

Compact for Safe Cosmetics
|
Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards |
Ingredients from packaging: Active Ingredients: Calamine (3.0%) (Skin Protectant), Pramoxine HCl (1.0%) (External Analgesic)Inactive Ingredients: Water, Glycerin, Distearlydimonium Chloride, Petrolatum, Isopropyl Palmitate, Cetyl Alcohol, Dimethicone, Avena Sativa Kernel Flour (Oat), Sodium Chloride
Directions from packaging: Adults and children 2 years and older: Apply no more than 4 times daily. Children under 2 years of age: Do not use, consult a physician. Store at 59° - 86° F
Warnings from packaging: WarningsFor external use only. Avoid contact with eyes. If condition does not improve or recurs within 7 days, discontinue use and consult a physician. Keep this and all drugs out of the reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
| score | data gap | concerns | |
| DIMETHICONE | 2 | 74% | Violations, restrictions & warnings |
| PETROLATUM | 2 | 94% | Organ system toxicity (non-reproductive), Contamination concerns (PAHS) |
| DISTEARYLDIMONIUM CHLORIDE DISTEARLYDIMONIUM CHLORIDE | 1 | 84% | Irritation (skin, eyes, or lungs) |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| CALAMINE | 0 | 94% | none identified |
| CETYL ALCOHOL | 1 | 87% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| ISOPROPYL PALMITATE | 1 | 87% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| PRAMOXINE HCL | 1 | 87% | Neurotoxicity, Organ system toxicity (non-reproductive) |
| AVENA SATIVA (OAT) KERNEL FLOUR AVENA SATIVA KERNEL FLOUR (OAT) | 0 | 94% | none identified |
| SODIUM CHLORIDE | 0 | 0% | innocuous |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM CHLORIDE, GLYCERIN |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | DIMETHICONE |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | GLYCERIN, DISTEARYLDIMONIUM CHLORIDE | |
| One or more animal studies show brain and nervous system effects at low doses | PRAMOXINE HCL |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | GLYCERIN |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Classified as expected to be toxic or harmful | PETROLATUM | |
| One or more animal studies show broad systemic effects at low doses | ISOPROPYL PALMITATE, PRAMOXINE HCL | |
| One or more animal studies show cardiovascular effects at high doses (low dose studies may be unavailable for this ingredient) | CETYL ALCOHOL, DISTEARYLDIMONIUM CHLORIDE | |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin | CETYL ALCOHOL | |
| Not suspected to be an environmental toxin | PETROLATUM | |
| Wildlife and environmental toxicity | DISTEARYLDIMONIUM CHLORIDE |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | SODIUM CHLORIDE | |
| Classified as irritant | DISTEARYLDIMONIUM CHLORIDE | |
| One or more animal studies show skin irritation at very low doses | CETYL ALCOHOL | |
| One or more animal studies show skin irritation at low doses | ISOPROPYL PALMITATE | |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | DIMETHICONE, ISOPROPYL PALMITATE, CETYL ALCOHOL | |
| Not assessed for safety in cosmetics by industry panel | PRAMOXINE HCL, PETROLATUM, DISTEARYLDIMONIUM CHLORIDE, GLYCERIN, CALAMINE, AVENA SATIVA (OAT) KERNEL FLOUR |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | GLYCERIN |
No items in basket.
Add this product
Looking for a product report that we don't have in Skin Deep? Sign up to enter it into the Skin Deep database and leave product reviews.
We always want Skin Deep to be free to the public, but delivering high-quality research costs time and money. Help by donating just the cost of a bar of soap or bottle of shampoo.
Stay informed with email updates on toxics in everyday products and how they can affect your health.
'I just wanted to let you know how much Skin Deep has changed my daughter's (and my) life.'
—Melissa M., Michigan