

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: HYDROQUINONE 2%, WATER, BUTYLENE GLYCOL, PHYTIC ACID, ALOE BARBADENSIS LEAF JUICE, SODIUM SULFITE, SODIUM BISULFATE, DIPOTASSIUM AZELATE, CITRIC ACID, XANTHAN GUM, IMIDAZOLIDINYL UREA, METHYLPARABEN.
Directions from packaging: Apply 2 to 4 drops to clean skin, both morning and night. (Add more drops, if needed.) Use with Glymed Plus Accelerator, Hydrator or Treatment Cream for best results. To help prevent further discoloration, use Glymed Plus sunscreen all day, every day.
| score | data gap | concerns | |
| METHYLPARABEN | 10 | 63% | Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| HYDROQUINONE | 10 | 52% | Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| IMIDAZOLIDINYL UREA | 5 | 70% | Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE) |
| SODIUM SULFITE | 3 | 87% | Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| CITRIC ACID | 3 | 72% | Violations, restrictions & warnings, Organ system toxicity (non-reproductive) |
| PHYTIC ACID | 1 | 87% | Organ system toxicity (non-reproductive) |
| SODIUM BISULFATE | 1 | 85% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| BUTYLENE GLYCOL | 1 | 79% | Irritation (skin, eyes, or lungs) |
| ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE | 1 | 72% | none identified |
| XANTHAN GUM | 0 | 94% | none identified |
| DIPOTASSIUM AZELATE | 0 | 94% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Limited evidence of carcinogenicity | HYDROQUINONE | |
| One or more in vitro tests on mammalian cells show positive mutation results | METHYLPARABEN, SODIUM SULFITE | |
| One or more in vitro tests non-mammalian cells show positive mutation results | SODIUM BISULFATE |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | BUTYLENE GLYCOL | |
| One or more animal studies show any effects at moderate doses | ALOE BARBADENSIS (ALOE VERA) GEL | |
| Human nervous system toxicant - moderate evidence | HYDROQUINONE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | HYDROQUINONE, ALOE BARBADENSIS (ALOE VERA) GEL, HYDROQUINONE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | HYDROQUINONE, CITRIC ACID | |
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Safe for brief discontinuous use followed by thorough rinsing | products that are intended to be left on the skin | HYDROQUINONE |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | BUTYLENE GLYCOL | |
| One or more animal studies show brain and nervous system effects at moderate doses | PHYTIC ACID, METHYLPARABEN | |
| One or more animal studies show brain and nervous system effects at low doses | SODIUM SULFITE | |
| Strong evidence of human neurotoxicity | HYDROQUINONE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show endocrine system disruption at high doses | HYDROQUINONE, BUTYLENE GLYCOL | |
| Human any disruptor - strong evidence | METHYLPARABEN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Human immune system toxicant - moderate evidence | SODIUM SULFITE | |
| Human skin toxicant - strong evidence | METHYLPARABEN | |
| Known human immune system toxicant | IMIDAZOLIDINYL UREA, HYDROQUINONE |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient) | IMIDAZOLIDINYL UREA | |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | ALOE BARBADENSIS (ALOE VERA) GEL, | |
| One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient) | products for use around the eyes, mouth, or lips | BUTYLENE GLYCOL |
| One or more animal studies show broad systemic effects at low doses | PHYTIC ACID | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | CITRIC ACID |
| Possible human immune system toxicant | SODIUM SULFITE | |
| Limited evidence of eye toxicity | products for use around the eyes | SODIUM BISULFATE |
| Known human respiratory toxicant | HYDROQUINONE, METHYLPARABEN |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Wildlife and environmental toxicity | HYDROQUINONE |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at high doses | SODIUM SULFITE | |
| One or more animal studies show skin irritation at moderate doses | CITRIC ACID | |
| One or more animal studies show skin irritation at low doses | METHYLPARABEN | |
| One or more animal studies show skin irritation at very low doses | HYDROQUINONE | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | BUTYLENE GLYCOL |
| Classified as irritant | SODIUM BISULFATE |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Missing safety data noted by cosmetic industry review | ALOE BARBADENSIS (ALOE VERA) GEL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | METHYLPARABEN, SODIUM SULFITE | |
| Not assessed for safety in cosmetics by industry panel | XANTHAN GUM, DIPOTASSIUM AZELATE, SODIUM BISULFATE | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | BUTYLENE GLYCOL, IMIDAZOLIDINYL UREA | |
| Not assessed for safety in cosmetics by industry panel | PHYTIC ACID, CITRIC ACID |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to low doses | HYDROQUINONE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CITRIC ACID | |
| Interferes with gene expresion | METHYLPARABEN |
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