

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns |
Ingredients from packaging: ACTIVE INGREDIENT: PYRETHRUM EXTRACT PYRETHRINS 0.33%, PIPERONYL BUTOXIDE 4%. INACTIVE INGREDIENTS : CANANGA ODORATA FLOWER OIL, FRAGRANCE, MELALEUCA ALTERNIFOLIA LEAF OIL TEA TREE, PEG-45 PALM KERNEL GLYCERIDES, PROPYLENE GLYCOL, CHAMOMILLA RECUTITA EXTRACT MATRICARIA, PROPYLENE GLYCOL, WATER, PIMPINELLA ANISUM FRUIT EXTRACT ANISE, SODIUM LAURETH SULFATE, WATER. DIRECTIONS: THE PRONTO PLUS A, B, C'S OF LICE ELIMINATION: A 3-STEP PROCESS TO ELIMINATE LICE FROM YOUR HEAD AND HOME AND TO HELP PREVENT REINFESTATION. WITH PRONTO PLUS, LICE TREATMENT IS AS EASY AS A, B, C. A - KILL LICE WITH PRONTO PLUS LICE KILLING SHAMPOO: APPLY PRONTO PLUS LICE KILLING SHAMPOO PLUS NATURAL EXTRACTS & OILS ACCORDING TO DIRECTIONS. REAPPLY IN 7-10 DAYS TO HELP PREVENT REINFESTATION OF NEWLY HATCHED LICE. B - COMB OUT LICE & EGGS: AFTER SHAMPOOING, APPLY PRONTO PLUS LICE EGG REMOVER PLUS ANTISEPTIC ON DAMP HAIR. COMPLETELY COMB OUT LICE AND NITS WITH THE COMB INCLUDED. C - CLEAN HOME: USE PRONTO LICE, TICK & FLEA KILLING SPRAY TO KILL LICE AND THEIR EGGS ON NON-WASHABLE ITEMS. IMPORTANT: READ DETAILED INSTRUCTIONS INSIDE BEFORE STARTING. SAVE INFORMATION FOR FUTURE USE. IMPORTANT: READ WARNINGS BEFORE USING. SHAKE WELL. APPLY TO DRY HAIR. APPLY TO AFFECTED AREA UNTIL ALL THE HAIR IS THOROUGHLY WET WITH PRODUCT. ALLOW PRODUCT TO REMAIN ON AREA FOR 10 MINUTES, BUT NOT LONGER. ADD SUFFICIENT WARM WATER TO FORM A LATHER. SHAMPOO AS USUAL. RINSE THOROUGHLY. A FINE-TOOTHED COMB OR A SPECIAL LICE/NIT-REMOVING COMB MAY BE USED TO HELP REMOVE DEAD LICE OR THEIR EGGS (NITS) FROM HAIR. A SECOND TREATMENT MUST BE DONE IN 7 TO 10 DAYS TO KILL ANY NEWLY HATCHED LICE. IT IS EXTREMELY IMPORTANT TO COMB OUT DEAD LICE AND THEIR EGGS (NITS). TIPS & TECHNIQUES: PRONTO PLUS LICE KILLING SHAMPOO PLUS NATURAL EXTRACTS & OILS KILLS LICE AND THEIR EGGS WITHOUT LEAVING A CHEMICAL RESIDUE. USE TWICE (DAY 1 & DAY 7) FOR MAXIMUM EFFECTIVENESS. PRODUCT USAGE WILL VARY BY HAIR LENGTH. SUGGESTED DOSAGE FOLLOWS: SHORT (EAR LENGTH OR SHORTER) - DAY 1: 1 OZ - 2 OZ DAY 7: 1 OZ - 2 OZ TOTAL: 2 OZ - 4 OZ MEDIUM (SHOULDER LENGTH) - DAY 1: 2 OZ - 3 OZ DAY 7: 2 OZ - 3 OZ TOTAL: 4 OZ - 6 OZ LONG (PAST SHOULDERS) - DAY 1: 3 OZ - 4 OZ DAY 7: 3 OZ - 4 OZ TOTAL: 6 OZ - 8 OZ IT IS EXTREMELY IMPORTANT TO COMB OUT ALL NITS AND LICE FROM THE HAIR. USUALLY NITS ARE ATTACHED TO THE SIDE OF THE HAIR STRAND CLOSER TO THE SCALP, WITH A GLUE-LIKE SUBSTANCE.
Directions from packaging: The Pronto Plus A, B, C's of Lice Elimination: A 3-step process to eliminate lice from your head and home and to help prevent reinfestation. With Pronto Plus, lice treatment is as easy as A, B, C. A - Kill Lice with Pronto Plus Lice Killing Shampoo: Apply Pronto Plus Lice Killing Shampoo Plus Natural Extracts & Oils according to directions. Reapply in 7-10 days to help prevent reinfestation of newly hatched lice. B - Comb Out Lice & Eggs: After shampooing, apply Pronto Plus Lice Egg Remover Plus Antiseptic on damp hair. Completely comb out lice and nits with the comb included. C - Clean Home: Use Pronto Lice, Tick & Flea Killing Spray to kill lice and their eggs on non-washable items. Important: Read detailed instructions inside before starting. Save information for future use. Important: Read warnings before using. Shake well. Apply to dry hair. Apply to affected area until all the hair is thoroughly wet with product. Allow product to remain on area for 10 minutes, but not longer. Add sufficient warm water to form a lather. Shampoo as usual. Rinse thoroughly. A fine-toothed comb or a special lice/nit-removing comb may be used to help remove dead lice or their eggs (nits) from hair. A second treatment must be done in 7 to 10 days to kill any newly hatched lice. It is extremely important to comb out dead lice and their eggs (nits). Tips & Techniques: Pronto Plus Lice Killing Shampoo Plus Natural Extracts & Oils kills lice and their eggs without leaving a chemical residue. Use twice (day 1 & day 7) for maximum effectiveness. Product usage will vary by hair length. Suggested Dosage Follows: Short (Ear length or shorter) - Day 1: 1 oz - 2 oz Day 7: 1 oz - 2 oz Total: 2 oz - 4 oz Medium (Shoulder length) - Day 1: 2 oz - 3 oz Day 7: 2 oz - 3 oz Total: 4 oz - 6 oz Long (Past shoulders) - Day 1: 3 oz - 4 oz Day 7: 3 oz - 4 oz Total: 6 oz - 8 oz It is extremely important to comb out all nits and lice from the hair. Usually nits are attached to the side of the hair strand closer to the scalp, with a glue-like substance. Additional Information
| score | data gap | concerns | |
| FRAGRANCE | 8 | 100% | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |
| PEG-45 PALM KERNEL GLYCERIDES | 6 | 76% | Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| SODIUM LAURETH SULFATE | 4 | 86% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |
| PROPYLENE GLYCOL | 4 | 60% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| PIPERONYL BUTOXIDE (Active Ingredient) | 2 | 77% | Cancer, Endocrine disruption |
| CANANGA ODORATA (YLANG YLANG) OIL CANANGA ODORATA FLOWER OIL | 3 | 75% | Violations, restrictions & warnings, Multiple, additive exposure sources |
| MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL MELALEUCA ALTERNIFOLIA LEAF OIL TEA TREE | 1 | 93% | Endocrine disruption, Allergies/immunotoxicity |
| ASCORBIC ACID (VITAMIN C) | 1 | 91% | none identified |
| MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT CHAMOMILLA RECUTITA EXTRACT MATRICARIA | 1 | 80% | Enhanced skin absorption |
| ANISE EXTRACT PIMPINELLA ANISUM FRUIT EXTRACT ANISE | 0 | 100% | none identified |
| TANACETUM COCCINEUM (PYRETHRUM) EXTRACT PYRETHRUM EXTRACT PYRETHRINS (Active Ingredient) | 0 | 100% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests non-mammalian cells show positive mutation results | ASCORBIC ACID (VITAMIN C) | |
| One or more in vitro tests on mammalian cells show positive mutation results | PROPYLENE GLYCOL, PIPERONYL BUTOXIDE |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | PIPERONYL BUTOXIDE | |
| One or more animal studies show reproductive effects at moderate doses | PROPYLENE GLYCOL |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PROPYLENE GLYCOL, PEG-45 PALM KERNEL GLYCERIDES | |
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin | products for use on damaged skin | PEG-45 PALM KERNEL GLYCERIDES |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at moderate doses | MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT | |
| One or more animal studies show brain and nervous system effects at high doses | PROPYLENE GLYCOL | |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
| One or more animal studies show brain and nervous system effects at high doses | PIPERONYL BUTOXIDE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | PIPERONYL BUTOXIDE | |
| Limited evidence of any disruption | MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL | |
| One or more animal studies show endocrine system disruption at high doses | MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Limited evidence of any toxicity | MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL | |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL | |
| Known human immune system toxicant | FRAGRANCE |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) | MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, PROPYLENE GLYCOL | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | SODIUM LAURETH SULFATE, PIPERONYL BUTOXIDE | |
| Limited evidence of sense organ toxicity | PEG-45 PALM KERNEL GLYCERIDES |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Ingredient not fully labeled - identity unknown | FRAGRANCE |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | PROPYLENE GLYCOL, PIPERONYL BUTOXIDE, PEG-45 PALM KERNEL GLYCERIDES, MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL, ASCORBIC ACID (VITAMIN C) | |
| Used in food or as an additive with limited or no toxicity information available | CANANGA ODORATA (YLANG YLANG) OIL | |
| Designated as safe for general or specific, limited use in food | ANISE EXTRACT |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at high doses | PIPERONYL BUTOXIDE | |
| One or more animal studies show skin irritation at moderate doses | CANANGA ODORATA (YLANG YLANG) OIL, PROPYLENE GLYCOL | |
| One or more animal studies show skin irritation at low doses | SODIUM LAURETH SULFATE | |
| One or more animal studies show skin irritation at moderate doses | MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | SODIUM LAURETH SULFATE | |
| Safety assessment was based on related chemical | ASCORBIC ACID (VITAMIN C) | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, ASCORBIC ACID (VITAMIN C) | |
| Not assessed for safety in cosmetics by industry panel | CANANGA ODORATA (YLANG YLANG) OIL, TANACETUM COCCINEUM (PYRETHRUM) EXTRACT, PIPERONYL BUTOXIDE, PEG-45 PALM KERNEL GLYCERIDES, MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL, MATRICARIA RECUTITA (GERMAN CHAMOMILE) EXTRACT, FRAGRANCE, ANISE EXTRACT |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | PIPERONYL BUTOXIDE, PROPYLENE GLYCOL |
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