

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: Active Ingredients: Glycerin (35%) (prediluted) (Oral Demulcent)Inactive Ingredients: Cetylpyridinium Chloride, Copovidone, Flavor, Methylparaben, PEG 60 Hydrogenated Castor Oil, Propylparaben, Sodium Benzoate, Sodium Saccharin, Water, Xanthan Gum, Xylitol
Directions from packaging: Use as required up to a maximum of 30 times or 60 sprays a day. Adults and children 2 years and older: Hold bottle upright, spray 1-2 times into the affected areas of your mouth, do not rinse out. Children under 12 years of age: should be supervised in the use of this product Children under 2 years of age: do not use, ask a doctor. Store below 30° C (86°F) Do not refrigerate. Do not use if tamper-evident tab on carton, printed "Sealed for Your Protection", is broken or missing.
Warnings from packaging: WarningsKeep out of reach of children. If an excessive amount of product is accidentally swallowed, get medical help or contact a Poison Control Center right away. Sore throat warning: severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea and vomiting may be serious. Consult a doctor promptly. Stop use and ask a doctor if sore throat does not improve in 7 days, or irritation, pain, or redness persists or worsens.
| score | data gap | concerns | |
| METHYLPARABEN | 10 | 63% | Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| COPOVIDONE | 8 | 62% | Cancer, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards |
| PEG-60 HYDROGENATED CASTOR OIL | 4 | 73% | Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| PROPYLPARABEN | 5 | 71% | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| FLAVOR | 4 | 100% | Miscellaneous |
| SODIUM SACCHARIN | 2 | 80% | Neurotoxicity |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| CETYLPYRIDINIUM CHLORIDE | 2 | 73% | Violations, restrictions & warnings, Irritation (skin, eyes, or lungs) |
| SODIUM BENZOATE | 2 | 69% | Organ system toxicity (non-reproductive) |
| XYLITOL | 1 | 88% | none identified |
| XANTHAN GUM | 0 | 94% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM SACCHARIN, METHYLPARABEN, PROPYLPARABEN, SODIUM BENZOATE, GLYCERIN | |
| Limited evidence of carcinogenicity | COPOVIDONE |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | SODIUM SACCHARIN, SODIUM BENZOATE | |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PEG-60 HYDROGENATED CASTOR OIL | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | CETYLPYRIDINIUM CHLORIDE | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | SODIUM BENZOATE | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | COPOVIDONE, METHYLPARABEN |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at very low doses | SODIUM SACCHARIN | |
| One or more animal studies show brain and nervous system effects at moderate doses | METHYLPARABEN, SODIUM BENZOATE | |
| One or more animal studies show brain and nervous system effects at high doses | GLYCERIN, XYLITOL | |
| nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | COPOVIDONE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human any disruptor - strong evidence | METHYLPARABEN | |
| One or more animal studies show endocrine system disruption at high doses | GLYCERIN | |
| Human any disruptor - strong evidence | PROPYLPARABEN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human skin toxicant - strong evidence | PROPYLPARABEN, METHYLPARABEN |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) | XYLITOL, SODIUM SACCHARIN | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | CETYLPYRIDINIUM CHLORIDE | |
| Limited evidence of sense organ toxicity | PEG-60 HYDROGENATED CASTOR OIL | |
| One or more animal studies show broad systemic effects at low doses | SODIUM BENZOATE | |
| Limited evidence of sense organ toxicity | PROPYLPARABEN | |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN | |
| Known human respiratory toxicant | COPOVIDONE, METHYLPARABEN |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | COPOVIDONE | |
| Ingredient not fully labeled - identity unknown | FLAVOR |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | XANTHAN GUM, XYLITOL, PEG-60 HYDROGENATED CASTOR OIL, COPOVIDONE, SODIUM SACCHARIN, SODIUM BENZOATE, PROPYLPARABEN, METHYLPARABEN, GLYCERIN, CETYLPYRIDINIUM CHLORIDE | |
| Used in food or as an additive with limited or no toxicity information available | COPOVIDONE |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Wildlife and environmental toxicity | PROPYLPARABEN |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Classified as irritant | COPOVIDONE | |
| One or more animal studies show skin irritation at low doses | CETYLPYRIDINIUM CHLORIDE, METHYLPARABEN | |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN | |
| One or more animal studies show skin irritation at high doses | SODIUM BENZOATE |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Safety unknown for products that may be inhaled | products that may be aerosolized (airborne) | SODIUM BENZOATE |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | PROPYLPARABEN | |
| Not assessed for safety in cosmetics by industry panel | COPOVIDONE | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | METHYLPARABEN | |
| Not assessed for safety in cosmetics by industry panel | XYLITOL, FLAVOR, PEG-60 HYDROGENATED CASTOR OIL, XANTHAN GUM, SODIUM SACCHARIN, GLYCERIN, CETYLPYRIDINIUM CHLORIDE |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN | |
| Allowed workplace exposures restricted to low doses | COPOVIDONE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Interferes with gene expresion | METHYLPARABEN | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | XYLITOL, SODIUM BENZOATE, GLYCERIN |
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