Crest Extra Whitening with Tartar Protection Fluoride Anticavity Toothpaste, Clean Mint || Skin Deep: Cosmetic Safety Reviews

CREST EXTRA WHITENING WITH TARTAR PROTECTION FLUORIDE ANTICAVITY TOOTHPASTE, CLEAN MINT

last updated: 04/01/08 brand: Crest by Procter & Gamble

SCORE

high hazard (out of 10)

74%

data gap

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98% of tooth whitenings have lower concerns
98% of toothpastes have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Active Ingredients: Sodium Fluoride 0.0243% - 0.16% W/V Fluoride Ion, Cetylpyridinium Chloride 0.07%, Other Ingredients: Hydrated Silica, Water, Sorbitol, Glycerin, PEG-6, Tetrasodium Pyrophosphate, Sodium Bicarbonate, Sodium Lauryl Sulfate, Poloxamer 407, Flavor, Cellulose Gum, Sodium Carbonate, Sodium Saccharin, Carnauba Wax, Titanium Dioxide, Blue 1, Yellow 5, Water, Glycerin, Propylene Glycol, Flavor, Poloxamer 407, Methylparaben, Propylparaben, Sodium Saccharin, Yellow 6, Green 3

Directions from packaging: Crest Extra Whitening with Tartar Protection:Adults and Children 2 Years & Older:Brush teeth thoroughly after meals or at least twice a day, or use as directed by a dentist.Do not swallow.To minimize swallowing use a pea-sized amount in children under 6.Supervise children's brushing until good habits are established.Children Under 2 Years:Ask a dentist.For healthy teeth, brush twice a day, floss daily and visit your dentist regularly.Crest Pro-Health Rinse:Use after your normal brushing and flossing routine; rinse toothpaste from mouth prior to use.Adults and Children 6 Years & Older:Rinse for 30 seconds with 20 ml / 4 teaspoonfuls twice a day.Do not swallow.Children 6 Years to Under 12 Years of Age:Supervise use.Children Under 6 Years of Age:Do not use.

Warnings from packaging: Crest Extra Whitening with Tartar Protection:Keep out of reach of children under 6 years of age.If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.Crest Pro-Health Rinse:Ask a dentist if symptoms persist or condition worsens after regular use.Keep out of reach of children under 6 years of age.If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away.Cap sealed with printed band.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
SODIUM FLUORIDE	9	63%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
PEG-6	4	74%	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
FLAVOR	4	100%	Miscellaneous
POLOXAMER 407	2	82%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
TITANIUM DIOXIDE (NON-NANO)	1	81%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes
FD&C GREEN 3	1	73%	none identified
FD&C YELLOW 6	1	70%	none identified
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
FD&C YELLOW 5	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive)
SODIUM LAURYL SULFATE	3	68%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
FD&C BLUE 1	1	83%	none identified
SODIUM CARBONATE	2	82%	Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TETRASODIUM PYROPHOSPHATE	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
SODIUM BICARBONATE	2	80%	none identified
SODIUM SACCHARIN	2	80%	Neurotoxicity
HYDRATED SILICA	2	79%	Persistence and bioaccumulation
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
CETYLPYRIDINIUM CHLORIDE	2	73%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs)
SORBITOL	1	88%	none identified
CELLULOSE GUM	1	80%	none identified
COPERNICIA CERIFERA (CARNAUBA) WAX	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show tumor formation at high doses		CELLULOSE GUM
One or more in vitro tests on mammalian cells show positive mutation results		TITANIUM DIOXIDE (NON-NANO), SORBITOL, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, SODIUM BICARBONATE, PROPYLPARABEN, PROPYLENE GLYCOL, METHYLPARABEN, GLYCERIN, FD&C YELLOW 5
One or more animal studies show tumor formation at low doses		SODIUM FLUORIDE
Cancer - not classifiable/not likely to be human carcinogen		HYDRATED SILICA, FD&C YELLOW 6, FD&C GREEN 3, FD&C BLUE 1

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive system effects at high doses		FD&C YELLOW 6, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, FD&C YELLOW 5
One or more animal studies show reproductive effects at moderate doses		SODIUM BICARBONATE, GLYCERIN, PROPYLENE GLYCOL, CELLULOSE GUM
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at very low doses		SODIUM CARBONATE
Human nervous system toxicant - moderate evidence		SODIUM FLUORIDE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		SODIUM LAURYL SULFATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		CETYLPYRIDINIUM CHLORIDE, SODIUM FLUORIDE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PEG-6, PROPYLENE GLYCOL
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		POLOXAMER 407, SODIUM BICARBONATE, PROPYLENE GLYCOL, PEG-6, GLYCERIN, FD&C YELLOW 6, FD&C BLUE 1
One or more animal studies show brain and nervous system effects at moderate doses		SODIUM LAURYL SULFATE, METHYLPARABEN
One or more animal studies show brain and nervous system effects at very low doses		SODIUM SACCHARIN
One or more animal studies show brain and nervous system effects at low doses		TETRASODIUM PYROPHOSPHATE
One or more animal studies show brain and nervous system effects at very low doses		FD&C YELLOW 5
Strong evidence of human neurotoxicity		SODIUM FLUORIDE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		SODIUM LAURYL SULFATE, GLYCERIN
One or more studies show endocrine system disruption at low doses		SODIUM FLUORIDE
Human any disruptor - strong evidence		METHYLPARABEN, PROPYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human skin toxicant - strong evidence		PROPYLPARABEN
One or more animal studies show immune effects at low doses		TITANIUM DIOXIDE (NON-NANO)
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human skin toxicant - strong evidence		METHYLPARABEN

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		POLOXAMER 407
Not suspected to be persistent		SODIUM LAURYL SULFATE
Not suspected to be bioaccumulative		TITANIUM DIOXIDE (NON-NANO)
Persistent, bioaccumulative in wildlife and humans		HYDRATED SILICA

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		FD&C YELLOW 6, SORBITOL, SODIUM SACCHARIN, CELLULOSE GUM
Limited evidence of sense organ toxicity		PROPYLPARABEN
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	PROPYLENE GLYCOL
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		FD&C BLUE 1
One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)		SODIUM BICARBONATE, CETYLPYRIDINIUM CHLORIDE
Limited evidence of sense organ toxicity		PEG-6
One or more animal studies show metabolic effects at low doses		TETRASODIUM PYROPHOSPHATE, POLOXAMER 407, SODIUM LAURYL SULFATE
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	SODIUM CARBONATE
One or more animal studies show musculoskeletal effects at very low doses		FD&C YELLOW 5, GLYCERIN, SODIUM FLUORIDE, TITANIUM DIOXIDE (NON-NANO)
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM FLUORIDE
Ingredient not fully labeled - identity unknown		FLAVOR

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		POLOXAMER 407, TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, SORBITOL, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, SODIUM FLUORIDE, SODIUM CARBONATE, SODIUM BICARBONATE, PROPYLENE GLYCOL, PROPYLPARABEN, PEG-6, METHYLPARABEN, FD&C YELLOW 6, GLYCERIN, FD&C YELLOW 5, FD&C GREEN 3, FD&C BLUE 1, CETYLPYRIDINIUM CHLORIDE, CELLULOSE GUM
Used in food or as an additive with limited or no toxicity information available		SODIUM FLUORIDE
Designated as safe for general or specific, limited use in food		COPERNICIA CERIFERA (CARNAUBA) WAX

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		POLOXAMER 407, SODIUM LAURYL SULFATE
Not suspected to be an environmental toxin		TITANIUM DIOXIDE (NON-NANO)
Wildlife and environmental toxicity		PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		TITANIUM DIOXIDE (NON-NANO), SODIUM BICARBONATE, GLYCERIN
One or more animal studies show skin irritation at low doses		METHYLPARABEN, CETYLPYRIDINIUM CHLORIDE
One or more animal studies show skin irritation at very low doses		SODIUM LAURYL SULFATE
Classified as skin irritant		PROPYLENE GLYCOL, SODIUM CARBONATE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Missing safety data noted by cosmetic industry review		POLOXAMER 407
Safety assessment was based on related chemical		POLOXAMER 407, PROPYLENE GLYCOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		POLOXAMER 407, SODIUM BICARBONATE, PROPYLPARABEN, CELLULOSE GUM, SODIUM CARBONATE, METHYLPARABEN, COPERNICIA CERIFERA (CARNAUBA) WAX
Not assessed for safety in cosmetics by industry panel		HYDRATED SILICA, FLAVOR, TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, SORBITOL, SODIUM SACCHARIN, GLYCERIN, CETYLPYRIDINIUM CHLORIDE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		SODIUM FLUORIDE
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO)
Allowed workplace exposures restricted to moderate doses		GLYCERIN, TETRASODIUM PYROPHOSPHATE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		SODIUM FLUORIDE, TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		SODIUM LAURYL SULFATE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CELLULOSE GUM, GLYCERIN, SODIUM BICARBONATE, PROPYLENE GLYCOL
Interferes with gene expresion		METHYLPARABEN