Avon NAIL EXPERTS Mira-Cuticle Vanishing Complex Antiseptic/Skin Protectant (2005 formulation) || Skin Deep: Cosmetic Safety Reviews

AVON NAIL EXPERTS MIRA-CUTICLE VANISHING COMPLEX ANTISEPTIC/SKIN PROTECTANT (2005 FORMULATION)

last updated: 04/01/05 brand: Avon by Avon Products, Inc.

SCORE

high hazard (out of 10)

79%

data gap

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COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company does not test on animals.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: ACTIVE INGREDIENTS :; DIMETHICONE; BENZALKONIUM CHLORIDE; OTHER INGREDIENTS :; WATER; AMMONIUM LACTATE; LACTIC ACID; GLYCERIN; PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE; STEARIC ACID; CETYL ALCOHOL; GLYCERYL STEARATE; PEG-100 STEARATE; HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL; SORBITAN STEARATE; GLYCINE SOJA (SOYBEAN) STEROLS; HYDROXYETHYLCELLULOSE; TOCOPHERYL ACETATE; RETINYL PALMITATE; TOCOPHEROL; CALCIUM PANTOTHENATE; PANTHENOL; BIOTIN; HYALURONIC ACID; AMP-ISOSTEARIC HYDROLYZED KERATIN; PRUNUS ARMENIACA (APRICOT) KERNEL OIL; ALOE BARBADENSIS LEAF JUICE; CHOLESTEROL; MAGNESIUM ALUMINUM SILICATE; METHYLPARABEN; PHENOXYETHANOL; TETRASODIUM EDTA; CHOLETH-24; CETETH-24; FRAGRANCE; BHT; SD ALCOHOL 40-B

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
PEG-100 STEARATE	4	69%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
BENZALKONIUM CHLORIDE (Active Ingredient)	7	62%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
BHT	6	61%	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes
LACTIC ACID	4	70%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs)
RETINYL PALMITATE	5	68%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
MAGNESIUM ALUMINUM SILICATE	4	88%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
CETETH-24	3	84%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
SD ALCOHOL 40B	4	81%	Cancer, Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Multiple, additive exposure sources, Enhanced skin absorption
TOCOPHERYL ACETATE	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
AMMONIUM LACTATE	4	74%	Violations, restrictions & warnings
PHENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
CHOLETH-24	3	92%	Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
DIMETHICONE (Active Ingredient)	2	74%	Violations, restrictions & warnings
PANTHENOL	2	88%	Multiple, additive exposure sources
TOCOPHEROL	2	87%	Contamination concerns (HYDROQUINONE)
BIOTIN	2	82%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive)
TETRASODIUM EDTA	2	81%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
CHOLESTEROL	2	74%	Persistence and bioaccumulation
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID	2	74%	Neurotoxicity, Irritation (skin, eyes, or lungs)
SORBITAN STEARATE	1	92%	none identified
PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE	0	90%	Enhanced skin absorption
GLYCERYL MONOSTEARATE GLYCERYL STEARATE	1	88%	none identified
CALCIUM PANTOTHENATE	1	87%	none identified
CETYL ALCOHOL	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
HYDROXYETHYLCELLULOSE	1	82%	none identified
ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE	1	72%	none identified
AMP-ISOSTEARIC HYDROLYZED KERATIN	0	100%	none identified
GLYCINE SOJA (SOYBEAN) STEROLS	0	100%	none identified
HELIANTHUS ANNUUS (SUNFLOWER) OIL HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL	0	94%	none identified
HYALURONIC ACID	0	94%	none identified
PRUNUS ARMENIACA (APRICOT) KERNEL OIL	0	94%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE
One or more in vitro tests on mammalian cells show positive mutation results		TOCOPHERYL ACETATE, TOCOPHEROL, PROPYLENE GLYCOL, METHYLPARABEN, GLYCERIN, BENZALKONIUM CHLORIDE
Cancer - not classifiable/not likely to be human carcinogen		LACTIC ACID, AMMONIUM LACTATE
Cancer - limited evidence		SD ALCOHOL 40B, RETINYL PALMITATE
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - not classifiable/not likely to be human carcinogen		CHOLESTEROL, BHT

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human nervous system toxicant - moderate evidence		MAGNESIUM ALUMINUM SILICATE
One or more animal studies show reproductive effects at high doses		PEG-100 STEARATE, BHT, HYDROXYETHYLCELLULOSE
One or more animal studies show reproductive effects at moderate doses		GLYCERIN, PROPYLENE GLYCOL
One or more animal studies show reproductive effects at low doses		RETINYL PALMITATE
One or more animal studies show reproductive effects at moderate doses		CHOLESTEROL,
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show reproductive effects at low doses		BIOTIN
Limited evidence of reproductive toxicity		SD ALCOHOL 40B

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PEG-100 STEARATE, PROPYLENE GLYCOL, LACTIC ACID, BENZALKONIUM CHLORIDE, AMMONIUM LACTATE, ALOE BARBADENSIS (ALOE VERA) GEL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		RETINYL PALMITATE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		LACTIC ACID, BENZALKONIUM CHLORIDE, BENZALKONIUM CHLORIDE, PHENOXYETHANOL
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits		AMMONIUM LACTATE, LACTIC ACID
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study		SD ALCOHOL 40B
One or more animal studies show brain and nervous system effects at high doses		CETETH-24, RETINYL PALMITATE, PROPYLENE GLYCOL, HYDROXYETHYLCELLULOSE, LACTIC ACID, GLYCERIN, CHOLESTEROL
One or more animal studies show brain and nervous system effects at moderate doses		PHENOXYETHANOL, METHYLPARABEN, CALCIUM PANTOTHENATE
One or more animal studies show brain and nervous system effects at low doses		BIOTIN, BHT
One or more animal studies show brain and nervous system effects at very low doses		STEARIC ACID
Moderate evidence of human neurotoxicity		FRAGRANCE
Strong evidence of human neurotoxicity		MAGNESIUM ALUMINUM SILICATE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		CHOLESTEROL, GLYCERIN, BHT
Human any disruptor - strong evidence		METHYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
Human skin toxicant - strong evidence		TOCOPHERYL ACETATE
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human skin toxicant - strong evidence		METHYLPARABEN
Known human immune system toxicant		FRAGRANCE, BHT, BENZALKONIUM CHLORIDE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be persistent		CETYL ALCOHOL
Persistent, bioaccumulative in wildlife		CHOLESTEROL

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		PROPYLENE GLYCOL, HYDROXYETHYLCELLULOSE, CETYL ALCOHOL, STEARIC ACID, CETETH-24, PANTHENOL, CHOLESTEROL
One or more animal studies show kidney or renal system effects at moderate doses (low dose studies may be unavailable for this ingredient)		TETRASODIUM EDTA, PHENOXYETHANOL, TOCOPHERYL ACETATE, LACTIC ACID, GLYCERYL MONOSTEARATE, CALCIUM PANTOTHENATE, ALOE BARBADENSIS (ALOE VERA) GEL
Limited evidence of skin toxicity		RETINYL PALMITATE, PEG-100 STEARATE, SD ALCOHOL 40B
One or more animal studies show blood effects at low doses		BHT, BIOTIN
Limited evidence of any toxicity		MAGNESIUM ALUMINUM SILICATE
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN
Possible human immune system toxicant		BENZALKONIUM CHLORIDE
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SD ALCOHOL 40B
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		PEG-100 STEARATE, TOCOPHERYL ACETATE, TOCOPHEROL, TETRASODIUM EDTA, STEARIC ACID, SORBITAN STEARATE, RETINYL PALMITATE, PRUNUS ARMENIACA (APRICOT) KERNEL OIL, PROPYLENE GLYCOL, METHYLPARABEN, LACTIC ACID, GLYCERYL MONOSTEARATE, GLYCERIN, DIMETHICONE, CETYL ALCOHOL, CALCIUM PANTOTHENATE, BIOTIN, BHT, ALOE BARBADENSIS (ALOE VERA) GEL
Used in food or as an additive with limited or no toxicity information available		SD ALCOHOL 40B, PANTHENOL

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		CETYL ALCOHOL

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at high doses		CHOLESTEROL, CETETH-24
One or more animal studies show skin irritation at low doses		METHYLPARABEN, STEARIC ACID, TETRASODIUM EDTA
One or more animal studies show skin irritation at moderate doses		GLYCERIN, SORBITAN STEARATE
One or more animal studies show skin irritation at very low doses		CHOLETH-24, LACTIC ACID, PEG-100 STEARATE
One or more animal studies show skin irritation at low doses		BENZALKONIUM CHLORIDE, BHT
Classified as irritant		PHENOXYETHANOL, PROPYLENE GLYCOL
One or more animal studies show skin irritation at very low doses		CETYL ALCOHOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE, PROPYLENE GLYCOL, CETETH-24, CETETH-24, PEG-100 STEARATE, CHOLETH-24
Missing safety data noted by cosmetic industry review		CHOLETH-24, ALOE BARBADENSIS (ALOE VERA) GEL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE, PEG-100 STEARATE, CETETH-24, TOCOPHERYL ACETATE, TETRASODIUM EDTA, TOCOPHEROL, SORBITAN STEARATE, RETINYL PALMITATE, METHYLPARABEN, PHENOXYETHANOL, PANTHENOL, STEARIC ACID, MAGNESIUM ALUMINUM SILICATE, BIOTIN, CETYL ALCOHOL, CHOLESTEROL, DIMETHICONE, GLYCERYL MONOSTEARATE, CHOLETH-24, HYDROXYETHYLCELLULOSE
Not assessed for safety in cosmetics by industry panel		GLYCINE SOJA (SOYBEAN) STEROLS, HELIANTHUS ANNUUS (SUNFLOWER) OIL, PRUNUS ARMENIACA (APRICOT) KERNEL OIL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		BHT
Not assessed for safety in cosmetics by industry panel		AMP-ISOSTEARIC HYDROLYZED KERATIN, CALCIUM PANTOTHENATE, FRAGRANCE, GLYCERIN
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		SD ALCOHOL 40B

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
No workplace limits set		LACTIC ACID
Allowed workplace exposures restricted to low doses		PHENOXYETHANOL
Allowed workplace exposures restricted to moderate doses		GLYCERIN
Allowed workplace exposures restricted to low doses		TETRASODIUM EDTA
Allowed workplace exposures restricted to low doses		BHT

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CETETH-24, PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE
Interferes with gene expresion		METHYLPARABEN
One or more animal studies show biochemical changes at low doses where the human health implications are not yet well understood		BHT
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CHOLESTEROL, GLYCERIN