

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards |
Ingredients from packaging: Ethyl Acetate, SD 35A, Water, Propylene Glycol & Triclosan, Glycerin, Fragrance, Vitamin E Acetate, D&C Red 33, Benzophenone 4, Denatonium Benzoate.
Directions from packaging: Use saturated pad to gently rub polish from all nails. Pad will absorb color while special Polish Off formula conditions cuticle and nails. For home use, try Polish Off pads in a jar. Wash hands after use.
Warnings from packaging: Flammable. Keep away from heat or flame. Keep away from children. Exposed pad may damage furniture or clothing.
| score | data gap | concerns | |
| FRAGRANCE | 8 | 100% | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |
| TRICLOSAN | 7 | 67% | Violations, restrictions & warnings, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (CHLOROFORM, DIOXIN) |
| ETHYL ACETATE | 4 | 78% | Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| ALCOHOL DENATURED SD 35A | 5 | 71% | Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards |
| TOCOPHERYL ACETATE VITAMIN E ACETATE | 4 | 81% | Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE) |
| D&C RED 33 | 1 | 75% | none identified |
| SULISOBENZONE (BENZOPHENONE-4) (Active Ingredient) | 3 | 66% | Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| PROPYLENE GLYCOL | 4 | 60% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| DENATONIUM BENZOATE | 1 | 90% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not likely to be mutagenic in humans | SULISOBENZONE (BENZOPHENONE-4) | |
| One or more in vitro tests non-mammalian cells show positive mutation results | TRICLOSAN, D&C RED 33 | |
| One or more in vitro tests on mammalian cells show positive mutation results | TOCOPHERYL ACETATE, PROPYLENE GLYCOL, GLYCERIN, ETHYL ACETATE | |
| Cancer - limited evidence | ALCOHOL DENATURED |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | TRICLOSAN | |
| One or more animal studies show reproductive effects at moderate doses | PROPYLENE GLYCOL | |
| Limited evidence of reproductive toxicity | ALCOHOL DENATURED | |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN | |
| Human nervous system toxicant - moderate evidence | ETHYL ACETATE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PROPYLENE GLYCOL | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit) | TRICLOSAN, TRICLOSAN | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmetics | D&C RED 33 |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | PROPYLENE GLYCOL, GLYCERIN | |
| One or more animal studies show brain and nervous system effects at moderate doses | DENATONIUM BENZOATE | |
| Strong evidence of human neurotoxicity | ETHYL ACETATE | |
| Moderate evidence of human neurotoxicity | FRAGRANCE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Associated with endocrine disruption | SULISOBENZONE (BENZOPHENONE-4) | |
| One or more animal studies show endocrine system disruption at high doses | GLYCERIN, ALCOHOL DENATURED | |
| One or more studies show endocrine disruption at very low doses | TRICLOSAN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL | |
| Human skin toxicant - strong evidence | TOCOPHERYL ACETATE, SULISOBENZONE (BENZOPHENONE-4) | |
| Known human immune system toxicant | FRAGRANCE |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be bioaccumulative | ALCOHOL DENATURED | |
| Persistent, bioaccumulative in wildlife | TRICLOSAN |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient) | PROPYLENE GLYCOL | |
| One or more animal studies show sense effects at moderate doses (low dose studies may be unavailable for this ingredient) | SULISOBENZONE (BENZOPHENONE-4) | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | TOCOPHERYL ACETATE | |
| One or more animal studies show broad systemic effects at low doses | TRICLOSAN | |
| Limited evidence of sense organ toxicity | ETHYL ACETATE, ALCOHOL DENATURED | |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | ETHYL ACETATE, ALCOHOL DENATURED | |
| Ingredient not fully labeled - identity unknown | FRAGRANCE |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | TOCOPHERYL ACETATE, GLYCERIN, PROPYLENE GLYCOL, ETHYL ACETATE, ALCOHOL DENATURED | |
| Used in food or as an additive with limited or no toxicity information available | ALCOHOL DENATURED |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be an environmental toxin | ALCOHOL DENATURED | |
| Wildlife and environmental toxicity | TRICLOSAN |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN | |
| One or more animal studies show skin irritation at low doses | ALCOHOL DENATURED | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | SULISOBENZONE (BENZOPHENONE-4) |
| Classified as skin irritant | PROPYLENE GLYCOL, TRICLOSAN, ETHYL ACETATE |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Insufficient data to determine safety | ALCOHOL DENATURED | |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | TOCOPHERYL ACETATE, ETHYL ACETATE, SULISOBENZONE (BENZOPHENONE-4) | |
| Not assessed for safety in cosmetics by industry panel | TRICLOSAN, GLYCERIN, FRAGRANCE, DENATONIUM BENZOATE |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN | |
| Allowed workplace exposures restricted to high doses | ALCOHOL DENATURED | |
| Allowed workplace exposures restricted to high doses | ETHYL ACETATE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | ALCOHOL DENATURED, GLYCERIN, PROPYLENE GLYCOL |
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