Avon Advance Techniques Keep Clear Anti-Dandruff 2-in-1 Shampoo & Conditioner (2005 formulation) || Skin Deep: Cosmetic Safety Reviews

AVON ADVANCE TECHNIQUES KEEP CLEAR ANTI-DANDRUFF 2-IN-1 SHAMPOO & CONDITIONER (2005 FORMULATION)

last updated: 04/01/05 brand: Avon by Avon Products, Inc.

SCORE

high hazard (out of 10)

77%

data gap

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94% of dandruff/scalp treatments have lower concerns
94% of shampoos have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company does not test on animals.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: ZINC PYRITHIONE; WATER; SODIUM LAURETH SULFATE; SODIUM LAURYL SULFATE; COCAMIDOPROPYL HYDROXYSULTAINE; COCAMIDE MEA; CREATINE; LAMINARIA DIGITATA EXTRACT; PELVETIA CANALICULATA EXTRACT; SODIUM LAUROYL SARCOSINATE; ACRYLATES COPOLYMER; FRAGRANCE; POLYGLYCERYL-3 LAURATE; METHYLPARABEN; GLYCOL DISTEARATE; PEG-12 DIMETHICONE; CETEARYL ALCOHOL; GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE; QUATERNIUM-80; DMDM HYDANTOIN; PPG-12-BUTETH-16; SODIUM HYDROXIDE; SODIUM CITRATE; BENZOPHENONE-4; PHOSPHORIC ACID; BENZOIC ACID; GLYCERIN; DM HYDANTOIN; MAGNESIUM NITRATE; DISODIUM EDTA; METHYLCHLOROISOTHIAZOLINONE; MAGNESIUM CHLORIDE; METHYLISOTHIAZOLINONE; GREEN 5; EXT. VIOLET 2; SODIUM CHLORIDE; RED 33

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
DMDM HYDANTOIN	7	71%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
PEG-12 DIMETHICONE	6	75%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
EXT D&C VIOLET 2 EXT. VIOLET 2	6	73%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
METHYLCHLOROISOTHIAZOLINONE	6	63%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
METHYLISOTHIAZOLINONE	6	63%	Violations, restrictions & warnings, Allergies/immunotoxicity
ZINC PYRITHIONE	5	66%	Violations, restrictions & warnings, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
SODIUM LAURETH SULFATE	4	88%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
COCAMIDE MEA	2	75%	Contamination concerns (NITROSAMINES)
D&C RED 33	1	75%	none identified
SODIUM LAUROYL SARCOSINATE	4	73%	Violations, restrictions & warnings, Enhanced skin absorption, Contamination concerns (NITROSAMINES)
SULISOBENZONE (BENZOPHENONE-4) (Active Ingredient)	3	66%	Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption
BENZOIC ACID	3	65%	Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
MAGNESIUM CHLORIDE	3	82%	Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive)
DISODIUM EDTA	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
SODIUM HYDROXIDE	3	77%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ACRYLATES COPOLYMER	3	75%	Contamination concerns (METHACRYLIC ACID, ACRYLIC ACID, 2-ETHYLHEXYL ACRYLATE)
SODIUM LAURYL SULFATE	3	68%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
PPG-12 BUTETH-16	2	89%	Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Contamination concerns (BUTYL ALCOHOL)
PHOSPHORIC ACID	2	79%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
CETEARYL ALCOHOL	0	93%	none identified
GLYCOL DISTEARATE	1	93%	Multiple, additive exposure sources
D&C GREEN 5	1	91%	none identified
MAGNESIUM NITRATE	1	89%	none identified
DM HYDANTOIN	1	88%	none identified
GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE	1	87%	none identified
LAMINARIA DIGITATA (HORSETAIL KELP) EXTRACT LAMINARIA DIGITATA EXTRACT	0	100%	none identified
PELVETIA CANALICULATA (CHANNELLED WRACK) EXTRACT PELVETIA CANALICULATA EXTRACT	0	100%	none identified
POLYGLYCERYL-3 LAURATE	0	100%	none identified
QUATERNIUM-80	0	100%	none identified
COCAMIDOPROPYL HYDROXYSULTAINE	0	94%	none identified
CREATINE	0	94%	none identified
SODIUM CITRATE	0	94%	none identified
SODIUM CHLORIDE	0	0%	innocuous
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not likely to be mutagenic in humans		SULISOBENZONE (BENZOPHENONE-4)
One or more in vitro tests non-mammalian cells show positive mutation results		METHYLCHLOROISOTHIAZOLINONE, D&C RED 33
One or more in vitro tests on mammalian cells show positive mutation results		SODIUM LAURYL SULFATE, SODIUM HYDROXIDE, SODIUM CHLORIDE, METHYLPARABEN, MAGNESIUM CHLORIDE, GLYCERIN, DISODIUM EDTA
Not likely to be carcinogenic in humans		BENZOIC ACID
Cancer - limited evidence		EXT D&C VIOLET 2

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		SODIUM LAURYL SULFATE, DISODIUM EDTA
One or more animal studies show reproductive effects at moderate doses		ZINC PYRITHIONE, GLYCERIN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		SODIUM LAUROYL SARCOSINATE, SODIUM LAURYL SULFATE, PEG-12 DIMETHICONE, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, EXT D&C VIOLET 2, COCAMIDE MEA
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		EXT D&C VIOLET 2
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmetics		D&C RED 33, BENZOIC ACID, ACRYLATES COPOLYMER
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		DMDM HYDANTOIN, ZINC PYRITHIONE, METHYLISOTHIAZOLINONE, SODIUM LAUROYL SARCOSINATE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only	products for use around the mouth, lips, eyes, or on damaged skin	EXT D&C VIOLET 2
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)		BENZOIC ACID, SODIUM LAUROYL SARCOSINATE, METHYLCHLOROISOTHIAZOLINONE, DMDM HYDANTOIN, METHYLCHLOROISOTHIAZOLINONE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use on injured or damaged skin	products for use on damaged skin	PEG-12 DIMETHICONE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells demonstrate neurotoxicity		METHYLISOTHIAZOLINONE
One or more animal studies show brain and nervous system effects at high doses		DM HYDANTOIN, GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE, GLYCERIN
One or more animal studies show brain and nervous system effects at moderate doses		ZINC PYRITHIONE, SODIUM LAURYL SULFATE, PHOSPHORIC ACID, METHYLPARABEN, BENZOIC ACID
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA
One or more animal studies show brain and nervous system effects at very low doses		SODIUM HYDROXIDE, MAGNESIUM CHLORIDE
Moderate evidence of human neurotoxicity		FRAGRANCE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		SODIUM LAURYL SULFATE
Associated with endocrine disruption		SULISOBENZONE (BENZOPHENONE-4)
One or more animal studies show endocrine system disruption at high doses		GLYCERIN, DISODIUM EDTA
One or more studies show endocrine system disruption at very low doses		MAGNESIUM CHLORIDE
Human any disruptor - strong evidence		METHYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of immune system toxicity		ZINC PYRITHIONE
Human skin toxicant - strong evidence		SULISOBENZONE (BENZOPHENONE-4), METHYLPARABEN, EXT D&C VIOLET 2
Known human immune system toxicant		METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, FRAGRANCE, DMDM HYDANTOIN

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		SODIUM HYDROXIDE, PHOSPHORIC ACID
Not suspected to be persistent		SODIUM LAURYL SULFATE
Persistent, bioaccumulative in wildlife		ZINC PYRITHIONE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		DM HYDANTOIN, PPG-12 BUTETH-16
One or more animal studies show sense effects at moderate doses (low dose studies may be unavailable for this ingredient)		SULISOBENZONE (BENZOPHENONE-4)
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		D&C GREEN 5
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		MAGNESIUM NITRATE
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		SODIUM LAURETH SULFATE, DMDM HYDANTOIN
Limited evidence of sense organ toxicity		PEG-12 DIMETHICONE, PHOSPHORIC ACID
One or more animal studies show broad systemic effects at low doses		ZINC PYRITHIONE, SODIUM LAURYL SULFATE, DISODIUM EDTA, BENZOIC ACID
One or more animal studies show metabolic effects at very low doses		SODIUM HYDROXIDE, GLYCERIN, MAGNESIUM CHLORIDE
Possible human immune system toxicant		METHYLCHLOROISOTHIAZOLINONE
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM HYDROXIDE, PHOSPHORIC ACID
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		SODIUM LAURYL SULFATE, SODIUM HYDROXIDE, SODIUM CITRATE, SODIUM CHLORIDE, PHOSPHORIC ACID, PEG-12 DIMETHICONE, METHYLPARABEN, MAGNESIUM CHLORIDE, GLYCERIN, DISODIUM EDTA, BENZOIC ACID
Used in food or as an additive with limited or no toxicity information available		PPG-12 BUTETH-16, GLYCOL DISTEARATE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		SODIUM LAURYL SULFATE, ZINC PYRITHIONE
Not suspected to be an environmental toxin		SODIUM HYDROXIDE, PHOSPHORIC ACID

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		SODIUM CHLORIDE, PPG-12 BUTETH-16, GLYCERIN, D&C GREEN 5
One or more animal studies show skin irritation at low doses		METHYLPARABEN, BENZOIC ACID
One or more animal studies show skin irritation at very low doses		SODIUM HYDROXIDE
Human skin irritant - moderate evidence		PHOSPHORIC ACID
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	SULISOBENZONE (BENZOPHENONE-4), SODIUM LAURYL SULFATE, SODIUM LAURETH SULFATE, DMDM HYDANTOIN

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		SULISOBENZONE (BENZOPHENONE-4), METHYLPARABEN
Considered safe based on assumption of low absorption		ACRYLATES COPOLYMER
Insufficient data to determine safety		BENZOIC ACID
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		DMDM HYDANTOIN, GLYCOL DISTEARATE, PEG-12 DIMETHICONE, SODIUM LAURETH SULFATE, DISODIUM EDTA, CETEARYL ALCOHOL
Not assessed for safety in cosmetics by industry panel		SODIUM HYDROXIDE, ZINC PYRITHIONE, DM HYDANTOIN, SODIUM CITRATE, QUATERNIUM-80, POLYGLYCERYL-3 LAURATE, PHOSPHORIC ACID, PELVETIA CANALICULATA (CHANNELLED WRACK) EXTRACT, MAGNESIUM NITRATE, MAGNESIUM CHLORIDE, LAMINARIA DIGITATA (HORSETAIL KELP) EXTRACT, GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE, GLYCERIN, FRAGRANCE, CREATINE, COCAMIDOPROPYL HYDROXYSULTAINE

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to moderate doses		GLYCERIN
No workplace limits set		SODIUM HYDROXIDE
Allowed workplace exposures restricted to low doses		PHOSPHORIC ACID

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Interferes with gene expresion		METHYLPARABEN
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		SODIUM LAURYL SULFATE
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		D&C GREEN 5, GLYCERIN, DM HYDANTOIN