

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: ACTIVE INGREDIENTS: SODIUM FLUORIDE 0.24% (ANTICAVITY TOOTHPASTE) INACTIVE INGREDIENTS: GLYCERIN, SODIUM BICARBONATE (BAKING SODA), WATER, SORBITOL, HYDRATED SILICA, CALCIUM SULFATE, SODIUM SULFATE, SODIUM LAURYL SULFATE, SILICA, FLAVOR, DIPOSTASSIUM PHOSPHATE, SODIUM CARBONATE, SODIUM SACCHARIN, CELLULOSE GUM, XANTHAN GUM, METHYLPARABEN, PROPYLPARABEN, BLUE 1, MAY ALSO CONTAIN SODIUM LAUROYL SARCOSINATE
Directions from packaging: + Do not swallow. + Supervise children as necessary until capable of using without supervision. + Adults and children 12 years and over: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist or physician. + Children under 6 years: i nstruct in good brushing and rinsing habits (to minimize swallowing). + Children under 2 years: ask a dentist or physician.
Warnings from packaging: Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.
| score | data gap | concerns | |
| METHYLPARABEN | 10 | 63% | Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| SODIUM FLUORIDE (Active Ingredient) | 9 | 63% | Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes |
| SILICA | 1 | 69% | Biochemical or cellular level changes |
| PROPYLPARABEN | 5 | 71% | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| FLAVOR | 4 | 100% | Miscellaneous |
| SODIUM LAUROYL SARCOSINATE (May Contain) | 4 | 73% | Violations, restrictions & warnings, Enhanced skin absorption, Contamination concerns (NITROSAMINES) |
| SODIUM LAURYL SULFATE | 3 | 68% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| FD&C BLUE 1 | 1 | 83% | none identified |
| SODIUM CARBONATE | 2 | 82% | Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| SODIUM SACCHARIN | 2 | 80% | Neurotoxicity |
| HYDRATED SILICA | 2 | 79% | Persistence and bioaccumulation |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| SORBITOL | 1 | 88% | none identified |
| CELLULOSE GUM | 1 | 80% | none identified |
| SODIUM SULFATE | 1 | 73% | none identified |
| CALCIUM SULFATE | 0 | 100% | none identified |
| DIPOTASSIUM PHOSPHATE DIPOSTASSIUM PHOSPHATE | 0 | 94% | none identified |
| XANTHAN GUM | 0 | 94% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests on mammalian cells show positive mutation results | SORBITOL | |
| One or more animal studies show tumor formation at high doses | CELLULOSE GUM | |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM SACCHARIN, SODIUM LAURYL SULFATE, PROPYLPARABEN, METHYLPARABEN, GLYCERIN | |
| One or more animal studies show tumor formation at low doses | SODIUM FLUORIDE | |
| Cancer - not classifiable/not likely to be human carcinogen | HYDRATED SILICA, FD&C BLUE 1 |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | SODIUM SACCHARIN, SODIUM LAURYL SULFATE | |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN, CELLULOSE GUM | |
| One or more animal studies show reproductive effects at very low doses | SODIUM CARBONATE | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN | |
| Human nervous system toxicant - moderate evidence | SODIUM FLUORIDE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | SODIUM SULFATE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | SODIUM FLUORIDE | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | SODIUM LAUROYL SARCOSINATE, SODIUM LAURYL SULFATE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics | SODIUM LAUROYL SARCOSINATE, SODIUM LAUROYL SARCOSINATE | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | GLYCERIN | |
| One or more animal studies show brain and nervous system effects at moderate doses | METHYLPARABEN, SODIUM LAURYL SULFATE | |
| One or more animal studies show brain and nervous system effects at high doses | FD&C BLUE 1 | |
| Strong evidence of human neurotoxicity | SODIUM FLUORIDE | |
| One or more animal studies show brain and nervous system effects at very low doses | SODIUM SACCHARIN |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | SODIUM LAURYL SULFATE, GLYCERIN | |
| One or more studies show endocrine system disruption at low doses | SODIUM FLUORIDE | |
| Human any disruptor - strong evidence | PROPYLPARABEN, METHYLPARABEN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human skin toxicant - strong evidence | PROPYLPARABEN, METHYLPARABEN |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be persistent | SODIUM LAURYL SULFATE | |
| Persistent, bioaccumulative in wildlife and humans | HYDRATED SILICA |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient) | SORBITOL, SODIUM SACCHARIN, CELLULOSE GUM | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | SILICA |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | FD&C BLUE 1, SODIUM SULFATE | |
| Limited evidence of sense organ toxicity | PROPYLPARABEN | |
| One or more animal studies show broad systemic effects at low doses | SODIUM LAURYL SULFATE | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | SODIUM CARBONATE |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN, SODIUM FLUORIDE | |
| Known human any toxicant | METHYLPARABEN |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | SODIUM FLUORIDE | |
| Ingredient not fully labeled - identity unknown | FLAVOR |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | XANTHAN GUM, SORBITOL, SODIUM SULFATE, SODIUM SACCHARIN, SODIUM LAURYL SULFATE, SODIUM FLUORIDE, SODIUM CARBONATE, PROPYLPARABEN, METHYLPARABEN, GLYCERIN, FD&C BLUE 1, DIPOTASSIUM PHOSPHATE, CALCIUM SULFATE, CELLULOSE GUM | |
| Used in food or as an additive with limited or no toxicity information available | SODIUM FLUORIDE |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin | SODIUM LAURYL SULFATE | |
| Wildlife and environmental toxicity | PROPYLPARABEN |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN | |
| One or more animal studies show skin irritation at low doses | METHYLPARABEN | |
| One or more animal studies show skin irritation at very low doses | SODIUM LAURYL SULFATE | |
| Classified as irritant | SODIUM CARBONATE |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | SODIUM CARBONATE, PROPYLPARABEN, METHYLPARABEN, CELLULOSE GUM | |
| Not assessed for safety in cosmetics by industry panel | HYDRATED SILICA, FLAVOR, XANTHAN GUM, SORBITOL, SODIUM SACCHARIN, GLYCERIN, DIPOTASSIUM PHOSPHATE, CALCIUM SULFATE |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN | |
| Allowed workplace exposures restricted to very low doses | SODIUM FLUORIDE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood | SILICA, SODIUM FLUORIDE | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | SODIUM LAURYL SULFATE | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CELLULOSE GUM, GLYCERIN | |
| Interferes with gene expresion | METHYLPARABEN |
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