B. Kamins Chemist Bio-Maple menopause skin cream (2006 formulation) || Skin Deep: Cosmetic Safety Reviews

B. KAMINS CHEMIST BIO-MAPLE MENOPAUSE SKIN CREAM (2006 FORMULATION)

last updated: 05/01/06 brand: B. Kamins by Kamins Dermatologics

SCORE

high hazard (out of 10)

80%

data gap

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99% of anti-agings have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: WATER/EAU, EPISPHERE-BLUE (TOCOPHEROL), CETYL ALCOHOL & CETEARETH-20, BIO-MAPLE COMPOUND (ACER SACCHARUM ISOLATE), SPHINGOLIPIDES AND PHOSPHOLIPIDES (PLANT CERAMIDES), UREA, BOTANICAL EXTRACT OF BILBERRY, LEMON, SUGAR MAPLE, SUGAR CANE & ORANGE, TITANIUM DIOXIDE, OCTYLMETHOXYCINNAMATE, SQUALANE, SORBITOL, SALICYLIC ACID, CHOLECALCIFEROL, HORSE CHESTNUT EXTRACT (AESCULUS HIPPOCASTANUM), PHENOXYETHANOL&METHYLPARABENÐYLPARABEN&PROPYLPARABEN, CETEARETH 12, MENTHYL LACTATE, DIMETHICONE, DIAZOLIDINYL UREA, RETINYL PALMITATE, SODIUM HYDROXIDE, DISODIUM EDTA, FRAGRANCE

Directions from packaging: Apply gently morning and night to cleansed face and neck. Repeat use throughout the day if needed. May be used alone or as a supplement to your daily routine in conjunction with other skin care products. Store at room temperature. Keep away from extreme heat or cold.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-12	5	71%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
CETEARETH-20	5	71%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
OCTINOXATE (OCTYL METHOXYCINNAMATE) (Active Ingredient)	8	65%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
SALICYLIC ACID	7	66%	Violations, restrictions & warnings, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
DIAZOLIDINYL UREA	6	59%	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
ETHYLPARABEN	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
RETINYL PALMITATE	5	68%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PROPRIETARY INGREDIENTS EPISPHERE-BLUE (TOCOPHEROL)	4	100%	Miscellaneous
TITANIUM DIOXIDE (NON-NANO)	4	81%	Cancer, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
PHENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
UREA	4	67%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption
CHOLECALCIFEROL	4	61%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Occupational hazards
DISODIUM EDTA	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
SODIUM HYDROXIDE	3	77%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
DIMETHICONE	2	74%	Violations, restrictions & warnings
AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRACT HORSE CHESTNUT EXTRACT (AESCULUS HIPPOCASTANUM)	2	88%	Neurotoxicity, Organ system toxicity (non-reproductive)
SQUALANE	1	93%	Irritation (skin, eyes, or lungs)
SORBITOL	1	88%	none identified
CETYL ALCOHOL	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ACER SACCHARUM (MAPLE) ISOLATE BIO-MAPLE COMPOUND (ACER SACCHARUM ISOLATE)	0	100%	none identified
ACER SACCHARUM (SUGAR MAPLE)	0	100%	none identified
ORANGE	0	100%	none identified
PHOSPHOLIPIDS PHOSPHOLIPIDES (PLANT CERAMIDES)	0	100%	none identified
SACCHARUM OFFICINARUM (SUGAR CANE) SUGAR CANE & ORANGE	0	100%	none identified
SPHINGOLIPIDS SPHINGOLIPIDES	0	100%	none identified
VACCINIUM MYRTILLUS (BILBERRY) EXTRACT	0	100%	none identified
LEMON	0	100%	none identified
MENTHYL LACTATE	0	94%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results		UREA
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL
One or more in vitro tests on mammalian cells show positive mutation results		SORBITOL, SODIUM HYDROXIDE, PROPYLPARABEN, ETHYLPARABEN, METHYLPARABEN, DISODIUM EDTA, DIAZOLIDINYL UREA
Cancer - not classifiable/not likely to be human carcinogen		SALICYLIC ACID
Cancer - limited evidence		RETINYL PALMITATE
Limited evidence of carcinogenicity	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at moderate doses		SALICYLIC ACID,
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at high doses		DISODIUM EDTA, ETHYLPARABEN, UREA
One or more animal studies show reproductive effects at moderate doses		CHOLECALCIFEROL
One or more animal studies show reproductive effects at low doses		RETINYL PALMITATE,
One or more animal studies show any effects at low doses		PROPYLPARABEN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		SALICYLIC ACID
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		CETEARETH-12, CETEARETH-20, DIAZOLIDINYL UREA
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		CHOLECALCIFEROL, RETINYL PALMITATE, SALICYLIC ACID, UREA
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		PHENOXYETHANOL, SALICYLIC ACID
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at low doses		AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRACT, DISODIUM EDTA, SALICYLIC ACID
One or more animal studies show brain and nervous system effects at moderate doses		CETEARETH-12, CETEARETH-20, CHOLECALCIFEROL, METHYLPARABEN, PHENOXYETHANOL, UREA
One or more animal studies show brain and nervous system effects at high doses		DIAZOLIDINYL UREA, RETINYL PALMITATE
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		SODIUM HYDROXIDE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		ETHYLPARABEN, METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE), PROPYLPARABEN
One or more animal studies show endocrine system disruption at high doses		DIAZOLIDINYL UREA, DISODIUM EDTA

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
Known human immune system toxicant		FRAGRANCE
Human skin toxicant - strong evidence		PROPYLPARABEN
Known human immune system toxicant		DIAZOLIDINYL UREA
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show immune effects at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
Human skin toxicant - strong evidence		ETHYLPARABEN, METHYLPARABEN

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TITANIUM DIOXIDE (NON-NANO), SODIUM HYDROXIDE
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Not suspected to be persistent		CETYL ALCOHOL
Persistent, bioaccumulative in wildlife		SALICYLIC ACID

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		SORBITOL, DIAZOLIDINYL UREA
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	CETYL ALCOHOL
One or more animal studies show respiratory effects at moderate doses (low dose studies may be unavailable for this ingredient)	products that may be aerosolized (airborne)	UREA
Limited evidence of skin toxicity		RETINYL PALMITATE, PROPYLPARABEN, ETHYLPARABEN
One or more animal studies show sense organ effects at low doses	products for use around the eyes, mouth, or lips	CETEARETH-12, CETEARETH-20
One or more animal studies show broad systemic effects at low doses		DISODIUM EDTA, CHOLECALCIFEROL
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	SALICYLIC ACID, PHENOXYETHANOL
Known human any toxicant		METHYLPARABEN
One or more animal studies show broad systemic effects at very low doses		AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRACT, SODIUM HYDROXIDE,
One or more animal studies show respiratory effects at very low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM HYDROXIDE
Occupational hazards related to handling	products for use around the mouth; products for use on the lips; products for use on skin	CHOLECALCIFEROL
Ingredient not fully labeled - identity unknown		PROPRIETARY INGREDIENTS, FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		UREA, TITANIUM DIOXIDE (NON-NANO), SORBITOL, SODIUM HYDROXIDE, METHYLPARABEN, SALICYLIC ACID, RETINYL PALMITATE, PROPYLPARABEN, MENTHYL LACTATE, DISODIUM EDTA
Used in food or as an additive with limited or no toxicity information available		SALICYLIC ACID
Designated as safe for general or specific, limited use in food		CETYL ALCOHOL, CHOLECALCIFEROL, DIMETHICONE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		CETYL ALCOHOL
Not suspected to be an environmental toxin		SODIUM HYDROXIDE, TITANIUM DIOXIDE (NON-NANO)
Wildlife and environmental toxicity		PROPYLPARABEN
Wildlife and environmental toxicity		OCTINOXATE (OCTYL METHOXYCINNAMATE)

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		SALICYLIC ACID
One or more animal studies show skin irritation at low doses		UREA, SQUALANE, METHYLPARABEN, CETEARETH-20, CETEARETH-12,
One or more animal studies show significant but moderate pulmonary irritation at low doses	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show skin irritation at very low doses		SODIUM HYDROXIDE, CETYL ALCOHOL
Classified as irritant		PHENOXYETHANOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		RETINYL PALMITATE, PROPYLPARABEN, UREA, PHENOXYETHANOL, METHYLPARABEN, ETHYLPARABEN, DISODIUM EDTA, DIMETHICONE, CETYL ALCOHOL
Not assessed for safety in cosmetics by industry panel		LEMON, VACCINIUM MYRTILLUS (BILBERRY) EXTRACT, TITANIUM DIOXIDE (NON-NANO), SQUALANE, SPHINGOLIPIDS, SODIUM HYDROXIDE, SORBITOL, SACCHARUM OFFICINARUM (SUGAR CANE), PROPRIETARY INGREDIENTS, PHOSPHOLIPIDS, ORANGE, MENTHYL LACTATE, FRAGRANCE, CHOLECALCIFEROL, AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRACT, ACER SACCHARUM (SUGAR MAPLE), ACER SACCHARUM (MAPLE) ISOLATE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CHOLECALCIFEROL
Allowed workplace exposures restricted to low doses		TITANIUM DIOXIDE (NON-NANO), PHENOXYETHANOL
No workplace limits set		SODIUM HYDROXIDE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show respiratory changes at very low doses where the human health implications are not yet well understood	products that may be aerosolized (airborne)	TITANIUM DIOXIDE (NON-NANO)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRACT
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		METHYLPARABEN