L'Oréal Excellence Creme Triple Protection Color Creme, Medium Maple Brown, 5AR || Skin Deep: Cosmetic Safety Reviews

L'ORéAL EXCELLENCE CREME TRIPLE PROTECTION COLOR CREME, MEDIUM MAPLE BROWN, 5AR

last updated: 04/01/08 brand: L'Oréal by L'Oréal

SCORE

high hazard (out of 10)

78%

data gap

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70% of hair color and bleachings have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Water Aqua, Cetearyl Alcohol, Propylene Glycol, Deceth-3, Laureth-12, Ammonium Hydroxide, Oleth-30, Hexadimethrine Chloride, Lauric Acid, Glycol Distearate, Polyquaternium-22, Ethanolamine, Silica Dimethyl Silylate, Titanium Dioxide CI 77891, 2,4-Diaminophenoxyethanol HCl, M-Aminophenol, P-Aminophenol, 2-Amino-3-Hydroxypyridine, Ascorbic Acid, Sodium Metabisulfite, 6-Hydroxyindole, Dimethicone, Pentasodium Pentetate, Linalool, P-Phenylenediamine, Carbomer, Resorcinol, Butylphenyl Methylpropional, Fragrance Parfum, Water Aqua, Hydrogen Peroxide, Cetearyl Alcohol, Trideceth-2 Carboxamide MEA, Ceteareth-30, Glycerin, Pentasodium Pentetate, Sodium Stannate, Tetrasodium Pyrophosphate, Water Aqua, Cetearyl Alcohol, Glycerin, Trideceth-2 Carboxamide MEA, Ceteareth-30, Phenoxyethanol, Fragrance Parfum, Hexadimethrine Chloride, Methylparaben, Polyquaternium-22, Pentasodium Pentetate, Hydrolyzed Oats, Butylparaben, Ethylparaben, Linalool, Benzyl Salicylate, Propylparaben, Isobutylparaben, Citric Acid, Amyl Cinnamal, Benzyl Benzoate, Citronellol, Geraniol, 2-Oleamino-1, 3-Octadecadiol, Water Aqua, Cetearyl Alcohol, Glycerin, Behentrimonium Chloride, Amodimethicone, Cetyl Esters, Isopropyl Alcohol, Hydroxypropyltrimonium Hydrolyzed Wheat Protein, Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde, Trideceth-12, Chlorhexidine Dihydrochloride, Panthenol, Candelilla Wax Candelilla Cera, Benzyl Salicylate, 2-Oleamido-1,3-Octadecanediol, Alpha-Isomethyl Ionone, Methylparaben, Cetrimonium Chloride, Citronellol, Butylphenyl Methylpropional, Fragrance Parfum

Directions from packaging: Important:Follow the usage advisory.Read and follow the insert.Store between 50 and 80 degrees F.

Warnings from packaging: Usage Advisory - Safety Warnings:Important - Haircolor products can cause an allergic reaction which, in certain rare cases, can be severe. Therefore, you must follow these precautions.Do not use if:you already had a reaction to a haircolor productyou have a sensitive, itchy or damaged scalpIf you have a tattoo, the risk of allergic reaction may be increased.Perform a skin allergy test 48 hours before each use of this product - see insert. Remember to buy your product 2 days ahead of time.Avoid contact with eyes and skin. If product gets into eyes, rinse immediately.Wear gloves provided in kit.Thoroughly rinse hair after application.Do not use over compound henna or progressive color.Keep product out of the reach of children.Do not apply on children.This product contains ingredients which may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made.This product must not be used for dyeing the eyelashes or eyebrows; to do so may cause blindness.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
P-PHENYLENEDIAMINE	10	52%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
RESORCINOL	10	52%	Cancer, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
P-AMINOPHENOL	8	57%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-30	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ETHANOLAMINE	7	66%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
BUTYLPARABEN	6	79%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
SODIUM METABISULFITE	6	70%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
HYDROGEN PEROXIDE	3	65%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
M-AMINOPHENOL	6	65%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Occupational hazards
LILIAL BUTYLPHENYL METHYLPROPIONAL	5	64%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
BENZYL SALICYLATE	6	62%	Violations, restrictions & warnings, Allergies/immunotoxicity
LYRAL HYDROXYISOHEXYL 3-CYCLOHEXENE CARBOXALDEHYDE	5	62%	Violations, restrictions & warnings, Allergies/immunotoxicity
AMYLCINNAMALDEHYDE	6	61%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
GERANIOL	6	61%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ETHYLPARABEN	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
CHLORHEXIDINE DIHYDROCHLORIDE	4	73%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
BENZYL BENZOATE	5	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Occupational hazards
CITRONELLOL	4	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LINALOOL	5	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
OLETH-30	3	87%	Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TITANIUM DIOXIDE (NON-NANO) TITANIUM DIOXIDE CI 77891	1	81%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
ISOPROPYL ALCOHOL	4	72%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
ALPHA-ISOMETHYL IONONE	4	68%	Violations, restrictions & warnings, Allergies/immunotoxicity
6-HYDROXYINDOLE	3	67%	Cancer, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PHENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
LAURETH-12	3	100%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
ISOBUTYLPARABEN	3	83%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
DIMETHICONE	2	74%	Violations, restrictions & warnings
CITRIC ACID	2	72%	Violations, restrictions & warnings
CETRIMONIUM CHLORIDE	3	71%	Allergies/immunotoxicity
PANTHENOL	2	88%	Multiple, additive exposure sources
TETRASODIUM PYROPHOSPHATE	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
AMMONIUM HYDROXIDE	2	81%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
LAURIC ACID	1	74%	Neurotoxicity
BEHENTRIMONIUM CHLORIDE	0	94%	none identified
CETEARYL ALCOHOL	0	93%	none identified
GLYCOL DISTEARATE	1	93%	Multiple, additive exposure sources
ASCORBIC ACID (VITAMIN C)	1	91%	none identified
SODIUM STANNATE	1	88%	Occupational hazards
TRIDECETH-12	1	88%	Organ system toxicity (non-reproductive)
2,4-DIAMINOPHENOXYETHANOL HCL	1	75%	Cancer
2-AMINO-3-HYDROXYPYRIDINE	1	75%	Cancer
PENTASODIUM PENTETATE	0	74%	none identified
2-OLEAMIDO-1,3-OCTADECANEDIOL 2-OLEAMINO-1 3-OCTADECADIOL	0	100%	none identified
DECETH-3	0	100%	none identified
HEXADIMETHRINE CHLORIDE	0	100%	none identified
HYDROLYZED OATS	0	100%	none identified
HYDROXYPROPYLTRIMONIUM HYDROLYZED WHEAT PROTEIN	0	100%	none identified
POLYQUATERNIUM-22	0	100%	none identified
SILICA DIMETHYL SILYLATE	0	100%	none identified
TRIDECETH-2 CARBOXAMIDE MEA	0	100%	none identified
AMODIMETHICONE	0	99%	none identified
EUPHORBIA CERIFERA (CANDELILLA) WAX CANDELILLA WAX CANDELILLA CERA	0	93%	none identified
CARBOMER	0	93%	none identified
CETYL ESTERS	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL, LINALOOL, AMMONIUM HYDROXIDE
One or more in vitro tests on mammalian cells show positive mutation results		TITANIUM DIOXIDE (NON-NANO), SODIUM METABISULFITE, PROPYLPARABEN, PROPYLENE GLYCOL, METHYLPARABEN, GLYCERIN, GERANIOL, ETHYLPARABEN, ETHANOLAMINE, CETRIMONIUM CHLORIDE, BUTYLPARABEN, ASCORBIC ACID (VITAMIN C)
Cancer - limited evidence		M-AMINOPHENOL, 6-HYDROXYINDOLE, 2-AMINO-3-HYDROXYPYRIDINE, 2,4-DIAMINOPHENOXYETHANOL HCL
Not likely to be carcinogenic in humans		LAURIC ACID
Mutagen - limited evidence		P-AMINOPHENOL
Cancer - not classifiable/not likely to be human carcinogen		RESORCINOL, HYDROGEN PEROXIDE, ISOPROPYL ALCOHOL, P-PHENYLENEDIAMINE

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		SODIUM METABISULFITE, M-AMINOPHENOL, ETHYLPARABEN, ETHANOLAMINE, LILIAL
One or more animal studies show reproductive effects at moderate doses		PROPYLENE GLYCOL, P-AMINOPHENOL, GLYCERIN
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show any effects at very low doses		BUTYLPARABEN
Human nervous system toxicant - moderate evidence		P-PHENYLENEDIAMINE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PROPYLENE GLYCOL, ETHANOLAMINE, CHLORHEXIDINE DIHYDROCHLORIDE, CETRIMONIUM CHLORIDE, RESORCINOL, CETEARETH-30, P-PHENYLENEDIAMINE, P-AMINOPHENOL, M-AMINOPHENOL, 6-HYDROXYINDOLE, 2-AMINO-3-HYDROXYPYRIDINE, 2,4-DIAMINOPHENOXYETHANOL HCL
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		P-PHENYLENEDIAMINE, P-AMINOPHENOL, M-AMINOPHENOL, DIMETHICONE, LYRAL, CITRONELLOL, GERANIOL, LILIAL, BENZYL SALICYLATE, BENZYL BENZOATE, AMYLCINNAMALDEHYDE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		P-PHENYLENEDIAMINE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limits, according to industry safety panel (International Fragrance Association)		LINALOOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		CITRIC ACID, CHLORHEXIDINE DIHYDROCHLORIDE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)		ALPHA-ISOMETHYL IONONE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		CHLORHEXIDINE DIHYDROCHLORIDE, RESORCINOL, PHENOXYETHANOL
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Unsafe in products left on skin and not rinsed off	products that are intended to be left on the skin	ETHANOLAMINE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		GLYCERIN, PROPYLENE GLYCOL, AMYLCINNAMALDEHYDE
One or more animal studies show brain and nervous system effects at moderate doses		SODIUM METABISULFITE, RESORCINOL, PHENOXYETHANOL, P-AMINOPHENOL, METHYLPARABEN, M-AMINOPHENOL, LINALOOL, GERANIOL, ETHANOLAMINE, CITRONELLOL, CETEARETH-30
One or more animal studies show brain and nervous system effects at low doses		LAURIC ACID, TETRASODIUM PYROPHOSPHATE
One or more animal studies show brain and nervous system effects at moderate doses		LILIAL
One or more animal studies show brain and nervous system effects at very low doses		HYDROGEN PEROXIDE
Moderate evidence of human neurotoxicity		FRAGRANCE
Strong evidence of human neurotoxicity		P-PHENYLENEDIAMINE, ISOPROPYL ALCOHOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Associated with endocrine disruption		LILIAL, BENZYL SALICYLATE, BENZYL BENZOATE
One or more animal studies show endocrine system disruption at high doses		P-PHENYLENEDIAMINE, HYDROGEN PEROXIDE
One or more animal studies show endocrine disruption at moderate doses		ISOBUTYLPARABEN
One or more animal studies show endocrine system disruption at high doses		GLYCERIN
Human any disruptor - strong evidence		RESORCINOL, PROPYLPARABEN, METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
One or more animal studies show immune effects at low doses		TITANIUM DIOXIDE (NON-NANO)
Human immune system toxicant - moderate evidence		CHLORHEXIDINE DIHYDROCHLORIDE
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Limited evidence of immune system toxicity	products for use on skin	6-HYDROXYINDOLE
Human skin toxicant - strong evidence		PROPYLPARABEN, METHYLPARABEN, M-AMINOPHENOL, ISOBUTYLPARABEN, ETHYLPARABEN, ETHANOLAMINE, CETRIMONIUM CHLORIDE, BUTYLPARABEN
Possible human immune system toxicant		LINALOOL, CITRONELLOL, LILIAL, BENZYL BENZOATE
Known human immune system toxicant		RESORCINOL
Possible human immune system toxicant		ALPHA-ISOMETHYL IONONE
Known human immune system toxicant		SODIUM METABISULFITE, P-PHENYLENEDIAMINE, P-AMINOPHENOL, LYRAL, GERANIOL, FRAGRANCE, BENZYL SALICYLATE, AMYLCINNAMALDEHYDE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TITANIUM DIOXIDE (NON-NANO), SODIUM METABISULFITE, ISOPROPYL ALCOHOL, AMMONIUM HYDROXIDE
Not suspected to be persistent		TRIDECETH-12

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		PROPYLENE GLYCOL, TRIDECETH-12, PANTHENOL, LINALOOL, LAURIC ACID
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)		CETEARETH-30
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		BENZYL SALICYLATE, CITRONELLOL
One or more animal studies show gastrointestinal effects at moderate doses (low dose studies may be unavailable for this ingredient)		PHENOXYETHANOL, OLETH-30, CITRIC ACID
Limited evidence of sense organ toxicity		ISOPROPYL ALCOHOL, PROPYLPARABEN
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		CETRIMONIUM CHLORIDE
Limited evidence of sense organ toxicity		ISOBUTYLPARABEN, ETHYLPARABEN, BUTYLPARABEN
One or more animal studies show metabolic effects at low doses		TETRASODIUM PYROPHOSPHATE, RESORCINOL, GERANIOL, AMMONIUM HYDROXIDE
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN, HYDROGEN PEROXIDE, TITANIUM DIOXIDE (NON-NANO)
Possible human immune system toxicant		SODIUM METABISULFITE, P-AMINOPHENOL, CHLORHEXIDINE DIHYDROCHLORIDE, ETHANOLAMINE
Known human respiratory toxicant		P-PHENYLENEDIAMINE, METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM METABISULFITE, ISOPROPYL ALCOHOL, HYDROGEN PEROXIDE, ETHANOLAMINE, AMMONIUM HYDROXIDE
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		TETRASODIUM PYROPHOSPHATE, DIMETHICONE, ETHANOLAMINE, GERANIOL, GLYCERIN, HYDROGEN PEROXIDE, ISOPROPYL ALCOHOL, LAURIC ACID, LINALOOL, TITANIUM DIOXIDE (NON-NANO), SODIUM METABISULFITE, RESORCINOL, PROPYLENE GLYCOL, PROPYLPARABEN, METHYLPARABEN, CITRONELLOL, CITRIC ACID, CHLORHEXIDINE DIHYDROCHLORIDE, EUPHORBIA CERIFERA (CANDELILLA) WAX, BUTYLPARABEN, BENZYL SALICYLATE, BENZYL BENZOATE, ASCORBIC ACID (VITAMIN C), AMYLCINNAMALDEHYDE, AMMONIUM HYDROXIDE, ALPHA-ISOMETHYL IONONE
Used in food or as an additive with limited or no toxicity information available		PANTHENOL, GLYCOL DISTEARATE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		TRIDECETH-12
Not suspected to be an environmental toxin		TITANIUM DIOXIDE (NON-NANO), SODIUM METABISULFITE, ISOPROPYL ALCOHOL
Wildlife and environmental toxicity		RESORCINOL, P-PHENYLENEDIAMINE, P-AMINOPHENOL, AMMONIUM HYDROXIDE, BENZYL BENZOATE, M-AMINOPHENOL, PROPYLPARABEN, 6-HYDROXYINDOLE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		TRIDECETH-12, TITANIUM DIOXIDE (NON-NANO), P-AMINOPHENOL, BUTYLPARABEN, CITRIC ACID, GLYCERIN, LAURIC ACID, LYRAL, M-AMINOPHENOL
One or more animal studies show skin irritation at low doses		OLETH-30, METHYLPARABEN, CETEARETH-30, LILIAL
One or more animal studies show skin irritation at very low doses		LINALOOL, GERANIOL, CITRONELLOL, AMYLCINNAMALDEHYDE
Human skin irritant - moderate evidence		HYDROGEN PEROXIDE, ETHANOLAMINE, CHLORHEXIDINE DIHYDROCHLORIDE, AMMONIUM HYDROXIDE
Classified as skin irritant		PROPYLENE GLYCOL, SODIUM METABISULFITE, RESORCINOL, PHENOXYETHANOL, P-PHENYLENEDIAMINE, ISOPROPYL ALCOHOL, 6-HYDROXYINDOLE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		ASCORBIC ACID (VITAMIN C), AMODIMETHICONE, OLETH-30, PROPYLENE GLYCOL, CETYL ESTERS, OLETH-30
Insufficient data to determine safety		P-PHENYLENEDIAMINE
Safety assessment was based on related chemical		ISOBUTYLPARABEN, PENTASODIUM PENTETATE
Insufficient data to determine safety		P-AMINOPHENOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		PROPYLPARABEN, RESORCINOL, OLETH-30
Missing safety data noted by cosmetic industry review		M-AMINOPHENOL, P-AMINOPHENOL, P-PHENYLENEDIAMINE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		P-AMINOPHENOL, P-PHENYLENEDIAMINE
Insufficient data to determine safety		M-AMINOPHENOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		SODIUM METABISULFITE, PHENOXYETHANOL
Missing safety data noted by cosmetic industry review		PENTASODIUM PENTETATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		LAURIC ACID, M-AMINOPHENOL, METHYLPARABEN, GLYCOL DISTEARATE, DIMETHICONE, PANTHENOL, CETYL ESTERS, ETHYLPARABEN, CETEARYL ALCOHOL, CARBOMER, BUTYLPARABEN, EUPHORBIA CERIFERA (CANDELILLA) WAX, ASCORBIC ACID (VITAMIN C), AMODIMETHICONE, PENTASODIUM PENTETATE
Not assessed for safety in cosmetics by industry panel		TRIDECETH-12, TRIDECETH-2 CARBOXAMIDE MEA, TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, SODIUM STANNATE, SILICA DIMETHYL SILYLATE, POLYQUATERNIUM-22, LAURETH-12, LINALOOL, LYRAL, ISOPROPYL ALCOHOL, HYDROXYPROPYLTRIMONIUM HYDROLYZED WHEAT PROTEIN, HYDROLYZED OATS, HYDROGEN PEROXIDE, HEXADIMETHRINE CHLORIDE, GLYCERIN, GERANIOL, FRAGRANCE, DECETH-3, CITRONELLOL, CITRIC ACID, LILIAL, BENZYL SALICYLATE, BENZYL BENZOATE, BEHENTRIMONIUM CHLORIDE, AMYLCINNAMALDEHYDE, AMMONIUM HYDROXIDE, ALPHA-ISOMETHYL IONONE, 6-HYDROXYINDOLE, 2-OLEAMIDO-1,3-OCTADECANEDIOL, 2,4-DIAMINOPHENOXYETHANOL HCL

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		P-AMINOPHENOL
Allowed workplace exposures restricted to high doses		ISOPROPYL ALCOHOL
Allowed workplace exposures restricted to moderate doses		TETRASODIUM PYROPHOSPHATE, GLYCERIN
Allowed workplace exposures restricted to low doses		SODIUM STANNATE,
Allowed workplace exposures restricted to low doses		HYDROGEN PEROXIDE, SODIUM METABISULFITE, RESORCINOL, PHENOXYETHANOL, M-AMINOPHENOL
Allowed workplace exposures restricted to very low doses		P-PHENYLENEDIAMINE
Allowed workplace exposures restricted to low doses		BENZYL BENZOATE, 6-HYDROXYINDOLE, TITANIUM DIOXIDE (NON-NANO), ETHANOLAMINE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		P-AMINOPHENOL, SODIUM METABISULFITE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CITRIC ACID, GLYCERIN, HYDROGEN PEROXIDE, PROPYLENE GLYCOL
Interferes with gene expresion		BUTYLPARABEN, METHYLPARABEN