Nix Creme Rinse Lice Treatment || Skin Deep: Cosmetic Safety Reviews

NIX CREME RINSE LICE TREATMENT

last updated: 10/01/09 brand: Nix by Insight Pharmaceuticals Corp.

SCORE

high hazard (out of 10)

75%

data gap

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COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Miscellaneous, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: ACTIVE INGREDIENTS: PER FLUID OUNCE: PERMETHRIN 280 MG (1%). INACTIVE INGREDIENTS: BALSAM CANADA, CETYL ALCOHOL, CITRIC ACID, FD&C YELLOW #6, FRAGRANCE, HYDROLYZED ANIMAL PROTEIN, HYDROXYETHYLCELLULOSE, POLYOXYETHYLENE 10 CETYL ETHER, PROPYLENE GLYCOL, STEARALKONIUM CHLORIDE, WATER, ISOPROPYL ALCOHOL, METHYLPARABEN, PROPYLPARABEN.

Directions from packaging: Nix Creme Rinse should be used after hair has been washed with your regular shampoo, rinsed with water and towel dried. A sufficient amount should be applied to saturate hair and scalp (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes but no longer. Rinse with water. A single application is usually sufficient. If live lice are observed seven days or more after the first application of this product, a second treatment should be given. For proper head lice management, remove nits with the nit comb provided. Head lice live on the scalp and lay small white eggs (nits) on the hair shaft close to the scalp. The nits are most easily found on the nape of the neck or behind the ears. All personal headgear, scarf's, coats, and bed linen should be disinfected by machine washing in hot water and drying, using the hot cycle of a dryer for at least 20 minutes. Personal articles of clothing or bedding that cannot be washed may be dry-cleaned, sealed in a plastic bag for a period of about 2 weeks, or sprayed with a product specifically designed for this purpose. Personal combs and brushes may be disinfected by soaking in hot water (above 130F) for 5 to 10 minutes. Thorough vacuuming of rooms inhabited by infected patients is recommended.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PERMETHRIN (Active Ingredient)	4	75%	Cancer, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
ISOPROPYL ALCOHOL	4	72%	Developmental/reproductive toxicity, Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
FD&C YELLOW 6	1	70%	none identified
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
CETETH-10 POLYOXYETHYLENE 10 CETYL ETHER	3	99%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
CITRIC ACID	2	72%	Violations, restrictions & warnings
HYDROLYZED COLLAGEN HYDROLYZED ANIMAL PROTEIN	0	88%	none identified
CETYL ALCOHOL	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
STEARALKONIUM CHLORIDE	1	85%	none identified
HYDROXYETHYLCELLULOSE	1	82%	none identified
ABIES BALSAMEA (BALSAM) BALSAM CANADA	0	94%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results		PROPYLENE GLYCOL, PROPYLPARABEN, METHYLPARABEN
Cancer - not classifiable/not likely to be human carcinogen		PERMETHRIN, ISOPROPYL ALCOHOL, FD&C YELLOW 6

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		HYDROXYETHYLCELLULOSE, FD&C YELLOW 6, PERMETHRIN
One or more animal studies show reproductive effects at moderate doses		PROPYLENE GLYCOL
Limited evidence of developmental toxicity		ISOPROPYL ALCOHOL
One or more animal studies show any effects at low doses		PROPYLPARABEN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PROPYLENE GLYCOL
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		CITRIC ACID
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		PERMETHRIN, PROPYLENE GLYCOL, HYDROXYETHYLCELLULOSE, FD&C YELLOW 6
One or more animal studies show brain and nervous system effects at moderate doses		STEARALKONIUM CHLORIDE, METHYLPARABEN
Moderate evidence of human neurotoxicity		FRAGRANCE
Strong evidence of human neurotoxicity		ISOPROPYL ALCOHOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human any disruptor - strong evidence		METHYLPARABEN
Human any disruptor - moderate evidence		PERMETHRIN
Human any disruptor - strong evidence		PROPYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Limited evidence of immune system toxicity	products for use on skin	PERMETHRIN
Human skin toxicant - strong evidence		PROPYLPARABEN, METHYLPARABEN
Known human immune system toxicant		FRAGRANCE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		PROPYLENE GLYCOL, FD&C YELLOW 6, HYDROXYETHYLCELLULOSE, CETYL ALCOHOL
Limited evidence of sense organ toxicity		PROPYLPARABEN
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		STEARALKONIUM CHLORIDE, CITRIC ACID
Limited evidence of general/multiple organ and system toxicity		PERMETHRIN, ISOPROPYL ALCOHOL
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		ISOPROPYL ALCOHOL
Ingredient not fully labeled - identity unknown		FRAGRANCE

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		CETYL ALCOHOL
Not suspected to be an environmental toxin		ISOPROPYL ALCOHOL
Wildlife and environmental toxicity		PERMETHRIN, PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at moderate doses		CITRIC ACID, PERMETHRIN, STEARALKONIUM CHLORIDE
One or more animal studies show skin irritation at low doses		METHYLPARABEN
One or more animal studies show skin irritation at very low doses		CETYL ALCOHOL
Classified as skin irritant		PROPYLENE GLYCOL, ISOPROPYL ALCOHOL

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		PROPYLENE GLYCOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		STEARALKONIUM CHLORIDE
Safety assessment was based on related chemical		CETETH-10
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		METHYLPARABEN
Safety assessment was based on related chemical		CETETH-10
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		HYDROLYZED COLLAGEN, PROPYLPARABEN, HYDROXYETHYLCELLULOSE, CETYL ALCOHOL
Not assessed for safety in cosmetics by industry panel		FRAGRANCE, ISOPROPYL ALCOHOL
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		CETETH-10
Not assessed for safety in cosmetics by industry panel		PERMETHRIN, CITRIC ACID, ABIES BALSAMEA (BALSAM)

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to high doses		ISOPROPYL ALCOHOL
Allowed workplace exposures restricted to low doses		PERMETHRIN

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		PERMETHRIN, CITRIC ACID, PROPYLENE GLYCOL
Interferes with gene expresion		METHYLPARABEN