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Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: ACTIVE INGREDIENTS: FLUORIDE ION FROM SODIUM MONOFLUOROPHOSPHATE 0.15% WT/VOL . INACTIVE INGREDIENTS: GLYCERIN, HYDRATED SILICA, UREA PEROXIDE, HYDRATED ALUMINA, MODIFIED STARCH, FLAVOR, SILICA, SODIUM CITRATE DIHYDRATE, MODIFIED CORN STARCH, PROPYLENE GLYCOL, COCAMIDOPROPYL BETAINE, PAPAIN, SODIUM LAURYL SULFATE, ACRYLIC POLYMER, SODIUM SACCAHARIN, CALCIUM DISODIUM EDTA .
Directions from packaging: + Children 6 Years and Over: Brush teeth thoroughly after each meal or at least twice a day, or as directed by a dentist or physician. + Children 2 Years to Under 6: Use a pea size amount and instruct in good brushing and rinsing habits - to minimize swallowing. + Children Under 2 Years:Ask a dentist or physician.Store at or below 75 degrees F - 23 degrees C.
Warnings from packaging: Keep out of the reach of children under 6 years of age. Supervise young children until capable of using without supervision. If more than amount used for brushing is swallowed, seek professional assistance or contact a Poison Control Center immediately.
| score | data gap | concerns | |
| SILICA | 1 | 69% | Biochemical or cellular level changes |
| ALUMINA | 6 | 85% | Developmental/reproductive toxicity, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Enhanced skin absorption, Occupational hazards |
| SODIUM MONOFLUOROPHOSPHATE (Active Ingredient) | 6 | 69% | Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards |
| PAPAIN | 5 | 68% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| COCAMIDOPROPYL BETAINE | 5 | 63% | Allergies/immunotoxicity, Contamination concerns (NITROSAMINES) |
| FLAVOR | 4 | 100% | Miscellaneous |
| PROPYLENE GLYCOL | 4 | 60% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| PERHYDROL UREA UREA PEROXIDE | 3 | 76% | Violations, restrictions & warnings |
| SODIUM LAURYL SULFATE | 3 | 68% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| SODIUM SACCHARIN SODIUM SACCAHARIN | 2 | 80% | Neurotoxicity |
| HYDRATED SILICA | 2 | 79% | Persistence and bioaccumulation |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| CALCIUM DISODIUM EDTA | 1 | 87% | Organ system toxicity (non-reproductive) |
| ACRYLIC POLYMER | 0 | 100% | none identified |
| CORN STARCH, MODIFIED MODIFIED CORN STARCH | 0 | 100% | none identified |
| MODIFIED STARCH | 0 | 100% | none identified |
| SODIUM CITRATE DIHYDRATE | 0 | 100% | none identified |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show tumor formation at moderate doses | ALUMINA | |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM SACCHARIN, SODIUM MONOFLUOROPHOSPHATE, SODIUM LAURYL SULFATE, PROPYLENE GLYCOL, GLYCERIN | |
| Cancer - not classifiable/not likely to be human carcinogen | HYDRATED SILICA |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN, PROPYLENE GLYCOL | |
| One or more animal studies show reproductive effects at high doses | SODIUM LAURYL SULFATE, SODIUM SACCHARIN, PAPAIN | |
| Human nervous system toxicant - moderate evidence | SODIUM MONOFLUOROPHOSPHATE, ALUMINA |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PROPYLENE GLYCOL, SODIUM LAURYL SULFATE, COCAMIDOPROPYL BETAINE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | SODIUM MONOFLUOROPHOSPHATE, PERHYDROL UREA | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | PERHYDROL UREA |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | PROPYLENE GLYCOL, GLYCERIN | |
| One or more animal studies show brain and nervous system effects at very low doses | SODIUM SACCHARIN | |
| One or more animal studies show brain and nervous system effects at moderate doses | SODIUM LAURYL SULFATE | |
| Strong evidence of human neurotoxicity | SODIUM MONOFLUOROPHOSPHATE, ALUMINA |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | SODIUM LAURYL SULFATE, GLYCERIN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Known human immune system toxicant | PAPAIN | |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL | |
| Known human immune system toxicant | COCAMIDOPROPYL BETAINE |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be bioaccumulative | ALUMINA | |
| Not suspected to be persistent | SODIUM LAURYL SULFATE | |
| Persistent, bioaccumulative in wildlife and humans | HYDRATED SILICA |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient) | SODIUM SACCHARIN | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | SILICA |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | ALUMINA | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | PROPYLENE GLYCOL |
| One or more animal studies show broad systemic effects at low doses | SODIUM LAURYL SULFATE | |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN, SODIUM MONOFLUOROPHOSPHATE, CALCIUM DISODIUM EDTA | |
| Possible human immune system toxicant | PAPAIN |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Ingredient not fully labeled - identity unknown | FLAVOR |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin | SODIUM LAURYL SULFATE, ALUMINA |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | GLYCERIN | |
| Classified as skin irritant | PROPYLENE GLYCOL | |
| One or more animal studies show skin irritation at very low doses | SODIUM LAURYL SULFATE | |
| Classified as irritant | PAPAIN |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL | |
| Not assessed for safety in cosmetics by industry panel | PAPAIN | |
| Safety assessment was based on related chemical | CALCIUM DISODIUM EDTA | |
| Not assessed for safety in cosmetics by industry panel | FLAVOR, HYDRATED SILICA, SODIUM SACCHARIN, SODIUM MONOFLUOROPHOSPHATE, SODIUM CITRATE DIHYDRATE, PERHYDROL UREA, MODIFIED STARCH, GLYCERIN, CORN STARCH, MODIFIED, ALUMINA, ACRYLIC POLYMER |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN, ALUMINA | |
| Allowed workplace exposures restricted to low doses | SODIUM MONOFLUOROPHOSPHATE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show blood sugar changes at high doses where the human health implications are not yet well understood | PROPYLENE GLYCOL, GLYCERIN, CALCIUM DISODIUM EDTA | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | SODIUM LAURYL SULFATE | |
| One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood | SILICA |
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