KINERASE CREAM, SPF 15
last updated: 04/03/08 brand: Kinerase by Valeant Pharmaceuticals International
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38% of anti-agings have lower concerns
45% of facial moisturizer/treatments have lower concerns
26% of sunscreen: SPF 15-30s have lower concerns
COMPANY POLICIES
Compact for Safe Cosmetics
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Animal Testing Policy |
Sunscreen effectiveness* breakdown
| 6 | UVB hazard/exposure score |
| 3 | UVA hazard/exposure score |
| 0 | sunscreen instability |
*Note that the same active ingredient combination may score differently in two different products depending on the concentration of the ingredients and the mixture of inactive ingredients.
Active ingredient UV |
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 Product total |
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| OCTOCRYLENE (8%) |
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| OXYBENZONE (BENZOPHENONE-3) (4%) |
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| AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) (3%) |
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Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
 | Cancer |
 | Developmental/reproductive toxicity |
| Violations, restrictions & warnings |
| Allergies/immunotoxicity |
| Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Note from EWG: Unlike many other kinds of personal care products, sunscreen can provide health benefits, protecting against the sun's cancer-causing UV radiation. More than one million cases of skin cancer are diagnosed in the U.S. every year. Health officials recommend wearing sunscreen as one of many important steps to minimize skin cancer risk. (more sun safety tips)
Ingredients from packaging: ACTIVE INGREDIENTS: OCTOCRYLENE (8%), OXYBENSONE (4%), AVOBENZONE (3%) OTHER INGREDIENTS: WATER, GLYCERYL STEARATE, ISOPROPYL PALMITATE, PROPYLENE GLYCOL, STEARIC ACID, CETYL ALCOHOL, SAFFLOWER SEED OIL, SOYBEAN STEROLS, STEARYL ALCOHOL, LAURETH-23, DIMETHICONE, CITRIC ACID, SODIUM HYDROXIDE, SOLUBLE COLLAGEN, KINETIN, CARBOMER, PANTHENOL, ASCORBIC ACID, HYDROLYZED ELASTIN, ALOE VERA LEAF JUICE, IMIDAZOLINDINYL UREA, TRIETHANOLAMINE, METHYLPARABEN, PROPYLPARABEN.
Directions from packaging: Warnings:For external use only. Do not use on children under 6 months of age unless directed by a doctor. When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash or irritation develops and lasts. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Sun Alert: Limiting sun exposure, wearing protective clothing, and using sunscreens may reduce the risks of skin aging, skin cancer, and other harmful effects of the sun. For topical dermatological use only. Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Tamper Resistant
Warnings from packaging: Warnings:For external use only. Do not use on children under 6 months of age unless directed by a doctor. When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash or irritation develops and lasts. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Sun Alert: Limiting sun exposure, wearing protective clothing, and using sunscreens may reduce the risks of skin aging, skin cancer, and other harmful effects of the sun. For topical dermatological use only. Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Tamper Resistant
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ingredients
| score | data gap | concerns | |
| METHYLPARABEN | 10 | 63% | Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| OXYBENZONE (BENZOPHENONE-3) OXYBENSONE (Active Ingredient) | 9 | 55% | Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes |
| TRIETHANOLAMINE | 6 | 58% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards |
| LAURETH-23 | 5 | 83% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| PROPYLPARABEN | 5 | 71% | Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| IMIDAZOLIDINYL UREA IMIDAZOLINDINYL UREA | 5 | 70% | Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE) |
| PROPYLENE GLYCOL | 4 | 60% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| SODIUM HYDROXIDE | 3 | 77% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| DIMETHICONE | 2 | 74% | Violations, restrictions & warnings |
| CITRIC ACID | 3 | 72% | Violations, restrictions & warnings, Organ system toxicity (non-reproductive) |
| OCTOCRYLENE (Active Ingredient) | 3 | 71% | Violations, restrictions & warnings, Biochemical or cellular level changes |
| PANTHENOL | 2 | 88% | Multiple, additive exposure sources |
| STEARIC ACID | 2 | 74% | Neurotoxicity, Irritation (skin, eyes, or lungs) |
| AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) (Active Ingredient) | 2 | 73% | Violations, restrictions & warnings, Contamination concerns (BENZOIC ACID, 4-T-BUTYLBENZOIC ACID, BENZALDEHYDE, P-ANISIC ACID, ACETOPHENONE, DIBENZOYLMETHANE) |
| ASCORBIC ACID (VITAMIN C) | 1 | 91% | none identified |
| GLYCERYL MONOSTEARATE GLYCERYL STEARATE | 1 | 88% | none identified |
| N6-FURFURYLADENINE KINETIN | 1 | 88% | Organ system toxicity (non-reproductive) |
| CETYL ALCOHOL | 1 | 87% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| ISOPROPYL PALMITATE | 1 | 87% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL SAFFLOWER SEED OIL | 1 | 84% | none identified |
| STEARYL ALCOHOL | 1 | 84% | Irritation (skin, eyes, or lungs) |
| ALOE BARBADENSIS (ALOE VERA) GEL ALOE VERA LEAF JUICE | 1 | 72% | none identified |
| GLYCINE SOJA (SOYBEAN) STEROLS | 0 | 100% | none identified |
| SOLUBLE COLLAGEN | 0 | 100% | none identified |
| HYDROLYZED ELASTIN | 0 | 94% | none identified |
| CARBOMER | 0 | 93% | none identified |
| WATER | 0 | 0% | innocuous |
Cancer*
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show tumor formation at high doses | STEARYL ALCOHOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL | |
| One or more in vitro tests non-mammalian cells show positive mutation results | OXYBENZONE (BENZOPHENONE-3), LAURETH-23 | |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM HYDROXIDE, PROPYLPARABEN, PROPYLENE GLYCOL, N6-FURFURYLADENINE, | |
| One or more in vitro tests on mammalian cells show positive mutation results | AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) | |
| One or more in vitro tests on mammalian cells show positive mutation results | ASCORBIC ACID (VITAMIN C), METHYLPARABEN | |
| Not likely to be carcinogenic in humans | STEARIC ACID | |
| Cancer - not classifiable/not likely to be human carcinogen | TRIETHANOLAMINE |
Developmental/reproductive toxicity*
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show any effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) GEL | |
| One or more animal studies show reproductive effects at moderate doses | PROPYLENE GLYCOL | |
| One or more animal studies show any effects at low doses | PROPYLPARABEN | |
| Limited evidence of developmental toxicity | OXYBENZONE (BENZOPHENONE-3) |
Violations, restrictions & warnings*
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PROPYLENE GLYCOL, TRIETHANOLAMINE, ALOE BARBADENSIS (ALOE VERA) GEL | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | DIMETHICONE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | CITRIC ACID, OXYBENZONE (BENZOPHENONE-3), OCTOCRYLENE, AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN |
Neurotoxicity*
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | PROPYLENE GLYCOL, OXYBENZONE (BENZOPHENONE-3) | |
| One or more animal studies show brain and nervous system effects at moderate doses | METHYLPARABEN | |
| One or more animal studies show brain and nervous system effects at low doses | LAURETH-23 | |
| One or more animal studies show brain and nervous system effects at very low doses | SODIUM HYDROXIDE, STEARIC ACID |
Endocrine disruption*
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | TRIETHANOLAMINE | |
| Human any disruptor - moderate evidence | OXYBENZONE (BENZOPHENONE-3) | |
| Human any disruptor - strong evidence | METHYLPARABEN, PROPYLPARABEN |
Allergies/immunotoxicity*
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Associated with immunotoxicity | AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) | |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL | |
| Possible human photoallergenic toxicant | OXYBENZONE (BENZOPHENONE-3) | |
| Human skin toxicant - strong evidence | METHYLPARABEN, PROPYLPARABEN | |
| Known human immune system toxicant | TRIETHANOLAMINE, IMIDAZOLIDINYL UREA |
Persistence and bioaccumulation*
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be bioaccumulative | TRIETHANOLAMINE, SODIUM HYDROXIDE | |
| Not suspected to be persistent | LAURETH-23, CETYL ALCOHOL | |
| Ingredient is suspected or measured to accumulate in people | OXYBENZONE (BENZOPHENONE-3) | |
| Found to be persistent and bioaccumulative in wildlife | OCTOCRYLENE |
Organ system toxicity (non-reproductive)*
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) | OCTOCRYLENE, IMIDAZOLIDINYL UREA, STEARIC ACID, PANTHENOL | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, CETYL ALCOHOL, STEARYL ALCOHOL, PROPYLENE GLYCOL |
| Limited evidence of sense organ toxicity | PROPYLPARABEN | |
| One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient) | OXYBENZONE (BENZOPHENONE-3) | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | GLYCERYL MONOSTEARATE, ALOE BARBADENSIS (ALOE VERA) GEL | |
| One or more animal studies show broad systemic effects at low doses | ISOPROPYL PALMITATE, N6-FURFURYLADENINE | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | LAURETH-23 |
| One or more animal studies show metabolic effects at very low doses | SODIUM HYDROXIDE, | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | CITRIC ACID |
| Possible human immune system toxicant | TRIETHANOLAMINE | |
| Known human any toxicant | METHYLPARABEN |
Multiple, additive exposure sources*
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | CITRIC ACID, DIMETHICONE, GLYCERYL MONOSTEARATE, ISOPROPYL PALMITATE, LAURETH-23, METHYLPARABEN, PROPYLENE GLYCOL, PROPYLPARABEN, SODIUM HYDROXIDE, STEARIC ACID, STEARYL ALCOHOL, TRIETHANOLAMINE, CETYL ALCOHOL, ASCORBIC ACID (VITAMIN C), ALOE BARBADENSIS (ALOE VERA) GEL | |
| Used in food or as an additive with limited or no toxicity information available | PANTHENOL |
Ecotoxicology*
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin | LAURETH-23, CETYL ALCOHOL | |
| Not suspected to be an environmental toxin | TRIETHANOLAMINE | |
| Wildlife and environmental toxicity | PROPYLPARABEN | |
| Wildlife and environmental toxicity | OCTOCRYLENE, OXYBENZONE (BENZOPHENONE-3) | |
| Not suspected to be an environmental toxin | SODIUM HYDROXIDE |
Irritation (skin, eyes, or lungs)*
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not likely to be a skin irritant in humans | OXYBENZONE (BENZOPHENONE-3) | |
| One or more animal studies show skin irritation at moderate doses | CITRIC ACID, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL | |
| One or more animal studies show skin irritation at low doses | STEARIC ACID, METHYLPARABEN, ISOPROPYL PALMITATE | |
| One or more animal studies show skin irritation at very low doses | TRIETHANOLAMINE, SODIUM HYDROXIDE, CETYL ALCOHOL | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | STEARYL ALCOHOL, LAURETH-23 |
| Classified as skin irritant | PROPYLENE GLYCOL |
Data gaps*
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | STEARYL ALCOHOL | |
| Safety assessment was based on related chemical | LAURETH-23, ASCORBIC ACID (VITAMIN C) | |
| Missing safety data noted by cosmetic industry review | ALOE BARBADENSIS (ALOE VERA) GEL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | STEARIC ACID, PANTHENOL, PROPYLPARABEN, OXYBENZONE (BENZOPHENONE-3), METHYLPARABEN, LAURETH-23, IMIDAZOLIDINYL UREA, DIMETHICONE, GLYCERYL MONOSTEARATE, ISOPROPYL PALMITATE, CETYL ALCOHOL, CARTHAMNUS TINCTORIUS (SAFFLOWER) OIL, CARBOMER, ASCORBIC ACID (VITAMIN C) | |
| Not assessed for safety in cosmetics by industry panel | SODIUM HYDROXIDE, SOLUBLE COLLAGEN, N6-FURFURYLADENINE, OCTOCRYLENE, GLYCINE SOJA (SOYBEAN) STEROLS, HYDROLYZED ELASTIN, CITRIC ACID, AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) |
Occupational hazards*
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to moderate doses | TRIETHANOLAMINE | |
| No workplace limits set | SODIUM HYDROXIDE |
Biochemical or cellular level changes*
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | LAURETH-23 | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CITRIC ACID, PROPYLENE GLYCOL | |
| Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease. | OXYBENZONE (BENZOPHENONE-3), OCTOCRYLENE | |
| Interferes with gene expresion | METHYLPARABEN |
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