Skin Effects Starter Kit (2007 formulation) || Skin Deep: Cosmetic Safety Reviews

SKIN EFFECTS STARTER KIT (2007 FORMULATION)

last updated: 08/15/07 brand: Skin Effects by Dr. Dover's Skincare

SCORE

	health hazard
	sun hazard

83%

data gap

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95% of exfoliant/scrubs have lower concerns
96% of facial cleansers have lower concerns
95% of around-eye creams have lower concerns
93% of anti-agings have lower concerns
99% of sunscreen: makeups have lower concerns

COMPANY POLICIES

Compact for Safe Cosmetics
Non-signer: This company has not signed the Compact.

Animal Testing Policy
This company's animal testing policy is unknown.

Sunscreen effectiveness* breakdown

6	UVB hazard/exposure score
6	UVA hazard/exposure score
5	sunscreen instability

*Note that the same active ingredient combination may score differently in two different products depending on the concentration of the ingredients and the mixture of inactive ingredients.

Active ingredient UV
blocking strength

Product total

OCTINOXATE (OCTYL METHOXYCINNAMATE) (7.5%)

OXYBENZONE (BENZOPHENONE-3) (7.5%)

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to one or more ingredients in this product -- not the product itself -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

Ingredients in this product are linked to:
	Cancer
	Developmental/reproductive toxicity
	Violations, restrictions & warnings
	Allergies/immunotoxicity
	Other concerns for ingredients used in this product: Neurotoxicity, Endocrine disruption, Persistence and bioaccumulation, Organ system toxicity (non-reproductive), Miscellaneous, Multiple, additive exposure sources, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns, Occupational hazards, Biochemical or cellular level changes

Ingredients from packaging: Active Ingredients: Deep-Cleaning Enzyme Scrub: Purified Water; Polyethylene; Butylene Glycol; Caprylic/Capric Triglyceride; Stearic Acid; Glyceryl Stearate SE; Propylene Glycol Dicaprylate/Dicaprate; Kaolin; Glycol Stearate; PEG-8; Isocetyl Stearoyl Stearate; PEG-100 Stearate; Dimethicone; Papain; Hydrogenated Jojoba Oil; Tocopheryl Acetate; Retinyl Palmitate; Cetyl Alcohol; Sodium PCA; Aloe Barbadensis Leaf Extract; Panthenol; Magnesium Ascorbyl Phosphate; Allantoin; Arnica Montana Flower Extract; Carica Papaya Fruit Extract; Parfum (Fragrance); Disodium EDTA; Triethanolamine; Phenoxyethanol; Methylparaben; Propylparaben; Butylparaben; Ethylparaben; Isobutylparaben; Green 3 (CI 42053); Yellow 5 (CI 19140). Intensive Eye Treatment With Vitamin C: Purified Water; Cyclopentasiloxane; Cyclomethicone; Butylene Glycol; PEG/PPG-18/18 Dimethicone; Glycerin; Glyceryl Polyacrylate; Phenyl Trimethicone; Polysilicone-11; Nylon 12; Ascorbic Acid Polypeptyde; Tocopheryl Polypeptide; Glycyrrhiza Glabra (Licorice) Extract; Sodium PCA; Glycine Soja (Soybean) Oil; Borago Officinalis (Borage) Seed Oil; Bisabolol; Sodium Acrylate/Acryloyldimethyl Taurate; Copolymer; Isohexadecane; Polysorbate 80; Echinacea Angustifolia (Coneflower) Extract; Archangelica Root (Angelica) Extract; Euphrasia Officinalis (Eyebright) Extract; Camellia Sinensis Leaf Extract; Equisetum Arvense (Horsetail) Extract; Centella Asiatica (Gotu Cola) Extract; Vitis Vinifera (Grape) Seed Extract; Sodium Hyaluronate; Parfum (Fragrance); Carbomer; Triethanolamine; Disodium EDTA; Diazolidinyl Urea; Iodopropynyl Butylcarbamate. Anti-Aging Cream: Octinoxate 7.5%; Oxybenzone 7.5% ; Inactive Ingredients: Anti-Aging Cream: Aqua (Water); Octyldecyl Noepentanoate; C12-15 Alkyl Benzoate; Cetyl Alcohol; Glyceryl Stearate; PEG-100 Stearate; Steareth-20; Ceteth-2; Glycerin; Dimethicone; Propylene Glycol; Hydrolyzed Rice Protein; Polyglyceryl-3 Laurate; Camellia Sinensis Leaf Extract; Cyclomethicone; Aloe Barbadensis Leaf Extract; Tocopheryl Acetate; Retinyl Palmitate; Ascorbyl Palmitate; Glycine Soja (Soybean) Oil; Ethylhexyl Cocoate; Lecithin; Glycolipids; Retinol; Bisabolol; Triticum Vulgare (Wheat) Germ Oil; Butyrospermum Parkii (Shea Butter); Glycol Stearate; Parfum (Fragrance); Carbomer; Triethanolamine; Phenoxyethanol; Methylparaben; Propylparaben; Butylparaben; Ethylparaben; Isobutylparaben

Warnings from packaging: Discontinue use if signs of irritation develop. Keep out of reach of children. For external use only; not to be swallowed. Anti-Aging Cream: For external use only. Discontinue use if signs of irritation develop. Keep out of reach of children.

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ingredients

	score	data gap	concerns
METHYLPARABEN (Active Ingredient)	10	63%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Biochemical or cellular level changes
OXYBENZONE (BENZOPHENONE-3) (Active Ingredient)	9	55%	Developmental/reproductive toxicity, Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
FRAGRANCE	8	100%	Neurotoxicity, Allergies/immunotoxicity, Miscellaneous
POLYETHYLENE (Active Ingredient)	6	69%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
OCTINOXATE (OCTYL METHOXYCINNAMATE) (Active Ingredient)	8	65%	Violations, restrictions & warnings, Endocrine disruption, Allergies/immunotoxicity, Persistence and bioaccumulation, Enhanced skin absorption, Biochemical or cellular level changes
PEG-100 STEARATE (Active Ingredient)	4	69%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
BUTYLPARABEN (Active Ingredient)	6	79%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PEG-8 (Active Ingredient)	4	76%	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
PEG/ PPG-18/ 18 DIMETHICONE (Active Ingredient)	4	75%	Organ system toxicity (non-reproductive), Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE)
LECITHIN	3	70%	Multiple, additive exposure sources, Enhanced skin absorption, Contamination concerns (NITROSAMINES)
IODOPROPYNYL BUTYLCARBAMATE (Active Ingredient)	4	65%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
DIAZOLIDINYL UREA (Active Ingredient)	6	59%	Allergies/immunotoxicity, Contamination concerns (FORMALDEHYDE)
TRIETHANOLAMINE (Active Ingredient)	6	58%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Contamination concerns (NITROSAMINES), Occupational hazards
ETHYLPARABEN (Active Ingredient)	5	80%	Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
PROPYLPARABEN (Active Ingredient)	5	71%	Developmental/reproductive toxicity, Endocrine disruption, Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
VITAMIN A RETINOL	5	70%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
RETINYL PALMITATE (Active Ingredient)	5	68%	Cancer, Developmental/reproductive toxicity, Violations, restrictions & warnings, Organ system toxicity (non-reproductive), Biochemical or cellular level changes
PAPAIN (Active Ingredient)	5	68%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
HYDROLYZED RICE PROTEIN	4	99%	Contamination concerns (GOSSYPOL, HEAVY METALS, ORGANOCHLORINES, PESTICIDES)
TOCOPHERYL ACETATE (Active Ingredient)	4	81%	Allergies/immunotoxicity, Contamination concerns (HYDROQUINONE)
FD&C GREEN 3 GREEN 3 (CI 42053)	4	73%	Violations, restrictions & warnings
PHENOXYETHANOL (Active Ingredient)	4	67%	Violations, restrictions & warnings, Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Occupational hazards
PROPYLENE GLYCOL (Active Ingredient)	4	60%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs), Enhanced skin absorption
CETETH-2	3	99%	Contamination concerns (ETHYLENE OXIDE, 1,4-DIOXANE, ETHYLENE OXIDE, 1,4-DIOXANE)
ISOBUTYLPARABEN (Active Ingredient)	3	83%	Allergies/immunotoxicity, Organ system toxicity (non-reproductive)
FD&C YELLOW 5 YELLOW 5 (CI 19140)	2	82%	Neurotoxicity, Organ system toxicity (non-reproductive)
CYCLOPENTASILOXANE (Active Ingredient)	2	79%	Persistence and bioaccumulation
DISODIUM EDTA (Active Ingredient)	3	78%	Neurotoxicity, Organ system toxicity (non-reproductive), Enhanced skin absorption
DIMETHICONE (Active Ingredient)	2	74%	Violations, restrictions & warnings
GLYCERYL POLYACRYLATE (Active Ingredient)	3	74%	Violations, restrictions & warnings, Irritation (skin, eyes, or lungs), Enhanced skin absorption, Contamination concerns (GLYCERYL DIESTERS)
PANTHENOL (Active Ingredient)	2	88%	Multiple, additive exposure sources
CYCLOMETHICONE (Active Ingredient)	2	83%	Persistence and bioaccumulation, Organ system toxicity (non-reproductive)
POLYSORBATE-80 (Active Ingredient)	2	80%	Developmental/reproductive toxicity
KAOLIN (Active Ingredient)	1	79%	Occupational hazards
CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT CAMELLIA SINENSIS LEAF EXTRACT (Active Ingredient)	2	76%	Violations, restrictions & warnings
GLYCERIN (Active Ingredient)	2	74%	Organ system toxicity (non-reproductive), Occupational hazards
STEARIC ACID (Active Ingredient)	2	74%	Neurotoxicity, Irritation (skin, eyes, or lungs)
SODIUM PCA (Active Ingredient)	2	71%	Contamination concerns (NITROSAMINES)
VITIS VINIFERA (GRAPE) SEED EXTRACT	1	100%	Multiple, additive exposure sources
ANGELICA ARCHANGELICA ROOT EXTRACT ARCHANGELICA ROOT (ANGELICA) EXTRACT	1	100%	Multiple, additive exposure sources
C12-15 ALKYL BENZOATE	0	94%	none identified
CAPRYLIC/ CAPRIC TRIGLYCERIDE (Active Ingredient)	0	94%	none identified
ISOHEXADECANE (Active Ingredient)	0	94%	none identified
PHENYL TRIMETHICONE (Active Ingredient)	0	93%	none identified
ASCORBIC ACID (VITAMIN C) INTENSIVE EYE TREATMENT WITH VITAMIN C (Active Ingredient)	1	91%	none identified
TRITICUM VULGARE (WHEAT) GERM OIL	1	90%	none identified
PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE (Active Ingredient)	0	90%	Enhanced skin absorption
ASCORBYL PALMITATE (VITAMIN C PALMITATE)	1	88%	none identified
GLYCERYL MONOSTEARATE GLYCERYL STEARATE (Active Ingredient)	1	88%	none identified
GLYCINE SOJA (SOYBEAN) OIL	1	88%	none identified
STEARETH-20	1	88%	none identified
CETYL ALCOHOL (Active Ingredient)	1	87%	Organ system toxicity (non-reproductive), Irritation (skin, eyes, or lungs)
GLYCOL STEARATE (Active Ingredient)	1	87%	none identified
SODIUM HYALURONATE (Active Ingredient)	1	83%	none identified
BISABOLOL (Active Ingredient)	1	80%	Enhanced skin absorption
BUTYLENE GLYCOL (Active Ingredient)	1	79%	Irritation (skin, eyes, or lungs)
ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT ALOE BARBADENSIS LEAF EXTRACT (Active Ingredient)	1	75%	none identified
ARNICA MONTANA (ARNICA) FLOWER EXTRACT ARNICA MONTANA FLOWER EXTRACT (Active Ingredient)	0	100%	none identified
ASCORBIC ACID POLYPEPTIDE ASCORBIC ACID POLYPEPTYDE (Active Ingredient)	0	100%	none identified
BORAGO OFFICINALIS (BORAGE) SEED OIL	0	100%	none identified
CARICA PAPAYA (PAPAYA) FRUIT EXTRACT CARICA PAPAYA FRUIT EXTRACT (Active Ingredient)	0	100%	none identified
CENTELLA ASIATICA (GOTU KOLA) EXTRACT CENTELLA ASIATICA (GOTU COLA) EXTRACT	0	100%	none identified
ECHINACEA ANGUSTIFOLIA (CONEFLOWER) EXTRACT	0	100%	none identified
EQUISETUM ARVENSE (HORSETAIL) EXTRACT	0	100%	none identified
ETHYLHEXYL COCOATE	0	100%	none identified
GLYCOLIPIDS	0	100%	none identified
GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT GLYCYRRHIZA GLABRA (LICORICE) EXTRACT	0	100%	none identified
ISOCETYL STEAROYL STEARATE (Active Ingredient)	0	100%	none identified
OCTYLDODECYL NEOPENTANOATE OCTYLDECYL NOEPENTANOATE	0	100%	none identified
POLYGLYCERYL-3 LAURATE	0	100%	none identified
POLYSILICONE-11 (Active Ingredient)	0	100%	none identified
TOCOPHERYL POLYPEPTIDE (Active Ingredient)	0	100%	none identified
EUPHRASIA OFFICINALIS (EYEBRIGHT) EXTRACT	0	100%	none identified
HYDROGENATED JOJOBA OIL (Active Ingredient)	0	100%	none identified
SODIUM ACRYLATE/ACRYLOYLDIMETHYL TAURATE COPOLYMER (Active Ingredient)	0	100%	none identified
MAGNESIUM ASCORBYL PHOSPHATE (Active Ingredient)	0	99%	none identified
ALLANTOIN (Active Ingredient)	0	94%	none identified
BUTYROSPERMUM PARKII (SHEA BUTTER)	0	94%	none identified
NYLON-12 (Active Ingredient)	0	94%	none identified
CARBOMER (Active Ingredient)	0	93%	none identified
GLYCERYL STEARATE SE (Active Ingredient)	0	93%	none identified
WATER	0	0%	innocuous

Cancer*

*This table includes all possible cancer concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show tumor formation at moderate doses		PEG-100 STEARATE
One or more in vitro tests on mammalian cells show positive mutation results		PROPYLPARABEN
One or more in vitro tests non-mammalian cells show positive mutation results		TRITICUM VULGARE (WHEAT) GERM OIL, PHENOXYETHANOL, OXYBENZONE (BENZOPHENONE-3), GLYCINE SOJA (SOYBEAN) OIL
One or more animal studies show tumor formation at moderate doses		CYCLOPENTASILOXANE
One or more in vitro tests on mammalian cells show positive mutation results		TOCOPHERYL ACETATE, PROPYLENE GLYCOL, POLYSORBATE-80, METHYLPARABEN, GLYCERIN, FD&C YELLOW 5, ETHYLPARABEN, DISODIUM EDTA, DIAZOLIDINYL UREA, BUTYLPARABEN, ASCORBIC ACID (VITAMIN C)
Cancer - limited evidence		VITAMIN A, RETINYL PALMITATE
Not likely to be carcinogenic in humans		STEARIC ACID
Cancer - not classifiable/not likely to be human carcinogen		FD&C GREEN 3, POLYETHYLENE, TRIETHANOLAMINE

Developmental/reproductive toxicity*

*This table includes all possible developmental/reproductive toxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show reproductive effects at high doses		PEG-100 STEARATE, PAPAIN, KAOLIN, FD&C YELLOW 5, ETHYLPARABEN, DISODIUM EDTA, BUTYLENE GLYCOL
One or more animal studies show reproductive effects at moderate doses		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show reproductive effects at moderate doses		SODIUM HYALURONATE, PROPYLENE GLYCOL, GLYCERIN
Limited evidence of developmental toxicity		OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show reproductive effects at low doses		VITAMIN A, RETINYL PALMITATE,
One or more animal studies show any effects at low doses		PROPYLPARABEN
One or more animal studies show reproductive effects at very low doses		POLYSORBATE-80,
One or more animal studies show any effects at very low doses		BUTYLPARABEN

Violations, restrictions & warnings*

*This table includes all possible violations, restrictions & warnings concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		PEG-100 STEARATE, TRIETHANOLAMINE, SODIUM PCA, PEG/ PPG-18/ 18 DIMETHICONE, POLYETHYLENE, PROPYLENE GLYCOL, LECITHIN, PEG-8
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		GLYCERYL POLYACRYLATE
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications		ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT, IODOPROPYNYL BUTYLCARBAMATE, DIAZOLIDINYL UREA
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel		DIMETHICONE, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics		RETINYL PALMITATE, VITAMIN A
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)	products for use around the eyes; products for use on the lips	OCTINOXATE (OCTYL METHOXYCINNAMATE)
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)		OXYBENZONE (BENZOPHENONE-3), IODOPROPYNYL BUTYLCARBAMATE, PHENOXYETHANOL, IODOPROPYNYL BUTYLCARBAMATE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	products for use around the eyes	FD&C GREEN 3
Violation of government restrictions - Banned or found unsafe for use in cosmetics		METHYLPARABEN

Neurotoxicity*

*This table includes all possible neurotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show brain and nervous system effects at high doses		VITAMIN A, RETINYL PALMITATE, PROPYLENE GLYCOL, POLYSORBATE-80, POLYETHYLENE, OXYBENZONE (BENZOPHENONE-3), GLYCERIN, DIAZOLIDINYL UREA, BUTYLENE GLYCOL
One or more animal studies show brain and nervous system effects at moderate doses		SODIUM HYALURONATE, METHYLPARABEN, PHENOXYETHANOL, KAOLIN, LECITHIN, BISABOLOL
One or more animal studies show brain and nervous system effects at low doses		DISODIUM EDTA
One or more animal studies show any effects at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show brain and nervous system effects at very low doses		STEARIC ACID
Moderate evidence of human neurotoxicity		FRAGRANCE
One or more animal studies show brain and nervous system effects at very low doses		FD&C YELLOW 5

Endocrine disruption*

*This table includes all possible endocrine disruption concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show endocrine system disruption at high doses		TRIETHANOLAMINE, SODIUM PCA, GLYCERIN, DISODIUM EDTA, DIAZOLIDINYL UREA, BUTYLENE GLYCOL, BISABOLOL
One or more animal studies show endocrine disruption at moderate doses		CYCLOPENTASILOXANE
One or more animal studies show endocrine disruption at moderate doses		ISOBUTYLPARABEN
Human any disruptor - strong evidence		PROPYLPARABEN
Human any disruptor - moderate evidence		OXYBENZONE (BENZOPHENONE-3)
Human any disruptor - strong evidence		METHYLPARABEN, OCTINOXATE (OCTYL METHOXYCINNAMATE), ETHYLPARABEN, BUTYLPARABEN

Allergies/immunotoxicity*

*This table includes all possible allergies/immunotoxicity concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Limited evidence of skin and immune system toxicity		PHENOXYETHANOL
One or more human case studies show possible photoallergic effects		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Human immune system toxicant - moderate evidence		POLYETHYLENE
Human skin toxicant - strong evidence		ISOBUTYLPARABEN, METHYLPARABEN, PROPYLPARABEN, TOCOPHERYL ACETATE
Limited evidence of skin and immune system toxicity		PROPYLENE GLYCOL
Human skin toxicant - strong evidence		ETHYLPARABEN, BUTYLPARABEN, IODOPROPYNYL BUTYLCARBAMATE
Known human immune system toxicant		PAPAIN, DIAZOLIDINYL UREA
Possible human photoallergenic toxicant		OXYBENZONE (BENZOPHENONE-3)
Known human immune system toxicant		TRIETHANOLAMINE, FRAGRANCE

Persistence and bioaccumulation*

*This table includes all possible persistence and bioaccumulation concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not suspected to be bioaccumulative		TRIETHANOLAMINE
Ingredient is suspected or measured to accumulate in people		OXYBENZONE (BENZOPHENONE-3)
Not suspected to be persistent		CETYL ALCOHOL
Ingredient is suspected or measured to accumulate in people		OCTINOXATE (OCTYL METHOXYCINNAMATE)
Persistent, bioaccumulative in wildlife		CYCLOPENTASILOXANE, CYCLOMETHICONE

Organ system toxicity (non-reproductive)*

*This table includes all possible organ system toxicity (non-reproductive) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		OCTINOXATE (OCTYL METHOXYCINNAMATE)
One or more animal studies show liver effects at high doses (low dose studies may be unavailable for this ingredient)		BISABOLOL
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	PROPYLENE GLYCOL, SODIUM HYALURONATE, TRITICUM VULGARE (WHEAT) GERM OIL
One or more animal studies show broad systemic effects at high doses (low dose studies may be unavailable for this ingredient)		ASCORBYL PALMITATE (VITAMIN C PALMITATE), DIAZOLIDINYL UREA, GLYCINE SOJA (SOYBEAN) OIL, PANTHENOL, SODIUM PCA, STEARIC ACID
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	POLYSORBATE-80, CYCLOPENTASILOXANE, CYCLOMETHICONE, CETYL ALCOHOL
One or more animal studies show cardiovascular effects at moderate doses (low dose studies may be unavailable for this ingredient)		OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show sense organ effects at moderate doses (low dose studies may be unavailable for this ingredient)	products for use around the eyes, mouth, or lips	BUTYLENE GLYCOL
One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)		STEARETH-20, GLYCOL STEARATE, TOCOPHERYL ACETATE, GLYCERYL MONOSTEARATE
Limited evidence of skin toxicity		VITAMIN A, RETINYL PALMITATE, PEG/ PPG-18/ 18 DIMETHICONE, PEG-8, PROPYLPARABEN, ISOBUTYLPARABEN, IODOPROPYNYL BUTYLCARBAMATE, BUTYLPARABEN, ETHYLPARABEN, PEG-100 STEARATE
One or more animal studies show broad systemic effects at low doses		DISODIUM EDTA
One or more animal studies show sense organ effects at very low doses	products for use around the eyes, mouth, or lips	PHENOXYETHANOL
One or more animal studies show musculoskeletal effects at very low doses		FD&C YELLOW 5, GLYCERIN
Possible human immune system toxicant		PAPAIN, POLYETHYLENE, TRIETHANOLAMINE
Known human any toxicant		METHYLPARABEN

Miscellaneous*

*This table includes all possible miscellaneous concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Ingredient not fully labeled - identity unknown		FRAGRANCE

Multiple, additive exposure sources*

*This table includes all possible multiple, additive exposure sources concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Designated as safe for general or specific, limited use in food		PEG-100 STEARATE, PAPAIN, VITAMIN A, TRIETHANOLAMINE, TOCOPHERYL ACETATE, STEARIC ACID, RETINYL PALMITATE, PROPYLPARABEN, PROPYLENE GLYCOL, POLYSORBATE-80, POLYETHYLENE, PEG/ PPG-18/ 18 DIMETHICONE, PEG-8, METHYLPARABEN, LECITHIN, GLYCERYL STEARATE SE, GLYCERYL MONOSTEARATE, GLYCERIN, FD&C YELLOW 5, FD&C GREEN 3, DISODIUM EDTA, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, CETYL ALCOHOL, DIMETHICONE, ARNICA MONTANA (ARNICA) FLOWER EXTRACT, ASCORBIC ACID (VITAMIN C), ASCORBYL PALMITATE (VITAMIN C PALMITATE), BUTYLENE GLYCOL, BUTYLPARABEN
Used in food or as an additive with limited or no toxicity information available		PANTHENOL, VITIS VINIFERA (GRAPE) SEED EXTRACT, ANGELICA ARCHANGELICA ROOT EXTRACT, LECITHIN

Ecotoxicology*

*This table includes all possible ecotoxicology concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Wildlife and environmental toxicity		PROPYLPARABEN
Wildlife and environmental toxicity		OCTINOXATE (OCTYL METHOXYCINNAMATE), OXYBENZONE (BENZOPHENONE-3)
Not suspected to be an environmental toxin		TRIETHANOLAMINE
Suspected to be an environmental toxin		CETYL ALCOHOL, CYCLOMETHICONE

Irritation (skin, eyes, or lungs)*

*This table includes all possible irritation (skin, eyes, or lungs) concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Not likely to be a skin irritant in humans		OXYBENZONE (BENZOPHENONE-3)
One or more animal studies show skin irritation at high doses		IODOPROPYNYL BUTYLCARBAMATE
One or more animal studies show skin irritation at moderate doses		VITAMIN A, TRITICUM VULGARE (WHEAT) GERM OIL, SODIUM HYALURONATE, GLYCOL STEARATE, GLYCERIN, CYCLOPENTASILOXANE, CYCLOMETHICONE, BUTYLPARABEN, BISABOLOL
One or more animal studies show skin irritation at low doses		METHYLPARABEN, STEARIC ACID
One or more animal studies show skin irritation at very low doses		PEG-100 STEARATE, TRIETHANOLAMINE
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	POLYETHYLENE
One or more animal studies show skin irritation at very low doses		CETYL ALCOHOL
Classified as irritant		PHENOXYETHANOL, PAPAIN, PROPYLENE GLYCOL
Human any irritant - strong evidence	products for use around the eyes, on the skin, or may be aerosolized (airborne)	BUTYLENE GLYCOL, GLYCERYL POLYACRYLATE

Data gaps*

*This table includes all possible data gaps concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Safety assessment was based on related chemical		CETETH-2, PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE, ASCORBIC ACID (VITAMIN C), MAGNESIUM ASCORBYL PHOSPHATE, PROPYLENE GLYCOL, STEARETH-20, PEG-100 STEARATE, CETETH-2, IODOPROPYNYL BUTYLCARBAMATE, ISOBUTYLPARABEN, GLYCERYL POLYACRYLATE
Considered safe based on assumption of low absorption		POLYETHYLENE
Missing safety data noted by cosmetic industry review		ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT, POLYETHYLENE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product		STEARETH-20, PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE, PEG-100 STEARATE, VITAMIN A, CETETH-2, TRITICUM VULGARE (WHEAT) GERM OIL, TOCOPHERYL ACETATE, RETINYL PALMITATE, STEARIC ACID, PROPYLPARABEN, POLYSORBATE-80, POLYETHYLENE, PHENYL TRIMETHICONE, PEG/ PPG-18/ 18 DIMETHICONE, PHENOXYETHANOL, PANTHENOL, METHYLPARABEN, OXYBENZONE (BENZOPHENONE-3), MAGNESIUM ASCORBYL PHOSPHATE, HYDROLYZED RICE PROTEIN, GLYCERYL STEARATE SE, GLYCOL STEARATE, GLYCERYL MONOSTEARATE, GLYCERYL POLYACRYLATE, ETHYLPARABEN, DISODIUM EDTA, DIMETHICONE, CYCLOMETHICONE, CETYL ALCOHOL, CARBOMER, BUTYLPARABEN, ASCORBYL PALMITATE (VITAMIN C PALMITATE), BISABOLOL, BUTYLENE GLYCOL, ASCORBIC ACID (VITAMIN C)
Not assessed for safety in cosmetics by industry panel		SODIUM ACRYLATE/ACRYLOYLDIMETHYL TAURATE COPOLYMER, PAPAIN, HYDROGENATED JOJOBA OIL, EUPHRASIA OFFICINALIS (EYEBRIGHT) EXTRACT, ANGELICA ARCHANGELICA ROOT EXTRACT, VITIS VINIFERA (GRAPE) SEED EXTRACT, TOCOPHERYL POLYPEPTIDE, POLYSILICONE-11, POLYGLYCERYL-3 LAURATE, OCTYLDODECYL NEOPENTANOATE, NYLON-12, ISOHEXADECANE, ISOCETYL STEAROYL STEARATE, GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT, GLYCOLIPIDS, GLYCINE SOJA (SOYBEAN) OIL, GLYCERIN, FRAGRANCE, ETHYLHEXYL COCOATE, EQUISETUM ARVENSE (HORSETAIL) EXTRACT, CYCLOPENTASILOXANE, ECHINACEA ANGUSTIFOLIA (CONEFLOWER) EXTRACT, CENTELLA ASIATICA (GOTU KOLA) EXTRACT, CARICA PAPAYA (PAPAYA) FRUIT EXTRACT, CAPRYLIC/ CAPRIC TRIGLYCERIDE, C12-15 ALKYL BENZOATE, CAMELLIA SINENSIS (GREEN TEA) LEAF EXTRACT, BUTYROSPERMUM PARKII (SHEA BUTTER), BORAGO OFFICINALIS (BORAGE) SEED OIL, ASCORBIC ACID POLYPEPTIDE, ARNICA MONTANA (ARNICA) FLOWER EXTRACT, ALLANTOIN

Occupational hazards*

*This table includes all possible occupational hazards concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
Allowed workplace exposures restricted to low doses		PHENOXYETHANOL
Allowed workplace exposures restricted to low doses		KAOLIN
Allowed workplace exposures restricted to moderate doses		GLYCERIN, TRIETHANOLAMINE

Biochemical or cellular level changes*

*This table includes all possible biochemical or cellular level changes concerns for the ingredients used by this manufacturer. Some categorizations depend on how the product is used or formulated.

type of concern	product conditions	ingredient(s)
One or more animal studies show blood sugar changes at high doses where the human health implications are not yet well understood		PROPYLENE GLYCOL
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.		OXYBENZONE (BENZOPHENONE-3), RETINYL PALMITATE, VITAMIN A, OCTINOXATE (OCTYL METHOXYCINNAMATE)
Interferes with gene expresion		BUTYLPARABEN, METHYLPARABEN
One or more animal studies show biochemical changes at high doses where the human health implications are not yet well understood		CYCLOMETHICONE, CYCLOPENTASILOXANE, GLYCERIN, POLYETHYLENE