Murad Perfecting Serum || Skin Deep: Cosmetic Safety Reviews

MURAD PERFECTING SERUM

last updated: 10/01/09 brand: Murad by Murad, Inc.

SCORE

low hazard (out of 10)

87%

data gap

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16% of anti-agings have lower concerns
20% of facial moisturizer/treatments have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company does not test on animals.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns, Biochemical or cellular level changes

Ingredients from packaging: CERAMIDES, SPHINGOLIPIDS, CHOLESTEROL, TOCOPHERYL ACETATE, EVENING PRIMROSE OIL, AVOCADO OIL, RETINYL PALMITATE, SQUALANE

Directions from packaging: Every day after moisturizing and before makeup, massage a thin layer over face and neck. Start with a single drop, add more as needed.

Warnings from packaging: For external use only. Avoid contact with eyes. Keep out of reach of children.

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ingredients

	score	data gap	concerns
RETINYL PALMITATE	5	68%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
TOCOPHERYL ACETATE	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
CHOLESTEROL	2	74%	Persistence and bioaccumulation
SQUALANE	1	93%	Irritation (skin, eyes, or lungs)
PERSEA GRATISSIMA (AVOCADO) OIL	1	87%	Irritation (skin, eyes, or lungs)
CERAMIDE	0	100%	none identified
SPHINGOLIPIDS	0	100%	none identified
OENOTHERA BIENNIS (EVENING PRIMROSE) OIL	0	94%	none identified

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results		TOCOPHERYL ACETATE
Cancer - limited evidence		RETINYL PALMITATE
Cancer - not classifiable/not likely to be human carcinogen		CHOLESTEROL

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at moderate doses		CHOLESTEROL
One or more animal studies show reproductive effects at low doses		RETINYL PALMITATE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		RETINYL PALMITATE

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		RETINYL PALMITATE, CHOLESTEROL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		CHOLESTEROL

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human skin toxicant - strong evidence		TOCOPHERYL ACETATE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife		CHOLESTEROL

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show sense organ effects at high doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	PERSEA GRATISSIMA (AVOCADO) OIL, CHOLESTEROL
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		TOCOPHERYL ACETATE
Limited evidence of skin toxicity		RETINYL PALMITATE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at high doses		CHOLESTEROL
One or more animal studies show skin irritation at low doses		SQUALANE
One or more animal studies show skin irritation at very low doses		PERSEA GRATISSIMA (AVOCADO) OIL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		TOCOPHERYL ACETATE, RETINYL PALMITATE, PERSEA GRATISSIMA (AVOCADO) OIL, CHOLESTEROL
Not assessed for safety in cosmetics by industry panel		CERAMIDE, OENOTHERA BIENNIS (EVENING PRIMROSE) OIL, SPHINGOLIPIDS, SQUALANE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CHOLESTEROL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		RETINYL PALMITATE