Progaine Volumizing Root Lifter (2005 formulation) || Skin Deep: Cosmetic Safety Reviews

PROGAINE VOLUMIZING ROOT LIFTER (2005 FORMULATION)

last updated: 04/01/05 brand: Progaine by Pfizer

SCORE

high hazard (out of 10)

82%

data gap

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99% of hair-loss treatments have lower concerns
97% of styling gel/lotions have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company conducts animal tests.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: WATER, PVP, POLYSORBATE 80, DIMETHICONE COPOLYOL MEADOWFOAMATE, PROPYLENE GLYCOL, POLYSORBATE 20, QUATERNIUM-79 HYDROLYZED KERATIN, PANTHENYL HYDROXYPROPYL STEARDIMONIUM CHLORIDE, COCODIMONIUM HYDROXYPROPYL HYDROLYZED HAIR KERATIN, PEG-60 ALMOND GLYCERIDES, FRAGRANCE, SILICA, PANTHENOL, HYDROLYZED WHEAT PROTEIN, HYDROLYZED WHEAT STARCH, WHEAT AMINO ACIDS, POMEA PURPUREA FLOWER EXTRACT (MORNING GLORY), TETRASODIUM EDTA, PHENOXETHANOL, DMDM HYDANTOIN, IODOPROPYNYL BUTYLCARBAMATE

Directions from packaging: Using fingers to lift each section of hair, position applicator close to roots of the hair. Spray generously to wet or dry hair. Style as desired. For best results, use with Progaine Volumizing Shampoo and Progaine Weightless Conditioner.

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ingredients

	score	data gap	concerns
DMDM HYDANTOIN	9	71%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Contamination concerns (FORMALDEHYDE)
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
SILICA	7	69%	Cancer, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PEG-60 ALMOND GLYCERIDES	4	76%	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
IODOPROPYNYL BUTYLCARBAMATE	6	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PHENOXYETHANOL PHENOXETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
PANTHENOL	2	88%	Multiple, additive exposure sources
TETRASODIUM EDTA	2	81%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
POLYSORBATE-80	2	80%	Developmental/reproductive toxicity
HYDROLYZED WHEAT PROTEIN	1	95%	Allergies/immunotoxicity
POLYSORBATE-20	1	84%	none identified
PVP	1	81%	Organ system toxicity (non-reproductive)
DIMETHICONE COPOLYOL MEADOWFOAMATE	0	100%	none identified
HYDROLYZED WHEAT STARCH	0	100%	none identified
IPOMOEA PURPUREA (MORNING GLORY) FLOWER EXTRACT POMEA PURPUREA FLOWER EXTRACT (MORNING GLORY)	0	100%	none identified
PANTHENYL HYDROXYPROPYL STEARDIMONIUM CHLORIDE	0	100%	none identified
QUATERNIUM-79 HYDROLYZED KERATIN	0	100%	none identified
COCODIMONIUM HYDROXYPROPYL HYDROLYZED HAIR KERATIN	0	100%	none identified
WHEAT AMINO ACIDS	0	100%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results		PROPYLENE GLYCOL
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL
Cancer - not classifiable/not likely to be human carcinogen	products that may be aerosolized (airborne)	SILICA
Cancer - not classifiable/not likely to be human carcinogen		PVP
One or more in vitro tests on mammalian cells show positive mutation results		POLYSORBATE-80

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		POLYSORBATE-20
One or more animal studies show reproductive effects at very low doses		POLYSORBATE-80
One or more animal studies show reproductive effects at moderate doses		PROPYLENE GLYCOL

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PROPYLENE GLYCOL, PEG-60 ALMOND GLYCERIDES, IODOPROPYNYL BUTYLCARBAMATE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR)	products that may be aerosolized (airborne)	IODOPROPYNYL BUTYLCARBAMATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		IODOPROPYNYL BUTYLCARBAMATE, DMDM HYDANTOIN, PHENOXYETHANOL, DMDM HYDANTOIN, IODOPROPYNYL BUTYLCARBAMATE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Not safe for use in products intended to be aerosolized, according to industry safety panel (Cosmetic Ingredient Review, CIR)	products that may be aerosolized (airborne)	DMDM HYDANTOIN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		PROPYLENE GLYCOL
One or more animal studies show brain and nervous system effects at moderate doses		PHENOXYETHANOL
One or more animal studies show brain and nervous system effects at high doses		POLYSORBATE-80
Moderate evidence of human neurotoxicity		FRAGRANCE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		PVP

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
One or more human case studies show possible skin allergy effects		HYDROLYZED WHEAT PROTEIN
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human immune system toxicant - strong evidence	products that may be aerosolized (airborne)	SILICA
Human any toxicant - strong evidence		IODOPROPYNYL BUTYLCARBAMATE
Known human immune system toxicant		FRAGRANCE, DMDM HYDANTOIN

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		PVP
Persistent, bioaccumulative in wildlife and humans	products that may be aerosolized (airborne)	SILICA

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		POLYSORBATE-80, POLYSORBATE-20, PANTHENOL
One or more animal studies show kidney or renal system effects at moderate doses (low dose studies may be unavailable for this ingredient)		TETRASODIUM EDTA, PHENOXYETHANOL, PVP, DMDM HYDANTOIN
Limited evidence of sense organ toxicity		PEG-60 ALMOND GLYCERIDES, IODOPROPYNYL BUTYLCARBAMATE
Limited evidence of respiratory toxicity	products that may be aerosolized (airborne)	PROPYLENE GLYCOL
Known human respiratory toxicant	products that may be aerosolized (airborne)	SILICA

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Used in food or as an additive with limited or no toxicity information available		PANTHENOL
Designated as safe for general or specific, limited use in food	products that may be aerosolized (airborne)	SILICA
Designated as safe for general or specific, limited use in food		PEG-60 ALMOND GLYCERIDES, POLYSORBATE-20, POLYSORBATE-80, PROPYLENE GLYCOL, PVP, TETRASODIUM EDTA

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be an environmental toxin		PVP

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		POLYSORBATE-20
One or more animal studies show skin irritation at high doses		IODOPROPYNYL BUTYLCARBAMATE
One or more animal studies show skin irritation at low doses		TETRASODIUM EDTA
Classified as irritant		PHENOXYETHANOL, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	DMDM HYDANTOIN

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not assessed for safety in cosmetics by industry panel		FRAGRANCE, DIMETHICONE COPOLYOL MEADOWFOAMATE
Not assessed for safety in cosmetics by industry panel	products that may be aerosolized (airborne)	SILICA
Safety assessment was based on related chemical		PROPYLENE GLYCOL, IODOPROPYNYL BUTYLCARBAMATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		TETRASODIUM EDTA, PVP, POLYSORBATE-80, POLYSORBATE-20, PHENOXYETHANOL, PANTHENOL, DMDM HYDANTOIN
Not assessed for safety in cosmetics by industry panel		WHEAT AMINO ACIDS, COCODIMONIUM HYDROXYPROPYL HYDROLYZED HAIR KERATIN, QUATERNIUM-79 HYDROLYZED KERATIN, PEG-60 ALMOND GLYCERIDES, PANTHENYL HYDROXYPROPYL STEARDIMONIUM CHLORIDE, IPOMOEA PURPUREA (MORNING GLORY) FLOWER EXTRACT, HYDROLYZED WHEAT STARCH, HYDROLYZED WHEAT PROTEIN

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		TETRASODIUM EDTA, PHENOXYETHANOL

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show blood sugar changes at high doses where the human health implications are not yet well understood		PROPYLENE GLYCOL
One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood		SILICA