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Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards |
Ingredients from packaging: Active Ingredients: Aluminum Zirconium Tetrachlorohydrex GLY 20%, Other Ingredients: Water, Cyclopentasiloxane, Dimethicone, Dipropylene Glycol, Glycerin, PEG-12 Dimethicone Crosspolymer, PEG/PPG-18/18 Dimethicone, PEG/PPG-19/19 Dimethicone
Directions from packaging: Apply to underarms onlyCap tightly after use
Warnings from packaging: For external use onlyDo not use on broken skinStop use if rash or irritation occursAsk a doctor before use if you have kidney diseaseKeep out of reach of childrenIf swallowed, get medical help or contact a Poison Control Center right away
| score | data gap | concerns | |
| PEG-12 DIMETHICONE CROSSPOLYMER | 4 | 76% | Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| PEG/ PPG-18/ 18 DIMETHICONE | 4 | 75% | Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| PEG/PPG-19/19 DIMETHICONE | 4 | 75% | Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLYCINE COMPLEX | 1 | 91% | Organ system toxicity (non-reproductive) |
| CYCLOPENTASILOXANE | 2 | 79% | Persistence and bioaccumulation |
| DIMETHICONE | 2 | 74% | Violations, restrictions & warnings |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| DIPROPYLENE GLYCOL | 1 | 84% | Irritation (skin, eyes, or lungs) |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show tumor formation at moderate doses | CYCLOPENTASILOXANE | |
| One or more in vitro tests on mammalian cells show positive mutation results | GLYCERIN |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PEG/PPG-19/19 DIMETHICONE, PEG/ PPG-18/ 18 DIMETHICONE, PEG-12 DIMETHICONE CROSSPOLYMER | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | DIMETHICONE |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | GLYCERIN, DIPROPYLENE GLYCOL | |
| One or more animal studies show any effects at moderate doses | CYCLOPENTASILOXANE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | GLYCERIN | |
| One or more animal studies show endocrine disruption at moderate doses | CYCLOPENTASILOXANE |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Persistent, bioaccumulative in wildlife | CYCLOPENTASILOXANE |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Limited evidence of sense organ toxicity | PEG/PPG-19/19 DIMETHICONE | |
| One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) | DIPROPYLENE GLYCOL, CYCLOPENTASILOXANE | |
| Limited evidence of sense organ toxicity | PEG/ PPG-18/ 18 DIMETHICONE, PEG-12 DIMETHICONE CROSSPOLYMER, ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLYCINE COMPLEX | |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN, CYCLOPENTASILOXANE | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | DIPROPYLENE GLYCOL |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | PEG/PPG-19/19 DIMETHICONE, DIPROPYLENE GLYCOL, PEG/ PPG-18/ 18 DIMETHICONE, DIMETHICONE | |
| Not assessed for safety in cosmetics by industry panel | PEG-12 DIMETHICONE CROSSPOLYMER, GLYCERIN, CYCLOPENTASILOXANE, ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLYCINE COMPLEX |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CYCLOPENTASILOXANE, GLYCERIN |
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