CloSYS Oral Spray (2007 formulation) || Skin Deep: Cosmetic Safety Reviews

CLOSYS ORAL SPRAY (2007 FORMULATION)

last updated: 08/15/07 brand: by

SCORE

moderate hazard (out of 10)

73%

data gap

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COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Water; Flavor; Chlorine Dioxide; Glycerin; Tween 20; Menthol; Saccharin; Methyl Paraben; Sodium Citrate; Sodium Benzoate

Warnings from packaging: Avoid spraying into eyes or on clothes. Keep out of reach of children.

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ingredients

	score	data gap	concerns
METHYLPARABEN	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
FLAVOR	4	100%	Miscellaneous
MENTHOL	2	85%	Multiple, additive exposure sources
SACCHARIN	3	84%	Cancer, Developmental/reproductive toxicity, Multiple, additive exposure sources
CHLORINE DIOXIDE	3	76%	Developmental/reproductive toxicity, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
GLYCERIN	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
SODIUM BENZOATE	2	69%	Organ system toxicity (non-reproductive)
POLYSORBATE-20 TWEEN 20	1	84%	none identified
SODIUM CITRATE	0	94%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more in vitro tests on mammalian cells show positive mutation results		SODIUM BENZOATE, METHYLPARABEN, MENTHOL, GLYCERIN
Cancer - not classifiable/not likely to be human carcinogen		CHLORINE DIOXIDE
Cancer - not classifiable/not likely to be human carcinogen		SACCHARIN

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		SODIUM BENZOATE, POLYSORBATE-20
Limited evidence of reproductive toxicity		CHLORINE DIOXIDE
One or more animal studies show reproductive effects at moderate doses		GLYCERIN
Limited evidence of developmental toxicity		SACCHARIN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		SODIUM BENZOATE
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		GLYCERIN
One or more animal studies show brain and nervous system effects at moderate doses		SODIUM BENZOATE, METHYLPARABEN, MENTHOL

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		GLYCERIN
Human any disruptor - strong evidence		METHYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Human skin toxicant - strong evidence		METHYLPARABEN

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Persistent, bioaccumulative in wildlife		CHLORINE DIOXIDE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show gastrointestinal effects at high doses (low dose studies may be unavailable for this ingredient)		POLYSORBATE-20
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)		SACCHARIN
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		MENTHOL
Limited evidence of respiratory toxicity		CHLORINE DIOXIDE
One or more animal studies show broad systemic effects at low doses		SODIUM BENZOATE
One or more animal studies show kidney or renal system effects at very low doses		GLYCERIN
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FLAVOR
Occupational hazards related to handling		CHLORINE DIOXIDE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		CHLORINE DIOXIDE, SODIUM CITRATE, SODIUM BENZOATE, SACCHARIN, POLYSORBATE-20, METHYLPARABEN, MENTHOL, GLYCERIN
Used in food or as an additive with limited or no toxicity information available		SACCHARIN, MENTHOL

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Wildlife and environmental toxicity		CHLORINE DIOXIDE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show skin irritation at high doses		SODIUM BENZOATE
One or more animal studies show skin irritation at moderate doses		POLYSORBATE-20, MENTHOL, GLYCERIN
One or more animal studies show skin irritation at low doses		METHYLPARABEN
Human skin irritant - moderate evidence		CHLORINE DIOXIDE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety unknown for products that may be inhaled	products that may be aerosolized (airborne)	SODIUM BENZOATE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		POLYSORBATE-20
Insufficient data to determine safety		CHLORINE DIOXIDE
Not assessed for safety in cosmetics by industry panel		FLAVOR, CHLORINE DIOXIDE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		METHYLPARABEN
Not assessed for safety in cosmetics by industry panel		SODIUM CITRATE, SACCHARIN, MENTHOL, GLYCERIN

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to very low doses		CHLORINE DIOXIDE
Allowed workplace exposures restricted to moderate doses		GLYCERIN

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		GLYCERIN, SODIUM BENZOATE
Interferes with gene expresion		METHYLPARABEN