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Compact for Safe Cosmetics
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Animal Testing Policy |


Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
Ingredients in this product are linked to: | |
![]() | Cancer |
![]() | Developmental/reproductive toxicity |
![]() | Violations, restrictions & warnings |
![]() | Allergies/immunotoxicity |
![]() | Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes |
Ingredients from packaging: Developer: Aqua/Water; Hydrogen Peroxide; Cetearyl Alcohol; Trideceth-2 Carboxamide MEA; Ceteareth-30; Glycerin; Pentasodium Pentetate; Sodium Stannate; Tetrasodium Pyrophosphate. Colorant: Aqua/Water; Deceth-3; Laureth-12; Oleth-30; Deceth-5; Trideceth-2 Carboxamide MEA; Ammonium Hydroxide; Glycerin; Oleic Acid; Hexadimethrine Chloride; Oleyl Alcohol; Polyquaternium-22; p-Phenylenediamine; 2,4-Diaminophenoxyethanol HCl; m-Aminophenol; Ascorbic Acid; Ethanolamine; Polyquaternium-24; Ammonium Thiolactate; p-Methylaminophenol Sulfate; N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate; Alpha-Isomethyl lonone; Resorcinol; EDTA; Parfum/Fragrance. Conditioner: Aqua/Water; Cetearyl Alcohol; Behentrimonium Chloride; PEG-180; Amodimethicone; Cetyl Esters; Parfum/Fragrance; Methylparaben; Hydroxyethylcellulose; Niacinamide*; Pyridoxine HCl**; Citric Acid; Trideceth-12; Linalool; Mica; Chlorhexidine Dihydroxychloride; Limonene; Hexyl Cinnamal; Citronellol; Cetrimonium Chloride; CI 77891/Titanium Dioxide; Benzyl Salicylate; Butylphenyl Methylpropional; *Vitamin B3; **Vitamin B6
Warnings from packaging: USAGE ADVISORY - SAFETY WARNINGS: IMPORTANT: HAIRCOLOR CAN CAUSE AN ALLERGIC REACTION WHICH, IN CERTAIN RARE CASES, CAN BE SEVERE. THEREFORE, YOU MUST FOLLOW THESE PRECAUTIONS: DO NOT USE IF: You have already had a reaction to a haircolor product. You have a sensitive, itchy or damaged scalp. IF YOU HAVE A TATTOO, the risks of allergic reaction may be increased. PERFORM A SKIN ALLERGY TEST 48 HOURS BERORE EACH USE OF THIS PRODUCT (see insert). REMEMBER TO BUY YOUR PRODUCT 2 DAYS AHEAD OF TIME. Avoid contact of this product with eyes and skin. If product gets into eyes, rinse immediately. Wear gloves provided in kit. Thoroughly rinse hair after application. Wait at least 14 days after bleaching, relaxing or perming before coloring. Do not use over compound henna or progressive color. Keep product out of the reach of children. Do not apply on children. THIS PRODUCT CONTAINS INGREDIENTS WHICH MAY CAUSE SKIN IRRITATION ON CERTAIN INDIVIDUALS AND A PRELIMINARY TEST ACCORDING TO ACCOMPANYING DIRECTIONS SHOULD FIRST BE MADE. THIS PRODUCT MUST NOT BE USED FOR DYEING EYELASHES OR EYEBROWS; TO DO SO MAY CAUSE BLINDNESS. READ AND FOLLOW THE INSERT.
| score | data gap | concerns | |
| METHYLPARABEN | 10 | 63% | Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes |
| P-PHENYLENEDIAMINE | 10 | 52% | Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| RESORCINOL | 10 | 52% | Cancer, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| FRAGRANCE | 8 | 100% | Neurotoxicity, Allergies/immunotoxicity, Miscellaneous |
| CETEARETH-30 | 5 | 71% | Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |
| PEG-180 | 5 | 69% | Developmental/reproductive toxicity, Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| ETHANOLAMINE | 5 | 66% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| HYDROGEN PEROXIDE | 3 | 65% | Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards |
| M-AMINOPHENOL | 6 | 65% | Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Occupational hazards |
| LILIAL BUTYLPHENYL METHYLPROPIONAL | 5 | 64% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| BENZYL SALICYLATE | 6 | 62% | Violations, restrictions & warnings, Allergies/immunotoxicity |
| P-METHYLAMINOPHENOL SULFATE | 5 | 60% | Cancer, Allergies/immunotoxicity, Occupational hazards |
| LIMONENE | 6 | 56% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| CHLORHEXIDINE DIHYDROCHLORIDE CHLORHEXIDINE DIHYDROXYCHLORIDE | 4 | 73% | Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| CITRONELLOL | 4 | 65% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| LINALOOL | 5 | 65% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| UNSPECIFIED COLOR COLORANT | 4 | 100% | Miscellaneous |
| OLETH-30 | 3 | 87% | Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE) |
| TITANIUM DIOXIDE (NON-NANO) CI 77891/TITANIUM DIOXIDE | 1 | 81% | Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards, Biochemical or cellular level changes |
| ALPHA-ISOMETHYL IONONE ALPHA-ISOMETHYL LONONE | 4 | 68% | Violations, restrictions & warnings, Allergies/immunotoxicity |
| HEXYL CINNAMAL | 4 | 65% | Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs) |
| LAURETH-12 | 3 | 100% | Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE) |
| PYRIDOXINE HCL | 3 | 79% | Developmental/reproductive toxicity, Neurotoxicity |
| EDTA | 3 | 78% | Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption |
| MICA | 3 | 75% | Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Occupational hazards |
| CITRIC ACID | 2 | 72% | Violations, restrictions & warnings |
| CETRIMONIUM CHLORIDE | 3 | 71% | Allergies/immunotoxicity |
| N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE | 3 | 69% | Cancer, Allergies/immunotoxicity |
| PYRIDOXINE **VITAMIN B6 | 2 | 83% | Multiple, additive exposure sources |
| OLEIC ACID | 1 | 82% | Irritation (skin, eyes, or lungs) |
| TETRASODIUM PYROPHOSPHATE | 2 | 82% | Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards |
| AMMONIUM HYDROXIDE | 2 | 81% | Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs) |
| NIACINAMIDE | 2 | 81% | Organ system toxicity (non-reproductive), Biochemical or cellular level changes |
| GLYCERIN | 2 | 74% | Organ system toxicity (non-reproductive), Occupational hazards |
| BEHENTRIMONIUM CHLORIDE | 0 | 94% | none identified |
| CETEARYL ALCOHOL | 0 | 93% | none identified |
| ASCORBIC ACID (VITAMIN C) | 1 | 91% | none identified |
| DECETH-5 | 1 | 88% | Irritation (skin, eyes, or lungs) |
| SODIUM STANNATE | 1 | 88% | Occupational hazards |
| TRIDECETH-12 | 1 | 88% | Organ system toxicity (non-reproductive) |
| OLEYL ALCOHOL | 1 | 87% | Irritation (skin, eyes, or lungs) |
| VITAMIN B3 | 1 | 87% | none identified |
| HYDROXYETHYLCELLULOSE | 1 | 82% | none identified |
| 2,4-DIAMINOPHENOXYETHANOL HCL | 1 | 75% | Cancer |
| PENTASODIUM PENTETATE | 0 | 74% | none identified |
| DECETH-3 | 0 | 100% | none identified |
| HEXADIMETHRINE CHLORIDE | 0 | 100% | none identified |
| POLYQUATERNIUM-22 | 0 | 100% | none identified |
| TRIDECETH-2 CARBOXAMIDE MEA | 0 | 100% | none identified |
| AMMONIUM THIOLACTATE | 0 | 100% | none identified |
| AMODIMETHICONE | 0 | 99% | none identified |
| POLYQUATERNIUM-24 | 0 | 94% | none identified |
| CETYL ESTERS | 0 | 93% | none identified |
| WATER | 0 | 0% | innocuous |
*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Cancer - limited evidence | 2,4-DIAMINOPHENOXYETHANOL HCL, M-AMINOPHENOL | |
| Cancer - not classifiable/not likely to be human carcinogen | P-PHENYLENEDIAMINE, RESORCINOL | |
| One or more in vitro tests non-mammalian cells show positive mutation results | LINALOOL, AMMONIUM HYDROXIDE | |
| One or more in vitro tests on mammalian cells show positive mutation results | PEG-180, TITANIUM DIOXIDE (NON-NANO), PYRIDOXINE HCL, OLEIC ACID, NIACINAMIDE, METHYLPARABEN, GLYCERIN, ETHANOLAMINE, EDTA, CETRIMONIUM CHLORIDE, ASCORBIC ACID (VITAMIN C) | |
| Cancer - limited evidence | P-METHYLAMINOPHENOL SULFATE, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE | |
| Cancer - not classifiable/not likely to be human carcinogen | HYDROGEN PEROXIDE, LIMONENE |
*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show reproductive effects at very low doses | PYRIDOXINE HCL | |
| One or more animal studies show reproductive effects at high doses | PYRIDOXINE, M-AMINOPHENOL, HYDROXYETHYLCELLULOSE, ETHANOLAMINE, EDTA, LILIAL, | |
| One or more animal studies show developmental effects at high doses | LIMONENE | |
| One or more animal studies show reproductive effects at moderate doses | GLYCERIN | |
| One or more animal studies show reproductive effects at very low doses | PEG-180 | |
| Human nervous system toxicant - moderate evidence | P-PHENYLENEDIAMINE |
*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | CETRIMONIUM CHLORIDE, PEG-180, ETHANOLAMINE, CHLORHEXIDINE DIHYDROCHLORIDE, CETEARETH-30, P-PHENYLENEDIAMINE, RESORCINOL, M-AMINOPHENOL, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, P-METHYLAMINOPHENOL SULFATE | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn) | ALPHA-ISOMETHYL IONONE, BENZYL SALICYLATE | |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | 2,4-DIAMINOPHENOXYETHANOL HCL | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | M-AMINOPHENOL, P-PHENYLENEDIAMINE, CITRONELLOL, HEXYL CINNAMAL, LILIAL, LINALOOL | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | P-PHENYLENEDIAMINE | |
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limits, according to industry safety panel (International Fragrance Association) | LIMONENE | |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | CITRIC ACID, CHLORHEXIDINE DIHYDROCHLORIDE, CHLORHEXIDINE DIHYDROCHLORIDE, RESORCINOL | |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | METHYLPARABEN |
*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show brain and nervous system effects at high doses | NIACINAMIDE, HYDROXYETHYLCELLULOSE, HEXYL CINNAMAL, GLYCERIN | |
| One or more animal studies show brain and nervous system effects at moderate doses | VITAMIN B3, RESORCINOL, PYRIDOXINE, OLEIC ACID, METHYLPARABEN, M-AMINOPHENOL, LINALOOL, ETHANOLAMINE, EDTA, CITRONELLOL, CETEARETH-30, LILIAL | |
| One or more animal studies show brain and nervous system effects at low doses | TETRASODIUM PYROPHOSPHATE | |
| One or more animal studies show brain and nervous system effects at very low doses | HYDROGEN PEROXIDE | |
| Strong evidence of human neurotoxicity | P-PHENYLENEDIAMINE | |
| Moderate evidence of human neurotoxicity | FRAGRANCE | |
| One or more animal studies show brain and nervous system effects at low doses | PYRIDOXINE HCL |
*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Associated with endocrine disruption | LILIAL, BENZYL SALICYLATE | |
| One or more animal studies show endocrine system disruption at high doses | PYRIDOXINE HCL, P-PHENYLENEDIAMINE, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, HYDROGEN PEROXIDE, GLYCERIN | |
| One or more animal studies show endocrine disruption at moderate doses | NIACINAMIDE | |
| Human any disruptor - strong evidence | RESORCINOL, METHYLPARABEN |
*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show gastrointestinal effects at moderate doses | MICA | |
| One or more animal studies show immune effects at low doses | TITANIUM DIOXIDE (NON-NANO) | |
| Human immune system toxicant - moderate evidence | CHLORHEXIDINE DIHYDROCHLORIDE | |
| Human skin toxicant - strong evidence | N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, METHYLPARABEN, M-AMINOPHENOL, ETHANOLAMINE | |
| Possible human immune system toxicant | LINALOOL | |
| Human skin toxicant - strong evidence | CETRIMONIUM CHLORIDE | |
| Possible human immune system toxicant | HEXYL CINNAMAL, CITRONELLOL, LILIAL, ALPHA-ISOMETHYL IONONE | |
| Known human immune system toxicant | RESORCINOL, P-PHENYLENEDIAMINE, P-METHYLAMINOPHENOL SULFATE, FRAGRANCE, LIMONENE, BENZYL SALICYLATE |
*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Not suspected to be bioaccumulative | PEG-180, TITANIUM DIOXIDE (NON-NANO), AMMONIUM HYDROXIDE, EDTA | |
| Not suspected to be persistent | TRIDECETH-12 | |
| Persistent, bioaccumulative in wildlife and humans | MICA |
*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient) | TRIDECETH-12, HYDROXYETHYLCELLULOSE, VITAMIN B3, LINALOOL, HEXYL CINNAMAL, LIMONENE, CITRONELLOL, BENZYL SALICYLATE | |
| One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient) | PYRIDOXINE HCL, CETEARETH-30, OLETH-30, PYRIDOXINE, OLEIC ACID, N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE, CITRIC ACID, CETRIMONIUM CHLORIDE | |
| One or more animal studies show metabolic effects at low doses | TETRASODIUM PYROPHOSPHATE, RESORCINOL, EDTA | |
| One or more animal studies show liver effects at very low doses | NIACINAMIDE | |
| One or more animal studies show broad systemic effects at low doses | AMMONIUM HYDROXIDE | |
| One or more animal studies show kidney or renal system effects at very low doses | GLYCERIN, HYDROGEN PEROXIDE, TITANIUM DIOXIDE (NON-NANO), PEG-180 | |
| Possible human respiratory toxicant | MICA, ETHANOLAMINE, CHLORHEXIDINE DIHYDROCHLORIDE | |
| Known human respiratory toxicant | P-PHENYLENEDIAMINE, METHYLPARABEN |
*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Occupational hazards related to handling | HYDROGEN PEROXIDE, ETHANOLAMINE, LIMONENE, AMMONIUM HYDROXIDE | |
| Ingredient not fully labeled - identity unknown | UNSPECIFIED COLOR, FRAGRANCE |
*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Designated as safe for general or specific, limited use in food | PEG-180, OLEIC ACID, PYRIDOXINE HCL, TITANIUM DIOXIDE (NON-NANO), TETRASODIUM PYROPHOSPHATE, RESORCINOL, NIACINAMIDE, METHYLPARABEN, LINALOOL, HYDROGEN PEROXIDE, HEXYL CINNAMAL, GLYCERIN, ETHANOLAMINE, LIMONENE, CITRONELLOL, CITRIC ACID, CHLORHEXIDINE DIHYDROCHLORIDE, BENZYL SALICYLATE, ASCORBIC ACID (VITAMIN C), AMMONIUM HYDROXIDE, ALPHA-ISOMETHYL IONONE | |
| Used in food or as an additive with limited or no toxicity information available | PYRIDOXINE |
*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Suspected to be an environmental toxin | TRIDECETH-12 | |
| Not suspected to be an environmental toxin | PEG-180, TITANIUM DIOXIDE (NON-NANO), EDTA | |
| Wildlife and environmental toxicity | RESORCINOL, P-PHENYLENEDIAMINE, P-METHYLAMINOPHENOL SULFATE, M-AMINOPHENOL, AMMONIUM HYDROXIDE, LIMONENE |
*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show skin irritation at high doses | P-METHYLAMINOPHENOL SULFATE | |
| One or more animal studies show skin irritation at moderate doses | TRIDECETH-12, PEG-180, TITANIUM DIOXIDE (NON-NANO), M-AMINOPHENOL, GLYCERIN | |
| Classified as irritant | LIMONENE, EDTA, P-PHENYLENEDIAMINE, RESORCINOL | |
| Human any irritant - strong evidence | products for use around the eyes, on the skin, or may be aerosolized (airborne) | OLEYL ALCOHOL |
| Human skin irritant - moderate evidence | AMMONIUM HYDROXIDE, CHLORHEXIDINE DIHYDROCHLORIDE, ETHANOLAMINE, HYDROGEN PEROXIDE | |
| One or more animal studies show skin irritation at very low doses | CITRONELLOL, HEXYL CINNAMAL, LINALOOL | |
| One or more animal studies show skin irritation at low doses | LILIAL, CETEARETH-30, DECETH-5, METHYLPARABEN, OLEIC ACID, OLETH-30 | |
| One or more animal studies show skin irritation at moderate doses | CITRIC ACID |
*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| Allowed workplace exposures restricted to low doses | TITANIUM DIOXIDE (NON-NANO), ETHANOLAMINE | |
| Allowed workplace exposures restricted to moderate doses | GLYCERIN, TETRASODIUM PYROPHOSPHATE | |
| Allowed workplace exposures restricted to low doses | SODIUM STANNATE, MICA, | |
| Allowed workplace exposures restricted to low doses | RESORCINOL, P-METHYLAMINOPHENOL SULFATE, M-AMINOPHENOL, HYDROGEN PEROXIDE | |
| Allowed workplace exposures restricted to very low doses | P-PHENYLENEDIAMINE |
*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.
| type of concern | product conditions | ingredient(s) |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | HYDROGEN PEROXIDE | |
| Interferes with gene expresion | METHYLPARABEN | |
| One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood | CITRIC ACID, GLYCERIN | |
| One or more animal studies show biochemical changes at very low doses where the human health implications are not yet well understood | NIACINAMIDE, TITANIUM DIOXIDE (NON-NANO) | |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | PYRIDOXINE HCL |
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