doses		SODIUM SACCHARIN, SODIUM HYDROXIDE
Strong evidence of human neurotoxicity		SODIUM FLUORIDE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		SODIUM LAURYL SULFATE, PENTASODIUM TRIPHOSPHATE, GLYCERIN
One or more studies show endocrine system disruption at low doses		SODIUM FLUORIDE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show gastrointestinal effects at moderate doses		MICA
One or more animal studies show immune effects at low doses		TITANIUM DIOXIDE (NON-NANO)
Human immune system toxicant - moderate evidence		POLYETHYLENE
Known human immune system toxicant		COCAMIDOPROPYL BETAINE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TITANIUM DIOXIDE (NON-NANO), SODIUM HYDROXIDE
Not suspected to be persistent		SODIUM LAURYL SULFATE
Persistent, bioaccumulative in wildlife and humans		HYDRATED SILICA, MICA

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		CELLULOSE GUM, SODIUM SACCHARIN, SORBITOL
One or more animal studies show metabolic effects at low doses		TETRASODIUM PYROPHOSPHATE
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		FD&C BLUE 1
One or more animal studies show broad systemic effects at low doses		SODIUM LAURYL SULFATE, PENTASODIUM TRIPHOSPHATE
One or more animal studies show metabolic effects at very low doses		SODIUM HYDROXIDE, GLYCERIN, TITANIUM DIOXIDE (NON-NANO), SODIUM FLUORIDE, CARRAGEENAN
Possible human respiratory toxicant		MICA, POLYETHYLENE

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM HYDROXIDE, SODIUM FLUORIDE
Ingredient not fully labeled - identity unknown		FLAVOR

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, SORBITOL, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, SODIUM HYDROXIDE, SODIUM FLUORIDE, POLYETHYLENE, PENTASODIUM TRIPHOSPHATE, GLYCERIN, FD&C BLUE 1, CELLULOSE GUM, CARRAGEENAN
Used in food or as an additive with limited or no toxicity information available		SODIUM FLUORIDE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		SODIUM LAURYL SULFATE
Not suspected to be an environmental toxin		TITANIUM DIOXIDE (NON-NANO), SODIUM HYDROXIDE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		TITANIUM DIOXIDE (NON-NANO), GLYCERIN
One or more animal studies show skin irritation at low doses		PVM/ MA COPOLYMER, PENTASODIUM TRIPHOSPHATE
One or more animal studies show skin irritation at very low doses		SODIUM LAURYL SULFATE, SODIUM HYDROXIDE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Missing safety data noted by cosmetic industry review		POLYETHYLENE
Not assessed for safety in cosmetics by industry panel		FLAVOR, HYDRATED SILICA
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		CELLULOSE GUM, POLYETHYLENE
Considered safe based on assumption of low absorption		POLYETHYLENE
Not assessed for safety in cosmetics by industry panel		TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, SORBITOL, SODIUM SACCHARIN, SODIUM HYDROXIDE, PVM/ MA COPOLYMER, PENTASODIUM TRIPHOSPHATE, GLYCERIN, CARRAGEENAN

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
No workplace limits set		SODIUM HYDROXIDE
Allowed workplace exposures restricted to moderate doses		TETRASODIUM PYROPHOSPHATE, GLYCERIN
Allowed workplace exposures restricted to low doses		MICA,
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO)
Allowed workplace exposures restricted to very low doses		SODIUM FLUORIDE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		POLYETHYLENE, GLYCERIN, CELLULOSE GUM
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		SODIUM LAURYL SULFATE
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		SODIUM FLUORIDE, CARRAGEENAN