Rilastil, Suncare Cream, Ultra Protection UVB-UVA, SPF 50 (2006 formulation) || Skin Deep: Cosmetic Safety Reviews

RILASTIL, SUNCARE CREAM, ULTRA PROTECTION UVB-UVA, SPF 50 (2006 FORMULATION)

last updated: 05/01/06 brand: Rilastil by Donna Bella LLC

SCORE

	health hazard
	sun hazard

84%

data gap

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99% of sunscreen: SPF greater than 30s have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Sunscreen effectiveness* breakdown

0	UVB hazard/exposure score
4	UVA hazard/exposure score
1	sunscreen instability

*Note that the same active ingredient combination may score differently in two different products depending on the concentration of the ingredients and the mixture of inactive ingredients.

Active ingredient UV
blocking strength

Product total

OCTINOXATE (OCTYL METHOXYCINNAMATE) ( 7.3? %)

AVOBENZONE (PARSOL 1789 | BUTYL METHOXYDIBENZOYLMETHANE) ( 2.6? %)

TINOSORB S ( 5.0? %)

This product contains the following chemical(s) that may provide UV protection in addition to what is reflected above: NANO TITANIUM DIOXIDE. We did not find relevant chemical absorption spectrum in the publicly available technical literature that would allow us to estimate the impacts of these chemicals. Therefore, our rating system may underestimate the effectiveness of this product.

We have had to assume the percentage of the active ingredients in this product. If you own this product and it has the percentages printed on the package, you can help us fill in this missing information.

Note to manufacturers: We have assumed a typical particle size for the mineral(s) in your product based on typical industry use. We welcome specific data from manufacturers if actual particle size is different.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Note from EWG: Unlike many other kinds of personal care products, sunscreen can provide health benefits, protecting against the sun's cancer-causing UV radiation. More than one million cases of skin cancer are diagnosed in the U.S. every year. Health officials recommend wearing sunscreen as one of many important steps to minimize skin cancer risk. (more sun safety tips)

Ingredients from packaging: AQUA, ETHYLHEXYL METHOXYCINNAMATE, CETEARYL ISONONANOATE, OLEYL ERUCATE, BUTYL METHOXYDIBENZOYLMETHANE, TETRAMETHYLBUTHYLPHENOL, BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE, TRICONTANYL PVP, C12-15 ALKYL BENZOATE, CETEARYL GLUCOSIDE, CETEARYL ALCOHOL, GLYCERIN, CYCLOPENTASILOXANE, TITANIUM DIOXIDE, GLYCERYL STEARATE, PEG-100 STEARATE, CAPRYLYL METHICONE, THENOXYETHANOL, DECYL GLUCOSIDE, DIMETHICONE, PROPYLENE GLYCOL, ALUMINUM STEARATE, MAGNESIUM ALUMINUM SILICATE, TOCOPHERYL ACETATE, BISABOLOL, ORYZANOL, VITIS VINIFERA, HYPERICUM PERFORATUM, ARNICA MONTANA, HAMAMELIS VIRGINIANA, AESCULUS HIPPOCASTANUM, HEDERA HELIX, XANTHAN GUM, POLYHYDROXYSTEARIC ACID, ALUMINA, BUTYLENE GLYCOL, METHYLPARABEN, ETHYLPARABEN, O-CYMEN-5-OL, PROPYLPARABEN, SODIUM DEHYDROACETATE, DISODIM EDTA, PARFUM.

Warnings from packaging: Avoid intense midday sunlight. Reapply frequently, especially in case of prolonged sun exposure, excessive perspiration and after bathing or swimming. Do not expose babies to direct sunlight and keep them covered with the protective clothing. External use only – If products get in eyes, rinse thoroughly with water. Keep away from heat and keep properly sealed. Net Weight: 50 ml / 1.7 oz. Ingredients: Aqua, Ethylhexyl Methoxycinnamate, Cetearyl Isononanoate, Oleyl Erucate, Butyl Methoxydibenzoylmethane, Tetramethylbuthylphenol, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Tricontanyl PVP, C12-15 Alkyl Benzoate, Cetearyl Glucoside, Cetearyl Alcohol, Glycerin, Cyclopentasiloxane, Titanium Dioxide, Glyceryl Stearate, PEG-100 Stearate, Caprylyl Methicone, Thenoxyethanol, Decyl Glucoside, Dimethicone, Propylene Glycol, Aluminum Stearate, Magnesium Aluminum Silicate, Tocopheryl Acetate, Bisabolol, Oryzanol, Vitis vinifera, Hypericum perforatum, Arnica Montana, Hamamelis virginiana, Aesculus hippocastanum, Hedera helix, Xanthan Gum, Polyhydroxystearic Acid, Alumina, Butylene Glycol, Methylparaben, Ethylparaben, o-Cymen-5-ol, Propylparaben, Sodium Dehydroacetate, Disodim EDTA, Parfum.

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ingredients

	score	data gap	concerns
NANO TITANIUM DIOXIDE	2	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
FRAGRANCE PARFUM	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
OCTINOXATE (OCTYL METHOXYCINNAMATE) ETHYLHEXYL METHOXYCINNAMATE (Active Ingredient)	6	65%	Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
PEG-100 STEARATE	4	69%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ALUMINA	6	85%	Developmental/reproductive toxicity, Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Enhanced skin absorption, Occupational hazards
ALUMINUM STEARATE	5	83%	Developmental/reproductive toxicity, Neurotoxicity, Multiple, additive exposure sources, Occupational hazards
ETHYLPARABEN	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
MAGNESIUM ALUMINUM SILICATE	4	88%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
TOCOPHERYL ACETATE	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
PHENOXYETHANOL THENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
TETRAMETHYLBUTYLPHENOL TETRAMETHYLBUTHYLPHENOL	3	82%	Developmental/reproductive toxicity, Endocrine disruption, Organ system toxicity (non-reproductive)
CYCLOPENTASILOXANE	2	79%	Persistence and bioaccumulation
DISODIUM EDTA DISODIM EDTA	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
DIMETHICONE	2	74%	Violations, restrictions & warnings
O-CYMEN-5-OL	3	72%	Violations, restrictions & warnings, Neurotoxicity, Irritation (skin, eyes, or lungs)
ARNICA MONTANA	2	90%	Allergies/immunotoxicity
ORYZANOL	2	83%	Organ system toxicity (non-reproductive)
SODIUM DEHYDROACETATE	2	78%	Occupational hazards
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE) (Active Ingredient)	2	73%	Violations, restrictions & warnings, Contamination concerns (BENZOIC ACID, 4-T-BUTYLBENZOIC ACID, BENZALDEHYDE, P-ANISIC ACID, ACETOPHENONE, DIBENZOYLMETHANE)
HAMAMELIS VIRGINIANA (WITCH HAZEL)	1	97%	none identified
C12-15 ALKYL BENZOATE	0	94%	none identified
CETEARYL ALCOHOL	0	93%	none identified
GLYCERYL MONOSTEARATE GLYCERYL STEARATE	1	88%	none identified
BISABOLOL	1	80%	Enhanced skin absorption
BUTYLENE GLYCOL	1	79%	Irritation (skin, eyes, or lungs)
AESCULUS HIPPOCASTANUM (HORSE CHESTNUT)	0	100%	none identified
CAPRYLYL METHICONE	0	100%	none identified
CETEARYL GLUCOSIDE	0	100%	none identified
CETEARYL ISONONANOATE	0	100%	none identified
DECYL GLUCOSIDE	0	100%	none identified
HEDERA HELIX (IVY)	0	100%	none identified
HYPERICUM PERFORATUM (ST. JOHN'S WORT)	0	100%	none identified
TRICONTANYL PVP	0	100%	none identified
VITIS VINIFERA (GRAPE)	0	100%	none identified
TINOSORB S BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (Active Ingredient)	0	100%	none identified
OLEYL ERUCATE	0	94%	none identified
POLYHYDROXYSTEARIC ACID	0	94%	none identified
XANTHAN GUM	0	94%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL, HAMAMELIS VIRGINIANA (WITCH HAZEL)
One or more animal studies show tumor formation at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE, ALUMINA
One or more in vitro tests on mammalian cells show positive mutation results		NANO TITANIUM DIOXIDE
One or more in vitro tests on mammalian cells show positive mutation results		TOCOPHERYL ACETATE, SODIUM DEHYDROACETATE, PROPYLPARABEN, PROPYLENE GLYCOL, METHYLPARABEN, GLYCERIN, ETHYLPARABEN, DISODIUM EDTA,
One or more in vitro tests on mammalian cells show positive mutation results		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		PEG-100 STEARATE, SODIUM DEHYDROACETATE, ETHYLPARABEN, DISODIUM EDTA, BUTYLENE GLYCOL
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at moderate doses		PROPYLENE GLYCOL, GLYCERIN, ORYZANOL
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at low doses		TETRAMETHYLBUTYLPHENOL
Human nervous system toxicant - moderate evidence		ALUMINA, MAGNESIUM ALUMINUM SILICATE, ALUMINUM STEARATE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		O-CYMEN-5-OL
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		O-CYMEN-5-OL
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PEG-100 STEARATE, PROPYLENE GLYCOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		PHENOXYETHANOL

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		PROPYLENE GLYCOL, SODIUM DEHYDROACETATE, BUTYLENE GLYCOL, GLYCERIN
One or more animal studies show brain and nervous system effects at moderate doses		PHENOXYETHANOL, ORYZANOL, METHYLPARABEN, BISABOLOL
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA, O-CYMEN-5-OL
One or more animal studies show any effects at moderate doses		CYCLOPENTASILOXANE
Moderate evidence of human neurotoxicity		FRAGRANCE
Strong evidence of human neurotoxicity		MAGNESIUM ALUMINUM SILICATE, ALUMINUM STEARATE, ALUMINA

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		GLYCERIN, DISODIUM EDTA, BISABOLOL, BUTYLENE GLYCOL
Human any disruptor - strong evidence		ETHYLPARABEN, METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE), PROPYLPARABEN, TETRAMETHYLBUTYLPHENOL
One or more animal studies show endocrine disruption at moderate doses		CYCLOPENTASILOXANE

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Associated with immunotoxicity		AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE)
respiratory - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		NANO TITANIUM DIOXIDE
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human skin toxicant - strong evidence		ARNICA MONTANA, TOCOPHERYL ACETATE, PROPYLPARABEN, METHYLPARABEN, ETHYLPARABEN
Known human immune system toxicant		FRAGRANCE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		NANO TITANIUM DIOXIDE, ALUMINA
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Persistent, bioaccumulative in wildlife		CYCLOPENTASILOXANE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		PROPYLENE GLYCOL,
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		CYCLOPENTASILOXANE, BISABOLOL, BUTYLENE GLYCOL
One or more animal studies show gastrointestinal effects at moderate doses (low dose studies may be unavailable for this ingredient)		PHENOXYETHANOL,
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		ALUMINA
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		TOCOPHERYL ACETATE, SODIUM DEHYDROACETATE, GLYCERYL MONOSTEARATE
Limited evidence of sense organ toxicity		PEG-100 STEARATE, PROPYLPARABEN, ETHYLPARABEN, MAGNESIUM ALUMINUM SILICATE
One or more animal studies show broad systemic effects at low doses		TETRAMETHYLBUTYLPHENOL, ORYZANOL, DISODIUM EDTA
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN
Known human any toxicant		METHYLPARABEN
One or more animal studies show cardiovascular effects at very low doses		NANO TITANIUM DIOXIDE

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		ALUMINUM STEARATE
Designated as safe for general or specific, limited use in food		PEG-100 STEARATE, NANO TITANIUM DIOXIDE, XANTHAN GUM, TOCOPHERYL ACETATE, SODIUM DEHYDROACETATE, PROPYLPARABEN, GLYCERYL MONOSTEARATE, PROPYLENE GLYCOL, METHYLPARABEN, GLYCERIN, DISODIUM EDTA, DIMETHICONE, BUTYLENE GLYCOL, ALUMINUM STEARATE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		ALUMINA
Wildlife and environmental toxicity		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Wildlife and environmental toxicity		NANO TITANIUM DIOXIDE
Wildlife and environmental toxicity		PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		ORYZANOL, GLYCERIN, CYCLOPENTASILOXANE
One or more animal studies show skin irritation at low doses		O-CYMEN-5-OL
One or more animal studies show skin irritation at moderate doses		BISABOLOL
One or more animal studies show significant but moderate pulmonary irritation at low doses		NANO TITANIUM DIOXIDE
One or more animal studies show skin irritation at low doses		METHYLPARABEN
One or more animal studies show skin irritation at very low doses		PEG-100 STEARATE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	BUTYLENE GLYCOL
Classified as skin irritant		PROPYLENE GLYCOL, PHENOXYETHANOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		PROPYLPARABEN, SODIUM DEHYDROACETATE
Safety assessment was based on related chemical		ALUMINUM STEARATE, PEG-100 STEARATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		PEG-100 STEARATE, METHYLPARABEN, TOCOPHERYL ACETATE
Safety assessment was based on related chemical		PROPYLENE GLYCOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		PHENOXYETHANOL, GLYCERYL MONOSTEARATE, DISODIUM EDTA, ETHYLPARABEN, MAGNESIUM ALUMINUM SILICATE, BUTYLENE GLYCOL, CETEARYL ALCOHOL, DIMETHICONE, BISABOLOL, ALUMINUM STEARATE
Not assessed for safety in cosmetics by industry panel		NANO TITANIUM DIOXIDE, TINOSORB S, ARNICA MONTANA, XANTHAN GUM, VITIS VINIFERA (GRAPE), TRICONTANYL PVP, TETRAMETHYLBUTYLPHENOL, POLYHYDROXYSTEARIC ACID, ORYZANOL, OLEYL ERUCATE, HYPERICUM PERFORATUM (ST. JOHN'S WORT), HEDERA HELIX (IVY), HAMAMELIS VIRGINIANA (WITCH HAZEL), GLYCERIN, FRAGRANCE, DECYL GLUCOSIDE, CYCLOPENTASILOXANE, CETEARYL ISONONANOATE, CETEARYL GLUCOSIDE, CAPRYLYL METHICONE, C12-15 ALKYL BENZOATE, AVOBENZONE (PARSOL 1789 \| BUTYL METHOXYDIBENZOYLMETHANE), ALUMINA, AESCULUS HIPPOCASTANUM (HORSE CHESTNUT)

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		NANO TITANIUM DIOXIDE, PHENOXYETHANOL, SODIUM DEHYDROACETATE
Allowed workplace exposures restricted to low doses		ALUMINUM STEARATE
Allowed workplace exposures restricted to moderate doses		ALUMINA, GLYCERIN

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show blood sugar changes at high doses where the human health implications are not yet well understood		PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		METHYLPARABEN
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CYCLOPENTASILOXANE, GLYCERIN
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		NANO TITANIUM DIOXIDE