

Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: WATER, SODIUM LAURETH SULFATE, COCOMIDOPROPYL BETAINE, PPG-3 HYDROXYETHYL SOYAMIDE, SODIUM LAUROYL SARCONSINATE, GLYCOL STEARATE, ETHYL NICOTINATE, ARTEMIA EXTRACT, GLYCOLIC ACID, POLYQUATERNIUM-10, SODIUM PCA, SERENOA SERRULATA FRUIT EXTRACT, PUNICA GRANATUM EXTRACT, KERATIN AMINO ACIDS, PHYTANTRIOL, PANTHENYL ETHYL ETHER, MENTHOL, PROPYLENE GLYCOL,, TETRASODIUM EDTA, LACTAMIDE MEA, BENZOPHENONE-4, SODIUM CHLORIDE, BUTYLENE GLYCOL, METHYLPARABEN, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, FRAGRANCE.
Directions from packaging: Apply throughout wet hair. Massage into scalp and work to ends of hair, Leave on hair for one minute. Rinse thoroughly. Repeat. Use daily. Follow with Murad Professional Scalp Treatment Conditioner for fine hair.
Warnings from packaging: Slight redness may occur on scalp, neck or shoulders. This demonstrates effectiveness and will disappear within a few minutes.
| score | data gap | concerns | |
| METHYLPARABEN | 10 | 63% | Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| FRAGRANCE | 8 | 100% | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |
| METHYLCHLOROISOTHIAZOLINONE | 6 | 63% | Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive) |
| METHYLISOTHIAZOLINONE | 6 | 63% | Violations, restrictions & warnings, Allergies/immunotoxicity |
| COCAMIDOPROPYL BETAINE COCOMIDOPROPYL BETAINE | 5 | 63% | Allergies/immunotoxicity, Contamination concerns (NITROSAMINES) |
| SODIUM LAURETH SULFATE | 4 | 88% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |
| SODIUM LAUROYL SARCOSINATE SODIUM LAUROYL SARCONSINATE | 4 | 73% | Violations, restrictions & warnings, Enhanced skin absorption, Contamination concerns (NITROSAMINES) |
| GLYCOLIC ACID | 4 | 70% | Violations, restrictions & warnings |
| SULISOBENZONE (BENZOPHENONE-4) (Active Ingredient) | 3 | 66% | Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| PROPYLENE GLYCOL | 4 | 60% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| PHYTANTRIOL | 3 | 88% | Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| MENTHOL | 2 | 85% | Multiple, additive exposure sources |
| TETRASODIUM EDTA | 2 | 81% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards |
| SODIUM PCA | 2 | 71% | Contamination concerns (NITROSAMINES) |
| LACTAMIDE MEA | 1 | 91% | none identified |
| GLYCOL STEARATE | 1 | 87% | none identified |
| BUTYLENE GLYCOL | 1 | 79% | Irritation (skin, eyes, or lungs) |
| ARTEMIA EXTRACT | 0 | 100% | none identified |
| KERATIN AMINO ACIDS | 0 | 100% | none identified |
| PANTHENYL ETHYL ETHER | 0 | 100% | none identified |
| PPG-3 HYDROXYETHYL SOYAMIDE | 0 | 100% | none identified |
| PUNICA GRANATUM (POMEGRANATE) EXTRACT PUNICA GRANATUM EXTRACT | 0 | 100% | none identified |
| SERENOA SERRULATA FRUIT EXTRACT | 0 | 100% | none identified |
| ETHYL NICOTINATE | 0 | 94% | none identified |
| POLYQUATERNIUM-10 | 0 | 93% | none identified |
| SODIUM CHLORIDE | 0 | 0% | innocuous |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not likely to be mutagenic in humans | SULISOBENZONE (BENZOPHENONE-4) | |
| One or more in vitro tests non-mammalian cells show positive mutation results | METHYLCHLOROISOTHIAZOLINONE | |
| One or more in vitro tests on mammalian cells show positive mutation results | SODIUM CHLORIDE, PROPYLENE GLYCOL, METHYLPARABEN, MENTHOL, LACTAMIDE MEA |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at high doses | GLYCOLIC ACID, BUTYLENE GLYCOL | |
| One or more animal studies show reproductive effects at moderate doses | PROPYLENE GLYCOL |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | PROPYLENE GLYCOL, SODIUM LAUROYL SARCOSINATE, SODIUM PCA, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, GLYCOLIC ACID, COCAMIDOPROPYL BETAINE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, GLYCOLIC ACID, SODIUM LAUROYL SARCOSINATE, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, SODIUM LAUROYL SARCOSINATE | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN | |
| Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits | GLYCOLIC ACID | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s) | METHYLCHLOROISOTHIAZOLINONE |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more in vitro tests on mammalian cells demonstrate neurotoxicity | METHYLISOTHIAZOLINONE | |
| One or more animal studies show brain and nervous system effects at high doses | PROPYLENE GLYCOL, BUTYLENE GLYCOL | |
| One or more animal studies show brain and nervous system effects at moderate doses | METHYLPARABEN, MENTHOL, GLYCOLIC ACID | |
| Moderate evidence of human neurotoxicity | FRAGRANCE |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Associated with endocrine disruption | SULISOBENZONE (BENZOPHENONE-4) | |
| One or more animal studies show endocrine system disruption at high doses | BUTYLENE GLYCOL, SODIUM PCA | |
| Human any disruptor - strong evidence | METHYLPARABEN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Limited evidence of skin and immune system toxicity | PROPYLENE GLYCOL | |
| Human skin toxicant - strong evidence | SULISOBENZONE (BENZOPHENONE-4), PHYTANTRIOL, METHYLPARABEN | |
| Known human immune system toxicant | METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, FRAGRANCE, COCAMIDOPROPYL BETAINE |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient) | PROPYLENE GLYCOL, SODIUM PCA, LACTAMIDE MEA, BUTYLENE GLYCOL | |
| One or more animal studies show kidney or renal system effects at moderate doses (low dose studies may be unavailable for this ingredient) | TETRASODIUM EDTA, | |
| One or more animal studies show sense effects at moderate doses (low dose studies may be unavailable for this ingredient) | SULISOBENZONE (BENZOPHENONE-4) | |
| One or more animal studies show gastrointestinal effects at moderate doses (low dose studies may be unavailable for this ingredient) | GLYCOLIC ACID, SODIUM LAURETH SULFATE, MENTHOL, GLYCOL STEARATE | |
| Known human any toxicant | METHYLPARABEN | |
| Possible human immune system toxicant | METHYLCHLOROISOTHIAZOLINONE |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Ingredient not fully labeled - identity unknown | FRAGRANCE |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | TETRASODIUM EDTA, SODIUM CHLORIDE, PROPYLENE GLYCOL, METHYLPARABEN, MENTHOL, BUTYLENE GLYCOL | |
| Used in food or as an additive with limited or no toxicity information available | MENTHOL |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at moderate doses | SODIUM CHLORIDE, MENTHOL | |
| One or more animal studies show skin irritation at low doses | TETRASODIUM EDTA | |
| One or more animal studies show skin irritation at moderate doses | GLYCOL STEARATE | |
| One or more animal studies show skin irritation at low doses | METHYLPARABEN | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | PHYTANTRIOL, SODIUM LAURETH SULFATE, SULISOBENZONE (BENZOPHENONE-4), BUTYLENE GLYCOL |
| Classified as skin irritant | PROPYLENE GLYCOL |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Missing safety data noted by cosmetic industry review | PHYTANTRIOL | |
| Safety assessment was based on related chemical | PROPYLENE GLYCOL | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | PHYTANTRIOL, TETRASODIUM EDTA, SULISOBENZONE (BENZOPHENONE-4), SODIUM LAURETH SULFATE, POLYQUATERNIUM-10, GLYCOL STEARATE, METHYLPARABEN, BUTYLENE GLYCOL | |
| Not assessed for safety in cosmetics by industry panel | SERENOA SERRULATA FRUIT EXTRACT, PUNICA GRANATUM (POMEGRANATE) EXTRACT, PPG-3 HYDROXYETHYL SOYAMIDE, PANTHENYL ETHYL ETHER, MENTHOL, LACTAMIDE MEA, KERATIN AMINO ACIDS, FRAGRANCE, ETHYL NICOTINATE, ARTEMIA EXTRACT |
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to low doses | TETRASODIUM EDTA | |
| No workplace limits set | GLYCOLIC ACID |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Interferes with gene expresion | METHYLPARABEN | |
| One or more animal studies show blood sugar changes at high doses where the human health implications are not yet well understood | PROPYLENE GLYCOL |
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