Creme of Nature Permanent Hair Color 9.3 Ginger Blonde (2007 formulation) || Skin Deep: Cosmetic Safety Reviews

CREME OF NATURE PERMANENT HAIR COLOR 9.3 GINGER BLONDE (2007 FORMULATION)

last updated: 08/15/07 brand: Creme of Nature by Colomer Group

SCORE

high hazard (out of 10)

80%

data gap

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99% of hair color and bleachings have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Conditioning Shampoo: Water (Aqua); Trideceth-7 Carboxylic Acid; Decyl Glucoside; Glycol Stearate; Polyquaternium-10; Aloe Barbadensis Leaf Extract; Hydrolyzed Milk Protein; Honey (Mel); Citrus Medica Limonum (Lemon) Extract; Triticum Vulgare (Wheat) Germ Oil; Abies Balsamea (Balsam Canada) Resin; Pectin; Lecithin; Foeniculum Vulgare (Fennel) Fruit Extract; Barosma Betulina Leaf Extract; Commiphora Abyssinica Extract; Origanum Majorana Leaf Extract; Iris Florentina Root Extract; Sodium Hydroxide; Fragrance (Parfum); Disodium EDTA; Methylparaben; Propylparaben; Quaternium-15; Methylchloroisothiazolinone; Methylisothiazolinone; Red 4 (CI 14700); Yellow 5 (CI 19140); Red 33 (CI 17200); Blue 1 (CI 42090). Creme Developer: Water (Aqua); Hydrogen Peroxide; Cetearyl Alcohol; Amodimethicone; Cetrimonium Chloride; Trideceth-12; Ceteareth-60; Ceteareth-23; Acrylates/Steareth-20 Itaconate Copolymer; Pentasodium Pentetate; Methylparaben; Phosphoric Acid; Sodium Stannate. Blonding Powder: Ammonium Persulfate; Sodium Silicate; EDTA; Xanthan Gum; Magnesium Stearate; Hydrolyzed Collagen; Algin; Ultramarine Blue. Conditioning Creme Gel: Water (Aqua); Propylene Glycol; Laureth-1; Isostearic Acid; Glyceryl Stearate SE; Ammonium Hydroxide; Ethanolamine; Cocamidopropyl Betaine; Ammonium Lauryl Sulfate; Steartrimonium Chloride; Polyquaternium-10; Polyquaternium-28; Hydrolyzed Wheat Protein; Hydrolyzed Collagen; Tetrasodium EDTA; Fragrance (Parfum)

Warnings from packaging: THIS PRODUCT CONTAINS INGREDIENTS WHICH MAY CAUSE SKIN IRRITATION ON CERTAIN INDIVIDUALS AND A PRELIMINARY TEST ACCORDING TO ACCOMPANYING DIRECTIONS SHOULD FIRST BE MADE. THIS PRODUCT MUST NOT BE USED FOR DYEING EYELASHES OR EYEBROWS. TO DO SO MAY CAUSE BLINDNESS. AVOID CONTACT WITH EYES. IF PRODUCT COMES IN CONTACT WITH EYES OR SKIN, RINSE IMMEDIATELY WITH PLENTY OF WATER. BEFORE APPLICATION, WEAR SUITABLE GLOVES DURING HANDLING, APPLICATION AND RINSING PHASE. POUR POWDER IN CONTAINER CAREFULLY TO AVOID SPILLING AND INHALING DURING MIXING. DO NOT USE ON EYELASHES, EYEBROWS OR IRRITATED SCALP. KEEP AWAY FROM CHILDREN. FOR EXTERNAL USE ONLY.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
AMMONIUM PERSULFATE	8	66%	Violations, restrictions & warnings, Allergies/immunotoxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-60	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
CETEARETH-23	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
ETHANOLAMINE	5	66%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
LECITHIN	3	70%	Multiple, additive exposure sources, Enhanced skin absorption, Contamination concerns (NITROSAMINES)
HYDROGEN PEROXIDE	3	65%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
QUATERNIUM-15	6	65%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Contamination concerns (FORMALDEHYDE)
METHYLCHLOROISOTHIAZOLINONE	6	63%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
METHYLISOTHIAZOLINONE	6	63%	Violations, restrictions & warnings, Allergies/immunotoxicity
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
COCAMIDOPROPYL BETAINE	5	63%	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
D&C RED 33 RED 33 (CI 17200)	1	75%	none identified
FD&C RED 4 RED 4 (CI 14700)	1	73%	none identified
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
LAURETH-1	3	95%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
PECTIN	2	88%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
FD&C YELLOW 5 YELLOW 5 (CI 19140)	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive)
DISODIUM EDTA	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
EDTA	3	78%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
SODIUM HYDROXIDE	3	77%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
CETRIMONIUM CHLORIDE	3	71%	Allergies/immunotoxicity
QUATERNIUM-10 STEARTRIMONIUM CHLORIDE	3	70%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
SODIUM SILICATE	3	70%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ULTRAMARINES ULTRAMARINE BLUE	2	90%	Multiple, additive exposure sources
FD&C BLUE 1 BLUE 1 (CI 42090)	1	83%	none identified
AMMONIUM HYDROXIDE	2	81%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TETRASODIUM EDTA	2	81%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PHOSPHORIC ACID	2	79%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
HYDROLYZED WHEAT PROTEIN	1	95%	Allergies/immunotoxicity
HYDROLYZED MILK PROTEIN	1	94%	Multiple, additive exposure sources
CETEARYL ALCOHOL	0	93%	none identified
ISOSTEARIC ACID	0	93%	none identified
TRITICUM VULGARE (WHEAT) GERM OIL	1	90%	none identified
HYDROLYZED COLLAGEN	0	88%	none identified
SODIUM STANNATE	1	88%	Occupational hazards
TRIDECETH-12	1	88%	Organ system toxicity (non-reproductive)
ALGIN	1	87%	Organ system toxicity (non-reproductive)
GLYCOL STEARATE	1	87%	none identified
MAGNESIUM STEARATE	1	83%	Occupational hazards
ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT ALOE BARBADENSIS LEAF EXTRACT	1	75%	none identified
PENTASODIUM PENTETATE	0	74%	none identified
AMMONIUM LAURYL SULFATE	1	73%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER	0	100%	none identified
CITRUS MEDICA LIMONUM (LEMON) EXTRACT	0	100%	none identified
DECYL GLUCOSIDE	0	100%	none identified
FOENICULUM VULGARE (FENNEL) FRUIT EXTRACT	0	100%	none identified
ORRIS EXTRACT IRIS FLORENTINA ROOT EXTRACT	0	100%	none identified
POLYQUATERNIUM-28	0	100%	none identified
BAROSMA BETULINA LEAF EXTRACT	0	100%	none identified
COMMIPHORA ABYSSINICA EXTRACT	0	100%	none identified
ORIGANUM MAJORANA (SWEET MARJORAM) LEAF EXTRACT ORIGANUM MAJORANA LEAF EXTRACT	0	100%	none identified
AMODIMETHICONE	0	99%	none identified
ABIES BALSAMEA (BALSAM)	0	94%	none identified
TRIDECETH-7 CARBOXYLIC ACID	0	94%	none identified
XANTHAN GUM	0	94%	none identified
GLYCERYL STEARATE SE	0	93%	none identified
POLYQUATERNIUM-10	0	93%	none identified
HONEY	0	0%	innocuous
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests non-mammalian cells show positive mutation results		METHYLCHLOROISOTHIAZOLINONE, TRITICUM VULGARE (WHEAT) GERM OIL, QUATERNIUM-15, FD&C YELLOW 5, D&C RED 33, AMMONIUM HYDROXIDE
One or more in vitro tests on mammalian cells show positive mutation results		SODIUM HYDROXIDE, PROPYLPARABEN, PROPYLENE GLYCOL, METHYLPARABEN, LAURETH-1, HYDROGEN PEROXIDE, FD&C RED 4, FD&C BLUE 1, ETHANOLAMINE, EDTA, DISODIUM EDTA, CETRIMONIUM CHLORIDE

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		QUATERNIUM-15, ETHANOLAMINE, EDTA, DISODIUM EDTA, FD&C YELLOW 5
One or more animal studies show reproductive effects at moderate doses		PROPYLENE GLYCOL
One or more animal studies show any effects at low doses		PROPYLPARABEN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		AMMONIUM LAURYL SULFATE, AMMONIUM PERSULFATE, SODIUM SILICATE, CETEARETH-23, QUATERNIUM-10, PROPYLENE GLYCOL, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, LECITHIN, COCAMIDOPROPYL BETAINE, ETHANOLAMINE, CETRIMONIUM CHLORIDE, CETEARETH-60, ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT, D&C RED 33
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		METHYLISOTHIAZOLINONE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		AMMONIUM PERSULFATE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		METHYLCHLOROISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells demonstrate neurotoxicity		METHYLISOTHIAZOLINONE
One or more animal studies show brain and nervous system effects at high doses		ULTRAMARINES
One or more animal studies show brain and nervous system effects at moderate doses		CETEARETH-23
One or more animal studies show brain and nervous system effects at high doses		QUATERNIUM-15, PROPYLENE GLYCOL, FD&C BLUE 1
One or more animal studies show brain and nervous system effects at moderate doses		METHYLPARABEN, PHOSPHORIC ACID, QUATERNIUM-10
One or more animal studies show brain and nervous system effects at high doses		DISODIUM EDTA
One or more animal studies show brain and nervous system effects at moderate doses		HYDROGEN PEROXIDE, LECITHIN, CETEARETH-60, EDTA, ETHANOLAMINE
One or more animal studies show brain and nervous system effects at very low doses		FD&C YELLOW 5, SODIUM HYDROXIDE
Moderate evidence of human neurotoxicity		FRAGRANCE

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		QUATERNIUM-15
Limited evidence of any disruption		PROPYLPARABEN
One or more animal studies show endocrine disruption at moderate doses		ALGIN
One or more studies show weak endocrine disruption		METHYLPARABEN
One or more animal studies show endocrine system disruption at high doses		HYDROGEN PEROXIDE, DISODIUM EDTA

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of immune system toxicity		PECTIN
One or more human case studies show possible skin allergy effects		HYDROLYZED WHEAT PROTEIN
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human immune system toxicant - moderate evidence		ETHANOLAMINE
Limited evidence of immune system toxicity		METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE
Human skin toxicant - strong evidence		METHYLPARABEN, PROPYLPARABEN, QUATERNIUM-10, SODIUM SILICATE, CETRIMONIUM CHLORIDE
Known human immune system toxicant		AMMONIUM PERSULFATE, COCAMIDOPROPYL BETAINE, QUATERNIUM-15, FRAGRANCE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		MAGNESIUM STEARATE, TRIDECETH-12, ULTRAMARINES, PROPYLENE GLYCOL, PECTIN
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)		PHOSPHORIC ACID, CETEARETH-23
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		FD&C YELLOW 5
One or more animal studies show kidney or renal system effects at moderate doses (low dose studies may be unavailable for this ingredient)		TETRASODIUM EDTA, CETEARETH-60, QUATERNIUM-10,
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		QUATERNIUM-15, FD&C BLUE 1
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		PROPYLPARABEN, METHYLPARABEN, GLYCOL STEARATE, ETHANOLAMINE, EDTA, CETRIMONIUM CHLORIDE, AMMONIUM PERSULFATE
Limited evidence of sense organ toxicity		HYDROGEN PEROXIDE
One or more animal studies show blood effects at moderate doses (low dose studies may be unavailable for this ingredient)		ALGIN
Limited evidence of respiratory toxicity		AMMONIUM HYDROXIDE
One or more animal studies show broad systemic effects at low doses		DISODIUM EDTA
One or more animal studies show metabolic effects at very low doses		SODIUM HYDROXIDE
Possible human immune system toxicant		METHYLCHLOROISOTHIAZOLINONE

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		SODIUM HYDROXIDE, HYDROGEN PEROXIDE, PHOSPHORIC ACID, AMMONIUM PERSULFATE, ETHANOLAMINE
Ingredient not fully labeled - identity unknown		FRAGRANCE
Occupational hazards related to handling		AMMONIUM HYDROXIDE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		XANTHAN GUM, TETRASODIUM EDTA, SODIUM SILICATE, SODIUM HYDROXIDE, PROPYLPARABEN, PROPYLENE GLYCOL, PHOSPHORIC ACID, PECTIN, METHYLPARABEN, MAGNESIUM STEARATE, LECITHIN, HYDROGEN PEROXIDE, GLYCERYL STEARATE SE, FOENICULUM VULGARE (FENNEL) FRUIT EXTRACT, FD&C BLUE 1, FD&C YELLOW 5, ETHANOLAMINE, DISODIUM EDTA, CITRUS MEDICA LIMONUM (LEMON) EXTRACT, AMMONIUM HYDROXIDE, AMMONIUM PERSULFATE, ALGIN
Used in food or as an additive with limited or no toxicity information available		HYDROLYZED MILK PROTEIN, LECITHIN, ULTRAMARINES

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Wildlife and environmental toxicity		AMMONIUM HYDROXIDE, PROPYLPARABEN

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at high doses		METHYLPARABEN
One or more animal studies show skin irritation at moderate doses		TRIDECETH-12, TRITICUM VULGARE (WHEAT) GERM OIL, QUATERNIUM-15, QUATERNIUM-10, PROPYLENE GLYCOL, PHOSPHORIC ACID, GLYCOL STEARATE
One or more animal studies show skin irritation at low doses		CETEARETH-23, TETRASODIUM EDTA, ETHANOLAMINE, CETEARETH-60
One or more animal studies show skin irritation at very low doses		SODIUM SILICATE, SODIUM HYDROXIDE, AMMONIUM LAURYL SULFATE
Human skin irritant - moderate evidence		HYDROGEN PEROXIDE, AMMONIUM HYDROXIDE
Classified as irritant		EDTA, AMMONIUM PERSULFATE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		AMODIMETHICONE, MAGNESIUM STEARATE, PROPYLENE GLYCOL
Missing safety data noted by cosmetic industry review		PENTASODIUM PENTETATE, ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT
Safety assessment was based on related chemical		PENTASODIUM PENTETATE
Considered safe based on assumption of low absorption		SODIUM SILICATE
Missing safety data noted by cosmetic industry review		ISOSTEARIC ACID
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		TRITICUM VULGARE (WHEAT) GERM OIL, TETRASODIUM EDTA, POLYQUATERNIUM-10, PROPYLPARABEN, QUATERNIUM-15, SODIUM SILICATE, PENTASODIUM PENTETATE, ISOSTEARIC ACID, MAGNESIUM STEARATE, METHYLPARABEN, GLYCOL STEARATE, HYDROLYZED COLLAGEN, GLYCERYL STEARATE SE, EDTA, DISODIUM EDTA, CETEARYL ALCOHOL, AMODIMETHICONE
Not assessed for safety in cosmetics by industry panel		TRIDECETH-12, ORIGANUM MAJORANA (SWEET MARJORAM) LEAF EXTRACT, COMMIPHORA ABYSSINICA EXTRACT, BAROSMA BETULINA LEAF EXTRACT, XANTHAN GUM, TRIDECETH-7 CARBOXYLIC ACID, SODIUM STANNATE, SODIUM HYDROXIDE, POLYQUATERNIUM-28, PHOSPHORIC ACID, PECTIN, ORRIS EXTRACT, LAURETH-1, HYDROLYZED WHEAT PROTEIN, HYDROLYZED MILK PROTEIN, HYDROGEN PEROXIDE, FOENICULUM VULGARE (FENNEL) FRUIT EXTRACT, FRAGRANCE, DECYL GLUCOSIDE, CITRUS MEDICA LIMONUM (LEMON) EXTRACT, AMMONIUM HYDROXIDE, ALGIN, ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER, ABIES BALSAMEA (BALSAM)

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
No workplace limits set		SODIUM HYDROXIDE
Allowed workplace exposures restricted to low doses		SODIUM STANNATE
Allowed workplace exposures restricted to moderate doses		ETHANOLAMINE, MAGNESIUM STEARATE
Allowed workplace exposures restricted to very low doses		AMMONIUM PERSULFATE
Allowed workplace exposures restricted to low doses		TETRASODIUM EDTA
Allowed workplace exposures restricted to low doses		HYDROGEN PEROXIDE, PHOSPHORIC ACID

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Interferes with gene expresion		METHYLPARABEN
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		PROPYLENE GLYCOL, HYDROGEN PEROXIDE
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		ALGIN