Peter Thomas Roth Glycolic Acid 10% Clarifying Gel (2006 formulation) || Skin Deep: Cosmetic Safety Reviews

PETER THOMAS ROTH GLYCOLIC ACID 10% CLARIFYING GEL (2006 FORMULATION)

last updated: 05/01/06 brand: Peter Thomas Roth by Peter Thomas Roth Labs

SCORE

moderate hazard (out of 10)

67%

data gap

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35% of anti-agings have lower concerns
41% of facial moisturizer/treatments have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards

Ingredients from packaging: WATER, GLYCOLIC ACID, SD ALCOHOL 40, GLYCERIN, ARGININE, HYDROXYETHYLCELLULOSE, SALICYLIC ACID (BETA HYDROXY ACID), DMDM HYDANTOIN, AMMONIUM HYDROXIDE.

Directions from packaging: Skin should be clean and free of irritation. Apply a very thin layer to clean non-irritated skin every other night for two weeks. After two weeks, apply a very thin layer to clean skin every night. After one month of use, you may apply a very thin layer to clean, non-irritated skin all day and all night. Allow ten minutes for the product to absorb, and follow, if needed, with prescribed Peter Thomas Roth treatment products at night and prescribed moisturizer and oil-free sun care products during the day.

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ingredients

	score	data gap	concerns
DMDM HYDANTOIN	7	71%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
SD ALCOHOL 40	5	77%	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption, Contamination concerns (BRUCINE, T-BUTYL ALCOHOL, BRUCINE SULFATE, QUASSIN)
GLYCOLIC ACID	4	70%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive)
ARGININE	3	79%	Neurotoxicity, Organ system toxicity (non-reproductive)
AMMONIUM HYDROXIDE	2	81%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
HYDROXYETHYLCELLULOSE	1	82%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		AMMONIUM HYDROXIDE
One or more in vitro tests on mammalian cells show positive mutation results		GLYCERIN, ARGININE
Cancer - limited evidence		SD ALCOHOL 40

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		HYDROXYETHYLCELLULOSE, GLYCOLIC ACID
One or more animal studies show reproductive effects at moderate doses		GLYCERIN
Limited evidence of reproductive toxicity		SD ALCOHOL 40
One or more animal studies show reproductive effects at moderate doses		ARGININE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits		GLYCOLIC ACID
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmetics		DMDM HYDANTOIN, DMDM HYDANTOIN, GLYCOLIC ACID
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		GLYCOLIC ACID

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		SD ALCOHOL 40
One or more animal studies show brain and nervous system effects at high doses		HYDROXYETHYLCELLULOSE, GLYCERIN
One or more animal studies show brain and nervous system effects at moderate doses		GLYCOLIC ACID
One or more animal studies show brain and nervous system effects at very low doses		ARGININE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		GLYCERIN
One or more animal studies show endocrine disruption at moderate doses		ARGININE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Known human immune system toxicant		DMDM HYDANTOIN

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		AMMONIUM HYDROXIDE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		DMDM HYDANTOIN
One or more animal studies show cardiovascular effects at high doses (low dose studies may be unavailable for this ingredient)		HYDROXYETHYLCELLULOSE
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	AMMONIUM HYDROXIDE, GLYCOLIC ACID
Limited evidence of gastrointestinal or liver toxicity		SD ALCOHOL 40
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN, ARGININE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		AMMONIUM HYDROXIDE, ARGININE, GLYCERIN
Used in food or as an additive with limited or no toxicity information available		SD ALCOHOL 40

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Wildlife and environmental toxicity		AMMONIUM HYDROXIDE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		GLYCERIN
Human skin irritant - moderate evidence		AMMONIUM HYDROXIDE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	DMDM HYDANTOIN

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Insufficient data to determine safety		SD ALCOHOL 40
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		DMDM HYDANTOIN, HYDROXYETHYLCELLULOSE
Not assessed for safety in cosmetics by industry panel		GLYCERIN, ARGININE, AMMONIUM HYDROXIDE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to moderate doses		GLYCERIN
No workplace limits set		GLYCOLIC ACID

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		ARGININE, GLYCERIN