Donate Skin Deep

CREME OF NATURE NOURISHING PERMANENT HAIR COLORS, INTENSE RED 6.6

last updated: 04/01/08 brand: Creme of Nature by Colomer Group

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.


Ingredients in this product are linked to:
yesCancer
yesDevelopmental/reproductive toxicity
yesViolations, restrictions & warnings
yesAllergies/immunotoxicity
yesOther concerns for ingredients used in this product:
Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes


Ingredients from packaging: Ultra-Purified Water Aqua, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Glycol Stearate, Mentha Piperita Leaf Extract Peppermint, Ocimum Basilicum Extract Basil, Polygala Senega Root Extract, Nasturtium Officinale Extract Watercress, Salva Officinalis Leaf Extract Sage, Thymus Vulgaris Extract Thyme, Rosmarinus Officinalis Leaf Extract Rosemary, Citrus Grandis Seed Extract Grapefruit, Actinidia Chinensis Fruit Extract Kiwi, Mentha Piperita Oil Peppermint, Citrus Aurantifolia Oil Lime, Mentha Viridis Leaf Oil Spearmint, Cocos Nucifera Oil Coconut, Allantoin, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Hydrolyzed Wheat Starch, Wheat Amino Acids, Amodimethicone, Butylene Glycol, PEG-12 Dimethicone, Polyquaternium-10, Polyquaternium-59, Glycerin, Citric Acid, Polysorbate 20, Fragrance Parfum, Eugenia Caryophyllus Flower Oil Clove, Citrus Aurantium Dulcis Oil Orange, Citrus Grandis Seed Oil Grapefruit, Cymbopogon Schoenanthus Oil, Benzyl Salicylate, Citronellol, Coumarin, Hydroxycitronellal, Limonene, Linalool, Alpha-Isomethyl Ionone, Methylparaben, Propylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Yellow 5 CI 19140, Yellow 6 CI 15985, Caramel, Ultra-Purified Water Aqua, Stearyl Alcohol, Amodimethicone, Cetyl Alcohol, Stearamidopropyl Dimethylamine, Benzyl Alcohol, Mentha Piperita Leaf Extract Peppermint, Ocimum Basilicum Extract Basil, Polygala Senega Root Extract, Nasturtium Officinale Extract Watercress, Salva Officinalis Leaf Extract Sage, Thymus Vulgaris Extract Thyme, Rosmarinus Officinalis Leaf Extract Rosemary, Citrus Grandis Seed Extract Grapefruit, Chamomilla Recutita Extract Matricaria, Symphytum Officinale Leaf Extract, Citrus Aurantium Dulcis Oil Orange, Mentha Piperita Oil Peppermint, Citrus Aurantifolia Oil Lime, Mentha Viridis Leaf Oil Spearmint, Allantoin, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Lactic Acid, Ceteareth-20, Polyquaternium-37, Polyquaternium-59, Butylene Glycol, Propylene Glycol, Dicaprylate/Dicaprate, PPG-1 Trideceth-6, Fragrance Parfum, Eucalyptus Globulus Leaf Oil, Cymbopogon Schoenanthus Oil, Citrus Aurantium Bergamia Fruit Oil Bergamot, Citronellol, Coumarin, Hydroxycitronellal, Limonene, Linalool, Alpha-Isomethyl Ionone, Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isobutylparaben, Phenoxyethanol, Ultra-Purified Water Aqua, Hydrogen Peroxide, Cetearyl Alcohol, Amodimethicone, Cetrimonium Chloride, Trideceth-12, Ceteareth-60, Ceteareth-23, Acrylates/Steareth-20 Itaconate Copolymer, Pentasodium Pentetate, Methylparaben, Phosphoric Acid, Sodium Stannate, Ultra-Purified Water Aqua, Propylene Glycol, Laureth-1, Isostearic Acid, Glyceryl Stearate SE, Ammonium Hydroxide, 4-Amino-2-Hydroxytoluene, Ethanolamine, Cocamidopropyl Betaine, Ammonium Lauryl Sulfate, Steartrimonium Chloride, Polyquaternium-10, Polyquaternium-28, Hydrolyzed Wheat Protein, Hydrolyzed Collagen, Erythorbic Acid, Sodium Sulfite, Tetrasodium EDTA, P-Phenylenediamine, P-Aminophenol, HC Red No. 3, Basic Red 2

Directions from packaging: Read all instructions carefully before use.Allow 14 days after relaxer or permanent wave before applying permanent hair color.

Warnings from packaging: Do not apply if you damaged, irritated or itchy scalp.Important:Hair color use may cause allergic reaction, which in rare cases, can be serious.It is important to find out your sensitivity to hair coloring.Follow enclosed instructions carefully.Wait 48 hours without washing the area.If you do not show any abnormalities of the skin - redness, rashes, proceed with the use of Cream of Nature.If you show a reaction, wash thoroughly with water and do not use this product.Keep out of reach of children.This product contains ingredients which may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made.This product must not be used for dyeing eyelashes or eyebrows.To do so may cause blindness.

 

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ingredients

     score    data gap       concerns
METHYLPARABEN1063%Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
P-PHENYLENEDIAMINE1052%Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
P-AMINOPHENOL857%Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
FRAGRANCE8100%Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-20571%Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
CETEARETH-60571%Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
CETEARETH-23571%Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
ETHANOLAMINE766%Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
COUMARIN746%Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
BUTYLPARABEN679%Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PEG-12 DIMETHICONE475%Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
HC RED 3667%Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
HYDROGEN PEROXIDE365%Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
BENZYL ALCOHOL664%Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
METHYLCHLOROISOTHIAZOLINONE663%Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
METHYLISOTHIAZOLINONE663%Violations, restrictions & warnings, Allergies/immunotoxicity
BENZYL SALICYLATE662%Violations, restrictions & warnings, Allergies/immunotoxicity
HYDROXYCITRONELLAL562%Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LIMONENE656%Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
ETHYLPARABEN580%Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN571%Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
LACTIC ACID470%Violations, restrictions & warnings, Irritation (skin, eyes, or lungs)
4-AMINO-2-HYDROXYTOLUENE567%Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
CITRONELLOL465%Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LINALOOL565%Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
COCAMIDOPROPYL BETAINE563%Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
EUGENIA CARYOPHYLLUS (CLOVE)
EUGENIA CARYOPHYLLUS FLOWER OIL CLOVE
558%Violations, restrictions & warnings, Allergies/immunotoxicity
CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT
CITRUS GRANDIS SEED EXTRACT GRAPEFRUIT
4100%Multiple, additive exposure sources, Contamination concerns (BENZETHONIUM CHLORIDE, METHYLPARABEN, TRICLOSAN)
SODIUM LAURETH SULFATE486%Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TOCOPHERYL ACETATE481%Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
CYMBOPOGON SCHOENANTHUS OIL472%Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
FD&C YELLOW 6
YELLOW 6 CI 15985
170%none identified
ALPHA-ISOMETHYL IONONE468%Violations, restrictions & warnings, Allergies/immunotoxicity
PHENOXYETHANOL467%Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL460%Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
LAURETH-1395%Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
SODIUM SULFITE387%Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
ISOBUTYLPARABEN383%Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
FD&C YELLOW 5
YELLOW 5 CI 19140
282%Neurotoxicity, Organ system toxicity (non-reproductive)
MENTHA PIPERITA (PEPPERMINT) OIL
MENTHA PIPERITA OIL PEPPERMINT
373%Enhanced skin absorption, Contamination concerns (LIMONENE, MENTHOL, MENTHONE)
CITRIC ACID272%Violations, restrictions & warnings
BASIC RED 2272%Cancer, Neurotoxicity
CETRIMONIUM CHLORIDE371%Allergies/immunotoxicity
QUATERNIUM-10
STEARTRIMONIUM CHLORIDE
370%Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
AMMONIUM HYDROXIDE281%Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TETRASODIUM EDTA281%Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PHOSPHORIC ACID279%Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
GLYCERIN274%Organ system toxicity (non-reproductive), Occupational hazards
CITRUS AURANTIFOLIA (LIME) OIL
CITRUS AURANTIFOLIA OIL LIME
273%Violations, restrictions & warnings
CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL
CITRUS AURANTIUM BERGAMIA FRUIT OIL BERGAMOT
273%Violations, restrictions & warnings
OCIMUM BASILICUM (SWEET BASIL) EXTRACT
OCIMUM BASILICUM EXTRACT BASIL
1100%Multiple, additive exposure sources
THYMUS VULGARIS (COMMON THYME) EXTRACT
THYMUS VULGARIS EXTRACT THYME
1100%Multiple, additive exposure sources
HYDROLYZED WHEAT PROTEIN195%Allergies/immunotoxicity
SALVIA OFFICINALIS (SAGE) LEAF EXTRACT
SALVA OFFICINALIS LEAF EXTRACT SAGE
195%none identified
SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT
SYMPHYTUM OFFICINALE LEAF EXTRACT
195%Organ system toxicity (non-reproductive)
POLYQUATERNIUM-37094%none identified
STEARAMIDOPROPYL DIMETHYLAMINE094%none identified
CETEARYL ALCOHOL093%none identified
ISOSTEARIC ACID093%none identified
CARAMEL192%none identified
COCOS NUCIFERA (COCONUT) OIL
COCOS NUCIFERA OIL COCONUT
189%none identified
HYDROLYZED COLLAGEN088%none identified
SODIUM STANNATE188%Occupational hazards
TRIDECETH-12188%Organ system toxicity (non-reproductive)
CETYL ALCOHOL187%Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ERYTHORBIC ACID187%none identified
GLYCOL STEARATE187%none identified
EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL
EUCALYPTUS GLOBULUS LEAF OIL
186%Irritation (skin, eyes, or lungs)
POLYSORBATE-20184%none identified
STEARYL ALCOHOL184%Irritation (skin, eyes, or lungs)
MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT
CHAMOMILLA RECUTITA EXTRACT MATRICARIA
180%Enhanced skin absorption
BUTYLENE GLYCOL179%Irritation (skin, eyes, or lungs)
MENTHA PIPERITA (PEPPERMINT) LEAF EXTRACT
MENTHA PIPERITA LEAF EXTRACT PEPPERMINT
175%Enhanced skin absorption
PENTASODIUM PENTETATE074%none identified
AMMONIUM LAURYL SULFATE173%Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ALOE BARBADENSIS (ALOE VERA) GEL
ALOE BARBADENSIS LEAF JUICE
172%none identified
ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER0100%none identified
ACTINIDIA CHINENSIS (KIWI) EXTRACT
ACTINIDIA CHINENSIS FRUIT EXTRACT KIWI
0100%none identified
CITRUS ARANTIUM DULCIS OIL
CITRUS AURANTIUM DULCIS OIL ORANGE
0100%none identified
DICAPRYLATE/ DICAPRATE0100%none identified
HYDROLYZED WHEAT STARCH0100%none identified
MENTHA SPICATA (SPEARMINT) LEAF OIL
MENTHA VIRIDIS LEAF OIL SPEARMINT
0100%none identified
NASTURTIUM OFFICINALE (WATERCRESS) EXTRACT
NASTURTIUM OFFICINALE EXTRACT WATERCRESS
0100%none identified
POLYGALA SENEGA (SENEGA SNAKE) ROOT EXTRACT
POLYGALA SENEGA ROOT EXTRACT
0100%none identified
POLYQUATERNIUM-280100%none identified
POLYQUATERNIUM-590100%none identified
PPG-1 TRIDECETH-60100%none identified
ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT
ROSMARINUS OFFICINALIS LEAF EXTRACT ROSEMARY
0100%none identified
WHEAT AMINO ACIDS0100%none identified
CITRUS GRANDIS (GRAPEFRUIT) SEED OIL
CITRUS GRANDIS SEED OIL GRAPEFRUIT
0100%none identified
AMODIMETHICONE099%none identified
ALLANTOIN094%none identified
GLYCERYL STEARATE SE093%none identified
POLYQUATERNIUM-10093%none identified
WATER00%innocuous


Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results   PROPYLPARABEN, METHYLPARABEN, LAURETH-1, FD&C YELLOW 5, GLYCERIN, ETHYLPARABEN, ETHANOLAMINE, ERYTHORBIC ACID, CETRIMONIUM CHLORIDE, CARAMEL, BUTYLPARABEN, BENZYL ALCOHOL
Cancer - not classifiable/not likely to be human carcinogen   LACTIC ACID
Cancer - limited evidence   BASIC RED 2, 4-AMINO-2-HYDROXYTOLUENE
Not likely to be carcinogenic in humans   EUGENIA CARYOPHYLLUS (CLOVE)
Mutagen - limited evidence   P-AMINOPHENOL
Cancer - not classifiable/not likely to be human carcinogen   P-PHENYLENEDIAMINE, HYDROGEN PEROXIDE
One or more in vitro tests on mammalian cells show positive mutation results   PROPYLENE GLYCOL
Cancer - not classifiable/not likely to be human carcinogen   HC RED 3, FD&C YELLOW 6, LIMONENE, COUMARIN
One or more animal studies show tumor formation at high doses   STEARYL ALCOHOL
One or more in vitro tests non-mammalian cells show positive mutation results   PHENOXYETHANOL, METHYLCHLOROISOTHIAZOLINONE, MENTHA PIPERITA (PEPPERMINT) OIL, LINALOOL, CITRUS AURANTIFOLIA (LIME) OIL, AMMONIUM HYDROXIDE
One or more in vitro tests on mammalian cells show positive mutation results   TOCOPHERYL ACETATE, SODIUM SULFITE, SALVIA OFFICINALIS (SAGE) LEAF EXTRACT

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
One or more animal studies show reproductive system effects at high doses   FD&C YELLOW 6, POLYSORBATE-20, FD&C YELLOW 5, ETHYLPARABEN, ETHANOLAMINE, COUMARIN, BUTYLENE GLYCOL, BENZYL ALCOHOL,
One or more animal studies show developmental effects at high doses   LIMONENE
One or more animal studies show reproductive effects at moderate doses   PROPYLENE GLYCOL, P-AMINOPHENOL, GLYCERIN,
One or more animal studies show any effects at moderate doses   ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show any effects at low doses   PROPYLPARABEN
One or more animal studies show any effects at very low doses   BUTYLPARABEN
Human nervous system toxicant - moderate evidence   P-PHENYLENEDIAMINE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limits, according to industry safety panel (International Fragrance Association)   LIMONENE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications   CETEARETH-23, QUATERNIUM-10, PROPYLENE GLYCOL, PEG-12 DIMETHICONE, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, MENTHA PIPERITA (PEPPERMINT) OIL, LACTIC ACID, MENTHA PIPERITA (PEPPERMINT) LEAF EXTRACT, ETHANOLAMINE, HC RED 3, COCAMIDOPROPYL BETAINE, CETRIMONIUM CHLORIDE, ALOE BARBADENSIS (ALOE VERA) GEL, AMMONIUM LAURYL SULFATE, BENZYL ALCOHOL, CETEARETH-60, CETEARETH-20, P-PHENYLENEDIAMINE, BASIC RED 2, P-AMINOPHENOL, HC RED 3, 4-AMINO-2-HYDROXYTOLUENE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel   P-AMINOPHENOL, P-PHENYLENEDIAMINE, HC RED 3, EUGENIA CARYOPHYLLUS (CLOVE), 4-AMINO-2-HYDROXYTOLUENE, BENZYL ALCOHOL, HYDROXYCITRONELLAL, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, CITRUS AURANTIFOLIA (LIME) OIL, COUMARIN, CITRONELLOL, BENZYL SALICYLATE, BENZYL ALCOHOL, ALPHA-ISOMETHYL IONONE, LINALOOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics   LACTIC ACID, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, P-PHENYLENEDIAMINE, CITRIC ACID, PHENOXYETHANOL, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits   LACTIC ACID
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Unsafe in products left on skin and not rinsed off products that are intended to be left on the skin ETHANOLAMINE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)   METHYLCHLOROISOTHIAZOLINONE
Violation of government restrictions - Banned or found unsafe for use in cosmetics   METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
One or more in vitro tests on mammalian cells demonstrate neurotoxicity   METHYLISOTHIAZOLINONE
One or more animal studies show brain and nervous system effects at high doses   PROPYLENE GLYCOL, LACTIC ACID, GLYCERIN, FD&C YELLOW 6, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, BUTYLENE GLYCOL, 4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show brain and nervous system effects at moderate doses   CETEARETH-23, QUATERNIUM-10, PHOSPHORIC ACID, PHENOXYETHANOL, P-AMINOPHENOL, CETEARETH-60, CITRONELLOL, COUMARIN, ETHANOLAMINE, LINALOOL, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, MENTHA PIPERITA (PEPPERMINT) OIL, METHYLPARABEN
One or more animal studies show brain and nervous system effects at very low doses   BASIC RED 2
One or more animal studies show brain and nervous system effects at low doses   SODIUM SULFITE
One or more animal studies show brain and nervous system effects at moderate doses   CETEARETH-20
One or more animal studies show brain and nervous system effects at very low doses   HYDROGEN PEROXIDE
Moderate evidence of human neurotoxicity   FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses   FD&C YELLOW 5
Strong evidence of human neurotoxicity   BENZYL ALCOHOL, P-PHENYLENEDIAMINE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Associated with endocrine disruption   BENZYL SALICYLATE
One or more animal studies show endocrine system disruption at high doses   P-PHENYLENEDIAMINE, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, HYDROGEN PEROXIDE, HC RED 3, GLYCERIN, BUTYLENE GLYCOL
One or more animal studies show endocrine disruption at moderate doses   ISOBUTYLPARABEN
One or more animal studies show endocrine system disruption at high doses   4-AMINO-2-HYDROXYTOLUENE
Human any disruptor - strong evidence   PROPYLPARABEN, METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Known human immune system toxicant   BENZYL SALICYLATE, COCAMIDOPROPYL BETAINE, COUMARIN
Limited evidence of skin and immune system toxicity   PHENOXYETHANOL
One or more human case studies show possible skin allergy effects   HYDROLYZED WHEAT PROTEIN, BENZYL ALCOHOL
Human immune system toxicant - moderate evidence   SODIUM SULFITE
Limited evidence of skin and immune system toxicity   PROPYLENE GLYCOL
Human skin toxicant - strong evidence   TOCOPHERYL ACETATE, QUATERNIUM-10, PROPYLPARABEN, METHYLPARABEN, ISOBUTYLPARABEN, HC RED 3, ETHYLPARABEN, ETHANOLAMINE, CETRIMONIUM CHLORIDE, BUTYLPARABEN, 4-AMINO-2-HYDROXYTOLUENE
Possible human immune system toxicant   LINALOOL, CITRONELLOL, ALPHA-ISOMETHYL IONONE
Known human immune system toxicant   EUGENIA CARYOPHYLLUS (CLOVE), CYMBOPOGON SCHOENANTHUS OIL, P-PHENYLENEDIAMINE, P-AMINOPHENOL, METHYLISOTHIAZOLINONE, LIMONENE, METHYLCHLOROISOTHIAZOLINONE, HYDROXYCITRONELLAL, FRAGRANCE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Not suspected to be bioaccumulative   PHOSPHORIC ACID, AMMONIUM HYDROXIDE
Not suspected to be persistent   TRIDECETH-12, CETYL ALCOHOL

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)   BENZYL ALCOHOL, PROPYLENE GLYCOL
Classified as expected to be toxic or harmful   AMMONIUM LAURYL SULFATE, CYMBOPOGON SCHOENANTHUS OIL
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)   TRIDECETH-12, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, COCOS NUCIFERA (COCONUT) OIL, HC RED 3, POLYSORBATE-20, FD&C YELLOW 6, CETYL ALCOHOL, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, STEARYL ALCOHOL, MENTHA PIPERITA (PEPPERMINT) OIL, LINALOOL, ERYTHORBIC ACID, LIMONENE, CITRONELLOL, BUTYLENE GLYCOL, BENZYL SALICYLATE
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)   CETEARETH-23, CETEARETH-60, CETEARETH-20, TETRASODIUM EDTA, PHENOXYETHANOL, BASIC RED 2, TOCOPHERYL ACETATE, SODIUM LAURETH SULFATE, LACTIC ACID, GLYCOL STEARATE, CITRIC ACID, CETRIMONIUM CHLORIDE
Limited evidence of sense organ toxicity   PROPYLPARABEN
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)   4-AMINO-2-HYDROXYTOLUENE, ALOE BARBADENSIS (ALOE VERA) GEL
Limited evidence of sense organ toxicity   PEG-12 DIMETHICONE, ISOBUTYLPARABEN, BUTYLPARABEN, ETHYLPARABEN, PHOSPHORIC ACID
One or more animal studies show broad systemic effects at low doses   QUATERNIUM-10, COUMARIN, AMMONIUM HYDROXIDE
One or more animal studies show musculoskeletal effects at very low doses   FD&C YELLOW 5, GLYCERIN, HYDROGEN PEROXIDE
Possible human immune system toxicant   SODIUM SULFITE, P-AMINOPHENOL, METHYLCHLOROISOTHIAZOLINONE, ETHANOLAMINE
Limited evidence of any toxicity   SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT
Known human respiratory toxicant   P-PHENYLENEDIAMINE, METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Occupational hazards related to handling   PHOSPHORIC ACID, HYDROGEN PEROXIDE, ETHANOLAMINE, LIMONENE, AMMONIUM HYDROXIDE
Prohibited for use in food   COUMARIN
Ingredient not fully labeled - identity unknown   FRAGRANCE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Suspected to be an environmental toxin   TRIDECETH-12
Not suspected to be an environmental toxin   PHOSPHORIC ACID
Suspected to be an environmental toxin   CETYL ALCOHOL
Wildlife and environmental toxicity   P-PHENYLENEDIAMINE, P-AMINOPHENOL, LIMONENE, PROPYLPARABEN, AMMONIUM HYDROXIDE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
One or more animal studies show skin irritation at low doses   CETEARETH-20
Human skin irritant - moderate evidence   ETHANOLAMINE, HYDROGEN PEROXIDE, PHOSPHORIC ACID
One or more animal studies show skin irritation at very low doses   AMMONIUM LAURYL SULFATE, CETYL ALCOHOL, CITRONELLOL, LACTIC ACID, LINALOOL
One or more animal studies show skin irritation at low doses   BENZYL ALCOHOL
Human any irritant - strong evidence products for use around the eyes, on the skin, or may be aerosolized (airborne) STEARYL ALCOHOL
Human skin irritant - moderate evidence   AMMONIUM HYDROXIDE
Human any irritant - strong evidence products for use around the eyes, on the skin, or may be aerosolized (airborne) SODIUM LAURETH SULFATE
One or more animal studies show skin irritation at high doses   SODIUM SULFITE, 4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show skin irritation at moderate doses   TRIDECETH-12, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, QUATERNIUM-10, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, P-AMINOPHENOL, POLYSORBATE-20, GLYCOL STEARATE, GLYCERIN
Human any irritant - strong evidence products for use around the eyes, on the skin, or may be aerosolized (airborne) BUTYLENE GLYCOL
Classified as skin irritant   PROPYLENE GLYCOL, PHENOXYETHANOL
One or more animal studies show skin irritation at moderate doses   CITRUS AURANTIFOLIA (LIME) OIL, CITRIC ACID, BUTYLPARABEN
One or more animal studies show skin irritation at low doses   CYMBOPOGON SCHOENANTHUS OIL, CETEARETH-23, TETRASODIUM EDTA, METHYLPARABEN, HYDROXYCITRONELLAL, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, CETEARETH-60
Classified as irritant   P-PHENYLENEDIAMINE, LIMONENE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
Safety assessment was based on related chemical   AMODIMETHICONE, PENTASODIUM PENTETATE
Missing safety data noted by cosmetic industry review   PENTASODIUM PENTETATE
Insufficient data to determine safety   4-AMINO-2-HYDROXYTOLUENE, HC RED 3, P-AMINOPHENOL, P-PHENYLENEDIAMINE
Safety assessment was based on related chemical   ISOBUTYLPARABEN
Missing safety data noted by cosmetic industry review   ISOSTEARIC ACID, P-AMINOPHENOL, P-PHENYLENEDIAMINE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   TETRASODIUM EDTA, TOCOPHERYL ACETATE
Considered safe based on assumption of low absorption   4-AMINO-2-HYDROXYTOLUENE
Missing safety data noted by cosmetic industry review   4-AMINO-2-HYDROXYTOLUENE, ALOE BARBADENSIS (ALOE VERA) GEL, HC RED 3
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product   STEARYL ALCOHOL, PROPYLPARABEN, SODIUM LAURETH SULFATE, SODIUM SULFITE, POLYQUATERNIUM-10, POLYSORBATE-20, PHENOXYETHANOL, PENTASODIUM PENTETATE, P-PHENYLENEDIAMINE, PEG-12 DIMETHICONE, P-AMINOPHENOL, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, METHYLPARABEN, ISOSTEARIC ACID, HYDROLYZED COLLAGEN, GLYCOL STEARATE, GLYCERYL STEARATE SE, ETHYLPARABEN, CETYL ALCOHOL, ERYTHORBIC ACID, CETEARYL ALCOHOL, BUTYLPARABEN, AMODIMETHICONE, BUTYLENE GLYCOL, 4-AMINO-2-HYDROXYTOLUENE
Not assessed for safety in cosmetics by industry panel   CITRUS GRANDIS (GRAPEFRUIT) SEED OIL, WHEAT AMINO ACIDS, TRIDECETH-12, EUGENIA CARYOPHYLLUS (CLOVE), CYMBOPOGON SCHOENANTHUS OIL, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, BASIC RED 2, THYMUS VULGARIS (COMMON THYME) EXTRACT, SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT, STEARAMIDOPROPYL DIMETHYLAMINE, SODIUM STANNATE, SALVIA OFFICINALIS (SAGE) LEAF EXTRACT, ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT, PPG-1 TRIDECETH-6, POLYQUATERNIUM-59, POLYQUATERNIUM-37, POLYQUATERNIUM-28, POLYGALA SENEGA (SENEGA SNAKE) ROOT EXTRACT, PHOSPHORIC ACID, OCIMUM BASILICUM (SWEET BASIL) EXTRACT, NASTURTIUM OFFICINALE (WATERCRESS) EXTRACT, MENTHA SPICATA (SPEARMINT) LEAF OIL, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, LINALOOL, LAURETH-1, HYDROXYCITRONELLAL, HYDROLYZED WHEAT STARCH, HYDROLYZED WHEAT PROTEIN, HYDROGEN PEROXIDE, GLYCERIN, FRAGRANCE, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, LIMONENE, DICAPRYLATE/ DICAPRATE, COUMARIN, COCOS NUCIFERA (COCONUT) OIL, CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT, CITRUS AURANTIFOLIA (LIME) OIL, CITRUS ARANTIUM DULCIS OIL, CITRONELLOL, CITRIC ACID, CARAMEL, BENZYL SALICYLATE, AMMONIUM HYDROXIDE, ALPHA-ISOMETHYL IONONE, ALLANTOIN, ACTINIDIA CHINENSIS (KIWI) EXTRACT, ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER
Safety assessment was based on related chemical   PROPYLENE GLYCOL

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
No workplace limits set   LACTIC ACID
Allowed workplace exposures restricted to moderate doses   GLYCERIN
Allowed workplace exposures restricted to low doses   SODIUM STANNATE, PHOSPHORIC ACID,
Allowed workplace exposures restricted to low doses   TETRASODIUM EDTA, PHENOXYETHANOL, P-AMINOPHENOL, HYDROGEN PEROXIDE, ETHANOLAMINE, BENZYL ALCOHOL
Allowed workplace exposures restricted to very low doses   P-PHENYLENEDIAMINE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern product conditions ingredient(s)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood   COUMARIN, P-AMINOPHENOL
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood   CITRIC ACID, GLYCERIN, HYDROGEN PEROXIDE, PROPYLENE GLYCOL
Interferes with gene expresion   BUTYLPARABEN, METHYLPARABEN

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