Creme of Nature Permanent Hair Color 5.2 Mahogany Glow (2007 formulation) || Skin Deep: Cosmetic Safety Reviews

CREME OF NATURE PERMANENT HAIR COLOR 5.2 MAHOGANY GLOW (2007 FORMULATION)

last updated: 08/15/07 brand: Creme of Nature by Colomer Group

SCORE

high hazard (out of 10)

79%

data gap

BUY ONLINE/BETTER PRODUCTS

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97% of hair color and bleachings have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Kiwi & Citrus Moisture Active Shampoo: Ultra-Purified Water (Aqua) (Eau); Sodium Laureth Sulfate; Cocamidopropyl Betaine; Glycol Stearate; Mentha Piperita (Peppermint) Leaf Extract; Ocimum Basilicum (Basil) Extract; Polygala Senega Root Extract; Nasturtium Officinale (Watercress) Extract; Salvia Officinalis (Sage) Leaf Extract; Thymus Vulgaris (Thyme) Extract; Rosmarinus Officinalis (Rosemary) Leaf Extract; Citrus Grandis (Grapefruit) Seed Extract; Actinidia Chinensis (Kiwi) Fruit Extract; Mentha Piperita (Peppermint) Oil; Citrus Aurantifolia (Lime) Oil; Mentha Viridis (Spearmint) Leaf Oil; Cocos Nucifera (Coconut) Oil; Allantoin; Tocopheryl Acetate; Aloe Barbadensis Leaf Juice; Hydrolyzed Wheat Protein; Hydrolyzed Wheat Starch; Wheat Amino Acids; Amodimethicone; Butylene Glycol; PEG-12 Dimethicone; Polyquaternium-59; Glycerin; Citric Acid; Polysorbate 20; Fragrance (Parfum)*; Benzyl Salicylate; Citronellol; Coumarin; Hydroxycitronellal; Limonene; Linalool; Alpha Isomethyl Ionone; Methylparaben; Propylparaben; Methylchloroisothiazolinone; Methylisothiazolinone; Yellow 5 (CI 19140); Yellow 6 (CI 15985); Caramel; *Fragrance Contains: Eugenia Caryophyllus (Clove) Flower Oil; Citrus Aurantium Dulcis (Orange) Oil; Citrus Grandis (Grapefruit) Seed Oil; Cymbopogon Schoenanthus Oil. Chamomile & Comfrey Healing Conditioner With Color Protection: Ultra Purified Water (Aqua) (Eau); Stearyl Alcohol; Amodimethicone; Cetyl Alcohol; Stearamidopropyl Dimethylamine; Benzyl Alcohol; Mentha Piperita (Peppermint) Leaf Extract; Ocimum Basilicum (Basil) Extract; Polygala Senega Root Extract; Nasturtium Officinale (Watercress) Extract; Salvia Officinalis (Sage) Leaf Extract; Thymus Vulgaris (Thyme) Extract; Rosmarinus Officinalis (Rosemary) Leaf Extract; Citrus Grandis (Grapefruit) Seed Extract; Chamomila Recutita (Matricaria) Extract; Symphytum Offcinale Leaf Extract; Citrus Aurantium Dulcis (Orange) Oil; Mentha Piperita (Peppermint) Oil; Citrus Aurantifolia (Lime) Oil; Mentha Viridis (Spearmint) Leaf Oil; Allantoin; Tocopheryl Acetate; Aloe Barbadensis Leaf Juice; Lactic Acid; Ceteareth-20; Polyquaternium-37; Polyquaternium-59; Butylene Glycol; Propylene Glycol; Dicaprylate/Dicaprate; PPG-1 Trideceth-6; Fragrance (Parfum)*; Citronellol; Coumarin; Hydroxycitronellal; Limonene; Linalool; Alpha Isomethyl Ionone; Methylparaben; Ethylparaben; Propylparaben; Butylparaben; Isobutylparaben; Phenoxyethanol; *Fragrance Contains: Eucalyptus Globulus Leaf Oil; Cymbopogon Schoenanthus Oil; Citrus Aurantium Bergamia (Bergamot) Fruit Oil. Creme Developer: Ultra-Purified Water (Aqua) (Eau); Hydrogen Peroxide; Cetearyl Alcohol; Amodimethicone; Cetrimonium Chloride; Trideceth-12; Ceteareth-60; Ceteareth-23; Acrylates/Steareth-20 Itaconate Copolymer; Pentasodium Pentetate; Methylparaben; Phosphoric Acid; Sodium Stannate. Conditioning Colorant: Ultra-Purified Water (Aqua) (Eau); Propylene Glycol; Laureth-1; Isostearic Acid; Glyceryl Stearate SE; Ammonium Hydroxide; Ethanolamine; Cocamidopropyl Betaine; Ammonium Lauryl Sulfate; Steartrimonium Chloride; Polyquaternium-10; Polyquaternium-28; Hydrolyzed Wheat Protein; Hydrolyzed Collagen; Erythorbic Acid; Sodium Sulfite; Tetrasodium EDTA; p-Phenylenediamine; o-Aminophenol; 4-Amino-2-Hydroxytoluene; Phenyl Methyl Pyrazolone; p-Aminophenol

Warnings from packaging: KEEP OUT OF REACH OF CHILDREN. THIS PRODUCT CONTAINS INGREDIENTS WHICH MAY CAUSE SKIN IRRITATION ON CERTAIN INDIVIDUALS AND A PRELIMINARY TEST ACCORDING TO ACCOMPANYING DIRECTIONS SHOULD FIRST BE MADE. THIS PRODUCT MUST NOT BE USED FOR DYEING THE EYELASHES OR EYEBROWS; TO DO SO MAY CAUSE BLINDNESS.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
P-PHENYLENEDIAMINE	10	52%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
O-AMINOPHENOL	8	57%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
P-AMINOPHENOL	8	57%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Occupational hazards
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
CETEARETH-20	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
CETEARETH-60	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
CETEARETH-23	5	71%	Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
ETHANOLAMINE	5	66%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
COUMARIN	7	46%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
BUTYLPARABEN	6	79%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PEG-12 DIMETHICONE	4	75%	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
HYDROGEN PEROXIDE	3	65%	Neurotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
BENZYL ALCOHOL	6	64%	Violations, restrictions & warnings, Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
METHYLCHLOROISOTHIAZOLINONE	6	63%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
METHYLISOTHIAZOLINONE	6	63%	Violations, restrictions & warnings, Allergies/immunotoxicity
BENZYL SALICYLATE	6	62%	Violations, restrictions & warnings, Allergies/immunotoxicity
HYDROXYCITRONELLAL	5	62%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LIMONENE	6	56%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
ETHYLPARABEN	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
LACTIC ACID	4	70%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs)
PHENYL METHYL PYRAZOLONE	5	68%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
4-AMINO-2-HYDROXYTOLUENE	5	67%	Cancer, Violations, restrictions & warnings, Allergies/immunotoxicity
CITRONELLOL	4	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
LINALOOL	5	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs)
COCAMIDOPROPYL BETAINE	5	63%	Allergies/immunotoxicity, Contamination concerns (NITROSAMINES)
EUGENIA CARYOPHYLLUS (CLOVE) FLOWER OIL	5	58%	Violations, restrictions & warnings, Allergies/immunotoxicity
EUGENIA CARYOPHYLLUS (CLOVE)	5	58%	Violations, restrictions & warnings, Allergies/immunotoxicity
CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT	4	100%	Multiple, additive exposure sources, Contamination concerns (BENZETHONIUM CHLORIDE, METHYLPARABEN, TRICLOSAN)
SODIUM LAURETH SULFATE	4	86%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
TOCOPHERYL ACETATE	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
CYMBOPOGON SCHOENANTHUS OIL	4	72%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
FD&C YELLOW 6 YELLOW 6 (CI 15985)	1	70%	none identified
ALPHA-ISOMETHYL IONONE	4	68%	Violations, restrictions & warnings, Allergies/immunotoxicity
PHENOXYETHANOL	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
LAURETH-1	3	95%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
SODIUM SULFITE	3	87%	Neurotoxicity, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
ISOBUTYLPARABEN	3	83%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
FD&C YELLOW 5 YELLOW 5 (CI 19140)	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive)
MENTHA PIPERITA (PEPPERMINT) OIL	3	73%	Enhanced skin absorption, Contamination concerns (LIMONENE, MENTHOL, MENTHONE)
CITRIC ACID	2	72%	Violations, restrictions & warnings
CETRIMONIUM CHLORIDE	3	71%	Allergies/immunotoxicity
QUATERNIUM-10 STEARTRIMONIUM CHLORIDE	3	70%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
AMMONIUM HYDROXIDE	2	81%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
TETRASODIUM EDTA	2	81%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption, Occupational hazards
PHOSPHORIC ACID	2	79%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
CITRUS AURANTIFOLIA (LIME) OIL	2	73%	Violations, restrictions & warnings
CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL	2	73%	Violations, restrictions & warnings
OCIMUM BASILICUM (SWEET BASIL) EXTRACT OCIMUM BASILICUM (BASIL) EXTRACT	1	100%	Multiple, additive exposure sources
THYMUS VULGARIS (COMMON THYME) EXTRACT THYMUS VULGARIS (THYME) EXTRACT	1	100%	Multiple, additive exposure sources
HYDROLYZED WHEAT PROTEIN	1	95%	Allergies/immunotoxicity
SALVIA OFFICINALIS (SAGE) LEAF EXTRACT	1	95%	none identified
SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT SYMPHYTUM OFFCINALE LEAF EXTRACT	1	95%	Organ system toxicity (non-reproductive)
POLYQUATERNIUM-37	0	94%	none identified
STEARAMIDOPROPYL DIMETHYLAMINE	0	94%	none identified
CETEARYL ALCOHOL	0	93%	none identified
ISOSTEARIC ACID	0	93%	none identified
CARAMEL	1	92%	none identified
COCOS NUCIFERA (COCONUT) OIL	1	89%	none identified
CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL CITRUS AURANTIUM DULCIS (ORANGE) OIL	1	88%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
HYDROLYZED COLLAGEN	0	88%	none identified
SODIUM STANNATE	1	88%	Occupational hazards
TRIDECETH-12	1	88%	Organ system toxicity (non-reproductive)
CETYL ALCOHOL	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ERYTHORBIC ACID	1	87%	none identified
GLYCOL STEARATE	1	87%	none identified
EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL EUCALYPTUS GLOBULUS LEAF OIL	1	86%	Irritation (skin, eyes, or lungs)
POLYSORBATE-20	1	84%	none identified
STEARYL ALCOHOL	1	84%	Irritation (skin, eyes, or lungs)
BUTYLENE GLYCOL	1	79%	Irritation (skin, eyes, or lungs)
MENTHA PIPERITA (PEPPERMINT) LEAF EXTRACT	1	75%	Enhanced skin absorption
PENTASODIUM PENTETATE	0	74%	none identified
AMMONIUM LAURYL SULFATE	1	73%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
ALOE BARBADENSIS (ALOE VERA) GEL ALOE BARBADENSIS LEAF JUICE	1	72%	none identified
ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER	0	100%	none identified
ACTINIDIA CHINENSIS (KIWI) EXTRACT ACTINIDIA CHINENSIS (KIWI) FRUIT EXTRACT	0	100%	none identified
CHAMOMILLA RECUTITA (MATRICARIA) FLOWER EXTRACT CHAMOMILA RECUTITA (MATRICARIA) EXTRACT	0	100%	none identified
DICAPRYLATE/ DICAPRATE	0	100%	none identified
HYDROLYZED WHEAT STARCH	0	100%	none identified
NASTURTIUM OFFICINALE (WATERCRESS) EXTRACT	0	100%	none identified
POLYGALA SENEGA (SENEGA SNAKE) ROOT EXTRACT POLYGALA SENEGA ROOT EXTRACT	0	100%	none identified
POLYQUATERNIUM-28	0	100%	none identified
POLYQUATERNIUM-59	0	100%	none identified
PPG-1 TRIDECETH-6	0	100%	none identified
ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT	0	100%	none identified
CITRUS AURANTIFOLIA	0	100%	none identified
EUCALYPTUS GLOBULUS	0	100%	none identified
WHEAT AMINO ACIDS	0	100%	none identified
MENTHA VIRIDIS (SPEARMINT) LEAF OIL	0	100%	none identified
CITRUS GRANDIS (GRAPEFRUIT) SEED OIL	0	100%	none identified
AMODIMETHICONE	0	99%	none identified
ALLANTOIN	0	94%	none identified
GLYCERYL STEARATE SE	0	93%	none identified
POLYQUATERNIUM-10	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show tumor formation at high doses		STEARYL ALCOHOL, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL
One or more in vitro tests non-mammalian cells show positive mutation results		PHENOXYETHANOL, METHYLCHLOROISOTHIAZOLINONE, MENTHA PIPERITA (PEPPERMINT) OIL, LINALOOL, CITRUS AURANTIFOLIA (LIME) OIL, AMMONIUM HYDROXIDE
One or more in vitro tests on mammalian cells show positive mutation results		TOCOPHERYL ACETATE, SALVIA OFFICINALIS (SAGE) LEAF EXTRACT, SODIUM SULFITE, PROPYLPARABEN, PROPYLENE GLYCOL, METHYLPARABEN, LAURETH-1, GLYCERIN, FD&C YELLOW 5, ETHYLPARABEN, ETHANOLAMINE, ERYTHORBIC ACID, CETRIMONIUM CHLORIDE, CARAMEL, BUTYLPARABEN, BENZYL ALCOHOL
Cancer - not classifiable/not likely to be human carcinogen		LACTIC ACID
Cancer - limited evidence		PHENYL METHYL PYRAZOLONE, 4-AMINO-2-HYDROXYTOLUENE
Not likely to be carcinogenic in humans		EUGENIA CARYOPHYLLUS (CLOVE), EUGENIA CARYOPHYLLUS (CLOVE) FLOWER OIL
Mutagen - limited evidence		P-AMINOPHENOL, O-AMINOPHENOL
Cancer - not classifiable/not likely to be human carcinogen		P-PHENYLENEDIAMINE, HYDROGEN PEROXIDE, FD&C YELLOW 6, LIMONENE, COUMARIN

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		POLYSORBATE-20, FD&C YELLOW 6, PHENYL METHYL PYRAZOLONE, FD&C YELLOW 5, ETHYLPARABEN, ETHANOLAMINE, COUMARIN, BUTYLENE GLYCOL, BENZYL ALCOHOL,
One or more animal studies show developmental effects at high doses		LIMONENE
One or more animal studies show reproductive effects at moderate doses		PROPYLENE GLYCOL, P-AMINOPHENOL, O-AMINOPHENOL, GLYCERIN,
One or more animal studies show any effects at moderate doses		ALOE BARBADENSIS (ALOE VERA) GEL
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show any effects at very low doses		BUTYLPARABEN
Human nervous system toxicant - moderate evidence		P-PHENYLENEDIAMINE

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		QUATERNIUM-10, CETEARETH-23, PROPYLENE GLYCOL, PEG-12 DIMETHICONE, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, MENTHA PIPERITA (PEPPERMINT) OIL, LACTIC ACID, MENTHA PIPERITA (PEPPERMINT) LEAF EXTRACT, ETHANOLAMINE, BENZYL ALCOHOL, CETEARETH-20, CETEARETH-60, CETRIMONIUM CHLORIDE, COCAMIDOPROPYL BETAINE, AMMONIUM LAURYL SULFATE, ALOE BARBADENSIS (ALOE VERA) GEL, PHENYL METHYL PYRAZOLONE, P-PHENYLENEDIAMINE, P-AMINOPHENOL, O-AMINOPHENOL, 4-AMINO-2-HYDROXYTOLUENE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		P-PHENYLENEDIAMINE, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, EUGENIA CARYOPHYLLUS (CLOVE), PHENYL METHYL PYRAZOLONE, 4-AMINO-2-HYDROXYTOLUENE, BENZYL ALCOHOL, P-AMINOPHENOL, O-AMINOPHENOL, HYDROXYCITRONELLAL, COUMARIN, CITRONELLOL, CITRUS AURANTIFOLIA (LIME) OIL, EUGENIA CARYOPHYLLUS (CLOVE) FLOWER OIL, BENZYL SALICYLATE, BENZYL ALCOHOL, LINALOOL, ALPHA-ISOMETHYL IONONE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE, P-PHENYLENEDIAMINE
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only if satisfies manufacturing specifications or purity limits, according to industry safety panel (International Fragrance Association)		LIMONENE
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		LACTIC ACID, CITRIC ACID, PHENOXYETHANOL, METHYLCHLOROISOTHIAZOLINONE
Violation of industry recommendations - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Allowable pH limits		LACTIC ACID
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - concentration limit in some types of cosmetics when combined with certain other ingredient(s)		METHYLCHLOROISOTHIAZOLINONE, METHYLISOTHIAZOLINONE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at low doses		SODIUM SULFITE
One or more animal studies show brain and nervous system effects at very low doses		HYDROGEN PEROXIDE, FD&C YELLOW 5
Moderate evidence of human neurotoxicity		FRAGRANCE
Strong evidence of human neurotoxicity		P-PHENYLENEDIAMINE, BENZYL ALCOHOL
One or more in vitro tests on mammalian cells demonstrate neurotoxicity		METHYLISOTHIAZOLINONE
One or more animal studies show brain and nervous system effects at high doses		PROPYLENE GLYCOL, PHENYL METHYL PYRAZOLONE, LACTIC ACID, FD&C YELLOW 6, GLYCERIN, BUTYLENE GLYCOL, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL
One or more animal studies show brain and nervous system effects at moderate doses		QUATERNIUM-10, CETEARETH-23
One or more animal studies show brain and nervous system effects at high doses		4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show brain and nervous system effects at moderate doses		PHENOXYETHANOL, PHOSPHORIC ACID, METHYLPARABEN, O-AMINOPHENOL, P-AMINOPHENOL, ETHANOLAMINE, LINALOOL, MENTHA PIPERITA (PEPPERMINT) OIL, CITRONELLOL, COUMARIN, CETEARETH-60, CETEARETH-20

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Associated with endocrine disruption		BENZYL SALICYLATE
One or more animal studies show endocrine system disruption at high doses		P-PHENYLENEDIAMINE, HYDROGEN PEROXIDE, GLYCERIN, BUTYLENE GLYCOL, 4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show endocrine disruption at moderate doses		ISOBUTYLPARABEN
Human any disruptor - strong evidence		PROPYLPARABEN, METHYLPARABEN, ETHYLPARABEN, BUTYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more human case studies show possible allergenic effects		BENZYL ALCOHOL, HYDROLYZED WHEAT PROTEIN
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
Human skin toxicant - strong evidence		PROPYLPARABEN, QUATERNIUM-10, TOCOPHERYL ACETATE
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human immune system toxicant - moderate evidence		SODIUM SULFITE
Human skin toxicant - strong evidence		PHENYL METHYL PYRAZOLONE, METHYLPARABEN, ISOBUTYLPARABEN, ETHYLPARABEN, ETHANOLAMINE, CETRIMONIUM CHLORIDE, BUTYLPARABEN, 4-AMINO-2-HYDROXYTOLUENE
Possible human immune system toxicant		LINALOOL, CITRONELLOL, ALPHA-ISOMETHYL IONONE
Known human immune system toxicant		EUGENIA CARYOPHYLLUS (CLOVE), CYMBOPOGON SCHOENANTHUS OIL, O-AMINOPHENOL, P-AMINOPHENOL, P-PHENYLENEDIAMINE, METHYLISOTHIAZOLINONE, METHYLCHLOROISOTHIAZOLINONE, HYDROXYCITRONELLAL, LIMONENE, FRAGRANCE, COUMARIN, COCAMIDOPROPYL BETAINE, EUGENIA CARYOPHYLLUS (CLOVE) FLOWER OIL, BENZYL SALICYLATE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		AMMONIUM HYDROXIDE, PHOSPHORIC ACID
Not suspected to be persistent		TRIDECETH-12, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL, CETYL ALCOHOL

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Classified as expected to be toxic or harmful		CYMBOPOGON SCHOENANTHUS OIL, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL, AMMONIUM LAURYL SULFATE
One or more animal studies show metabolic effects at high doses (low dose studies may be unavailable for this ingredient)		PROPYLENE GLYCOL, BENZYL ALCOHOL, TRIDECETH-12, CITRONELLOL, COCOS NUCIFERA (COCONUT) OIL, POLYSORBATE-20, FD&C YELLOW 6, CETYL ALCOHOL, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, STEARYL ALCOHOL, MENTHA PIPERITA (PEPPERMINT) OIL, LINALOOL, ERYTHORBIC ACID, LIMONENE, BUTYLENE GLYCOL, BENZYL SALICYLATE
One or more animal studies show liver effects at moderate doses (low dose studies may be unavailable for this ingredient)		CETEARETH-23, PHENYL METHYL PYRAZOLONE, CETEARETH-60, PHENOXYETHANOL, TETRASODIUM EDTA, CETEARETH-20, TOCOPHERYL ACETATE, SODIUM LAURETH SULFATE, LACTIC ACID, GLYCOL STEARATE, CITRIC ACID, CETRIMONIUM CHLORIDE, ALOE BARBADENSIS (ALOE VERA) GEL, 4-AMINO-2-HYDROXYTOLUENE
Limited evidence of sense organ toxicity		PROPYLPARABEN, PEG-12 DIMETHICONE, ISOBUTYLPARABEN, ETHYLPARABEN, BUTYLPARABEN, PHOSPHORIC ACID
One or more animal studies show broad systemic effects at low doses		QUATERNIUM-10, COUMARIN, AMMONIUM HYDROXIDE
One or more animal studies show musculoskeletal effects at very low doses		FD&C YELLOW 5, GLYCERIN, HYDROGEN PEROXIDE
Possible human immune system toxicant		SODIUM SULFITE, P-AMINOPHENOL, O-AMINOPHENOL, METHYLCHLOROISOTHIAZOLINONE, ETHANOLAMINE
Limited evidence of any toxicity		SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT
Known human respiratory toxicant		P-PHENYLENEDIAMINE, METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Occupational hazards related to handling		PHOSPHORIC ACID, HYDROGEN PEROXIDE, ETHANOLAMINE, LIMONENE, AMMONIUM HYDROXIDE
Prohibited for use in food		COUMARIN
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, CYMBOPOGON SCHOENANTHUS OIL, EUGENIA CARYOPHYLLUS (CLOVE), TOCOPHERYL ACETATE, THYMUS VULGARIS (COMMON THYME) EXTRACT, TETRASODIUM EDTA, STEARYL ALCOHOL, SODIUM SULFITE, ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT, PROPYLPARABEN, PROPYLENE GLYCOL, POLYSORBATE-20, PHOSPHORIC ACID, PEG-12 DIMETHICONE, OCIMUM BASILICUM (SWEET BASIL) EXTRACT, LINALOOL, MENTHA PIPERITA (PEPPERMINT) OIL, METHYLPARABEN, LACTIC ACID, HYDROXYCITRONELLAL, HYDROGEN PEROXIDE, GLYCERYL STEARATE SE, GLYCERIN, FD&C YELLOW 5, FD&C YELLOW 6, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, ETHANOLAMINE, ERYTHORBIC ACID, LIMONENE, COCOS NUCIFERA (COCONUT) OIL, EUGENIA CARYOPHYLLUS (CLOVE) FLOWER OIL, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL, CITRUS AURANTIFOLIA (LIME) OIL, BUTYLPARABEN, CARAMEL, CETYL ALCOHOL, CITRIC ACID, CITRONELLOL, BUTYLENE GLYCOL, BENZYL SALICYLATE, BENZYL ALCOHOL
Used in food or as an additive with limited or no toxicity information available		THYMUS VULGARIS (COMMON THYME) EXTRACT
Designated as safe for general or specific, limited use in food		ALOE BARBADENSIS (ALOE VERA) GEL, ALPHA-ISOMETHYL IONONE, AMMONIUM HYDROXIDE
Used in food or as an additive with limited or no toxicity information available		OCIMUM BASILICUM (SWEET BASIL) EXTRACT, CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Suspected to be an environmental toxin		TRIDECETH-12
Wildlife and environmental toxicity		PROPYLPARABEN, AMMONIUM HYDROXIDE, LIMONENE, P-AMINOPHENOL, P-PHENYLENEDIAMINE
Not suspected to be an environmental toxin		PHOSPHORIC ACID
Suspected to be an environmental toxin		CETYL ALCOHOL, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at low doses		CETEARETH-20, BENZYL ALCOHOL
One or more animal studies show skin irritation at very low doses		LINALOOL, LACTIC ACID, AMMONIUM LAURYL SULFATE, CETYL ALCOHOL, CITRONELLOL
Human skin irritant - moderate evidence		PHOSPHORIC ACID, HYDROGEN PEROXIDE, ETHANOLAMINE, AMMONIUM HYDROXIDE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	STEARYL ALCOHOL, SODIUM LAURETH SULFATE, BUTYLENE GLYCOL
Classified as skin irritant		PROPYLENE GLYCOL, PHENOXYETHANOL, P-PHENYLENEDIAMINE, LIMONENE
One or more animal studies show skin irritation at high doses		SODIUM SULFITE, 4-AMINO-2-HYDROXYTOLUENE
One or more animal studies show skin irritation at moderate doses		TRIDECETH-12, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, POLYSORBATE-20, QUATERNIUM-10, GLYCOL STEARATE, P-AMINOPHENOL, CITRUS AURANTIFOLIA (LIME) OIL, GLYCERIN, CITRIC ACID
One or more animal studies show skin irritation at low doses		CYMBOPOGON SCHOENANTHUS OIL
One or more animal studies show skin irritation at moderate doses		BUTYLPARABEN
One or more animal studies show skin irritation at low doses		TETRASODIUM EDTA, CETEARETH-23, METHYLPARABEN, HYDROXYCITRONELLAL, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL, CETEARETH-60

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Missing safety data noted by cosmetic industry review		PENTASODIUM PENTETATE, PHENYL METHYL PYRAZOLONE
Safety assessment was based on related chemical		PROPYLENE GLYCOL, AMODIMETHICONE, PENTASODIUM PENTETATE, ISOBUTYLPARABEN
Insufficient data to determine safety		PHENYL METHYL PYRAZOLONE, P-PHENYLENEDIAMINE, 4-AMINO-2-HYDROXYTOLUENE, O-AMINOPHENOL, P-AMINOPHENOL
Missing safety data noted by cosmetic industry review		P-PHENYLENEDIAMINE, P-AMINOPHENOL, O-AMINOPHENOL, ISOSTEARIC ACID, ALOE BARBADENSIS (ALOE VERA) GEL
Considered safe based on assumption of low absorption		4-AMINO-2-HYDROXYTOLUENE
Missing safety data noted by cosmetic industry review		4-AMINO-2-HYDROXYTOLUENE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		TOCOPHERYL ACETATE, TETRASODIUM EDTA, STEARYL ALCOHOL, SODIUM SULFITE, SODIUM LAURETH SULFATE, POLYQUATERNIUM-10, POLYSORBATE-20, PROPYLPARABEN, PHENYL METHYL PYRAZOLONE, PHENOXYETHANOL, PENTASODIUM PENTETATE, PEG-12 DIMETHICONE, P-PHENYLENEDIAMINE, O-AMINOPHENOL, P-AMINOPHENOL, METHYLPARABEN, ISOSTEARIC ACID, GLYCERYL STEARATE SE, GLYCOL STEARATE, HYDROLYZED COLLAGEN, ERYTHORBIC ACID, ETHYLPARABEN, AMODIMETHICONE, CETYL ALCOHOL, CETEARYL ALCOHOL, BUTYLPARABEN, BUTYLENE GLYCOL, 4-AMINO-2-HYDROXYTOLUENE
Not assessed for safety in cosmetics by industry panel		CITRUS GRANDIS (GRAPEFRUIT) SEED OIL, MENTHA VIRIDIS (SPEARMINT) LEAF OIL, WHEAT AMINO ACIDS, TRIDECETH-12, EUGENIA CARYOPHYLLUS (CLOVE), EUCALYPTUS GLOBULUS, CYMBOPOGON SCHOENANTHUS OIL, CITRUS AURANTIUM BERGAMIA (BERGAMOT) FRUIT OIL, CITRUS AURANTIFOLIA, THYMUS VULGARIS (COMMON THYME) EXTRACT, SYMPHYTUM OFFICINALE (COMFREY) LEAF EXTRACT, STEARAMIDOPROPYL DIMETHYLAMINE, SODIUM STANNATE, SALVIA OFFICINALIS (SAGE) LEAF EXTRACT, ROSMARINUS OFFICINALIS (ROSEMARY) LEAF EXTRACT, PPG-1 TRIDECETH-6, POLYQUATERNIUM-59, POLYQUATERNIUM-37, POLYQUATERNIUM-28, POLYGALA SENEGA (SENEGA SNAKE) ROOT EXTRACT, PHOSPHORIC ACID, OCIMUM BASILICUM (SWEET BASIL) EXTRACT, NASTURTIUM OFFICINALE (WATERCRESS) EXTRACT, LINALOOL, LAURETH-1, HYDROXYCITRONELLAL, HYDROLYZED WHEAT STARCH, HYDROLYZED WHEAT PROTEIN, HYDROGEN PEROXIDE, GLYCERIN, FRAGRANCE, EUCALYPTUS GLOBULUS (EUCALYPTUS) LEAF OIL, LIMONENE, DICAPRYLATE/ DICAPRATE, COUMARIN, COCOS NUCIFERA (COCONUT) OIL, EUGENIA CARYOPHYLLUS (CLOVE) FLOWER OIL, CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL, CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT, CITRUS AURANTIFOLIA (LIME) OIL, CITRONELLOL, CITRIC ACID, CHAMOMILLA RECUTITA (MATRICARIA) FLOWER EXTRACT, CARAMEL, BENZYL SALICYLATE, AMMONIUM HYDROXIDE, ALPHA-ISOMETHYL IONONE, ALLANTOIN, ACTINIDIA CHINENSIS (KIWI) EXTRACT, ACRYLATES/ STEARETH-20 ITACONATE COPOLYMER

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
No workplace limits set		LACTIC ACID
Allowed workplace exposures restricted to moderate doses		GLYCERIN
Allowed workplace exposures restricted to low doses		SODIUM STANNATE, PHOSPHORIC ACID,
Allowed workplace exposures restricted to low doses		TETRASODIUM EDTA, PHENOXYETHANOL, P-AMINOPHENOL, O-AMINOPHENOL, HYDROGEN PEROXIDE, ETHANOLAMINE, BENZYL ALCOHOL
Allowed workplace exposures restricted to very low doses		P-PHENYLENEDIAMINE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Interferes with gene expresion		METHYLPARABEN, BUTYLPARABEN
One or more animal studies show blood sugar changes at high doses where the human health implications are not yet well understood		PROPYLENE GLYCOL, HYDROGEN PEROXIDE, GLYCERIN
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		P-AMINOPHENOL
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CITRIC ACID
One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood		COUMARIN